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Doctor insights on: Increased Gamma Globulin Levels In Blood

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I recently received blood results showing gamma globulin levels of 0.37 when normal range is 0.7-1.6. Is it possible that this is a one-time thing?

I recently received blood results showing gamma globulin levels of 0.37 when normal range is 0.7-1.6. Is it possible that this is a one-time thing?

Maybe: Reference ranges are set so that several percent of healthy folks fall outside on either side. This may just be you. It is no danger. Stop worrying. If this continues or you are very curious, you can get the various types quantitated. Some folks run way-low on one of the three major types. Usually they still do okay. ...Read more

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Dr. Robert Dracker
97 doctors shared insights

Immune Globulin (Definition)

The immune globulins are a class of blood proteins elaborated by the immune system to fight infection, and then remember the antigens of the infecting agent to use for ...Read more


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In blood work, does elevated gamma globulin (m-spike) often cause the total serum globulin to be elevated as well?

In blood work, does elevated gamma globulin (m-spike) often cause the total serum globulin to be elevated as well?

Tt could: Since, total globulin level usually includes all kinds of globulins (alpha, m spike etc). An immunoelectrophoresis can further characterize the m spike. ...Read more

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What is the day to day variability of gamma globulin levels?

What is the day to day variability of gamma globulin levels?

Don't know: I don't know because there can be considerable variability so we normally don't monitor immunoglobulins so closely. Especially IgG can vary by multiples in response to an infection but I'm sure there will be some variation in samples taken even just minutes apart. Perhaps if provided a specific context I could give a better answer ...Read more

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What do you recommend if I have elevated gamma globulin levels following obstruction?

What do you recommend if I have elevated gamma globulin levels following obstruction?

Underlying disease: Elevated gamma globulin is not a disorder by itself but a manifestation of some underlying disease and that cause needs to be treated. ...Read more

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Can a simple infection cause gamma globulin levels to decrease below normal range? (0.37 when normal is 0.7-1.6)?

Can a simple infection cause gamma globulin levels to decrease below normal range? (0.37 when normal is 0.7-1.6)?

No: Very unlikely, unless the patient is already immune compromised, other causes for this low level would be diseases/disorders leading to loss of protein from gut, kidneys or malnutrition, are mainly the causes for such, low level of immunoglobulins has other causes in addition,mainly lymphocytes problems, either T cells or B cells problems mainly are the causes for immunodeficiency states 1ry / 2ry ...Read more

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Can gamma globulin levels of 0.37 recover? How long would natural recovery take? If they don't recover (over 3 months-3 tests), immune deficient?

Can gamma globulin levels of 0.37 recover? How long would natural recovery take? If they don't recover (over 3 months-3 tests), immune deficient?

Lo gamma globulins: Well that isn't an isolated number, meaning it should be interpreted in the context of a clinical picture, so why did you have this done and repeated in the first place? Several reasons for such, mainly protein losing disorders either from a gut or from kidneys, malnutrition/ primary immunodeficiency can be a cause too, replacement therapy available,but you need to be rightfully diagnosed,goodluck ...Read more

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Blood tests shows high gamma globulin & high igg. Ifx shows no monoclonal protein & free light chains are within normal range. What does this mean?

Blood tests shows high gamma globulin & high igg. Ifx shows no monoclonal protein & free light chains are within normal range. What does this mean?

It might be a benign: Many benign processed can cause hypergammaglobulinemia, which are benign elevations without a para -protein or m-spike on serum protein electrophoresis(spe)> it all depends on how high is the gammaglobulin level and making sure the liver functions are ok and there is no chronic inflammation(like rheumatoid arthritis, sarcoidosis etc) going on inside the body. ...Read more

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Why would pcp refer me to hematologist due to elevated protein in blood (elevated gamma globulin)? Is this something to be concerned about?

Why would pcp refer me to hematologist due to elevated protein in blood (elevated gamma globulin)? Is this something to be concerned about?

Further evaluation: There are many reasons for elevation of the serum protein. The hematologist is the best person to guide the work-up to determine if you have something like myeloma or other plasma cell dyscrasia or a non-malignant cause of the elevated protein level. ...Read more

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