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Doctor insights on: Iga Lambda Monoclonal Gammopathy

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IgA lambda monoclonal gammopathy meaning?

IgA lambda monoclonal gammopathy meaning?

It is a medical diso: A medical disorder where your body is making excess of proteins (Gamma Globulins). It can manifest in 2-3 different ways (MGUS or Multiple Myeloma). So you need your doctor to explain which of these conditions do you have and theen get further testing, monitoring and you may or may not need treatment depending on whether it is mGUS (early) or Myeloma (later developemnt...that is a type of Blood Cancer ...Read more

Dr. Hamid Sajjadi
31 Doctors shared insights

Gammopathy (Definition)

A gammopathy is an abnormal gammaglobulin or gammaglobulin level. A monoclonal gammopathy is a single abnormal protein that can indicate a bone marrow cancer called multiple myeloma, or a lymphoma. Further evaluation is required to determine if a monoclonal gammopathy ...Read more


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Free kappa light chain is high, FLC ratio is 2.205, no monoclonal gammopathy. IgA 389.43, lgM 125.95 and lgG 1771.02 H. Should we be worried? Thanks.

No: Abnormal FLC ratio is not diagnostic of any disease. More than 50% of the people with increased levels of gamma globulins have abnormal FLC ratio without a disorder of the plasma cells. ...Read more

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What can cause monoclonal gammopathy?

What can cause monoclonal gammopathy?

Mayo Clinic say: Plasma cells are a type of white blood cell. They are found in your bone marrow. Plasma cells produce some of the antibodies that help your body fight infection. Monoclonal gammopathy of undetermined significance occurs when plasma cells in your bone marrow produce an abnormal protein called monoclonal protein (m protein). ...Read more

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What's monoclonal gammopathy of undetermined significance?

MGUS: Is a common precancerous condition affecting people 50 years of age and older. It was first described by mayo clinic researchers in 1978 and is characterized by the presence of an abnormal protein in the blood called a (monoclonal) protein or m protein. Mgus has a small risk (1 percent each year) of progressing to a blood cancer called multiple myeloma or a related condition. ...Read more

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Is mononuclueosis associated at all with monoclonal gammopathy?

Is mononuclueosis associated at all with monoclonal gammopathy?

No: Ebv infection, the cause of mononucleosis is not usually related to monoclonal gammopathy. Ebv induced lymphoma may produce monoclonal gammopathy, but that would be an uncommon situation. ...Read more

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Can monoclonal gammopathy cause osteomyelitis?

Can monoclonal gammopathy cause osteomyelitis?

Not realy: It's estimated that between 10 and 25 percent of people with monoclonal gammopathy of undetermined significance develop a more serious condition, such as multiple myeloma or other cancers or blood disorders. Other complications include fractures and blood clots. ...Read more

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How reliable are blood tests that look for monoclonal gammopathy in elevated ImM levels? Are false negatives possible?

How reliable are blood tests that look for monoclonal gammopathy in elevated ImM levels? Are false negatives possible?

Very: The testing for gammoparhy at at the present time is very sensitive. The means by how this gets measured and analyzed is so sensitive that I can t out all of the different Antibody types. ...Read more

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What is monoclonal gammopathy about?

MonoclonalGammopathy: Is paraproteinemia associated with multiple myeloma. The most important fact that it is not cancer. ...Read more

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What is monoclonal gammopathy of undetermined significance (mgus)?

Blood & urine tests: Mgus is the presence of an abnormal protrein in the blood made by a type of white blood cell called a plasmacyte. In most cases, it is at a low level and is something that just has to be followed. However, it can be the precursor of the disease called multiple myeloma and as such a hematologist or medical oncologist will order tests to rule this out which may include blood, urine and simple x-rays. ...Read more

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Can you have a monoclonal gammopathy (and not mgus) while having a normal CBC w/differential?

Can you have a monoclonal gammopathy (and not mgus) while having a normal CBC w/differential?

Yes you can: CBC typically remains normal unless the bone marrow is heavily involved by multiple myeloma. Please check what the cause of your monoclonal gammopathy if it is not mgus? ...Read more

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What is monoclonal gammopathy?

