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Doctor insights on: Intrahepatic Cholestasis Of Pregnancy Inr

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Is intrahepatic cholestasis of pregnancy painful?

Is intrahepatic cholestasis of pregnancy painful?

NO: Cholestasis of pregnancy does not generally cause pain. The most common symptoms is pruritis (itching). It almost always starts with itching on the palms of the hands and soles of the feet, and it is first noticed at night. The itching spreads to other parts of the body over time. Treatment with ursodiol (bile salts) can improve symptoms. Consultation with a high risk OB is recommended. ...Read more

Dr. Al Hegab
4 doctors shared insights

Pregnancy (Definition)

When your due date arrives, you will be more than ready to have your baby! Most women deliver the baby somewhere between 37 and 42 weeks. According to the American College of Obstetricians and Gynecologists, only 5% of babies arrive on the exact due date. Approximately 7% of babies are not delivered by 42 weeks, and when that happens, it is referred to ...Read more


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What are the tests for intrahepatic cholestasis of pregnancy?

What are the tests for intrahepatic cholestasis of pregnancy?

LFTs, bile acids.: Liver function tests (alt/ast/alkaline phosphatase) and bile acids can clinch the clinical diagnosis of intrahepatic cholestasis of pregnancy - in the absence of cholelithiasis. ...Read more

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Are some people more prone to getting intrahepatic cholestasis of pregnancy?

Yes: There may be some familial predisposition to this disorder as it seems to apear in clusters of related women. It is also more common with multiple pregnancies (twins/triplets) and recurrence risk is as high as 50% or more in subsequent pregnancies. Resolution of symptoms is usually very prompt after delivery. ...Read more

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Are there things I can do for intrahepatic cholestasis of pregnancy at home?

Are there things I can do for intrahepatic cholestasis of pregnancy at home?

Uncertain: Cause and treatment of intra-hepatic cholestasis are uncertain. Since it is often associated with itching, you need to protect your skin with emollients and refrain from scratching your skin. ...Read more

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Could I have icp (intrahepatic cholestasis of pregnancy)? What are the risks?

Icp causes itching: I have only had one patient with icp in 27 years of practicing obstetrics. Diagnosis is made by elevated bile salts (detectable by lab test) and the treatment is cholestyramine. Pregnancy outcome should be unaffected by the condition. So icp is rare and makes you miserable, but should not affect your baby. One case however hardly makes me an expert so second opinions welcome. ...Read more

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How long does pruritus associated with intrahepatic cholestasis of pregnancy last?

Until pregnancy ends: Cholestasis of pregnancy is a considition which generally occurs in the 3rd trimester and is characterized by intense pruritis without rash and increase serum levels of free bile acids. The condition lasts until the pregnancy ends. The pruritis sometimes can be controlled with medications, such as ursodiol. ...Read more

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Which treatment works the best and fastest for intrahepatic cholestasis of pregnancy?

Which treatment works the best and fastest for intrahepatic cholestasis of pregnancy?

See your doc: The one we know it works in relieving the symptoms if itching is the ursodeoxycolic acid. But in pregnancy this is a very serious condition that requires frequent fetal monitoring, maternal monitoring and potentially delivery before your due date. Please see and ob/gyn specialized in high risk pregnancy if you dont have one. ...Read more

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What is the result of liver function tests in intrahepatic cholestasis of pregnancy?

Cholestasis: You could elevated bilirrubin and alkaline phosphatase predominantly. Others sucn as transaminases can be elevated too. They will all normalize upon delivery. ...Read more

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How long does abdominal pain associated with intrahepatic cholestasis of pregnancy last?

How long does abdominal pain associated with intrahepatic cholestasis of pregnancy last?

24-48 hrs: Usually all symptoms of intrahepatic cholestasis of pregnancy resolve within 24-48 hrs after delivery, in rare cases sx may continue to up to one week after and may signify retained placenta. But if you have this condition pregnancy needs to be monitored by obgyn very closely as poor outcomes for the baby are not uncommon if not monitored. ...Read more

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I had intrahepatic cholestasis due to alcohol 8 months ago.I didn't drink 6 months.Now i drink.My GGT is 67, indirect bilirubin is1.2 is it ok to drink?

I had intrahepatic cholestasis due to alcohol 8 months ago.I didn't drink 6 months.Now i drink.My GGT is 67, indirect bilirubin is1.2 is it ok to drink?

Probably not: If you have already had liver problems associated with drinking alcohol, it is likely that you are at risk of recurrance and you likely have some permanent liver damage as well. The safest thing that you can do to optimize your health would be to abstain from drinking alcohol at all. I would discuss this with your GI physician. ...Read more

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What can be done for intraheptic cholestasis of pregnancy?

What can be done for intraheptic cholestasis of pregnancy?

Ursodiol/hydroxyzine: Delivery is the ultimate therapy for cholestasis gravidarum, by 36-38 weeks with 1-2/week fetal surveillance to avoid fetal demise. Oral ursodiol and Hydroxyzine cab help control the bile acid level in the mother's blood stream and decrease her pruritus. ...Read more

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What are the chances of having cholestasis of pregnancy in consecutive pregnancies?

70% recurrance risk: Recurrance risk for cholestasis of pregnancy can be as high as 70% in subsequent pregnancies. There is no current therapy to lessen the risk or prevent those recurrances. ...Read more

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What are tests, treatment for cholestasis of pregnancy?

What are tests, treatment for cholestasis of pregnancy?

Med, early delivery: Intrahepatic cholestasis is usually first noticed when a pregnant woman complains of itching all over the body but no rash. Testing will show abnormal bile salt levels and liver function tests. There is a medication that relieves the itching and lowers bile salt, but there is increased risk for stillbirth, so close monitoring of the pregnancy and delivery as soon as feasible is usual management. ...Read more

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How long does it take ursodeoxycholic acid to work when you have cholestasis of pregnancy?

How long does it take ursodeoxycholic acid to work when you have cholestasis of pregnancy?

Not long.: Ursodiol can pretty quickly decrease the bile acid levels in cases of intrahepatic cholestasis of pregnancy, however the pruritius may continue until Hydroxyzine is taken. ...Read more

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How is cholestasis of pregnancy diagnosed?

History/Physical/Lab: Cholestasis is diagnosed by doing a complete medical history, physical examination, and blood tests that evaluate liver function, bile acids, and bilirubin. Additionally, an ultrasound can de done to rule out gall bladder stones causing blockage. 1-2 preg/1000 is affected by cholestasis of pregnancy. It may be related to adverse pregnancy events like preterm labor, or at worse, stillbirth. ...Read more

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Dr. Katherine Kohari
38 doctors shared insights

Cholestasis Of Pregnancy (Definition)

A condition where the flow of bile, a digestive fluid produced by the liver, slows or stops. As a result, the bile enters the bloodstream and causes "intense itching" in the mother on the palms and ...Read more


Dr. Scott Keith
78 doctors shared insights

Cholestasis (Definition)

When the flow of bile (chole) is held back (stasis). It can be from the liver cells not moving it (often from medications), or from the biliary tree being plugged by ...Read more