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Doctor insights on: Igg Kappa Multiple Myeloma

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Which groups are most frequently affected by multiple myeloma?

Which groups are most frequently affected by multiple myeloma?

Blacks in US: Twice the incidence in african americans than caucasians. Some families have a higher incidence. ...Read more

Dr. Creighton Wright
126 Doctors shared insights

Kahler Disease (Definition)

I had not heard of "kahler's disease" until seeing multiple questions on healthtap. It is multiple myeloma (mm). "multiple" is from the often seen "multiple" bone lesions (especially in advanced disease). Mm is a cancer of plasma cells [highly specialized b white blood cells (lymphocytes)] that produce antibodies. Sx are crab: hypercalcemia, renal insufficency, anemia, ...Read more


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How will my doctor know if I have multiple myeloma?  

Labs, xrays: There are a series of blood and urine tests that will give the doctor a good idea if you have the disease. These are usually followed by x-rays looking for tell-tale signs of myeloma and a bone marrow test which would identify the cancer cells themselves. ...Read more

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What is the difference in testing an IgG and IgM bands for Lyme versus multiple myeloma?

What is the difference in testing an IgG and IgM bands for Lyme versus multiple myeloma?

Different Diseases: Lyme and multiple myeloma are two very different diseases which are not likely to be confused for one another on a test like this. Igg and igm are two different types of proteins made by the immune system, and within each category you have thousands of different proteins in your body. For lyme, the test looks for a protein that proves your body has "seen" lyme organisms before. ...Read more

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Parents -nh-lymphoma and multiple myeloma. My blood work - "igg lambda monoclonol protein migrating in gamma region. Thoughts?

It may or may not be: A hematologist should be able to help you, because there are many benign cases with abnormalities like yours. We see these type of consultations quite frequently and there is a pretty standard evaluation routine. ...Read more

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Can monoclonal IgM kappa light chain gammopathy turn into multiple myeloma?

It can: Yes, it can. It will depend on how much is the quantity of the monoclonal proteine, how many plasma cells on the bone marrow and ultimately whether one has end organ damages/ whether some other organs are affected significantly by the monoclonal protein. That is why some blood work, imaging study and bone marrow biopsy need to be done. ...Read more

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Resent blood work states IgM 875, an appearant polyclonal glammopathy IgM, kappa and Lambda light chains appear increased. Possible Multiple myeloma?

No: Myeloma is monoclonal. I trust you do not have urinary light chains. Most polyclonal stuff means nothing. If you are symptomatic, look for another cause of any symptoms. ...Read more

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I have high IgG kappa paraproteins & swollen lymph nodes in my neck. My haemo has requested scans. What is he looking for? I thought pps were myeloma.

I have high IgG kappa paraproteins & swollen lymph nodes in my neck. My haemo has requested scans. What is he looking for? I thought pps were myeloma.

See details: This is a preliminary step. You will ultimately need a bone marrow and possible biopsy of a node. Other diagnostic considerations include waldenstrom's macroglobulinemia and lymphoma. ...Read more

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Pl suggest any alternative remedy/ies for multiple myeloma I am 48 yer old and no m band seen at this moment after 6 months of chemo?

Pl suggest any alternative remedy/ies for multiple myeloma I am 48 yer old and no m band seen at this moment after 6 months of chemo?

Homeopathy, herbs ;: There are no proven alternatives for multiple myeloma but that does not mean they may not help; but I would continue standard treatments too. A healthy diet, tonifying herbs, reducing body burden of heavy metals ; other environmental toxins, stress reduction ; working to clear unresolved anger/grief etc. Can only help. I also advise classical homeopathy with a good homeopath. See comments for more:. ...Read more

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How common is multiple myeloma?

How common is multiple myeloma?

Uncommon: Approximately 1% of all cancers and slightly more than 10 % of blood cancers in the United States. ...Read more

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What other tests for multiple myeloma?

What other tests for multiple myeloma?

Blood/Urine/Imaging: Usually workup involves blood and urine tests (spep / upep - serum and urine protein electrophoresis). The preferred initial imaging study is the skeletal survey (x-ray of multiple sites of the body including skull, axial skeleton, and proximal long bones). Bony lesions are usually lytic. ...Read more

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What is Multiple myeloma a risk factor for?

What is Multiple myeloma a risk factor for?

Multiple issues: It can lead to anemia, increased calcium, renal failure, bone pain and fractures to name a few ...Read more

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What are some of the tests for Multiple myeloma?

The tests for Multiple myeloma include:: Albumin, Basic metabolic panel, Bone marrow biopsy, Complete blood count, Ionized calcium, Lactate dehydrogenase, MRI, Skeletal survey, C reactive protein, Protein electrophoresis, 24 hour urine protein electrophoresis, Free kappa lambda light chains, Beta 2 microglobulin. ...Read more

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What is the definition or description of: multiple myeloma?

