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Doctor insights on: Intrahepatic Cholestasis Of Pregnancy Encephalopathy

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Is intrahepatic cholestasis of pregnancy painful?

Is intrahepatic cholestasis of pregnancy painful?

NO: Cholestasis of pregnancy does not generally cause pain. The most common symptoms is pruritis (itching). It almost always starts with itching on the palms of the hands and soles of the feet, and it is first noticed at night. The itching spreads to other parts of the body over time. Treatment with ursodiol (bile salts) can improve symptoms. Consultation with a high risk OB is recommended. ...Read more

Dr. Hirenkumar Italia
4 doctors shared insights

Pregnancy (Definition)

When your due date arrives, you will be more than ready to have your baby! Most women deliver the baby somewhere between 37 and 42 weeks. According to the American College of Obstetricians and Gynecologists, only 5% of babies arrive on the exact due date. Approximately 7% of babies are not delivered by 42 weeks, and when that happens, it is referred to ...Read more


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What is the result of liver function tests in intrahepatic cholestasis of pregnancy?

What is the result of liver function tests in intrahepatic cholestasis of pregnancy?

Cholestasis: You could elevated bilirrubin and alkaline phosphatase predominantly. Others sucn as transaminases can be elevated too. They will all normalize upon delivery. ...Read more

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What are the tests for intrahepatic cholestasis of pregnancy?

What are the tests for intrahepatic cholestasis of pregnancy?

LFTs, bile acids.: Liver function tests (alt/ast/alkaline phosphatase) and bile acids can clinch the clinical diagnosis of intrahepatic cholestasis of pregnancy - in the absence of cholelithiasis. ...Read more

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What are the early signs of hepatic encephalopothy?

What are the early signs of hepatic encephalopothy?

Confusion: It can vary in how it manifests which can be mild confusion to coma. ...Read more

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Could I have icp (intrahepatic cholestasis of pregnancy)? What are the risks?

Icp causes itching: I have only had one patient with icp in 27 years of practicing obstetrics. Diagnosis is made by elevated bile salts (detectable by lab test) and the treatment is cholestyramine. Pregnancy outcome should be unaffected by the condition. So icp is rare and makes you miserable, but should not affect your baby. One case however hardly makes me an expert so second opinions welcome. ...Read more

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What is acute fatty liver of pregnancy?

What is acute fatty liver of pregnancy?

Fatty liver: Acute fatty liver of pregnancy (aflp) is a rare, potentially fatal complication that occurs in the third trimester or early postpartum period. Although the exact pathogenesis is unknown, this disease has been linked to an abnormality in fetal fatty acid metabolism. Early diagnosis of aflp sometimes can be difficult because it shares features with other common conditions such as pre-eclampsia, vira. ...Read more

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Fatty liver of pregnancy fatal?

Fatty liver of pregnancy fatal?

Possible: Most fatty liver of pregnancy resolves without problems, a very small number of pts can progress to cirrhosis and liver failure. ...Read more

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What is mild intra and extrahepatic biliary ductal dilatation?

What is mild intra and extrahepatic biliary ductal dilatation?

Widened biliary duct: This term comes from the radiologist and GI doctors who look for a dilated biliary duct as evidence of obstruction or blockage of the biliary duct. The intra- and extra- descriptors just refer to where along the rout of the duct they notice the dilation. ...Read more

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Explain the condition called acute fatty liver of pregnancy.?

Explain the condition called acute fatty liver of pregnancy.?

Fatty liver: It is a rare medical condition that relates to a lack of enzyme in the mytochondria that is involved in metabolism of fat. As a result fat buils in liver cells leading to acute liver failure which is fatal in high percentage. The only treatment is delivery and intensive care measures to preserve liver function. ...Read more

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How is cholestasis of pregnancy diagnosed?

History/Physical/Lab: Cholestasis is diagnosed by doing a complete medical history, physical examination, and blood tests that evaluate liver function, bile acids, and bilirubin. Additionally, an ultrasound can de done to rule out gall bladder stones causing blockage. 1-2 preg/1000 is affected by cholestasis of pregnancy. It may be related to adverse pregnancy events like preterm labor, or at worse, stillbirth. ...Read more

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What are the symptoms of hepatic encephalopathy?

