Doctor insights on:
Immunoglobulin G Serum
You IgG level while at the low side is still within normal limits. If you do not have any symptoms, do not worry about the number. You may consult this site for info on this topic:
https://medlineplus. Gov/ency/article/003545.htm ...Read more
Don't worry: I presume that these tests were done because of recurrent sinus or lung infections. Ig g is a measurement of the major antibody type which is involved in fighting against infections. If the total is normal but the igg3 is low, it has little meaning. But if your total igg1 is low, then this may be of concern. ...Read more
I had an immunoglobulin g, qn, serum appear on my blood test result of 2364, yet my doctor said it's not an issue. Is he right?
Correct.: Look at the person. Look at the numbers only when they shed light on the person. ...Read more
My 3 yr old took an allergy test her immunoglobulin e total was 12 immunoglobulin g qn serum total 1111 they said was high immunoglobulin a 90 means?
Immunoglobulins: Ige is the allergic antibody (this was normal). An elevated igg level might simply be if he was fighting an active infection at the time (this is a good sign). Iga protects mucosal membranes (sinus, lungs, GI tract, urinary tract) and his level is normal. Feel reassured that these labs look very good. ...Read more
IgA Deficiency: Sounds like selective IgA deficiency, if these are the results. Selective IgA deficiency is the most common immunodeficiency in the world and is usually benign but needs to be followed. IgA def in women is more significant since it can convert to common variable immune deficiency and there is HUGE risk of lymphoma development in the 50's-60's. See an immunologist ...Read more
See an immunologist: Immunoglobulin g (igg) is the main type of antibody found in the blood and is used by your body to help fight off infections. Some people may have a slightly low igg but be perfectly healthy. In others, it may indicate a problem with the immune system that can put one at risk for getting infections. An immunologist can perform additional tests to determine the cause of the low igg. ...Read more
Don't worry but first: Thing I would be wondering is why did you have those tests done? Are you having recurrent infections? (not just "regular colds"?),,, but if you were my pt. First thing I would do is repeat the tests to confirm results. If you are having recurrent sinus infections, bronchitis, etc & the repeat tests are similar, next step would be see an allergist/immunologist to further evaluate. Good luck ...Read more
Hard to know: Without more information, it is difficult to know if the levels are low due to lack of production (primary immune deficiency syndrome, medication side effect) or loss of antibodies (protein losing gastrointestinal disease). Also, most people will do well with these levels, but it would be important to know if you have had any recent, or a long history of recurrent, infections. ...Read more
Can you tell me physically and structurally what is the difference between immunoglobulin g and m etc.?
Simply Put: Both IgG and IgM are immunoglobulin proteins with a roughly "Y" shape which binds to an antigen (foreign substance in the body) at one end and a cellular receptor at the other end. The principal differences lie in how and when they form. IgM is made early in infections and form pentamers. IgG is made later in infections, is more specific, and circulates as monomers. ...Read more
Low gamma globulin: By itself, a slightly low level of one igg subclass is a very nonspecific finding. A very low level would be worrisome, but really, what is needed is to look at this information in the context of vaccine responses to Pneumovax vaccine. If the functional antibodies made by the immune system are at normal levels, the gross levels of antibody are less worrisome. ...Read more
? H E S: Hyper Eosinophilic Syndrome, (HES), kind of rare, other possibilities as leukemia may be the case, again those are just mere numbers, can't be read out-of-context, more clinical information, history and physical examination are important, see an Immunologist/allergist and a hematologist for assessment, best to go to a Tertiary Care facility, ask your doctor about referral / coordination of care ...Read more
I just rec'd more bloodwork results. Immunoglobulin g subclass is low & lymphocytes absolute is low, what does it mean?
Deoends: Having one low igg subclass does not mean you have a problem. See a board- certified allergist (take your lab) and they can help you. ...Read more
Yes: It depends on the type of deficiency (IgG subtype or total) and the level. You should see an immunologist or a rheumatologist with specific training in this area for evaluation ...Read more
Only: If profoundly low and you are getting recurrent infections. ...Read more
Wbc 11.8, Rbc 5.2, rdw 16.9, Neutrophil %cc 80.3 Neutrophil count cc 7.6, lymphocyte 9.5, Tsh 10.61, Immunoglobulin g 1660, a1 globulin 1.9 a2 globulin 10.6?
