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Doctor insights on: Igg Deficiency Diseases

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What can cause secondary (acquired) IgM deficiency? Cancer? Infections? Autoimmunity?

What can cause secondary (acquired) IgM deficiency?  Cancer?  Infections?  Autoimmunity?

Acquired is rare: The common primary igm deficiency is genetically transmitted , the acquired ( or secondary ) isolated with out other deficiencies , igm deficiency alone is are , usually due to infections like HIV , whipple's etc. ...Read more

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Could IgG subclass deficiencies be caused by plasma b cell diseases/disorders?

Could IgG subclass deficiencies be caused by plasma b cell diseases/disorders?

Yes: It is possible to have malfunction of immunoglobulins or low levels in b cell disorders. A subclass deficiency by itself is usually not clinically significant and does not warrant treatment but if an underlying b cell disorder exists, it should be remedied. ...Read more

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Can deficiency of vitamin D cause autoimmune diseases?

Can deficiency of vitamin D cause autoimmune diseases?

Good question: Vit D3 is considered important in immune regulation. Thus theoretically, the answer is yes, but in reality, no such association has been proven. ...Read more

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Is auto immune deficiency treatable?

Is auto immune deficiency  treatable?

Absolutely: 1st: are you talking about an immune deficiency or an autoimmune disease? Both can be treated but they require different specialists so you need to know your diagnosis before you decide whom to see. ...Read more

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Is auto immune deficiency treatable?

Is auto immune deficiency treatable?

Clear definition: Immune deficiency means that there is a defect in the immune system, and the person is more susceptible to have infectious diseases and cancer. There are ways to help be free of infections. Autoimmunity is a disorder in which the immune system attacks one or more of our own organs, due to a defect of regulation/tolerance. Treatment is with medications to suppress the immune responses. ...Read more

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IGG. Transfusion for m-GUS disease?

IGG. Transfusion for m-GUS disease?

No.: MGUS is not a disease per se. It is an abnormal antibody in blood by definition not caused by serious diseases like myeloma or lymphoma and therefore is not treated. It's importance is that MGUS has an annual cancer risk of 0.1 - 1%. ...Read more

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What is acquired immune deficiency syndrome aids?

What is acquired immune deficiency syndrome aids?

Advanced HIV : The advanced stage of HIV infection, when people have severely compromised immune systems and are at risk for opportunistic infections and malignancies. ...Read more

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Is IgG subclass 3 deficiency a primary or secondary immunodeficiency?

Is IgG subclass 3 deficiency a primary or secondary immunodeficiency?

Great question: You already know that most folks who are discovered to have real igg3 deficiency are troubled primarily by recurrent nasal sinus infections. Until we know whether there's one of more genes for this, or whether it's the result of some other change in the immune system (igg3 can drop after other illnesses), i think the mainstream medical community will remain undecided. Glad you're proactive. ...Read more

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What causes acute immune deficiency syndrome?

What causes acute immune deficiency syndrome?

HIV: I think you mean "acquired, " not "acute." the cause is HIV infection. ...Read more

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Is there CSF IgG subclass deficiency? I have lowish IgG and IgG subclass deficiencies (1, 3, 4) and CSF IgG of 685 .

Csf labs: Lab values for cerebrospinal fluid tests must be interpreted in the context of the symptoms and signs and the time course, as well as imaging information. Your question cannot be answered in isolation. Please consult a neurologist. ...Read more

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Which vitamin deficiencies does graves disease have?

Which vitamin deficiencies does graves disease have?

Not vitamin: Deficiency. Graves disease is hyperactive thyroid gland. It is not due to vitamin deficiency but may be associated with nutriotional problems due to increased metabolic rate. See this site for more info. http://www.mayoclinic.com/health/graves-disease/ds00181. ...Read more

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Is autoimmune hemolytic anemia hereditary?

Is autoimmune hemolytic anemia hereditary?

No: It can be due to an underlying autoimmune disorder, such as lupus or rheumatoid arthritis. In this case, the underlying autoimmune disorder may be hereditary; but the autoimmune hemolytic anemia is not hereditary. It is simply the manifestation of the underlying disorder. There are also several causes of autoimmune hemolytic anemia that are not inherited. ...Read more

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Elevated EBV ab VCA IgG <8 and EBV nucleaer antigen ab IgG test 4.2. & anti-dna(ss)igg ab qn ( 119)& c react protien(5.6) what are implications?