Plasma cell cancer: Multiple myeloma is a cancer of plasma cells (pcs). Pcs are the specialized b lymphocytes that produce antibodies. When there is a cancer or one (mono-) clone (= monoclonal, m) PC population they can product m-proteins. Symptoms include crab - hypercalcemia, renal (kidney) insufficiency, anemia, bone disease; also infection and pain.
More: http://www. Cancer. Net/cancer-types/multiple-myeloma. ...Read more

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Can you tell me which are the signs of smoulding multiple myeloma?

None: If truly smoldering myeloma, there are no signs. If there are symptoms, then it may be myeloma. Hope this helps. ...Read more

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What is the prognosis of multiple myeloma in terms of survival rates by stage?

See below: Treatment for multiple myeloma has improved markedly and drug treatment alone or drug treatment with auto or donor stem cell transplants can produce decades long remissions. See this site for more info.
http://www. Mayoclinic. Org/diseases-conditions/multiple-myeloma/basics/definition/con-20026607 ...Read more

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Is multiple myeloma is still not curable?

Not curable: There are many treatments for multiple myeloma and the survival of patients with myeloma is much better than 10 years ago. But we still do not consider this a curable disease. ...Read more

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Doctors, what are the symptoms of smoulding multiple myeloma?

Asymptomatic: Smoldering myeloma is a stage of Myeloma before patients become symptomatic. So it is discovered on routine checking of blood proteins or show up in a serum protein electrophoresis (SEP). Many of these patients develop symptoms within one or two years and the symptoms are bone/back pain or a broken bone due to myeloma. ...Read more

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Can you have a predisposition to multiple myeloma or lymphoma?

Yes - RR 2.0 to 4.0: Relative risk (rr) incr mgus 2.8, myeloma 2.9, lpl/wm 4.0, cll 2.0. From landgren et al.
http://www. Ncbi. Nlm. Nih. Gov/pubmed/19182202
the myeloma cytogenetics are reviewed in greenberg et al. May 2013 -- http://www. Ncbi. Nlm. Nih. Gov/pubmed/23647020. ...Read more

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I have smouldering multiple myeloma. Just bought neoprene dumbbells; should I be returning them?

Unrelated: Hi. Why would you return neoprene dumbbells because of having multiple myeloma? I must be missing your point. Use the dumbbells! Unless you're ready to give up and check out now. Again, I'm sorry, but I think there's a point you're trying to make that I'm missing. Good luck! ...Read more

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Is multiple myeloma genetic?

Is multiple myeloma genetic?

Yes/No: In a sense all cancer is "genetic" involving changes to the DNA or epi-genetic - changes to DNA modifiers such as methylation. A related question is is multiple myeloma inherited. The answer is sometimes. The risk is about double with a family history. Here is one clinical trial studying this: https://clinicaltrials. Gov/ct2/show/NCT00582621 ...Read more

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Can multiple myeloma affect the liver?

Can multiple myeloma affect the liver?

Yes. Not common.: Yes. Multiple myeloma can effect any organ. However, liver involvement is not common. Myeloma generally involves the bones predominantly; however there are reports of nearly every organ being involved in including the brain. Liver involvement by any cancer can make some types of chemotherapy (that is processed by the liver) more difficult to give. ...Read more

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Can nephrotic syndrome be caused by multiple myeloma?

Can nephrotic syndrome be caused by multiple myeloma?

Yes: This can happen but usually myeloma causes a decrease in the kidney function. Some patients with myeloma can also have a protein deposited in the kidney (amyloidosis) that can lead to nephrotic syndrome. ...Read more

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What are your treatment options for multiple myeloma?

Many: There are many options. One source of updated, risk-stratified treatment are the Mayo Clinic Stratification for Myeloma And Risk-adapted Therapy (mSMART) guidelines:
http://www. Msmart. Org/msmart_mar09_002.htm
Treatment depends on disease (MM) and host (patient) characteristics as well as the goals of therapy. ...Read more

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What are some homeopathic remedies for multiple myeloma?

None specific for MM: For multiple myeloma, you need to work with a hematologist-oncologist. Homeopathy is a whole different way of addressing imbalance ; helps @ deeper level. You'll need an experienced homeopathic doctor who's also able to communicate clearly with your other physicians. Homeopathic remedies are prescribed for the specific individual rather than the pathologic diagnosis -- 3000-4000 are possible. ...Read more

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In what way is the liver is affected by multiple myeloma?

In what way is the liver is affected by multiple myeloma?

Usually not: The liver is not usually affected by myeloma however clusters of myeloma cells can rarely deposit in the liver. These are called plasmacytomas. ...Read more

Dr. Liawaty Ho
754 Doctors shared insights

Multiple Myeloma (Definition)

A cancer of the plasma cells, which are responsible for producing antibodies for your body. Symptoms include kidney insufficiency, anemia, bone ...Read more