Doctor insights on:
Inconclusive Thyroid Biopsy Results
Why would a thyroidectomy final pathology report (not fna) be inconclusive (goiter vs follicular neoplasm)?
Biopsy is tissue removed by needle or cutting to remove part of a body part. It is usually a small amount of material that is processed by a pathologist. Most of the time it is stained and looked at through a microscope to arrive at a diagnosis. Special processes are done for some tissues or problems. The purpose is to tell what the problem is (diagnosis). ...Read more
Need more info: Not sure what you mean by "test results" but u cannot know that u have multinodular goiter from a blood test. A thyroid ultrasound can give u this diagnosis in which case u will need a blood test called TSH to know what to do next. No thyroid scan needed unless the TSH is low. Thyroid ultrasound vs. Biopsy might be needed depends on the size and characteristics of the nodules but need more info. ...Read moreSee 2 more doctor answers
Is afirma thyroid fna analysis-molecular marker test by veracyte any good for diagnosing papillary thyroid cancer?
Sampling error: Fine needle aspirate of lymph nodes are not ideal for ruling out abnormal findings. Especially, with lymphomas there may be areas within the ln that are not involved and sampling of these areas may be misleading. Excisional biopsy is the gold standard, as it allows for assessment of individual cells and architecture of lymph node and adequate tissue for specialty workup. ...Read moreSee 1 more doctor answer
Better to wait: Cytopathologists may preferr that you wait a couple of months if it is slightly suspicious but inconclusive. Inflammation can make interpretion harder. On the other hand, if the fna was nondiagnostic because of too few cells, it is desirable to repeat it within a reasonably short period of time. ...Read moreSee 1 more doctor answer
Thyroid sono showed heterogeneous gland with multinodular goiter(positive hashimoto's diagnosis;on synthroid)-follow up sono when?
Ultrasound showed circumscribed solid 2.7cm nodule. FNA showed Follicular lesion.Thyroseq was non diagnostic. Need 2nd FNA and 2nd thyroseq.Why?
More information: Dear patalbre34: Are you referring to a thyroid ultrasound? If so, most likely, the FNA and Thyroseq were not enought to make an accurate diagnosis. The needles used for this procedure are very tiny and sometimes the amount of tissue that you get from them is not enough to make an accurate diagnosis. Hope this helps. All the best, Ariel ...Read more
Yes: In general, if a nodule is very large, there is a higher chance that it can be called benign although it still could be cancerous because not all of the nodule is typically cancerous. You could have one little speck of cancer that hide within the big mass and a biopsy could miss it because we can't "poke" you forever. However, if a biopsy came back "cancerous", it almost always is true. ...Read moreSee 2 more doctor answers
Low TSH Borderline low T4 normal t3 (liothyronine). Thyroid uptake scan..low uptake noted w\o nodules. Radiologist said HYPOTHYROIDISM?! All other possible test norm
Need follow-up: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, there is inconsistency in your results. Both TSH and T4 being low does not add up. You may need to repeat the lab tests, not necessarily the scan, in about 6 months to see what direction these results are going in. ...Read more
Thyroid biopsy: Hard to answer. No test is perfect. With an ultrasound-guided needle bx, the pathologist looks at the sample of cells that he gets. He may not get a good sample. In some kinds of thyroid cancer, it is hard to distinguish normal from abnormal cells. Sometimes decisions need to be made in spite of "test results", i.e. A judgement call. Talk to your endocrinologist. ...Read more
FNA nodule , AFIRMA result suspic thyroid cancer had tot thyroidectomy, pathology has entire specimen yet can't determine if cancer or not why?
False-pos Afirma?: Afirma testing has been in clinical use for several years. It now appears that Afirma testing is clinically useful when it is negative and not when it is positive. This has been my experience and I am not sure there is supporting data regarding this. So, in your case, the Afirma test was probably falsely positive, and that the nodule was benign. My best guess. ...Read moreSee 1 more doctor answer
Pathology cytology report of Left thyroid biopsy says NO malignant cells... changes suggestive of Colloid nodule/ nodular Goiter. What's next?
MNG + cyst: Hello ~ this is a nodule in MNG (multi-nodular goitre). Previously thought to have no risk of Ca and DOMINANT nodule to have 1% risk and solitary nodule 10% risk. Retrospective studies now show up to 13.7% risk of cancer overall in MNG. Thats high. I would see a surgeon to discuss if this warrants thyroidectomy. thanks ...Read moreSee 1 more doctor answer
Bronchoscopy with biopsy of lung nodules was done, biopsy result shows normal bt bronchial washing shows poorly differentiate cancer, confused?
See below: I'm not sure how your procedure was done, but nodules can be very difficult to biopsy, depending on size and if any type of imaging guidance is used. So in your case, the biopsy may have only gotten normal lung tissue and the nodule itself wasn't biopsied. The washing gets a large area - normal tissue and where the nodules are. It is sent for cytology. the Biopsy would be for histology. ...Read moreSee 2 more doctor answers
Thyroid us: diffusely heterogeneous thyroid w/o well-defined dominant nodule, isthmus enlarged. Thyroid ab tests are neg, tg = 88.7 (<55). Diagnosis?
Thyroid Ultrasound heterogenous thyroid parynchema with hypervascularity. Blood test normal tsh t4 t3 (liothyronine) etc but >1300 TPo antibodies?have Hypo symptoms
Elevated: TPO levels are associated with autoimmune thryroid disease/thryoiditis, for example Hashimoto disease. The thyroid US findings are also consistent with thyroiditis. Talk to your doc about next steps. ...Read more
Thyroid biopsy cold nodule showed Follicular cells 2x4cm. Being sent out for generic testing? Will this show if it's benign?
Thyroid nodules: This is a good question and not totally resolved in the thyroid cancer field. On needle aspiration, it is often impossible to distinguish between a follicular adenoma (benign) or follicular cancer. The genetic tests theoretically help make the distinction. But they are not perfect. Many doctors would send you to a good thyroid surgeon and remove a 2x4 cm thyroid nodule with follicular cells. ...Read more
Thyroid ultrasound showed heterogenous echogenicity hypervascular thyroid. Thyroid labs normal. Any thoughts on what this is?
Thyroid glands can develop nodules and an important way to determine whether the nodule is cancerous is a needle biopsy. This is done under ultrasound guidance and uses a very fine needle. The procedure in not as bad as it may sound and is done as an outpatient. It is best done by someone who does this all the time so that adequate material is ...Read more
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