Elevated EBV ab VCA IgG <8 and EBV nucleaer antigen  ab IgG test 4.2. & anti-dna(ss)igg ab qn ( 119)& c react protien(5.6)  what are implications?

Nothing.: Ebv antibodies indicate you had a previous infection, but not active. The c-reactive protein needs a units indicator - that is either normal or somewhat elevated. The anti ss dna is extremely nonspecific and very rarely indicated; I have no idea why that was ordered, discuss with your doctor. ...Read more

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Is a vitamin B12 deficiency associated with Lyme disease?

Is a vitamin B12 deficiency associated with Lyme disease?

No : There is no literature or study showing any correlation between Lyme disease a.nd B12 deficiency. ...Read more

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What causes high IgG antibodies but negative igm?

What causes high IgG antibodies but negative igm?

Immunity: Igm is the first line of defense and reacts first, then long term immunity is provided by igg. So a positive igg and negative igm to something means an old exposure. ...Read more

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I have an IgG subclass 3 deficiency. What diseases/disorders are associated with this? Are you more likely to acquire certain diseases/disorders?

IgG3 subclass def: Igg has four types. Igg3 is involved in fighting against carbohydrate covered infectious organisms. Igg1 is the most numerous and igg3 is of much less quantity. If you have normal antibody titers to vaccines, then you are likely safe. I would simply monitor all of your immunoglobulin levels yearly. ...Read more

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Can an allergist/immunologist ever help with chronic inflammatory polyneuropathy? Have seen neuro, but have been told I have IgG deficiency as well.

Can an allergist/immunologist ever help with chronic inflammatory polyneuropathy?  Have seen neuro, but have been told I have IgG deficiency as well.

Together: There is an overalp, and a neuroimmunologist should be able to treat it and if in doubt, an allergist can prescribe ivig if needed. Your neurologist should be able to tell you if they can treat the igg deficiency or not. ...Read more

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I was diagnosed by allergist with IGA & IGG deficiency due to recurrent infections. Had 2 miscarriages within 3 yrs. Can this be cause of miscarriage?

I was diagnosed by allergist with IGA & IGG deficiency due to recurrent infections. Had 2 miscarriages within 3 yrs. Can this be cause of miscarriage?

Unlikely: Not a direct cause,? infection leads to miscarriage, may be, but even individuals without your condition miscarry for no known reason.IgA deficiency is the most common primary immunodeficiency amongst the already rare immunodeficiency disorders,many afflicted persons are asymptomatic and lead normal lives, follow up with your immunologist/allergist for possible IVIG replacement therapy,good luck ...Read more

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I recently miscarried at 7 weeks. Diagnosed with IGA and possibly IGG deficiency . Also have bicornuate uterus. Can IGG and IGA def. cause miscarriage?

I recently miscarried at 7 weeks. Diagnosed with IGA and possibly IGG deficiency . Also have bicornuate uterus. Can IGG and IGA def. cause miscarriage?

Clarification: See your doctor to go over the test results to get clarification. It is unclear here if your doctor was testing IgG and IgA as part of an antiphospholipid antibody workup for miscarriage or if you are referring to the genetic disorder of the immune system referred to as IgA deficiency. The impact on pregnancy depends on the diagnosis. ...Read more

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What would prevent me from having a tummy tuck procedure done. I have type 2 diabetes and an IgG deficiency (hypogammaglobulinemia). I have had ivig.?

What would prevent me from having a tummy tuck procedure done. I have type 2 diabetes and an IgG deficiency (hypogammaglobulinemia). I have had ivig.?

Medical Clearance.: Patients who have “medical conditions” should have these conditions under good control prior to undergoing elective surgery. Therefore, best to be evaluated by your internist to check how well these conditions are “optimized” and whether you are a good candidate to proceed with elective surgery. It is very likely that your plastic surgeon will ask for this medical clearance. Best wishes. ...Read more

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Could IgG subclass deficiencies be caused by plasma b cell diseases/disorders?

