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Doctor insights on: Interferon Beta Ifnb Ig G W Rflex

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My HBV DNA IS 500 iu/ml, HBE AG NEG, ANTI HBE AG POSITIVE, ALT IS 57, ? Can i start using Interferon???

My HBV DNA IS 500 iu/ml, HBE AG NEG, ANTI HBE AG POSITIVE, ALT IS 57, ? Can i start using Interferon???

Talk to doc: It appears that you do have an active infection and thus treatment is worthwhile. However you need to discuss with your doctor re. the pros and cons of interferon treatment. ...Read more

Interferon (Definition)

Interferons are a diverse group of proteins that belong to a class of glycoproteins known as cytokines. Interferons were first discovered for their ability to block viral replication within host cells. They also have been found to activate immune cells for many disease processes. There are several classes of interferons, types i, ii and iii, depending on ...Read more


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Elevated EBV ab VCA IgG <8 and EBV nucleaer antigen ab IgG test 4.2. & anti-dna(ss)igg ab qn ( 119)& c react protien(5.6) what are implications?

Elevated EBV ab VCA IgG <8 and EBV nucleaer antigen  ab IgG test 4.2. & anti-dna(ss)igg ab qn ( 119)& c react protien(5.6)  what are implications?

Nothing.: Ebv antibodies indicate you had a previous infection, but not active. The c-reactive protein needs a units indicator - that is either normal or somewhat elevated. The anti ss dna is extremely nonspecific and very rarely indicated; I have no idea why that was ordered, discuss with your doctor. ...Read more

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Plz interpret. ANA via ELISA 74 units, strong positive (negative via IFA) Anti-Cardiolipin IgG 22 CU, moderate positive others neg. symptom fatigue?

Plz interpret.  
ANA via ELISA 74 units, strong positive (negative via IFA)
Anti-Cardiolipin IgG 22 CU, moderate positive 
others neg.
symptom fatigue?

Short answer is : Needing more info on labs and clinical symptoms. ANA positive is sensitive for possible autoimmune disease.but not very specific. Every lab on your ENA panel is important esp they are moderate positive and they all mean something different. Lab is never enough for diagnosis esp rheumatic condition. It is important for you to find a rheumatologist for thorough history and physical exam. ...Read more

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What would cause a high positive ANA (1:640) speckled, nucleolar with a low positive smooth muscle antibody (1:40) but negative SS-A, SS-B, anti-Smith, RNP, SCL-70, Anti Jo antibodies? Liver disease?

What would cause a high positive ANA (1:640) speckled, nucleolar with a low positive smooth muscle antibody (1:40) but negative SS-A, SS-B, anti-Smith, RNP, SCL-70, Anti Jo antibodies? Liver disease?

Probably normal: Many people have a positive ANA without being sick. If you also have elevated liver enzymes, a workup for autoimmune hepatitis may be continued, but if there's nothing to suggest a liver problem biochemically, I'd not be in a hurry to diagnose despite anti-smooth-muscle. ANA means nothing apart from the clinical picture. Best wishes. ...Read more

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Can you please explain ENA. Negative anti-CCP antibody 5 (<5) positive RF <14(0-14) antinuclear 80 (<80) a low titre is present?

Can you please explain ENA. Negative anti-CCP antibody 5 (<5) positive RF <14(0-14) antinuclear 80 (<80)  a low titre is present?

See details: None of those results is impressive and all are negative except for a borderline ANA. Why were the tests ordered in the first place? These tests must be evaluated in the context of the clinical symptoms. ...Read more

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I've been sick for about 3 weeks, mostly fatigue. My EBV levels are VCA IgG 153, VCA IgM <10, early AG IgG 25.7, nuclear antigen IgG 158. Any ideas?

I've been sick for about 3 weeks, mostly fatigue. My EBV levels are VCA IgG 153, VCA IgM <10, early AG IgG 25.7, nuclear antigen IgG 158. Any ideas?

No idea: First you would need to give us more details on the sickness other than just fatigue. The tests you have had are not helpful in making a diagnosis. I would recommend that you consult an internist to get a thorough workup since there are many causes for fatigue= both physiologic and psychologic. ...Read more

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My brother is hbe ag neg and antibody hbe ag positive. His viral load is 50000iu/ml. Alt is 33. U/s noramal. GE prescribed Entecavir 0.5mg.is it good?

