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Doctor insights on: Igg Monoclonal Protein With Lambda Light Chain Specificity

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High KAPPA/LAMBDA LIGHT CHAIN/slightly high ratio. No Monoclonal protein immunofixation or serum electrophoresis. Is this a type of cancer? Normal WBC

High KAPPA/LAMBDA LIGHT CHAIN/slightly high ratio. No Monoclonal protein immunofixation or serum electrophoresis. Is this a type of cancer? Normal WBC

I bet it's nothing: Without free light chains or a monoclonal protein in blood or urine, the ratio's meaningless. And like most lab tests, the reference range is set so that a few percent of healthies fall outside on either end. ...Read more

Protein (Definition)

Proteins are large molecules made up of a smaller class of molecules called amino acids. Proteins play an enormous role in the function of our bodies including enzymes, messengers, replicating dna, ...Read more


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I had serum immunofixation. Scared. No monoclonol proteins. But read'"faint igg. Lambda. Cannot be excluded?

I had serum immunofixation. Scared. No monoclonol proteins. But read'"faint igg. Lambda. Cannot be excluded?

Need more info: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, your results suggest a low level of a monoclonal protein. Such findings are not uncommon in people over 50. Do follow your doctor's advise about follow up testing. See this site for more info.
http://www. Mayoclinic. Org/diseases-conditions/mgus/basics/definition/con-20026422 ...Read more

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Parents -nh-lymphoma and multiple myeloma. My blood work - "igg lambda monoclonol protein migrating in gamma region. Thoughts?

Parents -nh-lymphoma and multiple myeloma. My blood work - "igg lambda monoclonol protein migrating in gamma region. Thoughts?

It may or may not be: A hematologist should be able to help you, because there are many benign cases with abnormalities like yours. We see these type of consultations quite frequently and there is a pretty standard evaluation routine. ...Read more

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I've just found out that 3 tests show low kappa/lambda ratio, with lambda light chain levels increased. Do these results mean a thing without m protein?

I've just found out that 3 tests show low kappa/lambda ratio, with lambda light chain levels increased. Do these results mean a thing without m protein?

Check with your doc: Kappa and lambda are parts of immunoglobulins which are proteins certain white blood cells make to fight infections. These are referred to as polyclonal since they come from different cells. Some blood disorders can produce lots of m (monoclonal) kappas or lambdas that come from a single, usually malignant cell. Ask your doctor who ordered the lab test to help interpret your specific results. ...Read more

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Ideop Neurop, IPE=Monoclonal IGGlambada present. No free lambda light chains seen. Mprotein seen below threshold IPE. SI all in ranges Igg 1.4. mean?

Ideop Neurop, IPE=Monoclonal IGGlambada present. No free lambda light chains seen. Mprotein seen below threshold IPE. SI all in ranges Igg 1.4. mean?

Neuropathy in MGUS: Periphral neuropathy is common in gammopathies. If just sensory (numbness/tingling) we follow it or treat symptoms. If there is motor involvement (muscle weakness) it may need treatment. Risk of converson to a bone marrow disease is about 1% per year. You need to be followed by a neurologist/rheumatologist (if interested in neuropathies). MGUS means monoclonal gammopathy of unknown signifcance. ...Read more

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Blood tests shows high gamma globulin & high igg. Ifx shows no monoclonal protein & free light chains are within normal range. What does this mean?

Blood tests shows high gamma globulin & high igg. Ifx shows no monoclonal protein & free light chains are within normal range. What does this mean?

It might be a benign: Many benign processed can cause hypergammaglobulinemia, which are benign elevations without a para -protein or m-spike on serum protein electrophoresis (spe)> it all depends on how high is the gammaglobulin level and making sure the liver functions are ok and there is no chronic inflammation (like rheumatoid arthritis, sarcoidosis etc) going on inside the body. ...Read more

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Kappa/lambda FLC ratio high (2.75) w/ normal K (10.21mg/dl) & low L (3.68mg/dl). Hem-onc unsure if ratio implies K monoclonality since serum/urine IFE ok & neither chain is elevated. Could monoclonal K be suppressing L? IgA a bit high IgG &IgM a bitlow

