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Doctor insights on: Igg Subclasses

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Igg Subclasses (Overview)

There are 5 types of immunoglobulins: iga, igg, ige, igm and igd. There are 4 types of igg simply called igg1, igg2, igg3, and igg4. You can have a normal total igg level but deficiencies in one or more subclasses.


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What makes IgG subclasses different from each other? Is it light chain/heavy chain component of IgG that differs for each subclass? I don't get it.

What makes IgG subclasses different from each other?  Is it light chain/heavy chain component of IgG that differs for each subclass? I don't get it.

Heavy chain: The heavy chain determines both the isotype (i.e., iga, igm, igg, ige) and subclass of the antibody. The structure of the constant region of the heavy chain is very different between isotypes, leading to different functions. Slight differences in the heavy-chain constant regions among antibodies of the same isotype result in what we call subclasses. ...Read more

Igg Subclasses (Overview)

There are 5 types of immunoglobulins: iga, igg, ige, igm and igd. There are 4 types of igg simply called igg1, igg2, igg3, and igg4. You can have a normal total igg level but deficiencies in one or more subclasses.


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What could it mean to have high absolute cd19+ b cells (627 cells/ul) but have low levels of total IgG and IgG subclasses?

What could it mean to have high absolute cd19+ b cells (627 cells/ul) but have low levels of total IgG and IgG subclasses?

See below: This is one of those problems where a visit to your doctor is necessary to figure out what's going on. Only after a thorough evaluation, including examination and possibly labs and other tests, can your doctor correctly diagnose you and treat you effectively. ...Read more

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Hi: What is significance of high IGM, (twice top reference range level), very high IGE, with low IGG, low IGG subclasses, and low IGA? Thanks much!

Hi: What is significance of high IGM, (twice top reference range level), very high IGE, with low IGG, low IGG subclasses, and low IGA?  Thanks much!

More info needed: The question asked can be intreperted in many ways. Normally these are levels in relation to a disease. A high IGM means recent infection, a high IGE means something allergic is bothering you and low IGG means less memory antibodies for an old infection. Low IGA is antibody for your gut/intestines. Hopefully this helps. See your doctor for more answers. ...Read more

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What is the definition or description of: IgG subclasses?

What is the definition or description of: IgG subclasses?

4 subclasses: There are 5 types of immunoglobulins: iga, igg, ige, igm and igd. There are 4 types of igg simply called igg1, igg2, igg3, and igg4. You can have a normal total igg level but deficiencies in one or more subclasses. ...Read more

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What could it mean to have high absolute cd19+ b cells (627 cells/ul) but have low levels of total IgG and IgG subclasses?

See below: This is one of those problems where a visit to your doctor is necessary to figure out what's going on. Only after a thorough evaluation, including examination and possibly labs and other tests, can your doctor correctly diagnose you and treat you effectively. ...Read more

See 1 more doctor answer
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What makes IgG subclasses different from each other? Is it light chain/heavy chain component of IgG that differs for each subclass? I don't get it.

Heavy chain: The heavy chain determines both the isotype (i.e., iga, igm, igg, ige) and subclass of the antibody. The structure of the constant region of the heavy chain is very different between isotypes, leading to different functions. Slight differences in the heavy-chain constant regions among antibodies of the same isotype result in what we call subclasses. ...Read more

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My results show low IgG but normal level igG subclasses, is the low igG level still significant?

My results show low IgG but normal level igG subclasses, is the low igG level still significant?

Don't know: Need to know why the tests were ordered in the first place. If you suffer from recurrent or chronic sinus or lung infections, then even a normal total IgG may not be enough since it is whether your body can produce specific defense against bacterial (qualitative) than the total number (quantitative) that matters most. See an allergist. ...Read more

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What produces IgG subclasses? Are b cells and/or t cells involved? Too complicated to explain? Is there a book that i can buy that explains this?

What produces IgG subclasses?  Are b cells and/or t cells involved?  Too complicated to explain?  Is there a book that i can buy that explains this?

