Doctor insights on:
Interpreting Acth Stimulation Test
Depends: I'm assuming no lab errors. If you get a very high cortisol spike after receiving the first dose of ACTH, you are reassured you do not have Addison's. No, or a very small spike, strongly suggests Addison's. In-between... that's why there are specialist endocrinologists. ...Read more
The acth stimulation test evaluate whether the adrenal gland can respond to stimulation from the pituitary gland by giving an artificial form of the pituitary hormone (acth) and measuring the adrenal gland hormone (cortisol) before and after the injection. Normally the cortisol level will rise after the injection; in most instances failure to do so indicates a problem ...Read more
Eval adrenal functio: The acth stimulation test evaluate whether the adrenal gland can respond to stimulation from the pituitary gland by giving an artificial form of the pituitary hormone (acth) and measuring the adrenal gland hormone (cortisol) before and after the injection. Normally the cortisol level will rise after the injection; in most instances failure to do so indicates a problem with the adrenal gland. ...Read more
Regarding acth stimulation test. Do I have to be experiencing symptoms at time of test in order for it to show positive result?
No symptoms needed: The test is designed to test the ability of your adrenal glands to respond to stimulation from the pituitary (by giving a synthetic form of the pituitary hormone), so it is not necessary to have symptoms for the test to be valid. The ability of the adrenal gland to respond to stimulation does not come and go on a short term basis, so the results will be the same no matter how one feels. ...Read more
Can I drive myself after acth stimulation test or should I have someone drive me? I don't know what to expect? Might I feel better or worse after?
An acth stim test. A cortisol blood test, an injection of cortrisyn followe by another cortisol blood test. It takes time, but you should be able to drive to and from work.
Best wishes. ...Read more
While there can be: Variation between labs, these results appear to be largely normal. The baseline is normal (5-23 micrograms per deciliter). A rise from baseline of at least 7 to 10 ug/dl of cortisol, reaching at least 18 ug/dl at 60 minutes post-stimulation rules out primary adrenal insufficiency. A blunted response (not sure yours qualifies) may suggest secondary AI. Your Doctor will advise you. Stay well. ...Read more
What is the difference between acth plasma and acth stimulation test? Which one is more reliable and accurate? Can you depend solely on acth plasma?
Adrenal test: It's a test to see if you have adrenal insufficiency (whether or not your adrenals are working). It typically requires a placement of an iv, blood draws from the IV line as well as injection of acth through the iv. It can be done in a doctor's office or in an infusion center. ...Read more
What is the indication and contraindication of acth stimulation test? What is the management for acth stimulation test?
Acth stimulation allows a doctor to distinguish primary adrenal disease from pituitary disease. This is not an issue for self testing or management. See this site for more information and discuss the matter with your doctor.
http://www. Nlm. Nih. Gov/medlineplus/ency/article/003696.htm. ...Read more
I had an acth stimulation test. Why would my cortisol level go up and then way down? (0mim-8.11mcg/dl) (30min-20.14mcg/dl) (60min.-10.76mcg/dl)
ACTH stim test: That may be normal depending on how much you got Ask the lab for their own normal values in women your age. ...Read more
Suspicion of Ncah. Had acth stimulation test. Baseline 17-0H = 3.70nmol/l. After 30 mins = 9.38nmol/l. After 60 mins = 12nmol/l.What does this say?
Normal.....says the ACTH-CORTISOL "axis" is OK
However since labs differ. Check this with your medical provider ...Read more
ACTH test: The lab can draw blood for measurement of cortisol, but someone has to give the injection of acth (cortrosyn). The injection can be given IV or im. A lab that only draws blood would probably not be able to do this. Someone needs to order the acth and give the injection. ...Read more
Does a positive 21 hydroxylase antibody test mean addision's disease even if the acth stimulation test comes back normal?
No: Unlikely to be addison's with normal acth stim. Need further testing. ...Read more
Acth Stimulation test: PRG 17-0H basal: 3.70nmol/l 30min interval: 9.83nmol/l 60min interval: 12nmol/l Heterozygous or Homozygous NCAH? Or Pcos?
NCAH or PCOS?: Not nonclassic adrenal hyperplasia with early morning 17-OH progesterone less than 200ng/dl. Yours, with conversion is 122ng/dl. Also, your stimulated level doesn't reach higher than 400ng/L. That means no 21-hydroxylase or 11beta-hydroxylase or 3-beta-hydroxysteroid dehydrogenase or 17-alpha-hydroxylase deficiency. PCOS. ...Read more
Can prednisone affect an acth stimulation test? I'm on 5 mg daily for months and will have test in 1 week!
