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Doctor insights on: Immunoglobulin Profile Serum

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What changes are seen in the immunoglobulin profile after a splenectomy?

What changes are seen in the immunoglobulin profile after a splenectomy?

Usually none: no changes in humoral immunity usually happens after splenectomy, however splenectomized patients should receive certain vaccines, pneumococcal, meningococcal, h flue and flu, ask your doctor about them, good luck ...Read more

Dr. Robert Dracker
99 doctors shared insights

Immune Globulin (Definition)

The immune globulins are a class of blood proteins elaborated by the immune system to fight infection, and then remember the antigens of the infecting agent to use for ...Read more


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Immunoglobulin a, qn, serum. came back 203 what does that mean?

Immunoglobulin a, qn, serum. came back 203 what does that mean?

Normal: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, your IgA level is normal. ...Read more

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My immunoglobulin g, qn, serum came back low at 635. What could that mean?

Likely nothing: You IgG level while at the low side is still within normal limits. If you do not have any symptoms, do not worry about the number. You may consult this site for info on this topic: https://medlineplus.gov/ency/article/003545.htm ...Read more

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What is immunoglobulin g, qn, serum? My results came back low for subclass 3 out of the four.

Don't worry: I presume that these tests were done because of recurrent sinus or lung infections. Ig g is a measurement of the major antibody type which is involved in fighting against infections. If the total is normal but the igg3 is low, it has little meaning. But if your total igg1 is low, then this may be of concern. ...Read more

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Is a serum immunofixation test focused on monoclonal immunoglobulins but can also detect polyclonal ones or just the former? Thanks.

Is a serum immunofixation test focused on  monoclonal immunoglobulins but can also detect polyclonal ones or just the former? Thanks.

Depends: This depends on what you are looking for. If you are just interested in antigen binding, any specific antibody would bind to the antigen. ...Read more

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What does it mean if I have high immunoglobulin m qn serum?

Waldenstrom's Dz: An elevation of immunoglobulin m (igm) in the serum esp. If monoclonal (of one kind) raises the possibility of waldenstrom's macroglobulinemia - a malignancy affecting lymphocytes or plasma cells that produce this abnormal IgM protein causing symptoms of hyperviscosity - confusion, shortness of breath, stroke, kidney damage etc. ...Read more

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My 3 year old immunoglobulin g qn serum level is high mg/dl 453-916 what does this mean?

IgG: It likely means nothing. Are they checking it for a possible immune deficiency or chronic/recurrent infections? You need to have a bit more information to truly get a better answer. ...Read more

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I have a very low igg3 and igg4, along with a very low immunoglobulin m and a high serum amyloid a - what does this mean?

See immunlogist: The low igg3 and igg4 in and of themselves may not mean much if your igg1 is normal. The fact that you also have low igm suggests that there may be an immune disorder. The high serum amyloid a likely signifies inflammation in your case. www.ncbi.nlm.nih.gov/.../10608507?. ...Read more

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I recently had a celiac panel done and it came back negative. However the immunoglobulin a, qn, serum level was low at 59. Is this serious?

I recently had a celiac panel done and it came back negative. However the immunoglobulin a, qn, serum level was low at 59. Is this serious?

Unlikely: Low IgA occurs in about 1/333 people. Most people with this isolated deficiency do not have problem. A very low IgA level may make a celiac test based on IgA antibody false-negative- ie. The disease is there but the test fails to detect it. However yours is not low enough. ...Read more

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My blood work indicated I have low Immunoglobulin A, QN, Serum and Low Igg 1 and 3as well as 14 low Pneumococcal types; could this be why I have fatig?

Possibly: The fatigue can be due to recurrent respiratory infections, secondary to the immunoglobulin defiencies, and the low antibodies titers, kindly keep the follow up with an allergist/immunologist preferably in a tertiary care facility, you may need intravenous immunoglobulins replacement therapy, wish you wellness ...Read more

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Immunofixation, Serum FAH = Monoclonal IgG kappa immunoglobulin. Beta FAH = 10.5% Abnormal band, immunofixation to follow. I'm IgA deficient too. ??

