Doctor insights on:
Igg Lambda Multiple Myeloma
Parents -nh-lymphoma and multiple myeloma. My blood work - "igg lambda monoclonol protein migrating in gamma region. Thoughts?
It may or may not be: A hematologist should be able to help you, because there are many benign cases with abnormalities like yours. We see these type of consultations quite frequently and there is a pretty standard evaluation routine. ...Read more
I had not heard of "kahler's disease" until seeing multiple questions on healthtap. It is multiple myeloma (mm). "multiple" is from the often seen "multiple" bone lesions (especially in advanced disease). Mm is a cancer of plasma cells [highly specialized b white blood cells (lymphocytes)] that produce antibodies. Sx are crab: hypercalcemia, renal insufficency, anemia, ...Read more
Different Diseases: Lyme and multiple myeloma are two very different diseases which are not likely to be confused for one another on a test like this. Igg and igm are two different types of proteins made by the immune system, and within each category you have thousands of different proteins in your body. For lyme, the test looks for a protein that proves your body has "seen" lyme organisms before. ...Read more
Multiple myeloma at age 22? Possibility of IgG kappa monoclonal band is observed in my blood work. I have the symptoms of mm. Is this possible at 22?
Resent blood work states IgM 875, an appearant polyclonal glammopathy IgM, kappa and Lambda light chains appear increased. Possible Multiple myeloma?
No: Myeloma is monoclonal. I trust you do not have urinary light chains. Most polyclonal stuff means nothing. If you are symptomatic, look for another cause of any symptoms. ...Read more
Pl suggest any alternative remedy/ies for multiple myeloma I am 48 yer old and no m band seen at this moment after 6 months of chemo?
Homeopathy, herbs ;: There are no proven alternatives for multiple myeloma but that does not mean they may not help; but I would continue standard treatments too. A healthy diet, tonifying herbs, reducing body burden of heavy metals ; other environmental toxins, stress reduction ; working to clear unresolved anger/grief etc. Can only help. I also advise classical homeopathy with a good homeopath. See comments for more:. ...Read more
Blood/Urine/Imaging: Usually workup involves blood and urine tests (spep / upep - serum and urine protein electrophoresis). The preferred initial imaging study is the skeletal survey (x-ray of multiple sites of the body including skull, axial skeleton, and proximal long bones). Bony lesions are usually lytic. ...Read more
The tests for Multiple myeloma include:: Albumin, Basic metabolic panel, Bone marrow biopsy, Complete blood count, Ionized calcium, Lactate dehydrogenase, MRI, Skeletal survey, C reactive protein, Protein electrophoresis, 24 hour urine protein electrophoresis, Free kappa lambda light chains, Beta 2 microglobulin. ...Read more
Plasma cell cancer:
Multiple myeloma is a cancer of plasma cells (pcs). Pcs are the specialized b lymphocytes that produce antibodies. When there is a cancer or one (mono-) clone (= monoclonal, m) PC population they can product m-proteins. Symptoms include crab - hypercalcemia, renal (kidney) insufficiency, anemia, bone disease; also infection and pain.
More: http://www. Cancer. Net/cancer-types/multiple-myeloma. ...Read more
None: If truly smoldering myeloma, there are no signs. If there are symptoms, then it may be myeloma. Hope this helps. ...Read more
Treatment for multiple myeloma has improved markedly and drug treatment alone or drug treatment with auto or donor stem cell transplants can produce decades long remissions. See this site for more info.
http://www. Mayoclinic. Org/diseases-conditions/multiple-myeloma/basics/definition/con-20026607 ...Read more
Asymptomatic: Smoldering myeloma is a stage of Myeloma before patients become symptomatic. So it is discovered on routine checking of blood proteins or show up in a serum protein electrophoresis (SEP). Many of these patients develop symptoms within one or two years and the symptoms are bone/back pain or a broken bone due to myeloma. ...Read more
Yes - RR 2.0 to 4.0:
Relative risk (rr) incr mgus 2.8, myeloma 2.9, lpl/wm 4.0, cll 2.0. From landgren et al.
http://www. Ncbi. Nlm. Nih. Gov/pubmed/19182202
the myeloma cytogenetics are reviewed in greenberg et al. May 2013 -- http://www. Ncbi. Nlm. Nih. Gov/pubmed/23647020. ...Read more
Yes/No: In a sense all cancer is "genetic" involving changes to the DNA or epi-genetic - changes to DNA modifiers such as methylation. A related question is is multiple myeloma inherited. The answer is sometimes. The risk is about double with a family history. Here is one clinical trial studying this: https://clinicaltrials. Gov/ct2/show/NCT00582621 ...Read more
Yes. Not common.: Yes. Multiple myeloma can effect any organ. However, liver involvement is not common. Myeloma generally involves the bones predominantly; however there are reports of nearly every organ being involved in including the brain. Liver involvement by any cancer can make some types of chemotherapy (that is processed by the liver) more difficult to give. ...Read more
There are many options. One source of updated, risk-stratified treatment are the Mayo Clinic Stratification for Myeloma And Risk-adapted Therapy (mSMART) guidelines:
http://www. Msmart. Org/msmart_mar09_002.htm
Treatment depends on disease (MM) and host (patient) characteristics as well as the goals of therapy. ...Read more
None specific for MM: For multiple myeloma, you need to work with a hematologist-oncologist. Homeopathy is a whole different way of addressing imbalance ; helps @ deeper level. You'll need an experienced homeopathic doctor who's also able to communicate clearly with your other physicians. Homeopathic remedies are prescribed for the specific individual rather than the pathologic diagnosis -- 3000-4000 are possible. ...Read more
Usually not: The liver is not usually affected by myeloma however clusters of myeloma cells can rarely deposit in the liver. These are called plasmacytomas. ...Read more
Myeloma specialist: There are many treatment options for multiple myeloma. You should get your father to an oncologist who specializes in multiple myeloma. There are a few good websites with information about myeloma. Try the multiple myeloma research foundation, and the International myeloma foundation or the leukemia and lymphoma society. ...Read more
The myeloma: Family is a proliferation of plasma cells, which produce antibodies or immunoglobulins. Igm is ass. Ociated with waldenstrom macro globulin, igg is the most familiar, but there is also iga, these further produce subunits, kappa and lambda chains. The abnormal clone usually is a xerox machine gone bad producing a copy of one of these chains. Myeloma causes problems by these cells destroying bone. ...Read more
Depends on heart: The light chain deposition disease is unlikely to affect survival. In fact a review of myeloma and kidney failure published last year demonstrated no change in outcome in myeloma patients with or without kidney failure. The biggest predictor of outcome is response to chemotherapy. Velcade (bortezomib) (new chemo) has been a game changer. In addition, patients with cardiac involvement do very poorly. ...Read more