What is an acth stimulation test for? What does it diagnose? I took one and it was a simple blood test. Is that normal?
Yes: Blood test is to see a rise in your cortisol level. ...Read more
After acth stimulation test confirms adrenal insufficiency does it always need to be treated and/or followed up and how often?
Yes: Adrenal insufficiency means that your body is not able to produce enough steroids. Depending on the cause of adrenal insufficiency, you can be deficient in more than one steroid (cortisol and/or aldosterone). Your body needs these hormones, so it is important to follow-up with your dr. The frequency depends on how stable the disease is for the patient. ...Read more
Acth plasma and cortisol blood tests were normal but I have strong addisons symptoms with bronzing. What to do? Should I do an acth stimulation test?
Not an issue for: Self diagnosis. I trust that you are under the care of an endocrinologist, if not, it would be prudent to consult one and follow his/her advice. ...Read more
Serum cortisol 145 ng/ml, acth plasma 25. I have skin bronzing since two years. Should I do acth stimulation test as well?
No: If it is 14.5 mcg/dl this is normal am cortisol. Bronzing is due to excess acth either from a low cortisol (addison's) or a pituitary or ectopic tumor making too much acth and elevated cortisol. See an endocrinologist. ...Read more
Acth stimulation test w/poor response. I was told to wear a med bracelet and take prednisone. How do I know if it's addison's vs adrenal isufficiency?
Is it possible to have addison's & have normal sodium and potassium level & only test abnormal is the acth stimulation test?
Yes: Without knowing more about your situation, the short answer is yes. ...Read more
Always so cold, low blood pressure 77/42 sometimes. Low blood sugar. ACTH stimulation test ok. But sometimes low cortisol. Ideas?
this is challenging - does sound like adrenal insufficiency - probably due to hypothalamic / pitiutary dsyfunction. The options are extensive work up, or limited work up with a trial of glucocorticoids and possibly mineralcorticoid - fludrocortisone. Steroid therapy has its own significant side effects, so needs to be expertly managed, with frequent attempts to wean off the steroids. ...Read more
Normal ACTH stimulation test could I still have secondary adrenal insufficiency? I have low blood pressure and low blood sugar
Yes: The ACTH stimulation test is primarily a test for primary adrenal insufficiency or long standing secondary adrenal insufficiency. If secondary adrenal insufficiency has not been there too long the ACTH stimulation test may very well be normal. Other tests, based on cause that can answer this including: Low dose ACTH Stim, Insulin Tolerance, Metyrapone (now available again) & CRH stimulation test. ...Read more
Inject syn. ACTH: Hi. It's a test for primary adrenal insufficiency (where the adrenal glands themselves have failed) where synthetic ACTH (1-24), the N-terminal 24 amino acid peptide of native ACTH, is injected IV, and the adrenal response in making cortisol is measured at 0, 30, and 60 minutes. Dead adrenals don't respond. The ACTH-stim test does not reliably test for pituitary disease. ...Read more
If an individual's adrenals may not be making enough cortisone to live (symptoms include fatigue, abdominal pain, dizziness, nausia), this is tested.
If someone has needed to be on repeated or prolonged Prednisone or quite high inhaled corticosteroids for a prolonged period, adrenal insufficiency is a possibility.
Adrenal insufficiency may also be related to autoimmune causes. ...Read more
Syncortropin?: If you're referring to the Cortrosyn or syncortropin test, it's an injection designed to stimulate cortisol production by your adrenal glands. Blood is drawn, generally one hour after injection, and values should increase by a certain amount to be considered normal. ...Read more
Low cortisol. Low acth but normal stimulation test. Could I still have secondary adrenal insufficiency?
Yes: Without more information, I can not say for sure you have it, but this is essentially the def of secondary adrenal insufficiency. Secondary AI is a condition where the adrenal gland still has function, but is not being told to produce cortisol by the pituitary gland. There are other tests, but initial dx usually made by low baseline cortisol with ACTH injection causing nl cortisol by adrenal gland ...Read more
ACTH stim test...I've seen so many reference ranges I don't know how to interpret mine with 12.8 baseline, 20.4 @ 30 and 21.1 @ 60 minutes?
Endocrinologist: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. An ACTH stimulation test is not a do it yourself matter and the results should be interpreted by an endocrinologist. ...Read more
It is one of several pituitary hormones - acth for short (the others control the thyroid gland, gonad glands, and others) that controls adrenal gland function in primarily making the hormone called cortisol (not to be confused with "adrenaline"), though the adrenal gland also ...Read more