A tumor type: There are various grades of monoclonal gammopathy. The three types, in increasing order of malignancy are monoclonal gammapathy of undetermined significance (MGUS), smoldering myeloma and the last one, which is a cancer, multiple myeloma. ...Read more

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Can I treat a possible monoclonal gammopathy of undetermined significance at home?

Nope: You don't treat an mgus, it is a condition that can ultimately lead to multiple myeloma (risk is about 1% per year) but as of itself does not need therapy (assuming it was correctly diagnosed). You need to have labs checked at least 1 or 2 times a year so you should follow up with your doc indefinitely. ...Read more

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What is the definition or description of: monoclonal gammopathy of undetermined significance?

What is the definition or description of: monoclonal gammopathy of undetermined significance?

A monoclonal: Gammopathy is an elevation in a specific type of immune protein in the blood. The work-up includes tests of urine protein, bones and blood production. If no serious associated disease is found then the clinical finding is called mgus. The patient is followed over time to see if the gammopathy becomes "significant." some patients declare themselves later with multiple myemoma or lymphoma. ...Read more

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What are possible causes of highly elevated ImM levels with low ImG levels with no monoclonal gammopathy present?

May not be a problem: This may depend on your genetic background and not be a medical problem. We would need an explanation of your problems, blurred vision, night sweats. Why are you on opiates ...Read more

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Can a IgM kappa light chain monoclonal gammopathy turn into macroglobulinemia?

Can a IgM kappa light chain monoclonal gammopathy turn into macroglobulinemia?

IgM is macroglobulin: Macroglobulinemia is the term for monoclonal igm. However what you described is confusing/erroneous term, igm kappa is not light chain gammopathy. Igm kappa, by definition is macroglobulin. ...Read more

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I had a blood test done, what does it mean? Kappa monoclonal gammopathy. Is this rare? Does this mean cancer? Is this anything to worry about?

Not necessarily: You don't tell me why the test was done in the first place. Kappa chain is one of 2 light protein chains that are part molecule of an immunoglobulin. In your case, it is half of an igg. Even if you are asymptomatic, you may develop a problem over 20 years. If you have symptoms, you need further evaluation. If there is no specialist where you live, go to the university of washington in seattle. ...Read more

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I understand that monoclonal gammopathy can cause a high CRP. As a matter of interest, does it typically elevate the WBC as well?

Neither: Neither an elevated CRP nor elevated WBC are part of the pathology in uncomplicated monoclonal gammopathy. ...Read more

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I understand that uncomplicated monoclonal gammopathy does not raise the WBC & CRP. But can MGUS lead to more serious conditions that do elevate both WBC & CRP? Would there be ANY other pathological data to look for if a worse condition comes about?

I understand that uncomplicated monoclonal gammopathy does not raise the WBC & CRP. But can MGUS lead to more serious conditions that do elevate both WBC & CRP? Would there be ANY other pathological data to look for if a worse condition comes about?

See below: About 1-2% of the patients with MGUS develop multiple myeloma, a form of bone cancer, each year. It would be prudent to have yearly check ups. You may consult this site for info: http://www. Mayoclinic. Org/diseases-conditions/mgus/home/ovc-20199535 ...Read more

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My husband is diagnosed with IgA lammda monoclonal gamopathy. The blood report says m-spike seen in beta region. Is this curable?

No: If it's a monoclonal gammopathy of uncertain significance, I'm sorry it was even found as usually nothing develops from these. There's a small risk of their turning into plasma cell myeloma. If this already is myeloma, you'll be advised on what to do next, and whether a marrow transplant is an option. ...Read more

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I just checked my health summary online and the doctor noted hyperglobulinemia and monoclonal gammopathies. I am also referred to a hematologist. What could be its meaning?

I just checked my health summary online and the doctor noted hyperglobulinemia and monoclonal gammopathies. I am also referred to a hematologist. What could be its meaning?

