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Doctor insights on: Igg Subclasses

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Dr. Dariush Saghafi
13 doctors shared insights

Igg Subclasses (Overview)

There are 5 types of immunoglobulins: iga, igg, ige, igm and igd. There are 4 types of igg simply called igg1, igg2, igg3, and igg4. You can have a normal total igg level but deficiencies in one or more subclasses.


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What makes IgG subclasses different from each other? Is it light chain/heavy chain component of IgG that differs for each subclass? I don't get it.

What makes IgG subclasses different from each other?  Is it light chain/heavy chain component of IgG that differs for each subclass? I don't get it.

Heavy chain: The heavy chain determines both the isotype (i.e., iga, igm, igg, ige) and subclass of the antibody. The structure of the constant region of the heavy chain is very different between isotypes, leading to different functions. Slight differences in the heavy-chain constant regions among antibodies of the same isotype result in what we call subclasses. ...Read more

Dr. Dariush Saghafi
13 doctors shared insights

Igg Subclasses (Overview)

There are 5 types of immunoglobulins: iga, igg, ige, igm and igd. There are 4 types of igg simply called igg1, igg2, igg3, and igg4. You can have a normal total igg level but deficiencies in one or more subclasses.


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What is the definition or description of: IgG subclasses?

What is the definition or description of: IgG subclasses?

4 subclasses: There are 5 types of immunoglobulins: iga, igg, ige, igm and igd. There are 4 types of igg simply called igg1, igg2, igg3, and igg4. You can have a normal total igg level but deficiencies in one or more subclasses. ...Read more

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What could it mean to have high absolute cd19+ b cells (627 cells/ul) but have low levels of total IgG and IgG subclasses?

What could it mean to have high absolute cd19+ b cells (627 cells/ul) but have low levels of total IgG and IgG subclasses?

See below: This is one of those problems where a visit to your doctor is necessary to figure out what's going on. Only after a thorough evaluation, including examination and possibly labs and other tests, can your doctor correctly diagnose you and treat you effectively. ...Read more

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Hi: What is significance of high IGM, (twice top reference range level), very high IGE, with low IGG, low IGG subclasses, and low IGA? Thanks much!

Hi: What is significance of high IGM, (twice top reference range level), very high IGE, with low IGG, low IGG subclasses, and low IGA?  Thanks much!

More info needed: The question asked can be intreperted in many ways. Normally these are levels in relation to a disease. A high IGM means recent infection, a high IGE means something allergic is bothering you and low IGG means less memory antibodies for an old infection. Low IGA is antibody for your gut/intestines. Hopefully this helps. See your doctor for more answers. ...Read more

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What could it mean to have high absolute cd19+ b cells (627 cells/ul) but have low levels of total IgG and IgG subclasses?

See below: This is one of those problems where a visit to your doctor is necessary to figure out what's going on. Only after a thorough evaluation, including examination and possibly labs and other tests, can your doctor correctly diagnose you and treat you effectively. ...Read more

See 1 more doctor answer
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What makes IgG subclasses different from each other? Is it light chain/heavy chain component of IgG that differs for each subclass? I don't get it.

Heavy chain: The heavy chain determines both the isotype (i.e., iga, igm, igg, ige) and subclass of the antibody. The structure of the constant region of the heavy chain is very different between isotypes, leading to different functions. Slight differences in the heavy-chain constant regions among antibodies of the same isotype result in what we call subclasses. ...Read more

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What is the definition or description of: IgG subclasses?

4 subclasses: There are 5 types of immunoglobulins: iga, igg, ige, igm and igd. There are 4 types of igg simply called igg1, igg2, igg3, and igg4. You can have a normal total igg level but deficiencies in one or more subclasses. ...Read more

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My results show low IgG but normal level igG subclasses, is the low igG level still significant?

My results show low IgG but normal level igG subclasses, is the low igG level still significant?

Don't know: Need to know why the tests were ordered in the first place. If you suffer from recurrent or chronic sinus or lung infections, then even a normal total IgG may not be enough since it is whether your body can produce specific defense against bacterial (qualitative) than the total number (quantitative) that matters most. See an allergist. ...Read more

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What produces IgG subclasses? Are b cells and/or t cells involved? Too complicated to explain? Is there a book that i can buy that explains this?

What produces IgG subclasses?  Are b cells and/or t cells involved?  Too complicated to explain?  Is there a book that i can buy that explains this?

Immune System: Its a very complicated topic and a good place for you to review the basics without going into medical books and lectures is http://www.Cancer.Gov/cancertopics/understandingcancer/immunesystem/immune.Pdf be careful in considering theories by writers of books, websites, etc who promise you cures to all ailments by some tweak in the immune system. If it were that easy, we would have cured cancer. ...Read more

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What does a IgG subclasses test for?

What does a IgG subclasses test for?

Exposure: Basically, this your body's memory protein and tells us that, at some point, you've been exposed to the agent (e.g. Virus, substance, etc...). ...Read more