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Gastric biopsy result: antral mucosa revealing mild to moderate chronic inflamation with associated extensive intestinal metaplesia. What that mean?
Precancer: The antrum is that portion of the lower stomach above the pylorus. Having chronic inflammation with extensive intestinal metaplasia is the precursor for developing gastric cancer. Left alone one would find an eventual gastric ulcer and invasive cancer. Partial gastrectomy would probably be indicated at this time. ...Read more
The gastrointestinal tract starts at the mouth, travel down the tunnel (esophagus), which connects to the stomach, which then empties into the duodenum, jejunum, and ileum---the three parts of the small intestine (@25 feet). This empties into the colon or large intestine (about 5 feet), which then becomes the sigmoid colon, rectum and out the anus. So, every morsel eaten ...Read more
It can get better: "barrett's esophagus" is the most common "intestinal metaplasia.". Repeated irritation of the esophagus from stomach acid causing heartburn can make the lining of the esophagus change to look like the intestinal lining. This is a warning sign; if repeated injury continues a cancer could form. A GI doctor can help your body fix things by minimizing the reflux & checking the area with a scope. ...Read moreSee 1 more doctor answer
Tissue change,,: Metaplasia is a change in tissue from one form to another, usually from an outside stress. For example squamous metaplasia is a change from another form of tissue like gland tissue to squamous or skin tissue. It's not cancerous, but can lead to cancer if it continues. It may have been found on your colonoscopy or some other test. See your doctor to discuss which report gave this result. ...Read more
Below: Type III IM has been shown to be a more specific marker of premalignancy, with relevance, in particular, to the early and intestinal type of cancer21. A particular type of very well differentiated adenocarcinoma of the stomach mimics Type 1IM, bringing into question the relevance of typing22 and critical reviews have found many exceptions to given types of IM as precursor lesions of cancer23. However, it is most likely that a combination of bacterial, host and environmental factors will lead to cancer rather than IM alone. Infection with cagA-positive H. pylori strains is associated with an increased prevalence and intensity of antral atrophy and intestinal metaplasia, in addition to higher degrees of gastritis24. Other studies have shown that a high PCNA-labelling index in the gastric mucosa, with a histological diagnosis of incomplete intestinal metaplasia, could constitute a good prognostic marker of the severity of the histological lesion. These parameters, together with others such as the presence of sulphomucins and of cells expressing anomalous Lewis a antigen, may be used to define patients with a high risk of developing a gastric neoplasia25 ...Read more
Is minor to moderate benign intestinal metaplasia reversible? What steps do I need to take to reverse the condition?
See answer: There is evidence that eradicating the H.pylori bacteria can prevent progression to intestinal metaplasia. Metaplasia is considered a reversible change of one type of cell into another. But I'm not certain that reversal has been demonstrated yet. Eradicate H.pylori, and reduce or eliminate high salt intake, smoking and alcohol consumption. ...Read moreSee 1 more doctor answer
What's most prevalent type of intestinal metaplasia? Type 1, 2, or 3? How common is it for people to have IM? What percentage develop further probs?
Site of biopsy?: What site was biopsied? Stomach or oesophagus? The finding indicates damage to the mucosa but the damage is not pre-cancerous. ...Read more
"metaplasia" refers to one tissue type undergoing a change to another, such as bronchial lining (which is usually a single layer of cells, "respiratory epithelium" becoming multi-layered and heavily keratinized, so-called squamous metaplasia. This is common in smokers. Other such changes can produce tissue such as ...Read more
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