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Doctor insights on: Igg Subclass Igg3

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My ch50 is 394 and normal range upper limit is 300. C3 and C4 are normal. Can you tell me what this means? My IgG subclass 2 serotypes are all low

My ch50 is 394 and normal range upper limit is 300.  C3 and C4 are normal.  Can you tell me what this means?  My IgG subclass 2 serotypes are all low

Ignore it: Ch50 is hard to do correctly, unless the value is way off i would ignore it, and it may just be up from a transient infection or be your normal. Unless your igg subclass is very low, i would ignore this as well. We pathologists say, "focus on the person, not the numbers." by the way, i attended lfhs and perhaps we know one another. ...Read more

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What to do if I have high neutrophilis, low lymphs & monocytes , high glucose and low IgG subclass 1 &3?

What to do if I have high neutrophilis, low lymphs & monocytes , high glucose and low IgG subclass 1 &3?

Talk with your Dr: Labs mean nothing in isolation. This is concerning and you have a right to talk with a specialist if need be -- an endocrinology and clinical immunology consult may be in order. ...Read more

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I have an IgG subclass 3 deficiency. What diseases/disorders are associated with this? Are you more likely to acquire certain diseases/disorders?

IgG3 subclass def: Igg has four types. Igg3 is involved in fighting against carbohydrate covered infectious organisms. Igg1 is the most numerous and igg3 is of much less quantity. If you have normal antibody titers to vaccines, then you are likely safe. I would simply monitor all of your immunoglobulin levels yearly. ...Read more

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Could IgG subclass deficiencies be caused by plasma b cell diseases/disorders?

Yes: It is possible to have malfunction of immunoglobulins or low levels in b cell disorders. A subclass deficiency by itself is usually not clinically significant and does not warrant treatment but if an underlying b cell disorder exists, it should be remedied. ...Read more

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What to do if I have high neutrophilis, low lymphs & monocytes , high glucose and low IgG subclass 1 &3?

Talk with your Dr: Labs mean nothing in isolation. This is concerning and you have a right to talk with a specialist if need be -- an endocrinology and clinical immunology consult may be in order. ...Read more

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Is there CSF IgG subclass deficiency? I have lowish IgG and IgG subclass deficiencies (1, 3, 4) and CSF IgG of 685 .

Csf labs: Lab values for cerebrospinal fluid tests must be interpreted in the context of the symptoms and signs and the time course, as well as imaging information. Your question cannot be answered in isolation. Please consult a neurologist. ...Read more

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What does quantitative igg subclass measurement blood test show?

What does quantitative igg subclass measurement blood test show?

IgG subclasses: There are several classes of immunoglobulins like IgA, IgM, and IgE. IgG also has subclasses that we test for. A subclass deficiency can be an explanation for susceptibility to certain types of infections. An Allergist/Immunologist can put the results in perspective for you in the context of your history. ...Read more

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If igg subclass tests were all normal range, does it mean my immune system is ok? Unclear on meaning of tests and what it represents as far as my body

If igg subclass tests were all normal range, does it mean my immune system is ok? Unclear on meaning of tests and what it represents as far as my body

IgG subclasses: Why tested for? Those are rather special tests done if there is a suspicion of subclass deficiency guided by history and physical examination, if they were fine, means generally your immune system is functional, but there are some subtleties that need to be checked if still suspecting an immune problem. Kindly ask your doctor or your allergist/Immunologist about the results/other tests needed ...Read more

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Is IgG subclass 3 deficiency a primary or secondary immunodeficiency?

Is IgG subclass 3 deficiency a primary or secondary immunodeficiency?

Great question: You already know that most folks who are discovered to have real igg3 deficiency are troubled primarily by recurrent nasal sinus infections. Until we know whether there's one of more genes for this, or whether it's the result of some other change in the immune system (igg3 can drop after other illnesses), i think the mainstream medical community will remain undecided. Glad you're proactive. ...Read more

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What does low IgG subclass 1 mean, 219 (422-1292) & IGM serum is high, 486 (40-230). Please explain what this means. I am always tired & I take b12.

What does low IgG subclass 1 mean, 219 (422-1292) & IGM serum is high, 486 (40-230). Please explain what this means. I am always tired & I take b12.

See an immunologist: A 63 year old female with low IgG subclass 1 and elevated IgM, also with fatigue. A low IgG1 with normal total IgG could indicate a selective IgG subclass deficiency. But this value alone doesn't really tell us much. You need further evaluation by an immunologist to take a good history, learn about your infectious history, and obtain more loans - specifically response to vaccine challenge. ...Read more

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My ch50 is 394 and normal range upper limit is 300. C3 and C4 are normal. Can you tell me what this means? My IgG subclass 2 serotypes are all low

Ignore it: Ch50 is hard to do correctly, unless the value is way off i would ignore it, and it may just be up from a transient infection or be your normal. Unless your igg subclass is very low, i would ignore this as well. We pathologists say, "focus on the person, not the numbers." by the way, i attended lfhs and perhaps we know one another. ...Read more

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I read that IgG subclass deficiencies are associated with fibromyalgia and chronic fatigue syndrome. Is this true? If so, what is the connection?

I read that IgG subclass deficiencies are associated with fibromyalgia and chronic fatigue syndrome.  Is this true?  If so, what is the connection?

