Doctor insights on:
Hypothyroid Increased Alkaline Phosphatase
Not really: It can be increased in severe hyperthyroid disease ...Read more
Not a problem: Low alk phos is never a problem. Reference ranges are set so that several percent of healthies arbitrarily fall outside. I'm glad you're interested in your labs but don't worry about this. ...Read more
Relax: First, food choices are almost never the key to getting well. This is rubbish. Second, labs reference ranges are set so that a few percent of healthies fall outside on either end. Third, if the specimen is non-fasting, elevated alk phos means nothing. Fourth, isolated elevated alk phos is not an indicator of any treatable illness. Stop worrying, stay physically fit, and be glad for good health. ...Read more
Alk Phos: While Primidone may be the culprit, bone or liver disease must be ruled out. I would recommend a fractionated alk phos (shows which isoenzyme is elevated) and then proceed accordingly -- you may benefit from a right upper quadrant ultrasound (if liver isoenzyme is elevated) or a bone scan (if bone isoenzyme is elevated). ...Read more
Stop worrying: Unless there is something else obviously wrong, the fact that your alk phos is slightly above the range for most (not all) apparently healthy middle-aged sedentary people shouldn't bother you. You may even still be growing, or might be one of those folks whose alk-phos is up on a non-fasting specimen. ...Read more
There are none.: An elevated alkaline phosphatase is a blood test lab finding. If elevated, could be liver, gall bladder or bone problem. If there is only a mild elevation with all other blood tests being normal, it is possible that there is no problem, and just follow up with repeat blood testing. As usual, don't self- or internet-diagnose. Every american needs a good pcp/team to turn to. (my mantra). ...Read more
Liver disease, etc..: This usually means liver involvement. It can also mean biliary obstruction, pregnancy, and bone diseases. If can be transiently elevated in acute pancreatitis. Other lab values need to be looked at to determine the specific cause. See your doctor to go over the rest of the blood work. ...Read more
My blood work showed a level of 228 for alkaline phosphatase test. Will I need more test? What could it mean?
Yes: An elevated alkaline phosphatase will need to be evaluated with additional blood tests to determine why it is elevated. Most commonly this is due to some form of insult to the liver, usually alcohol. But even a cold can cause an elevated alkaline phosphatase. If your other liver enzymes are elevated, particularly, ggt, your doctor will likely order an ultrasound. ...Read more
What could cause alkaline phosphatase levels to steadily increase over a period of years, now at an elevated level?
Alkaline phosphatase: Causes for elevated Alk phos: biliary obstruction stone, tumor, stricture; autoimmune biliary cirrhosis; liver infiltrates do to granuloma, fatty liver, amyloidosis, sarcoidosis, malignancy; meds like estrogen, chlorpromazine, erythromycin ; viral hepatitis; bone diseases: Paget's, osteomalacia, mets to bone, PTH disease, vitamin d def, fracture ...Read more
High ALKALINE phosphatase but EVERYTHING else normal. Had a total replacement 1month ago. Is this the reason or what else could be?
Varies: Alkaline phosphatase is an enzyme usually associated with bone turnover. If it is mildly elevated and normalizing, then it could potentially be related to your surgery. If it is highly elevated, then there may be other considerations, Paget's disease being just one possible consideration. ...Read more
I did blood work and the results were that my alkaline phosphatase was 128 when the normal was 39-117. What does that mean? Should I be worried?
No, not to worry: Alkaline phosphatase is not a very reliable test unless there is something seriously wrong with the liver. Since it is close to normal, I do not believe it is anything significant. If there was anything important going on in your liver, other tests like SGOT and SGPT will be the first ones to rise and sound an alarm. ...Read more
Two recent blood tests indicate alkaline phosphatase levels of 150 and 146. All my other blood tests are well within normal. Should I be worried?
Lab results: You may have a liver problem. See you foctor to get checked out for hepatitis ...Read more
Lots of things: Medication sensitivity, boozing, being overweight / sedentary, hepatitis b or c, a sports injury, just finishing a marathon, hemochromatosis, wilson's, autoimmune hepatitis, antitrypsin deficiency, a host of others. One good plan is no alcohol or meds for two weeks, see if this goes down. ...Read more
Elevated Alk Phos: Question would be why is your alkaline phosphatase elevated? ? If the levels are abnormal, there is usually a reason. Treating the symptoms without understanding why you have an elevated level is counter-productive. You should see your primary care physicians and have labs re-checked. If it's persistently high, then there should be referral to a rheumatologist or orthopedic surgeon. ...Read more
Wrong approach: Alkaline phosphatase is a lab value to tell a physician what is happening, not a medical problem to treat. It can be high just because you're growing (teens tend to be maybe 5x the upper limit of the reference range). About 5% of older folks have a high alk phos for "no reason", presumably paget's of the bone that never becomes evident; nonfasting samples may have it from the intestine. ...Read more
Bone turnover: It is an enzyme that is active in the process of bone turnover; so it will be elevated in situations in which bone turnover is high, even in conditions where there is metastatic disease to the bone. Patients with pagers disease have a very high bone turnover rate and a markedly elevated alkaline phosphatase. ...Read more
Above 140IU/L: The normal range is 20 to 140 iu/l in adult. ...Read more
Liver bone & GB: Liver disease, bone disease and gallbladder are most common. However an elevated alk phos does not absolutely mean there is a true disease present. ...Read more