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Doctor insights on: I Have Discoid Lupus Not Sle Could This Make Wbc Fluctuate

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I have discoid lupus not sle. Could this make WBC fluctuate?

I have discoid lupus not sle. Could this make WBC fluctuate?

DIscoid Lupus: Absolutely it can. Some people progress to sle from discoid lupus. And discoid is an autoimmune condition that can have effects on bloodwork. ...Read more

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Dr. Emily Altman
66 doctors shared insights

Discoid Lupus (Definition)

Discoid lupus (think singer seal) is seen by itself or with systemic lupus erythematosus (sle). Abut 25% of sle pts have discoid symptoms. If discoid lupus is by itself, 5-10% of them will go on to have sle, but the disease is relatively mild. Discoid lesions are areas of inflammation that go through the dermal layer of skin, causing scarring (like stretch marks). ...Read more


Dr. Liawaty Ho Dr. Ho
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How does having polyclonal gammopathy correlate with lupus- I have lupus and polyclonal gammopathy does having this mean you have a more severe form of lupus, they did an spep be4 lupus and i had that?

Dr. Liawaty Ho Dr. Ho
2 doctors agreed:

Polyclonal gamma pat: Polyclonal gammoparhy is seen frequently in chronic inflammation/ autoimmune disorder etc. Lupus is certainly one of the condition that causes/ associated with polyclonal gammopathy . The presence of polyclonal gammopathy does not tell you whether the lupus will be more severe or less severe . Discuss with your rheumatologist further. ...Read more

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I have sle lupus is it normal to be sweating?

I have sle lupus is it normal to be sweating?

Systemic disease: The sin sle is systemic meaning it can affect multipleorgsn systems including skin, joints, kidneys, lungs , heart, etc. Although sweating is not a common occurrence, any symptom is possible in an unique individual. Depending on the area absorbent powder, evening antiperspirant may be helpful. Have your doctor evaluate you for internal involvement re kdneys etc. ...Read more

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Not diagnosed with sle but am ANA and dsdna positive what does this mean going forward? I only show a couple related sle symptoms at the moment.

Not diagnosed with sle but am ANA and dsdna positive what does this mean going forward? I only show a couple related sle symptoms at the moment.

Vigilance: Positive ANA tests can be false positive, but are more meaningful if high titre. Anti-dsDNA more meaningful in high titre. Since both are two of 11 criteria to diagnose SLE, periodic assessment by you and your. doctor is recommended. Others are malar rash,discord rash, photosesitivity,oral ulcers,arthritis,serositis, and renal,neurologic or hematologic disorder. ...Read more

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Why might all inflammatory markers be negative during lupus flare? I do have consistent ANA of 1:640 though.Prednisone helps my recurring flares.

Why might all inflammatory markers be negative during lupus flare?  I do have consistent ANA of 1:640 though.Prednisone helps my recurring flares.

ANA: no correlation!: There is no correlation with ANA titer and lupus flares! there is with anti-dna antibodies, and various other tests including c2, c4, lymphocyte count. Sle does not raise CRP for unknown reasons! discuss this rheumatology issue with your rheumatologist or pcp. Irrespective of Prednisone helping flares, you should be on plaquenyl which prevents flares! ...Read more

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Is organ involvement required to diagnose SLE ? Also ENA is neg so dr says no SLE. But I have ANA 320, low wbc, raynauds, livedo reticulars, oral sore

Lupus: Four out of eleven criteria help diagnose lupus. For practical purposes that's two organ systems, a positive ANA and a lupus specific antibody. But positive ANAs are very common, and white cells can be low with viral infections. If your CBC normalizes, unlikely to be lupus. Good luck. ...Read more

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I have symptoms of behcets and lupus.Neg ana, but positive lupus skin biopsy. Could i still have lupus?

I have symptoms of behcets and lupus.Neg ana, but positive lupus skin biopsy. Could i still have lupus?

Unlikely: Technically yes, but practically no, at least not the systemic form. I cannot remember the last time i saw ANA negative systemic lupus but anything is possible. ...Read more

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Esr is elevated but my ANA and CRP are normal! does this mean that i don't have an autoimmune disease?

Esr is elevated but my ANA and CRP are normal! does this mean that i don't have an autoimmune disease?