Kappa/lambda FLC ratio high (2.75) w/ normal K (10.21mg/dl) & low L (3.68mg/dl). Hem-onc unsure if ratio implies K monoclonality since serum/urine IFE ok & neither chain is elevated. Could monoclonal K be suppressing L? IgA a bit high IgG &IgM a bitlow

Useless test: K/L ratio is not a useful test. About one third of patients without monoclonal immunoglboulin have an abnormal ratio, usually with kappa excess. If you must, the next step would be a bone marrow examination. You may consult this article that I wrote: https://www. Ncbi. Nlm. Nih. Gov/pubmed/27473738
At your age you are unlikely to have myeloma. ...Read more

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What does small m protein and IgG lambda spike mean?

What does small m protein and IgG lambda spike mean?

Monoclonal M-spikes: Antibodies such as igg are usually polyclonal. This means that many different b-cells are making antibodty with many different binding specificities. Monoclonal (m-spikes) suggest that the origin of the antibody is from one clone of blood cells, all originating from a sinle progenitor. This could mean a pre-malignant or malignant populations of cell are present. ...Read more

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What is monoclonal protein? How does this affect the body? What is IgG lamda and it's affects. What are the treatments.? What can this thing turn int?

What is monoclonal protein? How does this affect the body? What is IgG lamda and it's affects. What are the treatments.? What can this thing turn int?

Spike: You probably have either a monoclonal gammopathy of uncertain significance, which is a non-problem but has perhaps a 1% chance per year of turning into plasma cell ("multiple") myeloma, or myeloma itself. You need to get with your physician and find out which. Good luck. ...Read more

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What does high IgG kappa monoclonal protein in blood mean?

What does high IgG kappa monoclonal protein in blood mean?

See a specialist: You don't tell me how you were found to have that high level. If you have no symptoms to go with that finding and other laboratory blood tests are normal, you probably have what is called monoclonal gammopathy. If you have symptoms or tests are affected, there are several possible diagnosis. For proper evaluation, see an immunologist or hematologist. ...Read more

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Are IgG lambda monoclonal bands common?

IgG lambda rare: Only 20% of all human igg use lambda light chains. Monoclonal bands are not common in general and may be benign or a sign of myeloma. Most a kappa. ...Read more

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Is elevated kappa/lambda ratio on serum FLC test inherently monoclonal, even if neither kappa or lambda is elevated? Ratio high b/c lambda is low, not because of high kappa. SPEP/UPEP & IFE normal. High IgA, low IgG. Clean marrow biopsy. Polyclonal?

Is elevated kappa/lambda ratio on serum FLC test inherently monoclonal, even if neither kappa or lambda is elevated? Ratio high b/c lambda is low, not because of high kappa. SPEP/UPEP & IFE normal. High IgA, low IgG. Clean marrow biopsy. Polyclonal?

Clinical context: The use of light chains is limited in diseases other than monoclonal gammopathies, such as myeloma or amyloidosis. If this is the context that yours got checked the results do not suggest such a condition. With no gammopathy suggested by results the question regarding clonality has no grounds. As any other test, trending the results would help in integrating it in a meaningful clinical context. ...Read more

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More info on serum immunofixation. No monoclonal proteins detected. A faint IgG labda cannot be ruled out. Suggest repeat 6 mths. Igg 841 IgA 251 IgM 44.

More info on serum immunofixation. No monoclonal proteins detected. A faint IgG labda cannot be ruled out. Suggest repeat 6 mths. Igg 841 IgA 251 IgM 44.

Correct advice: It is prudent to retest in about six months to see which way the low level monoclonal spike is going. It may disappear, stay unchanged or increase in amount. The next step will depend on the direction of the quantity of the protein. Your immunoglobulin levels are normal. There is no need to worry. ...Read more

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Significance of mildly low IgG (691; 700-1600) & mildly high IgA (400; 90-386)? IgM ok. No monoclonal protein on serum electropho/immunofix & not getting sick more often. Am I immunocompromised? Will rabies vaccine fail? Titer >.5 IU/ml in Oct 2015.