IGG : Igg are sensitivities for foods or substances and cause significant gut inflammation. These then lead to impermeable or leaky gut. This inflammation can lead to joint and muscle pain. The fatigue is usually caused by the poor absorption of the cofactors needed in the body to produce energy. ...Read more

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What is the difference in the utility of these 2 tests: IgG subclass (1-4) serum blood test.......And......Serum protein electrophoresis?

What is the difference in the utility of these 2 tests:  IgG subclass (1-4) serum blood test.......And......Serum protein electrophoresis?

Proteins: Igg is an immunoglobulin produced in the body to defends us from infection and inflammation, it is subdivided in 4 subclasses which all have different fucntions, the serum protein electrophoresis is going to measure the distribution of proteins in the blood to determine if there is an abnormal protein production. ...Read more

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CTD? 3cm bilat cervical reactive nodes, ANA 1:640 speck, RNP 1.9, C3 comp 81, IGG subclass II 626, minor tingling, slight finger swelling, headaches

CTD? 3cm bilat cervical reactive nodes, ANA 1:640 speck, RNP 1.9, C3 comp 81, IGG subclass II 626, minor tingling, slight finger swelling, headaches

Possibly: The problem is that labs need to be combined with full clinical assessment and perhaps more detailed lab studies for other tissue antibodies. See a rheumatologist. ...Read more

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Can immunodeficiency of IgG subclass 1 and 4 cause pcos and by proxy underdevelopment of the breasts/high waist to hip ratio?

Can immunodeficiency of IgG subclass 1 and 4 cause pcos and by proxy underdevelopment of the breasts/high waist to hip ratio?

PCOS immune disorder: Pcos is an independant condition to immune deficiency disorder physical characteristics of pcos does not include decreased brest development high waist to hip ratio can have ethnic and genetic basis and associated with pcos however keeping weight down is helpful. ...Read more

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Hi, my son is 9 and takes Hizentra infusions weekly for hypogammaglobemnia. IgG is now normal but Subclass 3 is still low and subclass 2 is now high?

Hi, my son is 9 and takes Hizentra infusions weekly for hypogammaglobemnia. IgG is now normal but Subclass 3 is still low and subclass 2 is now high?

Focus on IgG: The goal of replacement IgG is to provide total IgG levels approximately in the normal range, and sustain them throughout the interval between injections. I would not focus on the subclasses, but on total level of IgG, as well as the response to therapy, i.e., is he having less frequent and severe infections? ...Read more

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What makes IgG subclasses different from each other? Is it light chain/heavy chain component of IgG that differs for each subclass? I don't get it.

What makes IgG subclasses different from each other?  Is it light chain/heavy chain component of IgG that differs for each subclass? I don't get it.

Heavy chain: The heavy chain determines both the isotype (i.e., iga, igm, igg, ige) and subclass of the antibody. The structure of the constant region of the heavy chain is very different between isotypes, leading to different functions. Slight differences in the heavy-chain constant regions among antibodies of the same isotype result in what we call subclasses. ...Read more

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Is an IgG level of 3.5g/l significantly low?

Is an IgG level of 3.5g/l significantly low?

Lowish: It's not going to make you sick, though. The strong medications you're taking may account for the value being down a bit. We all have much more igg than we need, and you do yourself a disservice by worrying overmuch about lab values -- "reference ranges" are simply where most people fall, not "ideal ranges for optimal health." this value may well be right for you. Best wishes. ...Read more

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What does it mean when for 3 year old IgG level is low?

-: Igg is a form of antibody the human body uses to fight infections. Low igg might be transient or if the child has had multiple infections in the last might need to be addressed seriously. Also igg subclasses also need to be checked to see which or if all subsets are low. Good luck with your child. ...Read more

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Hi my rubella igg result is 0.3 is that positive or not?

Hi my rubella igg result is 0.3 is that positive or not?

Yes: That number indicates that you are immune to rubella most commonly from vaccinations as a child or a past infection. It is a good thing. ...Read more

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Hello. My rubella igg is 416 and lgm is 0.3. Please help me what it means. Thanks a lot.

Hello. My rubella igg is 416 and lgm is 0.3. Please help me what it means. Thanks a lot.

Tests, tests, tests: There are 5 different classes of antibodies that our bodies produce. The first ones are in the IgM class and only stay around for 90 days or so. The IgG antibodies can stick around for years and give long lasting immunity. So you had rubella (German Measles) or the immunization for it at least 90 days ago and that waned but you have long lasting immunity to it (elevated IgG! ...Read more

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Can someone interprete what this means? In regards to strep.Pneumo. Igg ab(14 sero)...Type 3= .01 ug/ml, type 4=0.2, type 9v, 12f and 23f all = 0.5

Can someone interprete what this means?  In regards to strep.Pneumo.  Igg ab(14 sero)...Type 3= .01 ug/ml, type 4=0.2, type 9v, 12f and 23f all = 0.5

No antibodies: If you have not received the pneumococcal vaccine then you have probably not been infected with any of these strains of pneumococcus, a gram positive bacteria that causes pneumonia, sinus & ear infections & meningitis. If you have received the vaccine & these values represent antibody levels obtained 4-6 weeks later then you have hypogammaglobulinemia. Probably cvid. See your immunologist. ...Read more

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