Doctor insights on:
I Know This Dude Who Has Mixed Connective Tissue Disease What Is That
Lupus/scleroderma: Mixed connective tissue disease (mctd) is an autoimmune disease that usually has features of lupus and scleroderma. Many people have raynaud's (fingers change color) and puffy fingers, and a positive ANA with a more specific test called "rnp" and may also have rashes, arthritis, or inflammation in other organs. It is treated a lot like lupus. Seeing a rheumatologist is helpful. ...Read more
The body is composed of tissue that are classically described as beiing derived from three basic embyonic layers known as the endoderm, mesoderm and ectoderm that then differentiate into the structures that compose the body such as skin, soft tissues, bone, muscle, organs, etc. Stem cells are not differentiated and have the potential to ...Read more
Labs are coming back suggestive of Lupus or Mixed Connective Tissue Disease. What is the difference between the two?
Mystery of....: rheumatology! Lupus difficult to diagnose because of many manifestations and wide range of severity. No clear diagnostic criteria. Diagnosis made on clinical grounds with supporting labs- requires a great deal of expertise and exclusion of other causes for symptoms. If your doc cannot confidently diagnose lupus then you may be given an alternative Dx such as MCTD or undifferentiated CTD. ...Read moreSee 1 more doctor answer
What is a "connective tissue disease"? Had punch biopsy on rash, suggestive of early connective tissue disease. What is "connective tissue?"
Connective tissue: This is a constellation of disease affecting the supporting tissue throughout the body. It involves fat, cartilage,bone.there are different types with names such as Eleros Danlos , Marfans syndrome, Osteogensis imperfecta, they are all a result of gene dysfunction.ie are inheritable disorders. Most are fairly uncommon. The treatment varies depending on the specific areas involved ...Read moreSee 1 more doctor answer
Skin biopsy shows early connective tissue disease. What is connective tissue disease? Why would it cause a chest rash? Or flushing w/ stress, emotion?
Get 2nd pathologist: "Connective tissue disease" was an obsolete word for the lupus / scleroderma / dermatomyositis family decades ago. Unless this is a second-hand report of a biopsy that showed nonspecific inflammatory changes that anybody can have, I would ask that the case be reviewed by another pathologist if the rash might be a real problem. Lots of folks flush with stress ("stress urticaria"); it's normal. ...Read more
Labs can confuse.: The labs are just a fraction of what needed to get you better. Your history and physical exam will determine your treatment. Looking for which labs will delay and confuse. You need to develop a few paragraphs of all your issues and sit down with your doctor to put the pieces together. Began a wellness program and add in magnesium and acupuncture. ...Read more
Combination of CTD: Mixed connective tissue disease is an autoimmune conditions with a combination of autoimmune diseases systemic lupus erythematosus, rheumatoid arthritis, scleroderma and polymyositis. One of these conditions is usually more prominent than the others at one time and with time it can progress to the other autoimmune diseases. Thus you may have arthritis, or a rash, or internal medical probelm. ...Read more
Partly: The exact cause of this disease is still unknown. We believe that there is a genetic or inherited predisposition and a second enviorental trigger for this disease. It is rate to see 2 family members with this disease. Basically this means it is not an inherited disease. The abity to get this disease may be inherited but not the disease itself. ...Read more
Many ways: Different people have different mechanisms of mctd activity. The therapy is tailored to the individual activity. Knowledge is the best way to cope with mctd. The more you know your type of mctd the better you can cope. I sometimes refer to it as "mixed up" connective tissue disease. ...Read more
Mixed CT Disease: There's no cure for mixed connective tissue disease, but medication can help manage the signs and symptoms of the disease. Mild forms of mixed connective tissue disease may not require treatment. You may require treatment only during flares or, if you have a more serious form of the disease, you may require continuous medication. ...Read more
Mixed CT Disease: The medications include nonsteroidal anti-inflammatory drugs (nsaids), cortisone drugs/steroids (such as prednisone), antimalarial drugs (hydroxychloroquine), and cytotoxic drugs (such as methotrexate, azathioprine, and cyclophosphamide). Organ damage, such as in the kidneys, can require additional treatments directed at high blood pressure, etc. ...Read more
Joint, skin, interna: Mctd can have a variety of signs and sympotms whichcan change with times. By the name it is a mixture of a variety of connective tissue diseases: systemic lupus erythematosus, scleroderma, polymyositis and rheumatoid arthritis. Depending on which condition is prominent at the time. When you are evaluated your physician will look for causes of the symptoms from these categories. ...Read more
Overlap syndrome : This is an overlap syndrome with manifestations that can include those of rheumatoid arthritis systemic lupus, scleroderma, and polymyositis. Different patients will have different combination of these components, over the long term it appears that many can get scleroderma like findings. Two or more components can occur. It has a variety of specific laboratory studies especially the RNP blood test ...Read more
see details: It really depends on the severity of the disease and the specific areas involved. With proper treatment there can be a normal life expectancy in most cases. ...Read more
I display all symptoms of mixed connective tissue disease but ANA tests were only slightly above average. Can this still be what i have?
In a diagnosis of mixed connective tissue disease, is it the anas alone that makes one feel crummy during flares if the other labs are normal?
Not likely so..: Antinuclear antibodies (ANA) is helpful in the innitial work-up and diagnosis of a rheamatologic disease, but ANA does not indicate the level of disease actitivies. Once positive for ana, this will always be so. The esr, crp, rf (in rhematoid arthritis) levels do correlate with disease activities and likely how you feel. U should check for thyroid, lyme, mono, depression, insomnia etc..Good luck. ...Read moreSee 1 more doctor answer
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