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Doctor insights on: I'm Currently Taking Zoloft And Its Causing Me To Be Agitated Should I Just Stop Taking It

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I'm currently taking Zoloft (sertraline) and its causing me to be agitated. Should I just stop taking it?

I'm currently taking Zoloft (sertraline) and its causing me to be agitated. Should I just stop taking it?

Stop: Ssris may cause agitation from akathesia (a feeling of intense internal restlessness), unmasking of bipolar disorder, intensification of anxiety if started at too high a dose. And sometimes just because. But it can be dangerous. Get in touch with prescribing doc. ...Read more

Dr. Alan Ali
433 Doctors shared insights

Agitation (Definition)

Agitation can be demonstrated emotionally or physically. Agitation is an expression of emotion that is a little less than anger but a little more than mildly irritated. One may become agitated quickly. In this case it can be problematic and one might need ...Read more


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I can't stop moving my legs, can Zoloft (sertraline) cause restless leg syndrome.

I can't stop moving my legs, can Zoloft (sertraline) cause restless leg syndrome.

See below: Most selective serotonin reuptake inhibitors like zoloft (sertraline) can worsen or even initiate restless legs syndrome in some people. Have it evaluated by a sleep doctor, to check for other causes such as a low ferritin level. In some people it goes away after sometime and in some the RLS continues as long as zoloft (sertraline) is there. Discuss other options with your prescribing doctor. Also, avoid caffeine. ...Read more

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Zoloft caused restless leg syndrome and pgad (persistent genital arousal). If I stop taking zoloft will rls and pgad go away?

Zoloft caused restless leg syndrome and pgad (persistent genital arousal). If I stop taking zoloft will rls and pgad go away?

Yes: In general, findings of side effects related to medications are found in trials of reducing and/or stopping the medications to determine links between medications and side effects. There are many different antidepressants to discuss with your primary care provider as alternatives, but as always, discuss with your PCP and balance the benefits (reduced depression) vs. The harms (RLS and PGAD). ...Read more

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Zoloft (sertraline) is giving me restless leg syndrome, will it continue to do so or will it stop over time.

Zoloft (sertraline) is giving me restless leg syndrome, will it continue to do so or will it stop over time.

Side effect: If this side effect has persisted for several days to two weeks unfortunately it will likely persist

when antidepressants cause side effects consideration can be given to lowering the dose, changing medication, or adding a medicine to overcome the side effect. ...Read more

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Zoloft (sertraline) agitation, does it go away?

Zoloft (sertraline) agitation, does it go away?

Sometimes: If a patient has just started zoloft (sertraline) and has mild to moderate agitation from it, this often decreases over the first week or so as the body gets used to the drug. However, agitation that persists after this usually doesn't go away unless the dose is lowered or stopped. There are alternatives to try if zoloft causes side-effects, no need to suffer. ...Read more

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I am on day 6 of 25mg zoloft (sertraline). I feel very agitated and almost angry. I feel like I am in a dream. Is this all normal with starting this medication?

I am on day 6 of 25mg zoloft (sertraline). I feel very agitated and almost angry. I feel like I am in a dream. Is this all normal with starting this medication?

Go talk to your: General practioner doctor or psychiatrist whoever prescribed this and discuss the side effects. Its very hard to determine if this is normal side effect that will wear off or if they need to try something else with you. Good luck. ...Read more

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Is it possible 2get a bit of increased anxiety & agitation after first 4weeks on zoloft (sertraline)? I've had a few heart palps too, does that mean its dangerous?

Is it possible 2get a bit of increased anxiety & agitation after first 4weeks on zoloft (sertraline)? I've had a few heart palps too, does that mean its dangerous?

It is possible: It can cause an initial increase in anxiety, but after 4 weeks, that should go away and anxiety should decrease. Some people have paradoxical responses and become more anxious, which may mean it is not the best drug for you. Worst case, the drug could precipitate a manic episode in someone with undiagnosed bipolar disorder. Have a discussion with your doctor to discuss your treatment options. ...Read more

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I am on Depakote Zoloft (sertraline) and hydroxyzine now I cant sleep and very agitated?

I am on Depakote Zoloft (sertraline) and hydroxyzine now I cant sleep and very agitated?

Call your doctor: Need to adjust those medications, depakote interacts with zoloft, (sertraline) both can cause nervousness and anxiety, however your doctor had a reason to put you on both. Hydroxyzine interacts with depakote too, it can be withheld for now, but call your doctor for adjusting the others ...Read more

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26 yr Down syndrome daughter, tics, anxiety, ocd, agitation sadness Zoloft stopped working after 7 yrs on Effexor (venlafaxine) not helping any suggestions?