Immune System: Its a very complicated topic and a good place for you to review the basics without going into medical books and lectures is http://www.Cancer.Gov/cancertopics/understandingcancer/immunesystem/immune.Pdf be careful in considering theories by writers of books, websites, etc who promise you cures to all ailments by some tweak in the immune system. If it were that easy, we would have cured cancer. ...Read more

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What does a IgG subclasses test for?

What does a IgG subclasses test for?

Exposure: Basically, this your body's memory protein and tells us that, at some point, you've been exposed to the agent (e.g. Virus, substance, etc...). ...Read more

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Hi: What is significance of high IGM, (twice top reference range level), very high IGE, with low IGG, low IGG subclasses, and low IGA? Thanks much!

More info needed: The question asked can be intreperted in many ways. Normally these are levels in relation to a disease. A high IGM means recent infection, a high IGE means something allergic is bothering you and low IGG means less memory antibodies for an old infection. Low IGA is antibody for your gut/intestines. Hopefully this helps. See your doctor for more answers. ...Read more

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Tested for autoimmune and reoccurring chest/sinus/flu illness cause. Low gamma globulin and IgG but normal subclasses, is this significant to symptoms?

Tested for autoimmune and reoccurring chest/sinus/flu illness cause. Low gamma globulin and IgG but normal subclasses, is this significant to symptoms?

See allergist/immuno: Thought I have answered a very similar question. You need to get tested on how your body responds to vaccination (usually pneumococcal and tetanus toxoid) since it is not just the quantity but the function of your IgG which matters the most. A B/C allergist should be able to handle this for you ...Read more

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Vca IgG positive what is it?

Epstein-Barr: The anti-ebv (vca) igg is used for the confirmation of a prior infection with epstein-barr virus. Especially if one is looking for a mononucleosis infection. ...Read more

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What causes IgG deficency ?

What causes IgG deficency    ?

Many causes: If your IgM and IgA levels are normal or high, it's likely you have one of the still-not-fully-understood genetic glitches that come under the heading of "common variable immunodeficiency" which is very common. If your IgG is just a wee bit below the published "normal", consider ignoring it, but if one or more classes is way low, you deserve an official diagnosis. ...Read more

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Hepa patient with IgG shows what?

Hepa patient with IgG shows what?

Hepatitis? IgG4?: May need more information, but will venture to say anti-virus IgG in cases of viral hepatitis signifies an immune response. Diagnostically, need to know about the specific test to comment (eg IgG to HBsAg?). Also, for non-viral hepatitis, the total serum IgG4 is measured as a screen for autoimmune hepatitis. ...Read more

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What does herpes I IgG 5.88 mean?

What does herpes I IgG 5.88 mean?

Herpes IgG 5.88: It appears you were exposed in the past to herpes I -usually mouth sore , though with oral sex one can get it in the genital area as well. A titer of 5.88 is somewhat high so you may have had a recent recurrence, f/u/ w/ doc ...Read more

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Do family practice doctors do igg?

They can: Igg levels can be ordered by any doctor. However, they need to be correctly interpreted. ...Read more

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How accurate are IgG and IgE testing?

How accurate are IgG and IgE testing?

Very.: Generally pretty definitive. Testing for immunoglobulin is done by a highly sensitive and specific method. ...Read more

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What is the reason of decrease in igg?

What is the reason of decrease in igg?

Several: Igg is a protein made by our bodies that specifically fights infections. Low igg levels can be caused by insufficient production of igg or increased losses of igg through the gut or urine. ...Read more

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Is an IgG level of 3.5g/l significantly low?

Is an IgG level of 3.5g/l significantly low?

Lowish: It's not going to make you sick, though. The strong medications you're taking may account for the value being down a bit. We all have much more igg than we need, and you do yourself a disservice by worrying overmuch about lab values -- "reference ranges" are simply where most people fall, not "ideal ranges for optimal health." this value may well be right for you. Best wishes. ...Read more