Autoimmune disorders: Esr is an inflammatory marker tha is elevated in inflammatory disorders, anemia , pregnancy, , kidney cancers , tb, lymphoma to name a few. It measures rate at which red cells sediment in a test tube in 1 hour. It is used more to monitor response to treatmemt is such disorders and helps in diagnosis of certain conditions. Esr can be elevated with negative ANA in several autoimmune disorders. ...Read more

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1280 ANA, -ENA and compliments. lupus symptoms, but rheum said no lupus because I have Blau Syndrome, rare autoinflammatory, doesn't cause ANA. Help!

1280 ANA, -ENA and compliments. lupus symptoms, but rheum said no lupus because I have Blau Syndrome, rare autoinflammatory, doesn't cause ANA. Help!

Talk to your MD: Blau syndrome, systemic granulomatous syndrome, is a rare autoimmune disease affecting many organs. It can simulate, at least initially, other autoimmune diseases. There is effective treatment for most patients with the disease. Either talk with your rheumatologist or go to a tertiary medical center. ...Read more

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Can I have Lupus if my ANA is positive, tired is 1:320 homogeneous diffuse, but ENA panel is negative. I do have some s/s?

ANA 1:320: Not all autoimmune disease are totally differenciated into discrete diseases and also markers may appear over time, not initially . What was your double stranded DNA? Complement levels? Rheumatoid factor? Can get false positive ANA from RA, mono , Crohns, viral infection, thyroiditis(check TPO,), meds , silicon implants and 5% healthy. f/u w/ rheumatologist ...Read more

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If I have an elevated CRP and est with a negative ANA what could this indicate? I have type 1 dm and fibromyalgia. They were suspecting lupus

The : The ESR and CRP are both markers of inflammation. However, they are very non-specific and can be elevated in a wide variety of conditions including infections, malignancies, and auto-immune diseases. The ANA is the screening test for lupus and similar conditions. It has many false positives but very few false negatives. In your case, the negative ANA most likely means that you elevated ESR and CRP are not due to lupus. ...Read more

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My lupus flares are Skin manifestation only(malar rash)plus fatigue.But ESR n CRP keeps coming Normal including ANA.on plaquenil (hydroxychloroquine). Was dx not correct?

My lupus flares are Skin manifestation only(malar rash)plus fatigue.But ESR n CRP keeps coming Normal including ANA.on plaquenil (hydroxychloroquine). Was dx not correct?

Maybe, maybe not...: You may have a type of lupus called subacute cutaneous lupus erythematosus(SCLE)which can often be a milder form of systemic lupus(SLE) and can be seen with normal inflammatory markers (ESR).Can also be Sjogren's. However,half of people with SCLE also meet criteria for full blown SLE. SCLE patients can have more serious organ involvement than just skin that should be checked for.See rheumatologist ...Read more

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I believe that I have lupus but the doctors that I have seen are hesitant to diagnose it. I have auto immune hemolytic anemia and auto immune thrombocetapenia. What shouldi do?

I believe that I have lupus but the doctors that I have seen are hesitant to diagnose it. I have auto immune hemolytic anemia and auto immune thrombocetapenia. What shouldi do?

Treatment decisions: The real question is not "Do I have lupus?" but "How do I treat whatever this is?" There's no "magic bullet" for lupus and if it's not obvious, often the treatment is worse than the disease. The key is to manage your anemia to keep you able to function, and your thrombocytopenia to prevent serious bleeding. Decisions about administering immunosuppressants, IVIG, etc. are ahead. Be informed. ...Read more

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Diagnosed with fibromyalgia. I have CRP always 20-22 and ESR 52. Is is related to fibromylagia? Cbc always normal . Should is start worrying

Diagnosed with fibromyalgia. I have CRP always  20-22 and ESR 52. Is is related to fibromylagia? Cbc always normal . Should is start worrying

ESR: Should not be elevated with fibromyalgia. It is a noon-specific marker of inflammation. You should find out what is inflamed and CRP is high. You need further work up with rheumatologist. ...Read more

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I have a low IgA and lupus like symptoms. My ANA is negative. Can I develop lupus?

