Doctor insights on:
Why is secondary IgM deficiency seen in whipple's disease? I thought infection did not reduce immunoglobulin levels.
Protein-losing Enter: Protein-losing enteropathy is characterized by excessive loss of serum proteins into the gastrointestinal tract. Lymphopenia is a common finding associated with protein-losing enteropathy due to whipple disease. In addition to the loss of albumin, components of lymph are also lost into the bowel, including lymphocytes, immunoglobulins, as well as fat-soluble vitamins, lipids & cholesterol. ...Read more
Brucella can cause acquired IgM deficiency. Can borrelia, babesia, bartonella, or mycoplasma cause this? What other chronic infections?
What are CD4+ t cells? And what does it mean if they are raised? I have MBL deficiency, low IgM & IgG3. Raised CRP & Serum Amyloid A
Should vaccines i'm very low in (tetanus, hib, men c, pneuomococcle) be given when I have mannose-binding lectin deficiency, low igm, igg3 and igg4?
Yes.: They may need to be given more than once if your immune response is compromised, but you're still safer with them than without. ...Read more
Would ivig be considered in mannose-binding lectin deficiency, very low igm, igg3 and igg4 after no response to vaccines?
Yes: Mannose-binding lectin deficiency is a complement disorder. Low igm and subclass igg (in your case 3 ; 4) is a separate entity. With low immunoglobulins and no response to vaccines, ivig would be reasonable. See an immunologist to evaluate this. ...Read more
Have a mutation for immune deficiency (CVID2/IGAD2) associated with TACI. Normal IgA, IgM & IgG but long history of severe infections. How to test it?
?: Not adding up, you can't literally have those conditions, repeated severe infections and normal measures of Ig subtypes.You need to be re-evaluated, you may simply have IgG subclass deficiency,or specific antibodies deficiency,testing for recall antigens for tetanus and pneumococcus,pre and post vaccination can prove it,treatment remains the same: IVIG therapy.Too complex for this limited platform ...Read more
If u have Vitamin D deficiency, does this have any effect on immunoglobulin levels (IgG, IgM...etc.)? Would low Vitamin D cause lower IgG or IgM?
Daughter has tested positive for CMV and EBV IgM. Also microcytic anaemia with iron deficiency. Previously had RSV and adenovirus. Related to anaemia?
Hard to say: It is relatively common for a 1 yo to be a bit on the anemic side. Recurrent illness does increase metabolic demands on their system and they have been growing at a rate that can outpace their dietary intake of iron.A simple addition of proper medicinal iron can improve the anemia and working on diet can eliminate it in the future. With better iron levels their immune system also works better. ...Read more
Can you point me in the direction of the type of specialist I should see? Low igm, low vitamin d, low mvp, iron deficiency, low magnesium and low calcium.
Specialist: Either an internist or hematologist would be the best choice. ...Read more