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Doctor insights on: Inhibitory

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Glutamine excitatory or inhbitory?

Glutamine excitatory or inhbitory?

Both, indirectly: Glutamine is a major precursor of glutamate, the most potent excitatory neurotransmitter, & of gaba (gamma-aminobutyric acid), the most potent inhibitory neurotransmitter in mammalian brains. ...Read more

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Is histamine excitatory or inhibitory?

Is histamine excitatory or inhibitory?

Excitatory: Histamine is actually classified as an excitatory neurotransmitter in the brain responsible for the sleep wake cycle. Too much of it can keep you awake. That is why it is used in many commercial sleep aides seen with the letters "pm" attached to some kind of pain killer. A common side-effect of a histamine blocker like Diphenhydramine (benadryl) is drowsiness. ...Read more

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Do norepinephrine reuptake inhibitors suppress growth of brain?

Do norepinephrine reuptake inhibitors suppress growth of brain?

No: At this time, there is no evidence to suggest this. As one may imagine, few if any studies have been performed in humans to look for this. ...Read more

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What does "selective" mean in selective serotonin reuptake inhibitor?

What does "selective" mean in selective serotonin reuptake inhibitor?

Just one type: "selective" in this case refers to the fact that the previous generation of antidepressants, the tricyclics, worked on all 3 of the neurotransmitters in the brain thought to be involved in depression in varying degrees; serotonin, norepinephrine, and dopamine. Prozac, (fluoxetine) and the other ssris act almost entirely on serotonin. ...Read more

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Is the selective norepinephine reuptake inhibitor, reboxetine, effective ?

Is the selective norepinephine reuptake inhibitor, reboxetine, effective ?

Evidence says not: One meta-analysis* (a study pooling results from multiple other studies) suggested that reboxetine is ineffective & may be harmful. *(eyding d et.Al. "reboxetine for acute treatment of major depression: systematic review &meta-analysis of published &unpublished placebo &selective serotonin reuptake inhibitor controlled trials."bmj. 2010; 341:c4737). ...Read more

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Which is more effective? Tricyclics or SSRIs (selective serotonin reuptake inhibitors)?

Which is more effective? Tricyclics or SSRIs (selective serotonin reuptake inhibitors)?

TCA/SSRI: Both are, depending on what they are prescribed for. The difference is in tolerability & side-effects. ...Read more

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What antidepressant medications selectively block neurotransmitters?

What antidepressant medications selectively block neurotransmitters?

Most newer ones: Most of the newer antidepressant medications affect specific neurotransmitters. Each does it slightly differently, accounting for the different response rates amongst them. The SSRI's primarily increase serotonin, the SNRI's both serotonin and norepinephrine, and buproprion mostly norepinephrine alone, and Brintellix affects many of them in different ways and in different places in the brain. ...Read more

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Can autoantibodies against glutamate receptors cause glutamate metabolism disorders?

Can autoantibodies against glutamate receptors cause glutamate metabolism disorders?

Yes. Great Question!: The Amino Acid glutamate plays a central role in nitrogen metabolism & participates in multiple biochemical pathways. Disease examples: autoantibodies to the glutamate receptor kill neurons via activation of the receptor ion channel. Anti-nmda receptor encephalitis is a treatment-responsive inflammatory encephalopathic autoimmune disease associated with anti-nmda receptor antibodies. ...Read more

Dr. Alan Ali Dr. Ali
4 doctors agreed:
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Does Dexilant (dexlansoprazole) contain monoamine oxidase inhibitor?

Dr. Alan Ali Dr. Ali
4 doctors agreed:
Does Dexilant (dexlansoprazole) contain monoamine oxidase inhibitor?

Dexilant (dexlansoprazole): This is a proton pump inhibitor for treating gerd. It does not contain MAO inhibitor. ...Read more

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How do "serotonin antagonist and reuptake inhibitors" ssris work?

How do "serotonin antagonist and reuptake inhibitors" ssris work?

Still unclear: We know what they do--block reuptake at the neuron. But, why that helps with depression and anxiety, among other disorders, remains unclear. Especially puzzling is why it typically takes weeks or even months to produce the effect, suggesting strongly that it is not the direct effect that causes improvement but some change that induces downstream. ...Read more

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When should someone take selective serotonin re-uptake inhibitors?

Depression: These medications are usually a first line medication for depression although they have other uses. ...Read more

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Why does acetylcholine, an inhibitory neurotransmitter, cause the adrenal glands to release stimulatory hormones?

Why does acetylcholine, an inhibitory neurotransmitter, cause the adrenal glands to release stimulatory hormones?

Neurotransmitters: Neurotransmitters are not easily classified into inhibitory and stimulatory. It depends on where they are acting. ...Read more

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What are GABA antagonists that lead to gaba-a receptor up-regulation?

Not safe: GABA antagonists are not routinely prescribed for GABA A receptor upregulation. The main one flumazenil (clonazepam) is used for overdoses from benzodiazepines in an ER setting. It may cause withdrawal seizures. Your best bet is to detox and enter a drug tx program for alcohol or sedative-hypnotic dependence issues. ...Read more

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Does triavil block dopamine receptors in the central nervous system?

Does triavil block dopamine receptors in the central nervous system?

Yes: Triavil is an old medicine that is not often used anymore. It's a combination of Amitriptyline and perphenazine. The latter is a neuroleptic (antipsychotic) medication that mainly acts by blocking Dopamine receptors in the brain. ...Read more

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Side effects of angiotensin receptor blockers?

Side effects of angiotensin receptor blockers?

Generally : Well tolerated. Common side effects potentially include: dizziness, low blood pressure, headache, diarrhea, fatigue and elevated potassium to name a few. A serious side effect angioedema (swelling of throat/tongue etc) is relatively uncommon. ...Read more

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Since there's deep brain stimulation that stimulate neurons, is there deep brain "inhibition" that inhibits neurons?

Yes: It is interesting that it is called " stimulation", in fact it inhibits the neuron depending upon the degree of stimulation applied. For example the involuntary movement of Parkinson's disease are controlled by "inhibition". Similarly " interstim" is the technique to stimulate to cause inhibition of bladder contractions to cure loss of urinaty control. The entire process is well understood. ...Read more

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Does dopamite(dopamine supplement) increase more dopamine level or prescribed medicine like biperiden(dopamine reuptake inhibitor) does?

Does dopamite(dopamine supplement) increase more dopamine level or prescribed medicine like biperiden(dopamine reuptake inhibitor) does?

I'm curious: Why do you believe you need to take medication that claims to affect dopamine, especially OTC remedy which will NOT cross the brain-blood barrier? If you are depressed, you could see a psychiatrist, and if you have Parkinson's disease, a neurologist. ...Read more