Doctor insights on:
I Have Chronic Lymphocytic Leukemia What Can I Do To Fight Against This Disease
Options available: There are a lot of treatment options available. However not everybody with cll need to get treated right away at the first initial diagnosis. There are some indications to start one on therapy. Nowadays, treatment is personalized and tailored to the biology of the cancer. There are some prognostic/predictive markers that can be tested to guide treatment selection, discuss with your oncologist. ...Read moreSee 1 more doctor answer
A malignant hematologic neoplasm that originates in the bone marrow and represents a clonal proliferation of hematopoietic elements belonging to any of the myeloid, lymphoid, erythroid, and megakaryocytic lineages. Of note, other hematologic neoplasms like lymphoma or myeloma may demonstrate a leukemic phase without actually originating in the bone marrow ...Read more
CLL: Cll is a clonal disorder (cancer) of the white blood cells (specifically lymphocytes) in the blood (= -emia part). Other leukemias include cml, aml, all, etc. Cll is often diagnosed by flow cytometry on peripheral blood. Additional studies may include ct scans and bone marrow biopsy. One staging system is rai 0 to iv. Treatment ranges from observation (rai 0-1) to various tx individualized to pt. ...Read moreSee 1 more doctor answer
Are there any new findings on chronic lymphocytic leukemia regarding preventive treatment /protocol to slow progression of disorder while asymptomtic?
Yes (but...): Yes, but minimal and does not change the standard of care. Dr. Shanafelt and colleagues at mayo clinic have looked at green tea extract in rai 0-ii cll showing a 67% response rate. http://www.asco.org/ascov2/meetings/abstracts?&vmview=abst_detail_view&confid=74&abstractid=47574 -- conclusion: egcg containing green tea extracts may have potential as disease stabilizing agents... ...Read moreSee 1 more doctor answer
Yes: But it is quite rare before age 40. ...Read more
Depends on the stage: In early case, patient will be asymptomatic and the only thing abnormal is the blood test. In later stage- one can have low blood counts (anemia, low platelet), fatigue , tired, lack of energy, bruising easily/bleeding also, you could feel lymph nodes enlargement on the neck, arm pits, groin etc as cll involves more to the lymph nodes. Increase abdominal girth, fever, chils, weight loss can happen. ...Read moreSee 1 more doctor answer
Mostly unknown: Cll affects older white men more that other parts of the population and the cause is unknown in most cases. Exposure to certain herbicides and insecticides, including agent orange used during the vietnam war, have been linked to an increased risk. For more information consult: http://www.Mayoclinic.Com/health/chronic-lymphocytic-leukemia/ds00565/dsection=risk. ...Read more
See below...: Cll stands for chronic lymphocytic leukemia, a form of blood cancer. Cll is usually not an aggressive form of leukemia and has a relatively good prognosis overall. Many patients are asymptomatic for a long period of time (years) and do not need any form of therapy unless there are symptoms or adverse prognostic factors. ...Read moreSee 1 more doctor answer
CLL: Simplisticly it is an overgrowth of lymphocytes. Since these cells are usually slow growing the disease tends to progress at a relatively slow rate compared to other types of leukemias and in general may take years to begin to harm a patient. Treatment is usually withheld until the patient becomes symptomatic. ...Read more
Rare: There have been familial cases reported and my partner and i had a brother and a sister. The brother has never required therapy yet but the sister did. Mayo clinic is doing a study on familial cases. Mainly taking blood and studying it. It is an ongoing study so the results are not available yet. Hope this helps. ...Read more
A test 2 assess risk: The correct name is igvh mutational status assay. This is a gene test performed only on leukemic cells of patients with cll to assess risk of progression, and death from cll. The readout is either mutated (which is favorable) or unmutated (unfavorable). Igvh mutations happen during the normal generation of antibodies in white cells. ...Read moreSee 1 more doctor answer
See below...: The only known complete cure for cll is stem cell transplantation; however, many patients do not need any form of therapy in the beginning and treatment is only started if the patient develops symptoms or adverse prognostic factors are present. Cll is usually not an aggressive form of leukemia and has a relatively good prognosis overall. ...Read moreSee 1 more doctor answer
D/W yourHematologist: It depends on the biology /prgnostic factors of the cll. In majority cases, cll is an indolent disease/slowly progressing disease and patients will live for many years with the disease. However there are certain biology of cll that are behaving more agressively and requiring teatment usually earlier. Discuss in detail with your hematologist/oncologist. ...Read more
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