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Doctor insights on: Infliximab Infusion And Taking Methotrexate

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Methotrexate injections and pills didn't work for scleritis and was wondering if remicade (infliximab) is good medicine for the scletitis?

Methotrexate injections and pills didn't work for scleritis and was wondering if remicade (infliximab) is good medicine for the scletitis?

Resistant scleritis: Initial therapy always requires systemic nsaids, glucocorticoids, or other immunosuppressives (rituximab & cyclophosphamide). Cyclosporine & mycophenolate may also work. Azathioprine or mtx may be most beneficial for maintenance. Tnf Alpha inhibitors (eg infliximab) may be effective in resistant disease. Scleritis should ideally be managed by ophthalmologist+rheumatologist experts. ...Read more

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Methotrexate (Definition)

Methotrexate was originally used in the early 1950's as a treatment for cancer but was also found to be effective in many other diseases including rheumatoid arthritis and psoriasis. It has anti inflammatory and immunosuppressive properties which make it an excellent first line therapy for RA ...Read more


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Child on remicade (infliximab) and methotrexate what can I do to help her from getting sick when school starts back? Worried I can't keep her from sick kids

Child on remicade (infliximab) and methotrexate what can I do to help her from getting sick when school starts back? Worried I can't keep her from sick kids

Several things: Make sure your immunizations are up to date. Wash your hands frequently with soap and water after touching people or school things. You can carry a small bottle of hand sanitizer when soap not convenient. Keep your hands away from your face, eyes and head. Be careful not to get near those with colds, coughing and sneezing. Let the school nurse about your arthritis and medications. ...Read more

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Is remicade (infliximab) chemo if given at high does like methotrexate is? Nurse said remicade (infliximab) is in chemo family but not chemo. Unsure what she meant please expla

Is remicade (infliximab) chemo if given at high does like methotrexate is? Nurse said remicade (infliximab) is in chemo family but not chemo. Unsure what she meant please expla

No: Remicade (infliximab) is not chemotherapy...it is similar in that it is given IV. It is not a chemical structure and not a poison that is toxic to cell...it a biologic structure (an antibody) that blocks the overproduction of TNF, a messenger between immune cells. Hope this helps ...Read more

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I have been diagnosed with scleritis red and painful. The Remicade (infliximab) and Methotrexate took care of redness but pain still there.can I still have sclerit?

I have been diagnosed with scleritis red and painful. The Remicade (infliximab) and Methotrexate took care of redness but pain still there.can I still have sclerit?

Risk of damage: This can lead to damage of the sclera so you need to clarify with your ophthalmologist about surface damage. The pain is a clue to ongoing damage. ...Read more

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Doctor is offering me a choice of infliximab or methotrexate. Do I want either of these?

Doctor is offering me a choice of infliximab or methotrexate. Do I want either of these?

MTX 1st!: Go with mtx first . Preferably sc, rather than oral. Humira (adalimumab) works better when you are on mtx anyway! ...Read more

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If a child on methotrexate and remicade (infliximab) gets a abcescss/MRSA do they need to be admitted or in some cases will oral antibiotics work?

If a child on methotrexate and remicade (infliximab) gets a abcescss/MRSA do they need to be admitted or in some cases will oral antibiotics work?

Depends. : Depends on the examining doctor who is taking care of his medications. As u may have been explained Remicade ( infliximab) may allow infections to become life threatening. If IV antibiotics are contemplated they can be administered at home with an indwelling peripheral vein catheter and nurse home visits. Sometimes just drainage of abscess is all that may be required. Close follow up is key. ...Read more

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For medium-active Crohn's disease, is remicade (infliximab) better off as the first line of treatment than methotrexate? Azoran has been ruled out.

For medium-active Crohn's disease, is remicade (infliximab) better off as the first line of treatment than methotrexate? Azoran has been ruled out.

See details: Often the combination of both is the most effective therapy. Often Methotrexate is tried first because it is easier to administer, is much less expensive and can be effective as a single agent. However, for severe disease i would opt for Remicade (infliximab) either alone or in combination as the first choice. ...Read more

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Can Remicade (infliximab) and Methotrexate cause gastric ulcers?

Can Remicade (infliximab) and Methotrexate cause gastric ulcers?

Methotrexate usually: causes the GI upset, including nausea/vomiting, stomach ulceration and inflammation, abdominal discomfort, and diarrhea. If I were to to blame one of those, it would be Methotrexate! I would talk to your doctor more about this concern. ...Read more

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Can someone on methotrexate and remicade (infliximab) be admitted to hospital if they have staphylococcal folliculitis?