Significance of mildly low IgG (691; 700-1600) & mildly high IgA (400; 90-386)? IgM ok. No monoclonal protein on serum electropho/immunofix & not getting sick more often. Am I immunocompromised? Will rabies vaccine fail? Titer >.5 IU/ml in Oct 2015.

Blood tests: There are a few diseases that leap out from blood tests. Most of the time, however, blood tests don't tell the doctor much on their own. These results fall into the second group, not very specific. Your remark that you are not getting sick more often is the best indication that your immune system is working well. ...Read more

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Serum free light chain test shows normal kappa (8.7mg/dl), low lambda (3.80), high kap/lam ratio (2.31). Serum $ urine electrophoresis show no monoclonal protein, nor does serum immunofixation. Likely MGUS, myeloma, or admyloidosis? CBC/met panel ok.

Serum free light chain test shows normal kappa (8.7mg/dl), low lambda (3.80), high kap/lam ratio (2.31). Serum $ urine electrophoresis show no monoclonal protein, nor does serum immunofixation. Likely MGUS, myeloma, or admyloidosis? CBC/met panel ok.

False positive rate: There is 30% or so false positive rate of kappa/lambda ratio in people without MGUS, myeloma or other disorders.
For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form.
Practice safe sex. ...Read more

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Can you interpret, squam epi cells few a, alpha 2 protein 1.01 h, possible faint IgM lambda monoclonal protein present, ACE serum 75 h?

No: Can't interpret random blood test results without context. Talk to the doctor that ordered the tests. Most medical tests (x-rays, blood tests, etc.,) are better at telling us what you don't have rather than diagnosing what (if anything) you do have wrong with you. ...Read more

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Causes if a polyclonal gammopayhy with elevated kappa and lambda free light chains? Seems to be of the IGG type slightly elevated count.

Causes if a polyclonal gammopayhy with elevated kappa and lambda free light chains? Seems to be of the IGG type slightly elevated count.

Polyclonal IgG: It can be caused by numerous inflammatory, infectious, and malignant causes, for example; TB, Rheumatoid arthritis, cirrhosis of the liver, lymphoma, and MS. A more extensive list, click on Table 3 link inside article below.

http://www. Aafp. Org/afp/2005/0101/p105.html

http://www. Ncbi. Nlm. Nih. Gov/pmc/articles/PMC356447/

Mild elevation could simply be a mild cold with a rhinovirus. No worries. ...Read more

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Test by hemotologist s t/oncologist, kappa//lambda light chain, 24he urine ratio 3.51; kappa/lambda serum ratio 1.86; Erythropoietin = 41.1?

Test by hemotologist s t/oncologist, kappa//lambda light chain, 24he urine ratio 3.51; kappa/lambda serum ratio 1.86; Erythropoietin = 41.1?

Any symptoms?: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Talk to the doctor who ordered the tests. Having said that, kappa/lambda ratio is a generally useless test.
Wish you good health! - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form.
Practice safe sex, if you have sex. ...Read more

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Kappa (4 vs ref 2mg/dl) and sometimes lambda light chain in 24hr urine without mm. What can be suspected? Anemia, worsening ckd, improves with na co3

Kappa (4 vs ref 2mg/dl) and sometimes lambda light chain in 24hr urine without mm. What can be suspected? Anemia, worsening ckd, improves with na co3

K+L chains in ua: Hello, the fact that you are having this checked in your urine means that some person is already onto the fact that you may have MGUS or multiple myeloma. The worsening anemia and kidney deterioration is more indicative of myeloma. BUT you need the whole urine and blood protein electrophoresis to look at before making the diagnosis. You shd request referral to a Heme-Onc specialist to decide. Thx ...Read more

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Reasons for 3x normal kappa lambda light chain b2m=4.4 elevations in CKD? Oncologist says no myeloma or mgus. Asking because doctors couldn't answer.

Reasons for 3x normal kappa lambda light chain b2m=4.4 elevations in CKD? Oncologist says no myeloma or mgus. Asking because doctors couldn't answer.

