Doctor insights on:
Inclusion Body Myositis Diagnosis
Myopathy type: Ibm is atype of inflammatory myositis. It tends to affect people older than 50. People with ibm often have weakness of their upper and lower arms and legs. Sometimes the muscles look smaller known as atrophy. Unfortunately there are no treatments that are proven to help. However, patients are sometimes tried on a short course of steroids, ivig, etc. Phys therapy is extremely important. ...Read moreSee 1 more doctor answer
Basal body temperature is the taking of the oral temperature first thing in the morning approximately at the same time before even getting out of bed to do anything. Around midcycle or so about 1 to 2 days after ovulation the temperature will rise approximately 0.8 - 1.0° above the baseline. This rise signifies potential ovulation. The actual ovulation usually occurred ...Read more
Different diseases: Both are muscle diseases that are difficult to treat, polymyositis tending to affect shoulders and hips, inclusion body mysoitis the forearms. Polymyositis is the more treatable, but the more likely to become very serious, we know something of its cause unlike inclusion body myositis. Under the microscope they look different. Both are difficult and i wish you good luck and courage. ...Read more
A wide spectrum Pts.: This is an inflammatory muscle disease, with slowly progressive weakness and wasting of both distal and proximal muscles, most notably of the arms and legs. Because this randomly affects different people in different ways and at different rates, there is no "textbook case." there are two kinds, sporadic and hereditary. The hereditary case does not have inflammation and is thus not myositis. ...Read more
Ck emyograph biopsy: Ten fold increase creatine kinase enzyme,electromyography, muscle biopsy sent to neuropathologists, or human leucocyte gene assays using gene sequencing or similar tests will Narrow this down to sporadic type but this is a disease that begs more discoveries. Of course your doc needs to determine if your symptoms are those of IBM. ...Read moreSee 1 more doctor answer
Myxofibrosarcoma presenting in the skin: clinicopathological features and differential diagnosis with cutaneous myxoid neoplasms.?
Fairly common: The differential diagnosis will be made by the pathology team. My teacher hector battifora was among the world's most distinguished sarcoma pathologists but said he would never sign one out without another pathologist. The low nuclear grade ones rarely metastasize / kill, but all are prone to annoying local recurrences. Good luck, glad it's this relatively tame (still dangerous) cancer. ...Read more
Is there research into any genetic, autoimmune or other condition that links nerve sheath disorders (tarlov cysts, nerve sheath tumor) with autoimmune hypophysitis targeting acth cells? Ctla-4 gene?
Immune modulation: Ipilimumab is a drug used to treat melanoma. It targets ctla-4, which is a t cell receptor that downregulates part of the immune system. A side effect has been described: autoimmune hypophysitis (inflammation of the pituitary) which can knock out many hormones, including acth. There are a few articles on this. Torino et al, oncologist 2012; 17:525. ...Read more
May i know the simple explanation for this diagnosis: (post auricular area), excision biopsy: cellular spindle cell lesion favor nodular fascitis?
Get 2nd opinion: A pathologist who trained at one of my institutions self-diagnosed a sarcoma and had his arm amputated, only to discover later it was nodular fasciitis, which is very benign. I was trained by some of the great pathologists and even they said they'd never call nodular fasciitis without a second pathologist agreeing. I'd suggest showing 3-4 of us pathologists. Good luck. ...Read more
M77 , biopsy of vastus laterilus muscle says "secondary neurogenic atrophy with super imposed inflmatory myopathy" which disease this may be?thanks
Your doctor needs: to findout if you have any cause for your neuropathy. This can be from many causes - usually diabetes or alcohol or other drugs are the cause. You need to go over with your doctor what possible things in your life are responsible for it. The secondary inflammation suggests you have a compromised immune system or slightly weakened one. People usually do not get inflammation of the muscle. ...Read more
Trappd skin fragment: Due to a minor injury, pimple, etc., a piece of skin gets trapped under the normal skin. It doesn't know it is not on the surface, and so it makes oil and hair and it sheds dead skin normally. All of this accumulates under the surface and forms a small cyst. As more debris is added, the cyst gets bigger and bigger. They are recognized by their overlying enlarged pore and cured by excision. ...Read more
Muscle Biopsy Results Meaning? rare chronic inflammatory
cells, composed of CD3/CD8 positive T-lymphocytes and CD68 positive macrophages.
All lab test need ..: With data we need clinical context. That is why you are having trouble. There is not enough information to provide an interpretation. ...Read more
Ana 1:640 only +lab. Dx: undifferconnective tissue disease(sx: immense fatigue, jt pain, sicca, photosensitivity). Can vague diagnosis cause such havoc on life?
Yes: Symptons can be very disruptive. An elevated ANA by itself does not a diagnosis of autoimmune disease make, but in conjunction with your symptoms, especially if they are persistent, the findings are very suspicious for this. Some individuals without autoimmune disease have elevated ANA levels. Some medications can cause this. Further evaluation is necessary, including a complete lab workup. ...Read moreSee 1 more doctor answer
Which doctor helps with Autoimmune crossover Myositis/that affects all the body...How is a DX made and can Dystrophys, Scleroderma MCTD fall into it?
Rheumatologist: This is one you need to consult. ...Read more
Recent diagnosis w/autoimmune disease & skin biopsy result: urticaria or mast cell disease. Shouldn't biopsy give more definitive diagnosis?
Hard to tell: Mast cells are the cells that release histamine in the body. This is what happens in urticaria, so one will see mast cells in biopsies of urticarial (hive-like) lesions. Mast cells can also be found in increased numbers in people with mastocytosis. Thus the biopsies may be similar. As stated by my colleague, the clinical history can be key to the diagnosis. Talk with your doc. ...Read moreSee 1 more doctor answer
Help understand skin biopsy result: "There is a sparse perivascular lymphohistiocytic inflammatory infiltrate. CD117 highlights only a few scattered mast cells. Diagnosis: Mild superficial perivascular infiltrate." Anything of concern here?
See below: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, the findings listed in the report are non-specific and non-diagnostic. Do you have any symptoms? Why was the biopsy done? ...Read more
Which connective tissue diseases cause a skin rash? Punch biopsy suggestive of early connective tissue disease.
Red,painful,swollen: Orbital myositis (OM) falls in the spectrum of orbital inflammatory diseases, which are associated w/ autoimmune dz like rhuematoid arthritis, lupus, crohn's dz etc. When no cause is found (more common than not), it is called idiopathic orbital inflammation. Om is orbital inflammation focused on an eye muscle. Workup includes a search for underlying cause. First line treatment is w/ oral steroids. ...Read moreSee 1 more doctor answer
Is ganglion cyst on top of foot possibly gotten more easily or related to possible undifferentiated connective tissue disease?
Pet scanning is used for staging of a variety of cancers. Lesions seen on plain scans can be shown to be biologically active of pet scan this then suggests metastatic tumor and stages the disease. If a lesion on plain scan does not "light up" on pet scan, it is ...Read more