26 yr Down syndrome daughter, tics, anxiety, ocd, agitation sadness Zoloft stopped working after 7 yrs on Effexor (venlafaxine) not helping any suggestions?

Cbt: Having worked for years with adults with down's syndrome, cognitive therapy can be very effective. Learning procedures, relaxation techniques, action plans, scripted behaviors gives the person options that they often cannot access during episodes of anxiety, depression, or agitation. ...Read more

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Prozac, zoloft, celexa each improve my mood but make me unmotivated. Wellbutrin (bupropion) gives me more motivation but leaves me agitated and still sad. Ideas?

Prozac, zoloft, celexa each improve my mood but make me unmotivated. Wellbutrin (bupropion) gives me more motivation but leaves me agitated and still sad. Ideas?

Both together....: It is not unusual for a psychiatrist to prescribe both an ssri such as Prozac or zoloft together with wellbutrin (bupropion) to get the advantages that you mention of both. Ask your doctor about that. ...Read more

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If taking Zoloft (sertraline) can exacerbate my restless leg syndrome- does the time of day I take the meds matter? Currently taking it at bedtime.

If taking Zoloft (sertraline) can exacerbate my restless leg syndrome- does the time of day I take the meds matter? Currently taking it at bedtime.

Possible: Zoloft (sertraline) usually does NOT exacerbate RLS, but if so, you might take in morning and see if that helps. Also, you might benefit from use of a dopamine agonist at bedtime to control the restless legs. ...Read more

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I realized that my Zoloft (sertraline) might be the reason I all the sudden am restless at night, what would you recommend?

I realized that my Zoloft (sertraline) might be the reason I all the sudden am restless at night, what would you recommend?

Let your prescribing: Medical provider know. All ssri's can impact sleep. Insomnia is a potential side effect from zoloft (sertraline). If you take it at night would consider taking it in the morning instead. Sometimes taking it in a divided dose can help. Often the insomnia dissipates (but not always). ...Read more

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Is restless leg syndrome a side effect of zoloft (sertraline)?

Is restless leg syndrome a side effect of zoloft (sertraline)?

Occasionally yes: Genetics, alcohol and caffeine, changes in exercise patterns, certain meds, iron deficiency, kidney problems, nerve damage can all cause or worsen restless legs syndrome. Zoloft (sertraline) can sometimes. It looks like you're on Mellaril which can worsen RLS too. ...Read more

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This is my second day on Zoloft (sertraline) and I feel restless and tired. I'm also. Having heart palpitations will this go away soon?

This is my second day on Zoloft (sertraline) and I feel restless and tired. I'm also. Having heart palpitations will this go away soon?

Yes it will: It may take a couple of weeks for your body to get adjusted to the antidepressant. Initial symptoms Include an increase in anxiety, nausea, diarrhea and restlessness. If you stick to your prescribed regimen those initial symptoms will go away. Good luck with your treatment and remember it may take about 4-6 weeks before you start to see changes in your mood with the antidepressant-don't give up! ...Read more

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I'm now taking Zoloft 100mg cymbalta (duloxetine) 30mg for 2wks then I will stop Zoloft and just take cymbalta (duloxetine)... Will this cause weight loss or gain?

I'm now taking Zoloft 100mg cymbalta (duloxetine) 30mg for 2wks then I will stop Zoloft and just take cymbalta (duloxetine)... Will this cause weight loss or gain?

Generally: Some medications don't exactly cause weight gain but if you feel depressed sometimes you don't eat so when you take an antidepressant and start feeling better your appetite comes back and you end up gaining weight. This doesn't always happen but some people treat the weight gain as causal to the medication when in fact its due to improved mood which leads to improved appetite. Just watch what you eat. ...Read more

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How do I stop emotional numbness caused by ssri used? I have only been on one for 7 weeks and am currently tapering off 25 mgs of zoloft (sertraline).

How do I stop emotional numbness caused by ssri used? I have only been on one for 7 weeks and am currently tapering off 25 mgs of zoloft (sertraline).

Emotional numbness?: Some people feel detached from their emotions when on ssri's, but not all do. Emotional numbness can also come with depression, ptsd, dissociative disorders, drug use, and even some psychoses, etc. Please talk with your doctor about what you're experiencing. If it's related to zoloft (sertraline) and not to your primary condition, it will dissipate when zoloft (sertraline) is stopped. You'll be back at square 1, tho'. ...Read more

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Propranolol (40 mg pd, no bradycardia up to 40mg.)didn't really reduced my agitation, any alternative medicine? (together with sertraline&bupropion).Tnx

Propranolol (40 mg pd, no bradycardia up to 40mg.)didn't really reduced my agitation, any alternative medicine? (together with sertraline&bupropion).Tnx

Some options: If you have not tried therapy/counseling yet, that would be my first recommendation. Looking at diet and reducing stimulants could help. Good sleep, exercise, yoga & meditation can help some people. Short term use of Lorazepam can help. Clonidine might help. You didn't mention dose of wellbutrin, (bupropion) but it can be "activating" and cause akathisia in some. Review doses and symptoms with doc. ...Read more

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I started 100 mg sertraline and 75 mg venlafexine 3 weeks ago, my 40mg dose of citalopram no longer seemed to be working. I've been feeling anxious and agitated and today I had a severe panic attack. Is this average?