My brother is hbe ag neg and antibody hbe ag positive. His viral load is 50000iu/ml. Alt is 33. U/s noramal. GE prescribed Entecavir 0.5mg.is it good?

Probable resistance: Entecavir is a nucleoside analog and has potent antiviral activity against hepatitis B virus (HBV) - the emergence of drug resistance is rare. If indeed his HBV viral load is 50,000 (I would repeat), then he has probably developed a mutation. The addition of adefovir may result in suppression, but only in about half of patients. Tenofovir may be warranted. See a hematologist for advice ...Read more

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What would diagnosis be with test results 1:160 ANA- Positive-Speckl C4 Complement- 13 mg Anti-DS-DNA - 3 IU SM antib- 7 Index RNP Anti-5 SS-A-3

Part of the picture: those lab results should be put in perspective, what are the symptoms and signs present, the best to judge / give a diagnosis is the doctor who ordered the blood tests, all these results can just be insignificant in absence of other criteria, best wishes ...Read more

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Is this a lab error for Hepatitis B?: HBsAg(-), HBsAe(+), AntiHBc(+), AntiHBc IgM(-), AntiHBc IgG(-), AntiHBs(-). Repeated 3 more times with all (-)

Is this a lab error for Hepatitis B?: HBsAg(-), HBsAe(+), AntiHBc(+), AntiHBc IgM(-), AntiHBc IgG(-), AntiHBs(-). Repeated 3 more times with all (-)

False positive tests: With negative results on three more tests, almost certainly the positive results were false. This isn't necessarily a lab error, just a glitch in the biology of the test. That is, there probably is nothing the lab could have done to either cause or prevent it. In any case, you don't have hepatitis B. If potentially at risk, e.g. sexually active and not monogamous, get vaccinated. ...Read more

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I'm hebs ag negative with a high anti hbs antibody from vaccination. This week's test was reported as hebs ag detected with anti hbs antibody of 513 miu/ml. Lft normal....Scared....Lab error?

I'm hebs ag negative with a high anti hbs antibody from vaccination.  This week's test was reported as hebs ag detected with anti hbs antibody of 513 miu/ml. Lft normal....Scared....Lab error?

Yes: That sounds like lab error. Your hbsab would provide immunity; i'm assuming yoru hbcab (core) is negative; i wouldn't worry, talk to your doctor about a retest if you are concerned, but even if you were infected, there is no reason for treatment at this time. ...Read more

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Can you interpret, squam epi cells few a, alpha 2 protein 1.01 h, possible faint IgM lambda monoclonal protein present, ACE serum 75 h?

Can you interpret, squam epi cells few a, alpha 2 protein 1.01 h, possible faint IgM lambda monoclonal protein present, ACE serum 75 h?

No: Can't interpret random blood test results without context. Talk to the doctor that ordered the tests. Most medical tests (x-rays, blood tests, etc., ) are better at telling us what you don't have rather than diagnosing what (if anything) you do have wrong with you. ...Read more

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Sir, my HBV DNA levels is 507 iu/ml .HBE AG -ve, ANTIBOBY HBE AG +ve, ALT 57iu/ml. I can't understand why ALT is Increased? Do i need treatment?

Sir, my HBV DNA levels is 507 iu/ml .HBE AG -ve, ANTIBOBY HBE AG +ve, ALT 57iu/ml. I can't understand why ALT is Increased? Do i need treatment?

Yes: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, you did not state the level of ALT. More important is the presence of viral DNA in blood suggesting active infection, you should seek treatment for that. ...Read more

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Kappa/lambda FLC ratio high (2.75) w/ normal K(10.21mg/dl) & low L(3.68mg/dl). Hem-onc unsure if ratio implies K monoclonality since serum/urine IFE ok & neither chain is elevated. Could monoclonal K be suppressing L? IgA a bit high IgG &IgM a bitlow

Kappa/lambda FLC ratio high (2.75) w/ normal K(10.21mg/dl) & low L(3.68mg/dl). Hem-onc unsure if ratio implies K monoclonality since serum/urine IFE ok & neither chain is elevated. Could monoclonal K be suppressing L? IgA a bit high IgG &IgM a bitlow

Useless test: K/L ratio is not a useful test. About one third of patients without monoclonal immunoglboulin have an abnormal ratio, usually with kappa excess. If you must, the next step would be a bone marrow examination. You may consult this article that I wrote: https://www.ncbi.nlm.nih.gov/pubmed/27473738 At your age you are unlikely to have myeloma. ...Read more

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