Doctor insights on:
Hyposecretion Of Aldosterone
Gluconeogenesis: Hi. In prolonged fasting, cortisol plays an important role in a process the liver uses to make sugar from amino acids called gluconeogenesis. If glycogen (stored sugar) is depleted (happens in less than 24 hours of fasting), and the body cannot make enough new sugar from amino acids, low blood sugar can occur. Aldosterone does not play a role in gluconeogenesis. ...Read more
Tough to answer in a short space.
Please go online and type in "elevated aldosterone levels".
Start at the top and slowly work your way down.
It might be hard at first but the more you read the more you will understand.
There is also a section "Images" but that is much more difficult to fully understand. ...Read more
The concentration of a analyte is the amount of the substance in a specified volume of blood.
So is Aldo concentration is 10 it may mean there are 10 ng/ml.
Different labs express if differently as well. So best to ask your team what values your lab uses ...Read more
Counteracts effects: Aldosterone is a hormone produced by the body which acts to reabsorb sodium from the urine, which is very helpful during periods of dehydration. Diuretics counteract this activity by promotng sodium excretion in the urine. There are many types of diuretics but some like spironolactone directly inhibitthe activity of aldosterone. ...Read more
A cause of high BP: It is not very useful used alone without testing for plasma renin activity. Ask your doctor why he is recommending it. ...Read more
Aldo of 10: In order to be able to interpret an aldo level in the urine you must know your salt intake measured in that 24 hr urine. If urine Na is low then this is a low urine aldo as low salt in diet increases aldo. If your salt intake is high then this may be a normal urine aldo. You must ask the lab that did the test for their normal range based on salt intake. Has K ever been low? This may lower aldo ...Read more
Physiology: Hi. Aldosterone is primarily there to regulate renal handling of sodium, potassium, and acid. Urine concentration/osmolality is more a function of anti-diuretic hormone (ADH) regulating tubular luminal (phenobarbital) water channels and the ambient solute gradient in the loop of Henle. Water follows sodium in general, but the kidneys place quite a degree of regulation on this, so aldo has trivial effect on conc. ...Read more
Aldosterone was 2 ng/dL (fasted, early morning, upright) is this normal or low? Does it warrant further testing? Cortisol was high/normal 22.2 mcg/dL
More history: I don't know much about your history or what has caused you to have this testing in the first place so I won't be of much help, BUT the aldosterone level is low and may warrant further testing for Cushing's syndrome, 17-alpha-hydroxylase deficiency, Liddle's syndrome, ectopic ACTH syndrome, or mutations of your mineralcorticoid receptors. You need to talk to your doctor for more direction. ...Read more
I have been taking spiro for hyperaldosteronism for a year. By now has my aldosterone level returned to normal and will I ever be able to stop taking?
It is unlikely: If you have conn disease you will likely need for long. But have to know if your hyperaldestronism is temporary to suggest duration of treatment. ...Read more
Adjust chemistries: Aldosterone is important for adjusting the amount of salt excreted in the kidney. Too much salt excreted can cause low blood pressure and too little salt excreted can cause hypertension. Aldosterone is also important for regulating potassium excretion in the kidney. If blood potassium is allowed to go too high or too low, people can have life-threatening abnormal heart rhythms. ...Read more
Correct measurement: Aldosterone levels vary quite a bit with even position. First make sure that it is measured correctly. Truly high levels of aldosterone may be related to overgrowth or tumor in the adrenal gland, or be secondary to high renin levels driving higher production. Further labs and imaging may be needed to accurately diagnose. Discuss with your doctor. ...Read more
Is an a.m. Aldosterone of 6ng/dl on the low side? Range is < or = 28 which seems dumb because a value of 0 or 1 would be "in range".
No: That is an acceptable level in and of itself, but it must be evaluated in the context of other hormonal levels and other symptoms and signs you are experiencing. ...Read more
Function Aldosterone: 48 F form MI asks what is "function" of aldosterone. Its first function is to keep you from dying of salt depletion. Second it keeps you from dying of high blood potassium. It acts on the kidney to increase salt (Na) retention when your body salt is too low: such as from diarrhea, vomiting, sweating, low alt diet. If you have no aldo you die of salt depletion unless you eat salt by handful. ...Read more
ACTH ALDO Cortisol: I have seen two families in which ACTH is the major driver for aldo production. They have the syndrome called GRA (Glucocorticoid Remedial Aldosteronism) caused by a cross over mutation in the genes controlling aldo production so that the major controller of aldo is ACTH. As you are young and making this question if you also have HTN your team should consider this. Many do not have low K. ...Read more
An article from a credible source says to be tested for aldosterone when having a hypertension resistant situation (like me). Agree with testing?
See below: You shoulg be tested for several things, given your situaton. ...Read more
Saline intake aldo: Well depends on how much saline you are intaking. If you mean infusion IV or a very large salt meal aldo will go down within minutes unless you have a problem like an adrenal adenoma making too much aldo (and HTN). or a renal artery stenosis causing HBP. I can think of no reason it would go up unless the before and after saline infusion bloods were mixed up. ...Read more
Testosterone aldo: When testosterone is given as a supplement in men with "low T", fluid retention is often noted as a side effect. The cause of this fluid retention is complex, and not just related to aldosterone levels. In a normal male with normal testosterone, this is not really a factor. ...Read more
AII vs aldo and salt:
Aldo causes more Na retention and water follows salt.
But depends on circumstances. AII is major drive to aldo production so if AII high get same effect if you don't die form the severe HTN from excess AII.
Both can be counteracted if you eat less salt. I am a specialist in the renin angiotensin aldosterone system and happy to consult with you. ...Read more
High aldo: Could high aldosterone cause sodium retention? Could it cause hypernatremia? ANS: yes it is the strongest salt retaining hormone. And in classic Conn's syndrome, the most common cause it leads to hyperNa. I have specialized in this for 50 years and happy to help you and team figure out what is going on. Also go to hyperaldosteronism@yahoogroups. Com to meet over 1, 000 others with this problem ...Read more
Could be: Could be a sign of congenital adrenal hyperplasia with one of several enzyme defects. This is rare. Depends on who's ordering the test. If endocrinology, this is the reason. Adrenal fatigue is a popular diagnosis now but really represents metabolic stress and is a reaction of the system to stress. The answer is not to address the symptom of the stress but to address the stress itself. ...Read more
If someone was to have low angiotensin II and low aldosterone would you expect to see a lower renin also?
Renin levels: If one has a low aldosterone and angiotensin ii, one would expect a high renin level. Renin leads to angiotensin I and ii synthesis. If those levels are low and the person is ambulatory, the person's renin would be expected to be high. For a diagram of the renin-angiotensin-aldosterone system go to this link; http://www. Google. Com/search? Hl=en;site=imghp;tbm=isch;source=hp;biw=2556;bih=1234;q=renin+angiotensin+system;oq=+angiotensin+sy;gs_l=img.1.1.0j0i5l9.576.4679.0.9029.16.9.0.126.96.36.199.974.0j5j1.6.0....0...1ac.1.35.Img. 5.11.985.Luxw_l48srm#fa. ...Read more
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