Doctor insights on:
Hyposecretion Of Glucagon
Loss of glucagon: People with type 1 diabetes often lose their glucagon after many years. T1DM is a disease of the beta cell in the pancreas, and the alpha cells (which make glucagon) are initially ok. But after many years, diabetics lose the alpha cells too. They can't mobilize glucose from the liver and are prone to hypoglycemia. ...Read more
Secreted by cells in pancrease (pancrelipase) that is normally higher overnight-tells liver to make sugar for brain to use overnight, and low during day when sugars in foods are used by brain. Always inappropriately elevated in patients with diabetes. Some medications for diabetes can reduce glucagon to improve blood sugar. Sometimes used asto raise blood sugar in someone unconsious due to ...Read more
Sugar production: Glucagon made by the body tells your liver to make more sugar, and when all systems are functioning properly, should not cause 'hyper'glycemia...Should result in normal sugars. Bottled glucagon given by injection as a medication an cause transient hyperglycemia because the dose is large, and that is its intended effect. ...Read more
Why does: Asks why does alpha cells secrete more glucagon? ANS: "Why? " is a philosophical question. Some would say because "God". designed it that way. Others (me included) would say this is the way Evolutionary forces works. ...Read more
Possibly: Check the expiration date. If in doubt ask your doctor for a new rx. ...Read more
Person can't eat: Glucagon kits are available for the emergency treatment of someone with diabetes whose sugar has dropped so low that they cannot safely eat or drink to bring their sugar up themselves. If they do not answer questions, or their answers are very confused or sound slurred, and you believe their sugar is low, a glucagon shot may help them recover enough to eat or drink to keep the sugar up. ...Read more
Secreted by cells in pancrease (pancrelipase) that is normally higher overnight-tells liver to make sugar for brain to use overnight, and low during day when sugars in foods are used by brain.
Always inappropriately elevated in patients with diabetes.
Some medications for diabetes can reduce glucagon to improve blood sugar.
Sometimes used asto raise blood sugar in someone unconsious due to a very low sugar. ...Read more
Safe: Hi. Glucagon is very safe and effective for treating severe hypoglycemia WITHOUT having to have the paramedics called. I make sure all my diabetics on insulin have glucagon. It's only used if patient is unconscious or can't safely eat/drink. Therefore, the other people around the diabetic need to know about the glucagon, where it is, how to use it, etc. Great drug. If you used it, GET A REFILL! ...Read more
No: Hi. As long as glucagon is in the lyophilized (dry powder) stage, it's stable at room temp for eons. Once it's put in solution with the diluent, it's only good for 24 hours. The rule: don't put glucagon into solution until it's going to be used right then & there. ...Read more
Under secretion of glucagon is not common but does sometimes occur.
If you take insulin for example, glucagon will decrease without issue.
If you are not taking insulin, under secretion of glucagon, can occur with a limited number of other causes.
If you are concerned please contact your doctor. ...Read more
Check with the: Post office to see policies on sending medications to another country. ...Read more
No: Glycogen storage disease are rare genetic disorders associated with a defect in processing glycogen. Some forms can be treated by eating simple sugars (corn starch), some have no particular treatment. I am not aware of glucagon being used in any of these disorders. ...Read more
Storage & Release: Glycogen is a storage form of glucose. Glucagon is a hormone which, like insulin, also comes from the pancreas. When the body needs to utilize its stored glucose, glucagon is released to do it. Glycogen is mostly stored in the liver, but it is also contained in the kidneys and muscle. ...Read more
Very carefully!: Diabetic patients with severe hypoglycemia can be a challenge because they often won't agree with you what the best course of treatment is. As a rule, aim to give awake/conscious diabetic patients oral glucose (in any form - juice, pop, glucose gel, glucose tablets, candy, etc.). It will be easier to convince them to take that than a shot! Save the glucagon injection for unconscious patients. ...Read more
Why is diabetes attributed to the hyposecrection of insulin & not to the hypersecretion of glucagon?
Only if severe: Severe by meaning unresponsive or altered mental status. You may need a "mini" glucoagon dose if your hypoglycemia is refractory to simple sugar ingestion desoite several attempts (mostly seen in children). Your cde can help with further advise. Reminder: make sure your glucagon kit is not expired. Good luck. ...Read more
Can you tell me is glucagon or insulin secreted by the pancreas during the fight or flight response?
Glucagon and insulin: Glucagon will increase available sugar in the bloodstream and would be more useful during the "fight" part of the response. Insulin is secreted when there is excess in the bloodstream, e.g. as you eat a meal or after eating, during the relaxations phase "flight" part. ...Read more
I was wondering is glucagon or insulin secreted by the pancreas during the fight or flight response?
No: Hi. No, they don't really play a role in the fight or flight response. Epinephrine from the adrenal medulla can cause glycogenolysis at the liver just like glucagon can, and epi is flooding the system...don't need glucagon. Insulin is present, but is an anabolic hormone, and the fight or flight response is all about catabolism...insulin in very low levels works fine. Good endocrine physiology! ...Read more
What is a normal blood glucagon level? I had a mixed meal test and my baseline glucagon level was (36). Isn't that low? I have hypoglycaemia
Endocrinologist: Glucagon levels (50-100) are rarely ordered unless a patient has wide fluctuations in blood sugar or has problems with recurrent hypoglycemia. I imagine your levels fluctuate and would be elevated during episodes of hypoglycemia. I'm unsure as to the significance of a low level of glucagon is in a nondiabetic person. An endocrinologist is best qualified to answer your question, however. ...Read more
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