I started 100 mg sertraline and 75 mg venlafexine 3 weeks ago, my 40mg dose of citalopram no longer seemed to be working. I've been feeling anxious and agitated and today I had a severe panic attack. Is this average?

Drug interactions: You're taking 3 meds which have duplicate goals and significant drug interactions. You are at risk for serotonin syndrome which may explain your agitation. Call prescribing doctor right away or go to urgent care to be checked for blood pressure and heart rate. You should not be on all 3 meds at the same time. Please get medical supervision to adjust your meds without delay. Be safe and take care. ...Read more

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I'm taking Zoloft (sertraline) 75, can it cause liver enzymes higher?

I'm taking Zoloft (sertraline) 75, can it cause liver enzymes higher?

Transaminases: Can go up a bit. If your bilirubin is up or your albumen drops you need to discuss this with your doctor. ...Read more

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I'm on Zoloft (sertraline) and vistaril can that cause women not to orgasm?

I'm on Zoloft (sertraline) and vistaril can that cause women not to orgasm?

Possibly: Zoloft (sertraline) and others in its class (ssri antidepressants) can interfere with sexual functioning, including delayed orgasm. I have known some for whom orgasm became impossible with these medicines, and it may be a dose-related effect. Talk with your doctor about it; there are ways to adjust things or add other medicines that may be able to normalize this. ...Read more

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Will missing 1 Zoloft (sertraline) dose cause my panic attacks to return abruptly?? I forgot this morning, & now its evening. What do I do to make sure I'm fine?

Will missing 1 Zoloft (sertraline) dose cause my panic attacks to return abruptly?? I forgot this morning, & now its evening. What do I do to make sure I'm fine?

Should Be Okay: The half-life of Zoloft (sertraline) is over 24 hours, so you should have enough medicine in your system, even though you've missed a dose, to cover you until the morning. Many people who rely on daily medications occasionally miss doses, so know that you're not alone in that regard. Continue to be mindful of your medication regimen and the triggers for your anxiety as you are doing. ...Read more

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Celexa causes hard to reach orgasm. Would lowering the dose help and can it become permanent? I'm on 20 mg. It does help me though. Zoloft (sertraline) made me sick

Celexa causes hard to reach orgasm. Would lowering the dose help and can it become permanent? I'm on 20 mg. It does help me though. Zoloft (sertraline) made me sick

Almost immedicately: The side effect is dose related and improves as soon as the blood levels drop which could be the next day. Of course over time if the depression returns your libido could plummet. Lexapro (escitalopram) may have less sexual dysfunction than Celexa. Young men who are anorgasmic on low doses of SSRI, I wonder about Bipolar disorder and would consider Lamictal as alternate rx ...Read more

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Currently taking 200mg Zoloft. Effexor (venlafaxine) XR started 07/01/14. Since Effexor (venlafaxine) Iam losing weight. Went from 297 to 280. Is this a cause for concern?

Currently taking 200mg Zoloft. Effexor (venlafaxine) XR started 07/01/14. Since Effexor (venlafaxine) Iam losing weight. Went from 297 to 280. Is this a cause for concern?

No: losing weight is possible on these medications but you need to check with your provider to see if you should be on two drugs in the same family which could cause some problems like serontonin syndrome Please check with provider but I do see weight loss with some antidepressants (sometimes they gain weight) ...Read more

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I've been having night sweats. I'm on Zoloft (sertraline) for anxiety, I drink occasionally and I don't work out. I keep it cool in my room. What's the cause?

I've been having night sweats. I'm on Zoloft (sertraline) for anxiety, I drink occasionally and I don't work out. I keep it cool in my room. What's the cause?

Many possiblities: As my colleague dr. Ali said, zoloft (sertraline) is known to cause increased sweating & alcohol might also contribute. There are many other possible causes of night sweats, from hyperthyroidism to food allergies to infections (but acute & chronic)to certain cancers (probably not a great thing to tell someone prone to anxiety) but often we can't find the cause. Please discuss with the doc who prescribed zoloft (sertraline). ...Read more

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Can Zoloft (sertraline) cause apathy? I just started a couple days ago

Can Zoloft (sertraline) cause apathy? I just started a couple days ago

Yes it may...: Antidepressants as any other type of medication that works on your mood can cause these changes. If you are feeling more depressed, with suicidal ideations, manic, stop the medication immediately and get seen by your doctor as soon as possible. ...Read more

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When I haven't taken my Zoloft (sertraline) in 2 + days (rarely happens that I skip) why does it cause me headaches?