Unlikely: Lupus like symptoms is quite vague. As lupus potentially can affect any organ system in the body, many symptoms are consistent with those seen in lupus. Low IgA is not a typical feature of lupus. It is more commonly seen in certain bowel disorders in which, many symptoms overlap with those seen in lupus. ...Read more

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I have discoid lupus & panniculitis. May I know what explains my constantly elevated igg level (~2000)? I also have lymphopenia due to steroid intake.

I have discoid lupus & panniculitis. May I know what explains my constantly elevated igg level (~2000)? I also have lymphopenia due to steroid intake.

Just a bit high: That's not surprising in systemic autoimmune disease where there's often a polyclonal gammopathy. We don't usually treat discoid lupus with systemic glucocorticoids, and I'm wondering what the panniculitis is really about (Weber-Christian?). You may have some alternative to long-term steroids, which are brutal. Perhaps you can get a second opinion / clarification. ...Read more

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Ana positive c3c low and low phosphate no symptoms of anything does this mean lupus or since ANA was nucleolar scleroderma or not necessarily auto immune issue?

Why the test?: If you don't have symptoms of anything, why did you have the test in the first place? Tests should be ordered when there is a reasonable suspicion of disease through the questioning and physical examination. Having a positive ANA alone means nothing. ...Read more

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I have recurring flares of rashes, joint pain, muscle aches, debilitating fatigue, dizziness. I have photosensitity and one episode of my WBC at 2.0 years back. My ANA is 6:40. I'm on plaquenil. Why are all my other antibodies neg for lupus?

I have  recurring flares of  rashes, joint pain, muscle aches, debilitating fatigue, dizziness. I have photosensitity and one episode of my WBC at 2.0 years back.  My ANA is 6:40.  I'm on plaquenil. Why are all my other antibodies neg for lupus?

Maybe SLE maybe not.: Diagnosis of rheumatologic disease is generally based on symptoms with support from lab. Sounds like you have a rheumatologic disease and are being treated with a rheumatologic agent perhaps by a rheumatologist. They can explain your particular situation better, but suffice it to say tests are not always right and a single test does not generally make or break a diagnosis. ...Read more

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I have discoid lupus not sle. Could this make WBC fluctuate?

DIscoid Lupus: Absolutely it can. Some people progress to sle from discoid lupus. And discoid is an autoimmune condition that can have effects on bloodwork. ...Read more

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Hydroxychloriquine ,can it be used for Discoid Lupus (DLE) to prevent DLE becoming SLE ?

NO: Use it for whatever it does for you. If you have DLE you must protect strictly against sun, UV, any radiation. Your DR may give you something for DLE or SLE. ...Read more

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Is it true Hydroxychloriquine is not indicated in the treatment of Discoid Lupus for flare up ?And in fact long term use is only indicated for SLE?

It Depends: Hi Theresa905, According to drugs.com Hydroxychloriquine is used for SLE and Rhematoid Arthritis. As you know it is also used for Malaria treatment. Doctors can prescribe medications what is called off label. They may have seen improvement and know from experience that the medication is safe and effective. Hope that is helpful to you. Dr Lori Lange ...Read more

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Should people diagnosed with sle or discoid lupus avoid taking the drugs associated with drug-induced lupus?

If possible: Certain drugs can affect lupus so if there is a choice it may be prudent to avoid three drugs however depending on your circumstance there may not be other options. If you must take a drug associated with lupus be vigilant in reporting any joint pains, fever, or unusual symptoms to your doctor. ...Read more

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Are discoid lupus and sle different?

Are discoid lupus and sle different?

Yes: Discoid lupus is confined to the skin while systemic lupus can affect literally any organ of the body including the skin. ...Read more

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Does hashimoto thyroiditis have anything to do with discoid lupus or sle?

In a way: Lupus and Hashimoto's thyroiditis are both autoimmune diseases. Often the presence of one autoimmune disease makes a second one more likely to occur. These two conditions are treated separately. ...Read more

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What are the antibodies associated w/ discoid lupus? I have dle but i think its a symptom of sle. My aunt & mom have both & RA hurry up&wait game?

