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Doctor insights on: Interleukin

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Discuss monoclonal antibody production?

Discuss monoclonal antibody production?

Monospecific Ab.: Monoclonal antibodies are those that are produced by the identical immune cells that are descended from the same parent cell. They produce anitibodies that bind to only one epitope or site on an antigen. This means that they are monospecific. This makes them useful in things like research because they can isolate a strain purely and completely. ...Read more

Dr. Sheila Smith
13 doctors shared insights

Aldesleukin (Definition)

Aldesleukin is a cancer-related immune system affecting agent which is a ...Read more


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What is interleukin 12?

What is interleukin 12?

Signaling molecule: Interleukin-12 (il-12) is known as a cytokine, which are small cell-signaling protein molecules that are secreted by numerous cells and are used extensively in intercellular communication. Il-12 is secreted by certain types of immune cells (such as dendritic cells) to regulate other members of the immune cells (for example, natural killer (nk) cells). ...Read more

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Is Interleukin IL-6 typically elevated with advanced stage lymphoma???

Is Interleukin IL-6 typically elevated with advanced stage lymphoma???

Lymphoma: If you have advanced stage lymphoma, the IL-6 level will not make or break the diagnosis. IL-6 is an inflammatory cytokine and anything from infection to arthritis can increase levels. ...Read more

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Why is interleukin important?

Why is interleukin important?

Interleukins: One of a large group of proteins produced mainly by t cells and in some cases by mononuclear phagocytes or other cells. Interleukins participate in communication among leukocytes and are important in the inflammatory response. Most interleukins direct other cells to divide and differentiate. Each acts on a particular group of cells that have receptors specific to that interleukin. ...Read more

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What is nonclonal mast cell activation disorder?

What is nonclonal mast cell activation disorder?

Newly characterized: It's a mimic for disorders caused by a neoplastic clone of mast cells. This is hematology subspecialist stuff and i would much rather have this than one of the clonal forms. http://www.ncbi.nlm.nih.gov/pubmed/23212667. ...Read more

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Is cytoxan (cyclophosphamide) chemotherapy?

Is cytoxan (cyclophosphamide) chemotherapy?

Yes.: Generic name of Cytoxan is cyclophosphamide. It is a drug commonly used to treat a variety of cancers, but may also be used to treat some autoimmune disorders, such as lupus. ...Read more

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Describe polyclonal and monoclonal antibody production?

Cells vs, animals: A monoclonal antibody is produced by in-vitro manipulation by expoanding a single cell making a desired antibody. Polyclonal antibodies are usually derived from immunizing an animal and colletcting its blood/serum containing the antibody. Polyclonal antibodies are a mixture of a large number of different cells. ...Read more

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Neulasta (pegfilgrastim) cause white blood cell spike?

Neulasta (pegfilgrastim) cause white blood cell spike?

Yes!!: This is exactly what Neulasta (pegfilgrastim) does. It increases your white blood cell count, and it can sometimes raise it to very high levels. ...Read more

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Hypercellular Marrow,increased Trilineage Hematopoiesis,reactive lymphoplasmacytosis, Erythropoiesis normoblastic and decreased. Myeloblasts not increased Megakaryocytes increased, include young forms

Hypercellular Marrow,increased Trilineage Hematopoiesis,reactive lymphoplasmacytosis, Erythropoiesis normoblastic and decreased. Myeloblasts not increased Megakaryocytes increased, include young forms

Marrow confusion: Complex because the answer is dependent on the hematologists total examination and not just a marrow. There is a difference between dysmorphic cells and immature forms so no diagnosis can be made from your comments. Stick with the hematologist or concologist. ...Read more

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What are EPO and interleukin-11?

What are EPO and interleukin-11?

Important proteins: Epo (erythropoietin) is a key hormone (made by kidneys in adults, liver in babies) in stimulating/signalling the production of red blood cells--it is used to treat anemia in folks wth kidney failure. Interleukin-11 is a cellular protein encoded by the gene il-11 and is important is regulation of a megakaryocyte--the cell which makes platelets. Very complex processes. Have fun learning. Good luck. ...Read more

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Does Taxol (paclitaxel) stabilize microtubules?

Does Taxol (paclitaxel) stabilize microtubules?

Taxol (paclitaxel): Yes. You can read about this "Insights into the mechanism of microtubule stabilization by Taxol" See: http://www.pnas.org/content/103/27/10166.full ...Read more

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What immune cells induce apoptosis?

What immune cells induce apoptosis?

Many: T cells, b cells and natural killer or nk cells. ...Read more

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Is neulasta (pegfilgrastim) needed with weekly taxol?

Is neulasta (pegfilgrastim) needed with weekly taxol?

No!: Neulasta (pegfilgrastim) is a long-acting injection that increases your white blood cells. It should only be given during a two or three week window when you're not receiving chemotherapy. If you're receiving Taxol every week, you should not receive neulasta (pegfilgrastim). If you do, the Taxol can kill the dividing white blood cells, and harm your bone marrow stem cells. It is not fda-approved to give during weekly chemo! ...Read more

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Blood flow cytmtry shows dual positive cd4cd30 cells absolute count of 2354. IGG slightly elevated with elevated light chains, T cell Beta clone noted?

Blood flow cytmtry shows dual positive cd4cd30 cells absolute count of 2354. IGG slightly elevated with elevated light chains, T cell Beta clone noted?

Asking what?: If your are requesting a diagnosis online, this is not the appropriate venue. Though the flow cytometry results are not totally normal, your results should be reviewed with the physician who ordered it. This format does not give us the ability to determine if your clinical presentation and lab results are consistent with a specific diagnosis. ...Read more

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What are t-helper cells/cytotoxic cells?

What are t-helper cells/cytotoxic cells?

Lymphocyte family: These are a special group of white blood cells that actually kill cells that the body perceives to perhaps be infected. This is usually, but not always, a good thing. We pathologists recognize them as cd8+, staining brown with a special stain. I'm glad you're interested in the immune system, which still amazes scientists. Thanks for asking. ...Read more

Dr. Liawaty Ho Dr. Ho
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Is plasma cell myeloma hereditary?

Dr. Liawaty Ho Dr. Ho
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Is plasma cell myeloma hereditary?

Majority Not: Majority of myeloma cases is not hereditary. A small but unknown fraction of cases are familial. The risk of developing myeloma is approximately 3.7-fold higher for persons with a first degree relative with myeloma. ...Read more

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For what cancers does chemotherapy with cytoxan, (cyclophosphamide) 5-fu help?

Not a standard treat: Cytoxan (cyclophosphamide) and 5-fu jused to be used as first line chemo for breast cancer, but there are much more effacious drugs available now. I would not use these drugs now as first line treatment fofr anything except in special circumstances. ...Read more

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Does interleukin inhibit or turn down the immune response?

Does interleukin  inhibit or turn down the immune response?

Interleukins: One of a large group of proteins produced mainly by t cells and in some cases by mononuclear phagocytes or other cells. Interleukins participate in communication among leukocytes and are important in the inflammatory response. Most interleukins direct other cells to divide and differentiate. Each acts on a particular group of cells that have receptors specific to that interleukin. ...Read more

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What immune cells induce apoptosis in cancer?

What immune cells induce apoptosis in cancer?

Many: T cells, b cells and natural killer or nk cells. ...Read more