Doctor insights on:
Immunosuppressive Drugs Rituxan
Rituximab: Rituximab is one class of immunosuppresant therapy. It is an chimeric (composed of human and animal) monoclonal antibody directed against a surface marker (cd20) on your b-cells. Your b-cells naturally produce your own body's antibodies to help fight infections. There are other types of immunosuppresants which have different targets than b-cells, such as t-cells, and cytokines such as tnf-alpha. ...Read moreSee 1 more doctor answer
Immunosupressive : Immunosuppressive agents are agents that suppress immune function by one of several mechanisms of action-through t cell activation, ihbition of b cell helper, dna inhibition etc, such as cyclosporine, tacrolimus, sirolimus, corticosteroid. Rituxan is one of immunosupressive agents where it works by binding the cd 20 receptors on the b cell-lymphocytes which eventually leads to the cell’s death. ...Read more
To decrease immunity: Immunosuppresive agents are drugs that decrease immune function. While in most situations this would be undesirable, with certain conditions where the immune system is overactive or too aggressive, these drugs may be proper. Examples include to prevent rejection of transplanted organs, in autoimmune conditions to prevent tissue destruction, and in diseases with chronic inflammation like asthma. ...Read moreSee 1 more doctor answer
Immune disorders: Immune suppressive drugs works just as they sound- to suppress the type of overactive immune responses causing the illnesses . The type of drug used would depend on the type of immune reactions specific to that disease. ...Read more
A lot: Organ rejection is a complex and not entirely understood immunologic process. Different immunosuppressive drugs are designed to interrupt different parts of this cascade of processes. Each drug has different efficacy and side-effect profiles. Most of the time clinicians employ a combination of multiple drugs and adjust their dosages to maximize efficacy & minimize side-effects. ...Read more
In General, Yes: However, identical twins (same placenta) don't since they do not reject organs and tissues. In addition, there may be a few recipients with a sluggish immune system that don't appear to reject their transplanted organ. We call this tolerance, and it is a very hot area of research. The doses of is drugs usually can be decreased over time, and some recipients actually take very little. ...Read moreSee 1 more doctor answer
Rejection: Your immune system sees any transplant as a foreign object. It treats the cells of the transplant just like bacteria cells it works to destroy them. This would cause the transplant to be destroyed or rejected. The immunosuppression runs down the volume of the immune system so it cannot kill off the transplant so easily. ...Read more
Is it true that there are new techniques to remove antigens of donated organs to avoid rejection instead of using immunosuppressive drugs?
Not aware of any: Monoclonal antibody therapy, which blocks immune responses of key white cells (T-cell lymphocytes) is relatively new, but I am unaware of novel techniques to remove antigens from donor organs. You may want to discuss this with a large medical center transplant program if you are interested in new therapies or even in participating in a research study. ...Read more
Risk vs. Benefit: It depends on the drug.Get a more detailed answer ›
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