Sometimes low ANA : A small number of patients with discoid lupus will progress onto systemic lupus, but it is not likely. Your need followup, a physical examination and bloodwork and approprite workup to decide if there is systemic lupus. ...Read more

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Hi I've been getting pain on & off in my back which feels like my lungs, it feels like I've been punched in the back. I suffer from discoid lupus & recent blood tests show I might have slight SLE lupus aswell. The pains in my back come & go but can be ver

Hi I've been getting pain on & off in my back which feels like my lungs, it feels like I've been punched in the back. I suffer from discoid lupus & recent blood tests show I might have slight SLE lupus aswell. The pains in my back come & go but can be ver

See answer: Question is beyond the scope of this Q & A box. There are a number of possibilities and much more detail needed to give an intelligent reply. An online Health Tap consultation may be more helpful. A video or phone consultation is best, 2nd choice is an InBox Consult provided you will be available to reply to questions during the day. For more information> http://bit.ly/1OiIRcI ...Read more

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Does discoid lupus ever just go away?

Unlikely: Discoid lupus is a chronic inflammatory autoimmune disease that is unlikely to resolve spontaneously. ...Read more

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What's the difference between systemic and discoid lupus?

Serious vs, not: Systemic lupus affects multiple organs and is a serious auto-immune disorder. Discoid lupus is mostly limited to sun exposed skin areas. See the sites below for details. http://www.ncbi.nlm.nih.gov/pubmedhealth/pmh0001471/ http://emedicine.Medscape.Com/article/1065529-overview. ...Read more

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Is it possible to have discoid lupus and systemic lupus at the same time?

Skin deep: Discoid lupus is a type of skin lupus. Most patients with it do not get systemic lupus. Occasionally people with systemic lupus get .Discoid lupus rash as part of their disease. ...Read more

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Can someone with discoid lupus get microdermabrasion?

Can someone with discoid lupus get microdermabrasion?

Yes: Microdermabrasion is a very superficial treatment when performed correctly. Please go to an experienced dermatologist or plastic surgeon and not just any beautician with a microdermabrader. Be careful and choosy with your professional. All the best, dr. Fred www.Cornerstoneplasticsurgery.Com. ...Read more

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Could you get pregnant if you have discoid lupus?

Yes: Yes, but you need to confer with doctors first. Discoid on occasion can transition to systemic lupus so you would want to get checked. Also you would need to have medications reviewed with your doctor. Plaquenil (hydroxychloroquine) is safe in pregnancy, but if you are on medications such as methotrexate, these would have to be stopped long before any attempts at conception are made. See your doctor to talk more. ...Read more

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Does topicort LP cream work for discoid lupus?

Pretty good: Your physician may eventually add systemic Chloroquine or some other drug, and/or a topical agent such as tacrolimus. Discoid lupus can be a major nuisance and i hope that you are able to get a good result. ...Read more

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Are there safe alternative therapies for discoid lupus?

Are there safe alternative therapies for discoid lupus?

Avoid sun exposure: The most important therapy is to avoid sun exposure by using hats and or sun screen. ...Read more

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Can there be any pregnancy risks for women with discoid lupus?

No: Discoid le should prevent no problems. As a precaution, as a rheumatologist, i would make sure coagulation studies were normal prior to attempting pregnancy. ...Read more

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I might have discoid lupus erythematosus. What is it like to be a patient?

I might have discoid lupus erythematosus. What is it like to be a patient?

Your personality: Discoid lupus is a relatively benign disorder and can usually be treated with medication. Different people have different reactions to a diagnosis and their responses vary as with any other life event. If your concern is about being a patient with dle, you should consider yourself fortunate that you do not have a more serious illness. ...Read more

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What is the treatment for discoid lupus erythematosus?

Less sun, some Rx: Sun protection, topical steroids, avoidance of any drug which may have provoked the dle. If no better in 2-4 weeks, cortisone injections into the lesions or topical calcineurin inhibitors. If still no better in 2-4 more weeks, oral hydroxychloroquine, an anti-malarial medication. There are even further treatment for refractory cases but the above usually works. ...Read more

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How do you heal a discoid lupus sore on the face filled with pus?

How do you heal a discoid lupus sore on the face filled with pus?

Treat infection: Discoid lupus lesions are dry, scaly, raised circles that should not have pus. Keep your hands away from them as much as possible. Apply warm wet compresses until you can see a doctor about the infection. ...Read more

White Blood Cell (Definition)

Body blood cell that responds to inflamation or infection or ...Read more