Doctor insights on:
Igm Monoclonal Gammopathy
It is a medical diso: A medical disorder where your body is making excess of proteins(Gamma Globulins). It can manifest in 2-3 different ways(MGUS or Multiple Myeloma). So you need your doctor to explain which of these conditions do you have and theen get further testing, monitoring and you may or may not need treatment depending on whether it is mGUS(early) or Myeloma(later developemnt...that is a type of Blood Cancer ...Read more
A gammopathy is an abnormal gammaglobulin or gammaglobulin level. A monoclonal gammopathy is a single abnormal protein that can indicate a bone marrow cancer called multiple myeloma, or a lymphoma. Further evaluation is required to determine if a monoclonal gammopathy ...Read more
Cells vs, animals: A monoclonal antibody is produced by in-vitro manipulation by expoanding a single cell making a desired antibody. Polyclonal antibodies are usually derived from immunizing an animal and colletcting its blood/serum containing the antibody. Polyclonal antibodies are a mixture of a large number of different cells. ...Read more
Monospecific Ab.: Monoclonal antibodies are those that are produced by the identical immune cells that are descended from the same parent cell. They produce anitibodies that bind to only one epitope or site on an antigen. This means that they are monospecific. This makes them useful in things like research because they can isolate a strain purely and completely. ...Read more
Ebvab VCA IgM <36 (range 0-35.9), ebvearly antigenab IgG 37 (0-8.9), ebvab VCA IgG >600 (0-17.9), EBV nuclearantigenab IgG 409 (0-17.9) mono? No mono?
You had mono...: Your mono-like symptoms likely prompted the testing- i hope you are starting to feel a little better. Testing for different antibodies (igm and igg) against ebv, requires careful interpretation. In early phases of infection, the igm level peaks first followed by a decline; levels of igg peak afterwards, and may remain elevated for quite a while. ...Read more
MGUS: Is a common precancerous condition affecting people 50 years of age and older. It was first described by mayo clinic researchers in 1978 and is characterized by the presence of an abnormal protein in the blood called a (monoclonal) protein or m protein.Mgus has a small risk (1 percent each year) of progressing to a blood cancer called multiple myeloma or a related condition. ...Read more
Blood & urine tests: Mgus is the presence of an abnormal protrein in the blood made by a type of white blood cell called a plasmacyte. In most cases, it is at a low level and is something that just has to be followed. However, it can be the precursor of the disease called multiple myeloma and as such a hematologist or medical oncologist will order tests to rule this out which may include blood, urine and simple x-rays. ...Read moreSee 1 more doctor answer
Benign overgrowth: Monoclonal gammopathy of uncertain significance, made of an immunoglobulin g with a kappa light chain. It means nothing. You have a slightly increased chance of getting plasma cell myeloma when you're old. There's nothing you can do about it, so simply resolve not to worry about it. ...Read more
Ebv panel. Ebv nuc antigen igg=157, early ag igg=12.7, EBV VCA igg=112, EBV VCA igm=10.6. Please explain. Concerned about spleen. Symp=fatigue/fog?
? Active infection: It's impossible for me to answer with certainty since i don't know the normal ranges your lab uses. If early ag & vca igm are elevated above normal this indicates active ebv infection.I don't know if it is acute or chronic without knowing your history. If chronic i see that as a sign of poor immune function.Immune-boosting herbs/supplements & IV vit c drips may help, but find why immunity is poor. ...Read more
It can: Yes, it can . It will depend on how much is the quantity of the monoclonal proteine, how many plasma cells on the bone marrow and ultimately whether one has end organ damages/ whether some other organs are affected significantly by the monoclonal protein. That is why some blood work, imaging study and bone marrow biopsy need to be done. ...Read more
All the same: Antibodies are complex protein molecules made by the immune system. The have a variable portion that can be made specific to a target. "monoclonal" refers to antibodies whose variable regions are all the same. When directed at specific biological targets, e.g. Inflammatory mediators, they can be used as drugs ("biologics") to modify diseases. ...Read moreSee 1 more doctor answer
Excellent question.: Monoclonal lymphocytes mean that a single lymphocyte has been stimulated to divide and create an expanded number of identical daughter cells. There are enough of them to be identified by a test (flow cytometry) but not enough to meet criteria for a leukemia. There may be a genetic predisposition. This is a benign condition, but there is uncertainty as to whether it might progress to malignancy. ...Read moreSee 1 more doctor answer
Need more info: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, What is total gamma globulin level? If it is more than 2.0 gm/dL it needs to be evaluated. There are many causes of polyclonal gammopathy., and some of those are serious. ...Read moreSee 1 more doctor answer
Protein, antibody: An immunoglobulin, also called an antibody, is a protein that binds susbtances to eliminate or neutralize them. Most of immunoglobulins are in the blood, but also in the lining of the respiratory tract and the gastrointestinal tract. Immunoglobulins are produced with small variations that allow them to bind the millions of different microbes. There are 5 types; igg, igm, iga, IgD and ige. ...Read more
Immunofixation, Serum FAH = Monoclonal IgG kappa immunoglobulin. Beta FAH = 10.5% Abnormal band, immunofixation to follow. I'm IgA deficient too. ??
Possibly: If I am understaning this right you have a monoclonal protien band? The most important next steps here would be to identify the band (immunofixation) and then perfrom quantitvaive immunoglobulin levels. IF there is a monoclonal band, you may very well have reciprocal depriciation of alternative immunoglobulins and IgA deficiecny with an IgG monoclonal protein is possible. ...Read more
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