Possibly: If I am understaning this right you have a monoclonal protien band? The most important next steps here would be to identify the band (immunofixation) and then perfrom quantitvaive immunoglobulin levels. IF there is a monoclonal band, you may very well have reciprocal depriciation of alternative immunoglobulins and IgA deficiecny with an IgG monoclonal protein is possible. ...Read more

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My 3 yr old took an allergy test her immunoglobulin e total was 12 immunoglobulin g qn serum total 1111 they said was high immunoglobulin a 90 means ?

My 3 yr old took an allergy test  her immunoglobulin e total was 12
immunoglobulin g qn serum total 1111 they said was high
immunoglobulin a 90 means
?

Immunoglobulins: Ige is the allergic antibody (this was normal). An elevated igg level might simply be if he was fighting an active infection at the time (this is a good sign). Iga protects mucosal membranes (sinus, lungs, GI tract, urinary tract) and his level is normal. Feel reassured that these labs look very good. ...Read more

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Does low serum globulin affect blood tests that assess immunoglobulin levels? For example if an illness caused proteinuria, could a disease actually cause the test for it to be falsely negative?

Depends: If your immunoglobulin(s) is low especially when it involves igg, your immune system is likely impaired. It is not a "false-postive" result although the cause for the deficiency may vary and treated accordingly. ...Read more

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I have the following and no definitive diagnosis..low(8.3)hgb,hct(25), require IV iron every 4-6 mo. lately immunoglobulin m,qn serum 415.FATIGUE?

I have the following and no definitive diagnosis..low(8.3)hgb,hct(25), require IV iron every 4-6 mo.  lately immunoglobulin m,qn serum 415.FATIGUE?

SEVERE ANEMIA: Can cause the fatigue you are having. Hope you are under the care of a hematologist or other specialist to get the right DX. ...Read more

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What would cause free kappa &free lamba to be high but ratio normal also Immunoglobulin M, Qn, Serum high. platelets steady rising & WBC high for 1yr?

Polyclonal gammopath: Something is stimulating all the B cell lines to produce a lot of antibodies. That general condition is called polyclonal gammopathy. It can be caused by a chronic infection (virus) or 9 other broad categories of causes (liver problems, connective tissue diseases, bone marrow disorder like Waldenstrom's, drugs/meds, autoimmune probs, misc). It's too much to go into here. Use Healthtap Prime to tal ...Read more

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Can you tell me about immunoglobulins: help me for biology?

See Below: Immunoglobulins are a type of protein made by your body to help protect it against infections. There are five types of immunoglobulins: IgA, IgD, IgE, IgG, and IgM. Each of these has a slightly different function in infection fitting. ...Read more

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What makes all the types of immunoglobulins different? Do they look different?

What makes all the types of immunoglobulins different? Do they look different?

Yes, look different: Immunoglobulins also known as antibodies or gamma-globulins, are made are made of light chains and heavy chains. The different heavy chains are the bid difference between the immunoglobulins. Alpha1 abd alpha2 (IgA), Gamma 1-4 (IgG),Epsilon (IgE) and Delta (IgD). IgM is made up of 5 antibodies(a pentamer) arranged like the spokes of a wheel. It takes Xray diffraction optics to "see" the differen ...Read more

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What does a high immunoglobulin level mean for you?

It depends: There are several types of immunoglobulin, igg, iga, IgM and ige. Having a "high" level of each of them could mean different things. It is also important to know if it is a "high" overall level, or a "high" level of a specific kind of igg, iga, igm, or ige. In general, a high ige means "allergy". High igg/a/m can mean different things depending on their specificity (total or specific). ...Read more

Immunoglobulin (Definition)

Immunoglobulins are antibodies produced by b cells. They have a y shaped configuration. They are involved in protecting us ...Read more


Serum (Definition)

Serum is the component of blood that does not contain cells or clotting factors. It does contain electrolytes an ...Read more