Top
10
Doctor insights on: Igm Deficiency

Share
1

1
Why is secondary IgM deficiency seen in whipple's disease? I thought infection did not reduce immunoglobulin levels.

Why is secondary IgM deficiency seen in whipple's disease?  I thought infection did not reduce immunoglobulin levels.

Protein-losing Enter: Protein-losing enteropathy is characterized by excessive loss of serum proteins into the gastrointestinal tract. Lymphopenia is a common finding associated with protein-losing enteropathy due to whipple disease. In addition to the loss of albumin, components of lymph are also lost into the bowel, including lymphocytes, immunoglobulins, as well as fat-soluble vitamins, lipids & cholesterol. ...Read more

Dr. Gregory Lanza
811 doctors shared insights

Immunoglobulin M (Definition)

There are 5 classes of immune proteins: igg, iga, igm, ige and igd. Igm fights infection. If you produce too little then infections may occur and you have hypogammaglobulinemia. If you have too much you ...Read more


2

2
What can cause secondary (acquired) IgM deficiency? Cancer? Infections? Autoimmunity?

What can cause secondary (acquired) IgM deficiency?  Cancer?  Infections?  Autoimmunity?

Acquired is rare: The common primary igm deficiency is genetically transmitted , the acquired ( or secondary ) isolated with out other deficiencies , igm deficiency alone is are , usually due to infections like HIV , whipple's etc. ...Read more

4

4
What are CD4+ t cells? And what does it mean if they are raised? I have MBL deficiency, low IgM & IgG3. Raised CRP & Serum Amyloid A

What are CD4+ t cells? And what does it mean if they are raised? I have MBL deficiency, low IgM & IgG3. Raised CRP & Serum Amyloid A

Cd4 are lymphocytes: cd4 stands for cell determinant 4 which is a protein in the cell membrane. Cd4 are lymphocytes that help modulate the response in cellular immunity. Deficiencies in cell mediated immunity predisposes patients to infections like Pneumocystis jirovechi ...Read more

6

6
Would ivig be considered in mannose-binding lectin deficiency, very low igm, igg3 and igg4 after no response to vaccines?

Would ivig be considered in mannose-binding lectin deficiency, very low igm, igg3 and igg4 after no response to vaccines?

Yes: Mannose-binding lectin deficiency is a complement disorder. Low igm and subclass igg (in your case 3 ; 4) is a separate entity. With low immunoglobulins and no response to vaccines, ivig would be reasonable. See an immunologist to evaluate this. ...Read more

7

7
Have a mutation for immune deficiency (CVID2/IGAD2) associated with TACI. Normal IgA, IgM & IgG but long history of severe infections. How to test it?

Have a mutation for immune deficiency (CVID2/IGAD2) associated with TACI. Normal IgA, IgM & IgG but long history of severe infections. How to test it?

?: Not adding up, you can't literally have those conditions, repeated severe infections and normal measures of Ig subtypes.You need to be re-evaluated, you may simply have IgG subclass deficiency,or specific antibodies deficiency,testing for recall antigens for tetanus and pneumococcus,pre and post vaccination can prove it,treatment remains the same: IVIG therapy.Too complex for this limited platform ...Read more

9

9
Daughter has tested positive for CMV and EBV IgM. Also microcytic anaemia with iron deficiency. Previously had RSV and adenovirus. Related to anaemia?

Daughter has tested positive for CMV and EBV IgM. Also microcytic anaemia with iron deficiency. Previously had RSV and adenovirus. Related to anaemia?

Hard to say: It is relatively common for a 1 yo to be a bit on the anemic side. Recurrent illness does increase metabolic demands on their system and they have been growing at a rate that can outpace their dietary intake of iron.A simple addition of proper medicinal iron can improve the anemia and working on diet can eliminate it in the future. With better iron levels their immune system also works better. ...Read more