Doctor insights on:
Yes.: Yes, some patients on imatinib report graying of the hair due to the drug. The good news is that CML patients taking imatinib have the possibility of living long enough to get gray hair from old age, an option not available before that drug was developed. So keep the side effect in perspective. It is safe to use hair dye while on imatinib. ...Read more
Imatinib: "Imatinib mesylate is a protein-tyrosine kinase inhibitor that inhibits the BCR-ABL tyrosine kinase, the constitutive abnormal tyrosine kinase created by the Philadelphia chromosome abnormality in CML." See: http://www. Rxlist. Com/gleevec-drug/clinical-pharmacology. Htm ...Read more
C-kit analysis: Whether patients with gist are candidates for Gleevec (imatinib) depends on the status of a particular gene called c-kit, or cd117. This is a test that must be run on the tumor biopsy tissue and is generally coordinated with the help of the pathology laboratory. In select cases, some patients are candidates for Gleevec (imatinib) regardless of their c-kit results, but this is highly individualized. ...Read more
Please read here for detail answer:
http://www. Nlm. Nih. Gov/medlineplus/druginfo/meds/a606018.Html. ...Read more
Chemotherapy related: Pretty typical. Nausea, vomiting low blood counts, infection risk. ...Read more
What should I do if I have to take gleevec (imatinib) for leukemia and its hard to work because it makes me so sick?
There are a large amount of information on different approaches to manage toxicity based upon the response of the cml. It is expected that people will live for decades with CML on treatment. There are dose changes and other agents to be considered.
Don't stop the drug. Have a discussion with your oncologist about the options for you to be functional. ...Read more
No data yet...: Gleevec (imatinib) inhibits a number of tyrosine kinases in cells (c-kit, pdgfralpha, c-abl). There is very recent data that Gleevec (imatinib) may have activity in retinoblastoma, but these experiments where done on isolated retinoblastoma cells grown in culture. There are no clinical trials showing that Gleevec (imatinib) can treat retinoblastoma. Future clinical trials may be planned to address this question. ...Read more
Clarify question?: What is your question? Imatinib mesylate of Gleevec is one of the first line treatment and has been the standard of care for CML for the last 10 years or so. It is an oral tyrosine kinase inhibitor that inhibits the bcr-abl. In cml, Gleevec has demonstrated a very high response rate, complete hematological/molecular response rate. Newer medication like tasigna, (nilotinib) sprycel now are also available. ...Read more
As above: I am not aware of it. So my answer unlikely. ...Read more
Keep it: If you are past 3 months, then it is best to continue to taking Gleevec (imatinib). Stopping it for a few months is another option. The drug is generally safe although there is not a great deal of experience using it in pregnant women, but there have been close to 100 normal pregnancies in my limited experience. ...Read more
These have no: Established role in front line therapy. Are they being offered on a clinical trial? Both are costly, and possibly of theoretic use. Ask for the strength of the data (it will be called a phase ii trial), . ...Read more
It is the right medicine for cml.
In addition to imatinib mesylate- tasigna (nilotinib) is also available as a first line therapy for cml. ...Read more
Gleevac: Gleevac is not usually the first drug for the treatment of retinoblastoma. There are other drugs that are usually used ...Read more
Suspension OK: If you are unable to swallow tablets they can be dispersed in water or other beverage and stirred with a spoon. It should completely disintegrate but not necessarily completely dissolve. It's OK to drink a suspension. If you left some behind in the glass rinse it down with a little more water and drink that too. ...Read more
Inhibits enzyme: The drug fits precisely into a "pocket" in the enzyme encoded by the mutant gene, blocking the enzyme's function. ...Read more
Hi all, could someone tell me if you can heal blood cancer disease with gleevec (imatinib) medicine?
A treatment for CML: Gleevec (imatinib) is one of the treatments for one type of leukemia, chronic myelogenous leukemia. It is not a cure. ...Read more
What is the life expectancy of a man in good general health with cml x 6 years in remission with gleevec (imatinib) 400mgs po qd.?
Good: From the study, about 70-75% people are still being on Gleevec (imatinib) and still on complete remission for over 12 years now. In addition to gleevec, (imatinib) we have 3 other medications available- i.e. Dasatinib (sprycel), nilotinib (tasigna) and the newest one- bosutinib (bosulif) that you can use if needed. So, I will say that for a leukemia, the life expectancy in CML is actually pretty good. ...Read more
I am a cml patient till 10 years. Name of the medicine is gleevec (imatinib) imtanib. Is there any problem in pregnancy?
Yes: You can not take Gleevec (imatinib) during pregnancy as Gleevec (imatinib) is considered to be as category d meaning there is evidence of human fetal risk. If you are pregnant, interferon is something you can be on. Interferon is in category c. Please discuss in detail with you oncologist/hematologist. ...Read more
Is treatment necessary for systemic mastocytosis? I am taking gleevec (imatinib). What would happen if I stopped taking it?
D/w oncologist: There are indolent systemic masto, and agressive systemic mastocytosis (asm). Many times, with indolent disease- therapy will be aimed only to control the symptoms- itching, diarrhea etc. If you have an asm- then usually treatment is started. Asm can manifest from slowly progressive to rapid fatal disease. Organ involvement, transformation to other blood DX including acute leukemia can happen. ...Read more