What are the symptoms of hepatic encephalopathy?

Encephalopathy: Symptoms of hepatic encephalopathy may be mild at first then become severe. Mild symptoms may include mood changes, mild confusion, forgetfulness, and changes in sleep, while more severe symptoms may include agitation, disorientation or severe confusion, abnormal movements, sleepiness, and slurred speech. Patients may progress to coma and death in the most severe cases. ...Read more

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How long does pruritus associated with intrahepatic cholestasis of pregnancy last?

Until pregnancy ends: Cholestasis of pregnancy is a considition which generally occurs in the 3rd trimester and is characterized by intense pruritis without rash and increase serum levels of free bile acids. The condition lasts until the pregnancy ends. The pruritis sometimes can be controlled with medications, such as ursodiol. ...Read more

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What are the long-term effects of cholestatic jaundice?

What are the long-term effects of cholestatic jaundice?

Several: They depend on cause and age of patient. In preterm infants, it is frequently from prolonged use of TPN and late start of feeds. Majority resolve. In some cases it can cause gall bladder sludge, gall stones or inflammation/infection of the plumbing system of the liver (cholangitis). In extreme cases, these patients can develop cirrhosis and chronic liver failure and may need liver transplant. ...Read more

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What risks are associated with hemangioma of the liver during pregnancy?

Probably none: Unlike hepatic adenomas, the risk of pregnany related increase in size and associated bleeding is minimal to none. ...Read more

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What does diffuse dilatation of common bile duct & mild dilatation of hepatic ducts mean? Maximal luminal (phenobarbital) diam. of common is 14-15mm. MRI sched. Liver

What does diffuse dilatation of common bile duct & mild dilatation of hepatic ducts mean? Maximal luminal (phenobarbital) diam. of common is 14-15mm. MRI sched. Liver

Dilated bile duct: The bile duct is the duct the drains bile out of the river and into the intestines. Dilated bile duct can be a sign of pancreatic, bile duct, liver,or gallbladder disease. It is an important sign, and it definitely needs to be evaluated until a cause is identified and taken care of. Do not hesitate to get the MRI and follow up with your doctor on the results. Good luck. ...Read more

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What is the pathophysiology of hepatic encephalopathy?

What is the pathophysiology of hepatic encephalopathy?

Toxins in bloodstrea: Bacteria in the colon release toxins as part of their normal digestion of nutrients. Typically a normal functioning liver can handle that. When someone has cirrhosis and the liver doesn't work normally those toxins can build up and get into the brain to cause the sleepiness/confusion of hepatic encephalopathy. That is why we use drugs like lactulose for diarrhea to clear the colon. ...Read more

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MRCP "Persistent mild dilation of the central intrahepatic duct. There are areas of mild narrowing & irregularity of the intrahepatic ducts & proximal common duct. No dilation of common bile duct. Gallbladder sludge is present." What causes this?

MRCP "Persistent mild dilation of the central intrahepatic duct. There are areas of mild narrowing & irregularity of the intrahepatic ducts & proximal common duct. No dilation of common bile duct. Gallbladder sludge is present." What causes this?

Nonspecific: I believe that the ductal findings are nonspecific. Sludge in the gall bladder can cause abdominal distress and indigestion. A gastroenterologist would sit down with the radiologist and review the images and decide whether more imaging studies like an MRI or liver biopsy are advisable depending upon your symptoms or lack of symptoms. ...Read more

Dr. Katherine Kohari
38 doctors shared insights

Cholestasis Of Pregnancy (Definition)

A condition where the flow of bile, a digestive fluid produced by the liver, slows or stops. As a result, the bile enters the bloodstream and causes "intense itching" in the mother on the palms and ...Read more


Dr. Michael DePietro
139 doctors shared insights

Encephalopathy (Definition)

Encephalon means brain, pathy means abnormal, so the full term means abnormal brain. I see the statement used by many of my colleagues, but it is not a diagnosis, ...Read more