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Doctor insights on: Intravascular Hemolysis

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Doctors, what is the difference between extravascular and intravascular hemolysis?

Doctors, what is the difference between extravascular and intravascular hemolysis?

See below: Intravascular hemolysis refer to breakdown of red cells in the circulating blood. It the more dangerous of the two types. Extravascular hemolysis occurs when red cells are coated with antibody or complement and are taken up macrophages and destroyed outside the circulating blood. Both cause anemia. ...Read more

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Why are intravascular and extravascular hemolysis dangerous?

Why are intravascular and extravascular hemolysis dangerous?

Oxygen carrying RBC: The red blood cells carry oxygen to the tissues of the body. Hemolysis is breakdown or destruction of red blood cells. Without the RBCs, our tissues including heart and brain cannot get enough oxygen. Taken to the extreme, it could be fatal. ...Read more

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What are the options for treating hemolysis?

What are the options for treating hemolysis?

Depends on cause...: There are a number of causes for hemolysis. One of the most common is autoimmune hemolysis. This can be treated with steroids. Other causes of hemolysis can include medications (treatment is to discontinue medicine) and inherited defects in the red blood cell (g6pd deficiency, hereditary spherocytosis, sickle cell anemia - treatments are largely supportive). ...Read more

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Is it possible for hemolysis to cause hypocalcaemia?

Is it possible for hemolysis to cause hypocalcaemia?

Yes: It can cause it by directly binding calcium, or the subsequent transfusions can lead to hypocalcemia by binding calcium as well. ...Read more

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Why does acid cause hemolysis?

Why does acid cause hemolysis?

Denatures hemoglobin: In the lab, acidic solutions will denature hemoglobin, causing the red cell to hemolyze. Fetal hemoglobin is more resistant to this. This difference is the basis of a test to determine how much fetal blood is mixed in the maternal blood system of mom's who are rh negative, and thus need rhogam. ...Read more

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What does "moderate hemolysis" mean?

Moderate = 8-10 g/dL: Hemolysis = breaking of red cells hemolysis regardless of cause leads to anemia , low hemoglobin this is called anemia. mild anemia ( more than 10 g/ dL) moderate anemia 8-10 g/dL severe anemia less than 8 g/dL moderate hemolysis is hemolysis that leads to moderate anemia ...Read more

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What is hemolysis?

What is hemolysis?

Red cells destroyed: When red blood cells are burst / destroyed, either in the patient or in the specimen tube. In illness, this can result from anything from malaria to running hard and pounding the pavement with one's feet. There are at least a hundred hemolytic anemias. A hemolyzed specimen is dangerous as one can mistakenly think reported labs, especially potassium, are off. ...Read more

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What is the classic sign of hemolysis?

What is the classic sign of hemolysis?

Jaundice, dark urine: Commonly jaundice and dark urine can be seen in a patient having hemolysis. Other signs can be subtle such as increasing weakness, fatigue, shortness of breath etc. A hematologist can do the proper blood work to evaluate ongoing hemolysis. ...Read more

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If my blood results say "slight hemolysis, " what does that mean?

Nothing serious: Sometimes mild trauma can cause this. Sometimes if they used a needle that was too small it can also cause hemolysis. Unless it repeatedly happens, it's likely nothing to worry about. ...Read more

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Is it possible to prevent hemolysis?

Is it possible to prevent hemolysis?

Depends: Are you talking about hemolysis in vivo or in a specimen? There are many caused of hemolysis and each needs a different approach. See this site for info on hemolytic anemia. http://www.ncbi.nlm.nih.gov/pubmedhealth/pmh0001597/. ...Read more

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