Can someone on methotrexate and remicade (infliximab) be admitted to hospital if they have staphylococcal folliculitis?

Folliculitis: Hi, if the problem is just Folliculitis and there is no systemic infection the best way to treat that person is as outpatient, because being in the hospital would put that person more at risk for more serious infection. ...Read more

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Psoriasis+psor. Arthritis..Methotrexate 15mg for 2 mos. Already+humira weekly..Dr say stelera no good for arthr...Says remicade (infliximab) or enbrel maybe..Ok?

Psoriasis+psor. Arthritis..Methotrexate 15mg for 2 mos. Already+humira weekly..Dr say stelera no good for arthr...Says remicade (infliximab) or enbrel maybe..Ok?

Nod to others:: Humira is a tnfa antibody, and is similar to envbrel. Remicade (infliximab) is an antibody to the tnfa receptor, so it works differently. But i would have tried you on leflunomide, and oral drug, before starting biologics. ...Read more

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Child has a wart/mole on her head she keeps picking at it but it always grows back is this concerning? She is on remicade (infliximab) and methotrexate for JRA

Child has a wart/mole on her head she keeps picking at it but it always grows back  is this concerning? She is on remicade (infliximab) and methotrexate for JRA

Ask rheumatologist: This could be a nodule related to the JRA. There are other possibilities also. See your rheumatologist and ask if it needs to be removed. ...Read more

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Daughter on methotrexate and enbrel and indocin for JRA but hates getting shots every week. Could remicade (infliximab) be a better choice?

Daughter on methotrexate and enbrel and indocin for JRA but hates getting shots every week. Could remicade (infliximab) be a better choice?

An alternative: It is an alternative. However, it still requires being stuck for an IV every 4-8 weeks and sitting in an infusion chair for 2 hours. ...Read more

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When would a doctor use remicade (infliximab) when treating jra ? Currently on methotrexate , enbrel, indocin , and now. 3 weeks of steroids

Any time: It is always an option if your current meds are no longer effective. Sometimes changing from Enbrel to Remicade (infliximab) yields a better response as one can adjust the Remicade (infliximab) dose to a particular situation. ...Read more

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Is it safe for me to have botox facial injections whilst on infliximab, methotrexate and asacol (mesalamine) treatment for ulcerative colitis?

It is safe: Botox does not interact with these and almost all other medications. I have several patients with colitis on these drugs and have injected Botox for their chronic migraines without any side effects. ...Read more

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Psa have tried mtx w /remicade& w/ humara no help methotrexate caused blood issues but worked better. Now embrel/leflunomide.No relief frustrated help?

Psa have tried mtx w /remicade& w/ humara no help methotrexate caused blood issues but worked better. Now embrel/leflunomide.No relief frustrated help?

MTX sc ?: Mtx causes less liver issues given sc versus oral. Also mtx has more potent metabolites that take 10 weeks to develop. You did not specify what tests where abnormal. But you suggest that mtx was given alone. Was it? Mtx and Humira (adalimumab) are a good combo for psoriatic arthritis. ...Read more

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Is longterm infliximab infusion treament dangerous?

Is longterm infliximab infusion treament dangerous?

Yes and no: These is an increased risk of infection which is the major side-effect. Other possibile problems are reduced blood counts, liver inflammation, neurologic disorders and a possible increased risk of lymphoma. However the chances of having any of these issues is fairly small. ...Read more

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Is it necessary to take azathiroprine while taking remicade (infliximab) infusions?? What do the two drugs do to help you? Or help each other.

Is it necessary to take azathiroprine while taking remicade (infliximab) infusions?? What do the two drugs do to help you? Or help each other.

It depends: Azathioprine can reduce the rish of infusion reactions to Remicade (infliximab) and can inhibit the production of antibodies to Remicade (infliximab) that can compromise its effectiveness. However, it is not absolutely essential to take it while on Remicade (infliximab). ...Read more

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Remicade (infliximab) infusion make you lose your hair?

See below: It is is possible but the Imuran (azathioprine) and if you are on Prednisone that could be a contributing factor as well. ...Read more

Infusion (Definition)

An infusion implies a substance administered via IV 2 a person, such as blood (transfusion), antibiotics and pain meds or other meds. Some can be ...Read more


Dr. Jeremy Adler
128 doctors shared insights

Infliximab (Definition)

Infliximab is an ...Read more