MGUS: Monoclonal gammopathy is the presence of a protein in your blood all produced from the daughter cells of one type of cell (plasma cells, which are one type of white blood cell.). This protein may be of no significance. Your hematogist can do additional testing to see if you are at risk of this becoming a more serious problem. ...Read more

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Kappa/lambda FLC ratio high (2.75) w/ normal K (10.21mg/dl) & low L (3.68mg/dl). Hem-onc unsure if ratio implies K monoclonality since serum/urine IFE ok & neither chain is elevated. Could monoclonal K be suppressing L? IgA a bit high IgG &IgM a bitlow

Kappa/lambda FLC ratio high (2.75) w/ normal K (10.21mg/dl) & low L (3.68mg/dl). Hem-onc unsure if ratio implies K monoclonality since serum/urine IFE ok & neither chain is elevated. Could monoclonal K be suppressing L? IgA a bit high IgG &IgM a bitlow

Useless test: K/L ratio is not a useful test. About one third of patients without monoclonal immunoglboulin have an abnormal ratio, usually with kappa excess. If you must, the next step would be a bone marrow examination. You may consult this article that I wrote: https://www. Ncbi. Nlm. Nih. Gov/pubmed/27473738
At your age you are unlikely to have myeloma. ...Read more

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Is elevated kappa/lambda ratio on serum FLC test inherently monoclonal, even if neither kappa or lambda is elevated? Ratio high b/c lambda is low, not because of high kappa. SPEP/UPEP & IFE normal. High IgA, low IgG. Clean marrow biopsy. Polyclonal?

Is elevated kappa/lambda ratio on serum FLC test inherently monoclonal, even if neither kappa or lambda is elevated? Ratio high b/c lambda is low, not because of high kappa. SPEP/UPEP & IFE normal. High IgA, low IgG. Clean marrow biopsy. Polyclonal?

Clinical context: The use of light chains is limited in diseases other than monoclonal gammopathies, such as myeloma or amyloidosis. If this is the context that yours got checked the results do not suggest such a condition. With no gammopathy suggested by results the question regarding clonality has no grounds. As any other test, trending the results would help in integrating it in a meaningful clinical context. ...Read more

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What is monoclonal gammopathie IgM kappa?

What is monoclonal gammopathie IgM kappa?

Plasma cell disorder: Monoclonal gammopathy refers to an abnormal production of proteins by cells in the immune system (plasma cells) that are growing out of control. It can be one of the signs of myeloma. A hematologist-oncologist can help. ...Read more

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Is monoclonal paraproteinemia the same thing as myeloma?

Yes in most ways: Myeloma is one of the differential diagnosis, the other condition is called mgus ...Read more

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What causes monoclonal paraproteinemia?

What causes monoclonal paraproteinemia?

Excess of Plasma cel: Plasma cells in our bone marrow make antibodies. Sometimes they become overly active/reactive and produce abnormal proteins called paraproteins. Most such protein production is benign and not uncommon in older folks. Sometimes it is excessive (more than 1gram/day) then we get concerned about a condition called multiple myeloma (paraproteins over 3 grams). ...Read more

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I had a IgA Heavy Light Chains (HLC), S test done. Ig K/L HLC Ratio, IgA Kappa, S and IgA Lambda, S were in normal range. What does this test mean?

I had a IgA Heavy Light Chains (HLC), S test done. Ig K/L HLC Ratio, IgA Kappa, S and IgA Lambda, S were in normal range. What does this test mean?

Nothing: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, The tests you mentioned have a high number of false positives and false negatives and are or questionable value.
For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form.
Practice safe sex. ...Read more

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What does elevated Igg-2364 and gamma globulin 2.2 mean with polyclonal gammopathy and Kappa and lambda typing increased?

Nothing serious: Polyclonal gammopathy does not have the seriousness of monoclonal gammpathy. Firstly your IgG and total globulin levels are only mildly elevated, so It may not mean any disease. One cause is chronic inflammation (infections) such as Chronic arthritis or chronic liver disease, conditions which can be checked out or ruled out easily if you ask your doctor and seek his/her advice about it. ...Read more

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Can you explain what this might mean: "apparent polyclonal gammopathy: igm. Kappa and lambda increased". Immunoglobulin m is also high at 437.?

Can you explain what this might mean: "apparent polyclonal gammopathy: igm. Kappa and lambda increased". Immunoglobulin m is also high at 437.?

Monoclonal processes: Are often malignant or pre malignant. Polyclonal processes are usually reactive/infectious/inflammatory. ...Read more

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Been diagnosed with peripheral neuropathy blood test showed high immunoglobulin m w/polyclonal gammopathy. Kappa/lambda increase. Possible meaning?

