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Doctor insights on: Increased Gamma Globulin Levels In Blood

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I recently received blood results showing gamma globulin levels of 0.37 when normal range is 0.7-1.6. Is it possible that this is a one-time thing?

I recently received blood results showing gamma globulin levels of 0.37 when normal range is 0.7-1.6. Is it possible that this is a one-time thing?

Maybe: Reference ranges are set so that several percent of healthy folks fall outside on either side. This may just be you. It is no danger. Stop worrying. If this continues or you are very curious, you can get the various types quantitated. Some folks run way-low on one of the three major types. Usually they still do okay. ...Read more

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Dr. Robert Dracker
100 doctors shared insights

Immune Globulin (Definition)

The immune globulins are a class of blood proteins elaborated by the immune system to fight infection, and then remember the antigens of the infecting agent to use for ...Read more


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In blood work, does elevated gamma globulin (m-spike) often cause the total serum globulin to be elevated as well?

In blood work, does elevated gamma globulin (m-spike) often cause the total serum globulin to be elevated as well?

Tt could: Since, total globulin level usually includes all kinds of globulins (alpha, m spike etc). An immunoelectrophoresis can further characterize the m spike. ...Read more

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What is the day to day variability of gamma globulin levels?

What is the day to day variability of gamma globulin levels?

Don't know: I don't know because there can be considerable variability so we normally don't monitor immunoglobulins so closely. Especially IgG can vary by multiples in response to an infection but I'm sure there will be some variation in samples taken even just minutes apart. Perhaps if provided a specific context I could give a better answer ...Read more

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What do you recommend if I have elevated gamma globulin levels following obstruction?

What do you recommend if I have elevated gamma globulin levels following obstruction?

Underlying disease: Elevated gamma globulin is not a disorder by itself but a manifestation of some underlying disease and that cause needs to be treated. ...Read more

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Can a simple infection cause gamma globulin levels to decrease below normal range? (0.37 when normal is 0.7-1.6)?

Can a simple infection cause gamma globulin levels to decrease below normal range? (0.37 when normal is 0.7-1.6)?

No: Very unlikely, unless the patient is already immune compromised, other causes for this low level would be diseases/disorders leading to loss of protein from gut, kidneys or malnutrition, are mainly the causes for such, low level of immunoglobulins has other causes in addition,mainly lymphocytes problems, either T cells or B cells problems mainly are the causes for immunodeficiency states 1ry / 2ry ...Read more

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Can gamma globulin levels of 0.37 recover? How long would natural recovery take? If they don't recover (over 3 months-3 tests), immune deficient?

Can gamma globulin levels of 0.37 recover? How long would natural recovery take? If they don't recover (over 3 months-3 tests), immune deficient?

Lo gamma globulins: Well that isn't an isolated number, meaning it should be interpreted in the context of a clinical picture, so why did you have this done and repeated in the first place? Several reasons for such, mainly protein losing disorders either from a gut or from kidneys, malnutrition/ primary immunodeficiency can be a cause too, replacement therapy available,but you need to be rightfully diagnosed,goodluck ...Read more

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Blood tests shows high gamma globulin & high igg. Ifx shows no monoclonal protein & free light chains are within normal range. What does this mean?

Blood tests shows high gamma globulin & high igg. Ifx shows no monoclonal protein & free light chains are within normal range. What does this mean?

It might be a benign: Many benign processed can cause hypergammaglobulinemia, which are benign elevations without a para -protein or m-spike on serum protein electrophoresis(spe)> it all depends on how high is the gammaglobulin level and making sure the liver functions are ok and there is no chronic inflammation(like rheumatoid arthritis, sarcoidosis etc) going on inside the body. ...Read more

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Why would pcp refer me to hematologist due to elevated protein in blood (elevated gamma globulin)? Is this something to be concerned about?

Why would pcp refer me to hematologist due to elevated protein in blood (elevated gamma globulin)? Is this something to be concerned about?

Further evaluation: There are many reasons for elevation of the serum protein. The hematologist is the best person to guide the work-up to determine if you have something like myeloma or other plasma cell dyscrasia or a non-malignant cause of the elevated protein level. ...Read more

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I have history of elevated blood protein(8.3-8.7 since 09). Recently did spep with elevated gamma globulin. Why would pcp refer me to hematologist?

I have history of elevated blood protein(8.3-8.7 since 09). Recently did spep with elevated gamma globulin. Why would pcp refer me to hematologist?