Second opinion: You live in NYC. I don't know where you went but there are great oncologists in the City. Take your lab data with you and go to MSKCC or Columbia or Cornell or NYU. Somebody doesn't have their thinking cap on! ...Read more

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What does slightly-below normal levels of IgG proteins in the CNS indicate?

What does slightly-below normal levels of IgG proteins in the CNS indicate?

Maybe nothing: Igg levels in CSF are a reflection of igg levels in the CNS (fluid and tissue, respectively). What does "slightly" mean. Could it be a small difference compatible with lab measurement error? Or it might mean an immune system abnormality (suppressed or decreased function). ...Read more

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Recent bloodwork for IG. My IgG is elevated to1950 on 1650 scale, total protein normal range. Mild hypergammaglobulinemia polyclonal?

Recent bloodwork for IG. My IgG is elevated to1950 on 1650 scale, total protein normal range. Mild hypergammaglobulinemia polyclonal?

Stop worrying: You may be getting over a mild infection. Polyclonal elevations of IgG are common and never worth worrying about. If you have some other illness, this is a tip in diagnosing and following you. Otherwise, relax and keep an eye on how you actually feel. ...Read more

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I had a recent lp. What does slightly-below normal levels of IgG proteins in the CSF indicate?

I had a recent lp. What does slightly-below normal levels of IgG proteins in the CSF indicate?

Not of much concern: Why did you have an lp? Slightly low igg is not of much importance by itself. It would be prudent to the discus all of the results with your doctor as the context is important in interpreting lab results. ...Read more

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Can an increase in IgG + IgA proteins in the blood (serum) cause an overflow and therefore protein in the urine?

Can an increase in IgG + IgA proteins in the blood (serum) cause an overflow and therefore protein in the urine?

If kidney diseased..: Kidneys can leak protein if the kidneys are diseased. Proteinuria is a very sensitive predictor of development of progressive renal insufficiency, particularly when looking at high molecular weight proteins such as immunoglobulin g (igg), as predictors of chronic kidney disease progression. In some cases, mild proteinuria can occur without kidney disease. ...Read more

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Is m protein igg kappa 4.1 a low level?

Is m protein igg kappa 4.1 a low level?

Why do you ask?: If you've been found to have a paraprotein, the real question is, "Do we treat for plasma cell myeloma? " These paraproteins are very common, especially as folks get older; most never progress. The actual level of the paraprotein isn't the key. If this is grams per liter, a value below 10 is "low". If your labs are otherwise good and you feel well, I wouldn't give it another thought. Best wishes. ...Read more

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If ur light strands are high n IgG high what can thismean. No m protein. Copy in my chart. Ssa pos. Sjogrens?

If ur light strands are high n IgG high what can thismean. No m protein. Copy in my chart. Ssa pos. Sjogrens?

May be the Sjogrens: This could be a sign of light chain disease, caused by your sjogrens, or may be meaningless and never cause problems. Your best bet is to ask your doctor. Because they know your history and physical problems it will be easier to nswer your question. By ordering the test (this is not a test routinely ordered) your doctor has shown concern over a problem and most likely will have an explanation. ...Read more

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What does elevated Igg-2364 and gamma globulin 2.2 mean with polyclonal gammopathy and Kappa and lambda typing increased?

What does elevated Igg-2364 and gamma globulin 2.2 mean with polyclonal gammopathy and Kappa and lambda typing increased?

Nothing serious: Polyclonal gammopathy does not have the seriousness of monoclonal gammpathy. Firstly your IgG and total globulin levels are only mildly elevated, so It may not mean any disease. One cause is chronic inflammation (infections) such as Chronic arthritis or chronic liver disease, conditions which can be checked out or ruled out easily if you ask your doctor and seek his/her advice about it. ...Read more

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Gamma Globulin 1.8 slightly high The rest normal. No M-protein spike. IGE Serum 151 H IgG 1768 H What could cause these results...

Gamma Globulin 1.8 slightly high The rest normal. No M-protein spike. IGE Serum 151 H IgG 1768 H What could cause these results...

Reassurance: You just have very high immunity. All this number show a very good defense mechanism. Sometimes the questions is: from what? May be your doctor can answer that question. ...Read more