Yes: It is possible to have malfunction of immunoglobulins or low levels in b cell disorders. A subclass deficiency by itself is usually not clinically significant and does not warrant treatment but if an underlying b cell disorder exists, it should be remedied. ...Read more

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What is the best way to diagnose autoimmune disorders in immune deficient patient on IgG replacement? Rheumy suspicious of lupus, but not definitive

What is the best way to diagnose autoimmune disorders in immune deficient patient on IgG replacement? Rheumy suspicious of lupus, but not definitive

Related to the low gammaglobulin: Sometimes people with agammaglobulinemia can have musculoskeletal problems the diagnosis of lupus in this situation is unlikely sometimes one can have similar symptoms when infection is present. I would be very cautious in trying to say that lupus is present. ...Read more

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Is there CSF IgG subclass deficiency? I have lowish IgG and IgG subclass deficiencies (1, 3, 4) and CSF IgG of 685 .

Csf labs: Lab values for cerebrospinal fluid tests must be interpreted in the context of the symptoms and signs and the time course, as well as imaging information. Your question cannot be answered in isolation. Please consult a neurologist. ...Read more

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Is IgG subclass 3 deficiency a primary or secondary immunodeficiency?

Great question: You already know that most folks who are discovered to have real igg3 deficiency are troubled primarily by recurrent nasal sinus infections. Until we know whether there's one of more genes for this, or whether it's the result of some other change in the immune system (igg3 can drop after other illnesses), i think the mainstream medical community will remain undecided. Glad you're proactive. ...Read more

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My father has had low IgG levels for a year... Other igs are normal. Could this be a problem? His pcp suggested perhaps some immune deficiency.

Possibly: Igg being low can signal an immune deficiency. But more important than the amount is how well the igg works to fight infections. If he does not have many infections, this level might be his "normal". He should see an immunologist, who can tease out the likelihood of immune deficiency from your dad's history as well as lab tests (that look how well his immune system responds to vaccines, e.g.). ...Read more

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I read that IgG subclass deficiencies are associated with fibromyalgia and chronic fatigue syndrome. Is this true? If so, what is the connection?

I read that IgG subclass deficiencies are associated with fibromyalgia and chronic fatigue syndrome.  Is this true?  If so, what is the connection?

IGG : Igg are sensitivities for foods or substances and cause significant gut inflammation. These then lead to impermeable or leaky gut. This inflammation can lead to joint and muscle pain. The fatigue is usually caused by the poor absorption of the cofactors needed in the body to produce energy. ...Read more

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Have a mutation for immune deficiency (CVID2/IGAD2) associated with TACI. Normal IgA, IgM & IgG but long history of severe infections. How to test it?

Have a mutation for immune deficiency (CVID2/IGAD2) associated with TACI. Normal IgA, IgM & IgG but long history of severe infections. How to test it?

?: Not adding up, you can't literally have those conditions, repeated severe infections and normal measures of Ig subtypes.You need to be re-evaluated, you may simply have IgG subclass deficiency,or specific antibodies deficiency,testing for recall antigens for tetanus and pneumococcus,pre and post vaccination can prove it,treatment remains the same: IVIG therapy.Too complex for this limited platform ...Read more

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Varicella zoster igg level 2339. What does it mean, a recent infection or general immune deficiency?

See answer: Varicella zoster IgG level raised suggests a past infection with chicken pox or shingles. Raised IgM levels wld suggest a very recent or present infection. Either way it wld not suggest a general immune deficiency! ...Read more

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What causes IgG deficency ?

What causes IgG deficency    ?

Many causes: If your IgM and IgA levels are normal or high, it's likely you have one of the still-not-fully-understood genetic glitches that come under the heading of "common variable immunodeficiency" which is very common. If your IgG is just a wee bit below the published "normal", consider ignoring it, but if one or more classes is way low, you deserve an official diagnosis. ...Read more

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Does intravenous immunoglobulin (ivig) infusions help someone with IgG defiency?

Does intravenous immunoglobulin (ivig) infusions help someone with IgG defiency?

Primary reason: Ivig has many clinical uses but its primary use is to augment resistance to infections in patients with igg deficiency - either hypogammaglobulinemia or combined variable immunodeficiency (cvid). ...Read more

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Does intravenous immunoglobulin (ivig) infusions benefit someone with IgG defiency?

Does intravenous immunoglobulin (ivig) infusions benefit someone with IgG defiency?

Possibly: If you are deficient and symptomatic (recurrent infections), they can possibly help your body fight infections better. Just because you have an igg deficiency does not mean your are immune deficient, however. Many people with low numbers have normal function and really are asymptomatic. ...Read more

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