PlasmaCellDIsorder: May have plasma cell disorder/multiple myeloma. Plasma cells are a type of white blood cells that produces immunoglobulin (antibodies). Multiple myeloma is a cancerous or excessive proliferation of these plasma cells which may lead to excessive high levels of calcium/bone pain/renal failure/anemia (low blood counts). Need to see hematologist (blood doctor specialist). ...Read more

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What is IgA kappa monoclonal protein?

What is IgA kappa monoclonal protein?

IgA paraprotein: An IgA kappa monoclonal protein represents a single clone of bone marrow cells that have reproduced in an aberrant fashion. If this is what is found on immunofixation then a hematologist should be consulted for further workup. ...Read more

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Could type 1 vonwillebrand cause mildly low IgG of 691 (700-1600) and/or mildly high IgA of 400 (90-386)? Serum/urine electro negative for monoclonal.

Could type 1 vonwillebrand cause mildly low IgG of 691 (700-1600) and/or mildly high IgA of 400 (90-386)? Serum/urine electro negative for monoclonal.

Stop worrying: These are normal. Reference ranges are set so that a few percent of healthies fall outside on either end. People who get sick from this stuff have values way out of range. Best wishes. ...Read more

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What is the significance of IGA Kappa Monoclonal in Beta? 36 y.o. with slightly elevated wbc (14-21k) for past year.

MGUS: This type of protein disorder is difficult to characterize at first, but the good news is that it's not showing the definitive signs of multiple myeloma or one of the other related serious disorders. This needs to be monitored closely, though, by a rheumatologist or immunologist. Best of luck to you. ...Read more

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Can monoclonal IgM kappa light chain gammopathy turn into multiple myeloma?

It can: Yes, it can. It will depend on how much is the quantity of the monoclonal proteine, how many plasma cells on the bone marrow and ultimately whether one has end organ damages/ whether some other organs are affected significantly by the monoclonal protein. That is why some blood work, imaging study and bone marrow biopsy need to be done. ...Read more

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Immunofixation, Serum FAH = Monoclonal IgG kappa immunoglobulin. Beta FAH = 10.5% Abnormal band, immunofixation to follow. I'm IgA deficient too.??

Possibly: If I am understaning this right you have a monoclonal protien band?
The most important next steps here would be to identify the band (immunofixation) and then perfrom quantitvaive immunoglobulin levels. IF there is a monoclonal band, you may very well have reciprocal depriciation of alternative immunoglobulins and IgA deficiecny with an IgG monoclonal protein is possible. ...Read more

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More info on serum immunofixation. No monoclonal proteins detected. A faint IgG labda cannot be ruled out. Suggest repeat 6 mths. Igg 841 IgA 251 IgM 44.

More info on serum immunofixation. No monoclonal proteins detected. A faint IgG labda cannot be ruled out. Suggest repeat 6 mths. Igg 841 IgA 251 IgM 44.

Correct advice: It is prudent to retest in about six months to see which way the low level monoclonal spike is going. It may disappear, stay unchanged or increase in amount. The next step will depend on the direction of the quantity of the protein. Your immunoglobulin levels are normal. There is no need to worry. ...Read more

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Just found out that I have an IgA kappa monoclonal protein in my blood stream?! what can cause this? I have hep c and one kidney, lost other in 2008

Just found out that I have an IgA kappa monoclonal protein in my blood stream?! what can cause this? I have hep c and one kidney, lost other in 2008

Needs observation: If you are healthy otherwise you need to observe the level of soothing called m protein what you have is probably what it is calls monogamma pathy of undetermined significance this by itself is I harmful and warrants no treatment but rarely could developed into a blood disease call multiple myeloma which needs treatment please check the m protein level in your blood twice yearly. ...Read more

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Slightly elevated beta fraction from serum protein electrophoresis. Beta 1.07 (high) (0.52-0.98) increased beta fraction, no monoclonal or polyclonal gammopathy seen. Immunofixation normal.

Slightly elevated beta fraction from serum protein electrophoresis. Beta 1.07 (high) (0.52-0.98) increased beta fraction, no monoclonal or polyclonal gammopathy seen. Immunofixation normal.

This report is of no: These values are of no particular concern. This test is mainly useful to check for monoclonal peaks...Which you do not have. ...Read more