When I haven't taken my Zoloft (sertraline) in 2 + days (rarely happens that I skip) why does it cause me headaches?

Withdrawal symptom: When you miss your zoloft (sertraline) dose, you could be experiencing some withdrawal (or what the drug companies call "discontinuation") effects -- which can include headache. I'm glad you rarely skip your doses for 2+ days. ...Read more

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Can Zoloft (sertraline) cause irratabity. I'm annoyed very easily. I'm currently on 50mg and doc wants to up it to 100mg. Is it the Zoloft (sertraline) that causing it.

Can Zoloft (sertraline) cause irratabity. I'm annoyed very easily. I'm currently on 50mg and doc wants to up it to 100mg. Is it the Zoloft (sertraline) that causing it.

Yes it can: Yes, zoloft (sertraline) can cause irritability -- especially if you are bipolar and taking it without a mood stabilizer. Tell your physician what you're experiencing -- s/he needs to know. If not working with a psychiatrist, please see one asap. ...Read more

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Can Zoloft (sertraline) cause bad breath? Since taking it, breath has been bad. Recently had dental exam/cleaning, no issues there.

Can Zoloft (sertraline) cause bad breath? Since taking it, breath has been bad. Recently had dental exam/cleaning, no issues there.

Dry mouth=bad breath: A common side effect of zoloft (sertraline) as well as other anti depressants is a dry mouth. A chronic dry mouth can lead to bad breath. You can sip on water during the day as well as during meals. Also, you can chew sugar free gum preferably gum with xylitol in it. Biotene has products especially made for dry mouth syndrome, from toothpastes to mouth rinses. ...Read more

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Can zoloft (sertraline) cause narcolepsy? I've been taking it for awhile but recently have had day sleeping. Falling asleep for few secs repeatedly.

Can zoloft (sertraline) cause narcolepsy? I've been taking it for awhile but recently have had day sleeping. Falling asleep for few secs repeatedly.

Sleepiness: Zoloft (sertraline) is unlikely to cause sleepiness. You should evaluate your sleep habits and maintain a regular sleep pattern. Make a virtual apt to discuss your condition in detail in the mean time follow sleep hygiene protocols. I hope that was helpful. ...Read more

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I am taking 100 mgs of Zoloft (sertraline) for anxiety since last summer. Can taking 150mgs twice per day of Zantac cause the anxiety to come back, as it has?

I am taking 100 mgs of Zoloft (sertraline) for anxiety since last summer. Can taking 150mgs twice per day of Zantac cause the anxiety to come back, as it has?

Drug interactions: There shouldn't be any interactions in between sertraline (zoloft) and ranitidine (zantac) but there are reports of 6 persons having some kind of effect due to the combination: dysarthria (changes in speech) gait disturbance, dizziness, hypotension, TIA (as reported to the site www. Ehealthme. Com) please check with the doctor if an increase in the dose of zoloft is needed to decrease anxiety. ...Read more

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I've just started Zoloft (sertraline) and also am supposed to take 1 325mg aspirin per day per Dr instructions. I've read this can cause bleeding. Should I take?

I've just started Zoloft (sertraline) and also am supposed to take 1 325mg aspirin per day per Dr instructions. I've read this can cause bleeding. Should I take?

Discuss with your Dr: Zoloft (sertraline) and other SSRI type medications have the potential to cause bleeding because they increase the anti-platelet action of aspirin. A 2009 review of the medical literature http://1.usa. Gov/1zMVIjj concluded that Because the absolute risk of GI bleeds with SSRIs is low, precautions are probably necessary only in high-risk patients, such as those with history of gastritis, ulcer or bleeding. ...Read more

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Is it possible for Zoloft (sertraline) to cause hallucinations?

Is it possible for Zoloft (sertraline) to cause hallucinations?

Hallucinations: May occur with a zoloft (sertraline) overdose - but haven't seen it described as a side -effect. ...Read more

Dr. Heidi Fowler
1,094 Doctors shared insights

Sertraline (Definition)

Also called zoloft, (sertraline) is one of selective serotonin reuptake inhibitors, with antidepressant/anti-anxiety actions. May cause headaches, nausea & ...Read more


Dr. Heidi Fowler
1,048 Doctors shared insights

Zoloft (Definition)

Zoloft is a serotonin reuptake blocker which is a kind of ...Read more