See doctor: You have several abnormal blood tests but I don't know what your question is. The first step is to consult an internist to get these issues sorted out and you will likely be referred for further consultations. Don't delay. ...Read more
Normal: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, your IgA level is normal. ...Read more
Is a serum immunofixation test focused on monoclonal immunoglobulins but can also detect polyclonal ones or just the former? Thanks.
Waldenstrom's Dz: An elevation of immunoglobulin m (igm) in the serum esp. If monoclonal (of one kind) raises the possibility of waldenstrom's macroglobulinemia - a malignancy affecting lymphocytes or plasma cells that produce this abnormal IgM protein causing symptoms of hyperviscosity - confusion, shortness of breath, stroke, kidney damage etc. ...Read more
I have a very low igg3 and igg4, along with a very low immunoglobulin m and a high serum amyloid a - what does this mean?
See immunlogist: The low igg3 and igg4 in and of themselves may not mean much if your igg1 is normal. The fact that you also have low igm suggests that there may be an immune disorder. The high serum amyloid a likely signifies inflammation in your case. Www. Ncbi. Nlm. Nih. Gov/.../10608507. ...Read more
I recently had a celiac panel done and it came back negative. However the immunoglobulin a, qn, serum level was low at 59. Is this serious?
My blood work indicated I have low Immunoglobulin A, QN, Serum and Low Igg 1 and 3as well as 14 low Pneumococcal types; could this be why I have fatig?
Possibly: The fatigue can be due to recurrent respiratory infections, secondary to the immunoglobulin defiencies, and the low antibodies titers, kindly keep the follow up with an allergist/immunologist preferably in a tertiary care facility, you may need intravenous immunoglobulins replacement therapy, wish you wellness ...Read more
What can cause the Sedimentation Rate-Westergren - 70; Complement C4, Serum - 53; Immunoglobulin M, Qn, Serum - 36; Complement, Total (Ch50) >63?
Immunofixation, Serum FAH = Monoclonal IgG kappa immunoglobulin. Beta FAH = 10.5% Abnormal band, immunofixation to follow. I'm IgA deficient too.??
If I am understaning this right you have a monoclonal protien band?
The most important next steps here would be to identify the band (immunofixation) and then perfrom quantitvaive immunoglobulin levels. IF there is a monoclonal band, you may very well have reciprocal depriciation of alternative immunoglobulins and IgA deficiecny with an IgG monoclonal protein is possible. ...Read more
Does low serum globulin affect blood tests that assess immunoglobulin levels? For example if an illness caused proteinuria, could a disease actually cause the test for it to be falsely negative?
Depends: If your immunoglobulin (s) is low especially when it involves igg, your immune system is likely impaired. It is not a "false-postive" result although the cause for the deficiency may vary and treated accordingly. ...Read more
I have the following and no definitive diagnosis. Low (8.3)hgb, hct (25), require IV iron every 4-6 mo. Lately immunoglobulin m, qn serum 415.FATIGUE?
SEVERE ANEMIA: Can cause the fatigue you are having. Hope you are under the care of a hematologist or other specialist to get the right DX. ...Read more
What would cause free kappa &free lamba to be high but ratio normal also Immunoglobulin M, Qn, Serum high. Platelets steady rising & WBC high for 1yr?
Polyclonal gammopath: Something is stimulating all the B cell lines to produce a lot of antibodies. That general condition is called polyclonal gammopathy. It can be caused by a chronic infection (virus) or 9 other broad categories of causes (liver problems, connective tissue diseases, bone marrow disorder like Waldenstrom's, drugs/meds, autoimmune probs, misc). It's too much to go into here. Use Healthtap Prime to tal ...Read more
See immunologist: Immunoglobulin A and G are major parts of the immune system that protect us from serious bacterial infections. Lacking IgA is fairly common but lacking IgG can lead to severe infections. An immunologist can assess the rest of the immune system and review in detail the types of infections you have had to determine what the best treatment approach would be. ...Read more
Biochemistry: Globulins constitute all plasma proteins except albumin and pre-albumin, immunoglobulins are part of globulins, viz. Gamma globulins, there are also alpha globulins (alpha-1and alpha-2), and beta globulins (beta-1 and beta-2), globulins carry out many functions including carrier functions, immune functions, etc.. ...Read more
Check this link, would describe the complex market, supply and demand issues
http://aspe. Hhs. Gov/sp/reports/2007/IGIV/execsum. Htm ...Read more