Elevated gamma glob: Do you have an m-spike detected on your serum protein electrophoresis? Do you have an imimmunofixation electrophoresis? If you do have m-spike detected- your pcp refers you to see hematologist to make sure you don't have plasma cell disorder etc. Elevated gamma glob alone without m-spike or abnormal ife- could be caused by inflammation, infection etc. Ask this question to your pcp. ...Read more

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Adnorm. Blood & cfs results: high: CSF protein-47, high cfs albumin-30.9; low total protein-5.7, low gamma globulin-.5, low IgG quantitative -621 worry?

Adnorm. Blood & cfs results: high: CSF protein-47, high cfs albumin-30.9; low total protein-5.7, low gamma globulin-.5, low IgG quantitative -621 worry?

CSF: Some experts consider CSF protein levels to be normal if the value is equal to or below your age in years. I don't think in your case there is a reason to worry. Other CSF components are important as well. Check with your physician to see if there is any reasons to worry. Hope you feel well soon. ...Read more

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Hi, blood test results back and my globulin levels are 37g/l and believe this is above range- what can it mean? My albumin levels are 38g/l

Hi, blood test results back and my globulin levels are 37g/l and believe this is above range- what can it mean? My albumin levels are 38g/l

Insufficient info: There are many components in the fraction called globulin and you need serum protein electrophoresis and may be immunofixation to resolve the identity of the protein that is increased. ...Read more

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My globulin levels are elevated to a 4.2. All other things tested on my blood test were all normal. Can a high protein diet or stress cause it?

My globulin levels are elevated to a 4.2. All other things tested on my blood test were all normal. Can a high protein diet or stress cause it?

How do you feel?: Reference ranges are set so that a few percent of healthies fall outside on either end. If you feel okay, I would not give this another thought. ...Read more

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Does low serum globulin affect blood tests that assess immunoglobulin levels? For example if an illness caused proteinuria, could a disease actually cause the test for it to be falsely negative?

Depends: If your immunoglobulin(s) is low especially when it involves igg, your immune system is likely impaired. It is not a "false-postive" result although the cause for the deficiency may vary and treated accordingly. ...Read more

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How small is the so called "small" risk of acquiring something bad from hepatitis b immune globulin (hbig) used as HBV pep (blood-derived product)?

Very very small: Modern treatment of Immune Globulin products has pretty much eliminated fear for hepatitis or hiv. However one is always concerned over prion which is a particle not degraded by alcohol or heat and can cause a severe neurologic condition. However I have not heard of a single case of this condition induced by immune globulin. Thus there is a risk which is as remote as being struck by lightning. ...Read more

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Can malabsorption from small bowel Crohn's decrease sensitivity of IBD blood panel? Wouldn't low serum globulin = fewer antibodies for test 2 detect?

Can malabsorption from small bowel Crohn's decrease sensitivity of IBD blood panel? Wouldn't low serum globulin = fewer antibodies for test 2 detect?

>100,000 proteins: Globulin = total proteins less albumen, the most abundant protein. While globulins includes antibodies, it also includes many other proteins. Within the 5 antibody subclasses (IgM, IgG, IgA, IgE & IgD), with >100,000 specific binding activities for just IgG, the whole point is the ratio of relative targeting specifics, competing physiologic controls & responses. Globulin can be ? & targeting also ? ...Read more

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Recently I had lab work done. My globulin level was 5.8. My dr did further testing and total globulin was 4.9. My gamma globulin was a little elevated?

Recently I had lab work done. My globulin level was 5.8. My dr did further testing and total globulin was 4.9. My gamma globulin was a little elevated?

Need more info: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, it would have helped to have the actual results. Elevated gamma globulins may indicate the presence of inflammation. ...Read more

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Gamma globulin level in test is 22.6%, results page they gave says this is higher than normal, normal range is listed as 11.1-18.8%. Concerned Myeloma?

Gamma globulin level in test is 22.6%, results page they gave says this is higher than normal, normal range is listed as 11.1-18.8%. Concerned Myeloma?

Means nothing: Reference ranges are set so that several percent of healthy folks fall outside on either end. This has actually happened to me as well. At age 27 you do not have myeloma, and even myeloma patients usually suppress the other gamma globulins. ...Read more

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What does elevated Igg-2364 and gamma globulin 2.2 mean with polyclonal gammopathy and Kappa and lambda typing increased?

What does elevated Igg-2364 and gamma globulin 2.2 mean with polyclonal gammopathy and Kappa and lambda typing increased?

Nothing serious: Polyclonal gammopathy does not have the seriousness of monoclonal gammpathy. Firstly your IgG and total globulin levels are only mildly elevated, so It may not mean any disease. One cause is chronic inflammation(infections) such as Chronic arthritis or chronic liver disease, conditions which can be checked out or ruled out easily if you ask your doctor and seek his/her advice about it. ...Read more

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