Top
30
Doctor insights on: Hypocellular Marrow With Trilineage Hematopoiesis

Share
1

1
Just got back biopsy results....hypocellular marrow 10% with markedly reduced trilineage hematopoiesis with erythroid predominance... Is 10% cellularity cause for concern? What can this mean?

Just got back biopsy results....hypocellular marrow 10% with markedly reduced trilineage hematopoiesis with erythroid predominance... Is 10% cellularity cause for concern? What can this mean?

Discuss with doctor: Hypocellularity describes that there are fewer than average cells and this can mean many possible diagnoses so a conversation with your doctor is important to resolve this ...Read more

2

2
Hypercellular Marrow, increased Trilineage Hematopoiesis, reactive lymphoplasmacytosis, Erythropoiesis normoblastic and decreased. Myeloblasts not increased Megakaryocytes increased, include young forms

Hypercellular Marrow, increased Trilineage Hematopoiesis, reactive lymphoplasmacytosis, Erythropoiesis normoblastic and decreased. Myeloblasts not increased Megakaryocytes increased, include young forms

Marrow confusion: Complex because the answer is dependent on the hematologists total examination and not just a marrow. There is a difference between dysmorphic cells and immature forms so no diagnosis can be made from your comments. Stick with the hematologist or concologist. ...Read more

3

3
3 yrs lytic bone lesions through axial skeleton -skull. Extramedullary hematopoiesis. New MRI spots on brain-bone marrow expansion. Can this be fatal?

3 yrs lytic bone lesions through axial skeleton -skull. Extramedullary hematopoiesis. New MRI spots on brain-bone marrow expansion. Can this be fatal?

Depends: Bone marrow expansion throughout the skeleton typically signals either that the marrow is I appropriately expanding into these compartment such as in a myeloproliferative disorder or the present regions of marrow production are insufficient to keep up with current body needs. Regardless of the cause this is best answered by hands on evaluation, testing and management by an hematologist. ...Read more

4

4
What exactly is hypocellular bone marrow?

What exactly is hypocellular bone marrow?

Not enough cells: The bone marrow is the factory of the blood -- all blood cells begin life there. The "normal" amount of cells decreases with age, so we estimate normal as 100 - (age) +/- 20%. So, if a 50 year old has 50% of the space in the bone marrow filled with cells, we say this is normal. If it were 25%, it would be hypocellular. However, if a 90 year old had 25% cellularity, it is probably normal. Helps? ...Read more

5

5
Can you tell me about hypocellular bone marrow?

Can you tell me about hypocellular bone marrow?

Not enough cells: This means there are not as many blood-producing cells as would be expected for a person of this age.
Cellularity % refers to the amount of space in the bone marrow occupied by blood producing cells.
In general, you can estimate the EXPECTED cellularity of bone marrow as 100-Age. For example, a normal 20 year old might have about 80% ; a normal 90 yo 10%. ...Read more

6

6
Can any doc tell me what's hypocellular bone marrow and how does one get it?

Bone marrow disorder: Hypocellular bone marrow means that bone marrow continue less than normal blood producing progenitor cells, resulting in low blood counts in peripheral blood. There are many causes for that such as age, infection, drug, cancer, lymphoma, leukemia, and bone marrow disorders. For example, hepatitis virus can cause acquired aplastic anemia, typically presented with hypocellular bone marrow. ...Read more

7

7
What does it mean if a bone marrow biopsy/aspiration report shows hypocellular marrow?

Hypocellular marrow: The normal bone marrow is a mixture of cells and fat. Hypocellular marrow means the marrow has fewer cells in the bone marrow space that is expected for that patient's age.
There are many causes for this including nutritional deficiencies, bone marrow failure syndomes, pre-leukemia (myelodysplasia), prior chemotherapy, toxins and medications. ...Read more

8

8
Can you tell me about bone marrow biopsy/aspiration report shows hypocellular marrow?

Can you tell me about bone marrow biopsy/aspiration report shows hypocellular marrow?

Talk to doctor: This is a complicated issue to address in this forum. You should discuss it with your doctor and the two of you may wish to involve the pathologist who signed out the bone marrow report. ...Read more

9

9
Can any doc tell me what's meant when a bone marrow biopsy/aspiration report shows hypocellular marrow?

Can any doc tell me what's meant when a bone marrow biopsy/aspiration report shows hypocellular marrow?

Bone marrow: Bone marrow cellularity refers to how much of the marrow is making blood cells, and how much is fat. As people age, it tends to decline and move more centrally. Severe hypocellularity may indicate aplastic anemia or even leukemia, which needs treatment. Lesser degrees may or may not, depending on other symptoms and lab findings. ...Read more

11

11
Hypocellular marrow (50%) in 29yo f. Any longterm effects/impact? Biopsy {done cuz of bruises low CBCs fatigue sweats} results ok xcept low WBCs+plt

Hypocellular marrow (50%) in 29yo f. Any longterm effects/impact? Biopsy {done cuz of bruises low CBCs fatigue sweats} results ok xcept low WBCs+plt

Marrow CellularityOK: Your Bone marrow cellularity is within the normal range. Let us know the values of your CBC (? low but I can not tell without seeing the actual numbers) ...Read more

12

12
What would cause extremely low hypocellular bone marrow - 15% normal, 65% really hypocellular and 15% mild-moderately low; I am 40 yr old male with 20lbs weight loss, spinal pain, SOB, headaches, low ferritin and really high B12, folate; normal spep.

What would cause extremely low hypocellular bone marrow - 15% normal, 65% really hypocellular and 15% mild-moderately low; I am 40 yr old male with 20lbs weight loss, spinal pain, SOB, headaches, low ferritin and really high B12, folate; normal spep.

One marrow failure: Can be due to several causes as radiation, certain drugs, tumours, and others. You need to be under the care of a hematologist, whom you may have already seen, kindly keep the follow up, wish you all the best, at this limited platform we can't really offer much in your case, good luck ...Read more

13

13
my BMB report done for thrombocytosis and it stated "Marrow with patchy hypocellularity " also megas with abnormal spidery and/or bizarre nucleus?

my BMB report done for thrombocytosis and it stated "Marrow with patchy hypocellularity " also megas with abnormal spidery and/or bizarre nucleus?

Means little: Patchy hypocellularity is to be expected at your age; "spidery" nuclei doesn't mean anything in standard pathology, and the "bizarre" nuclei might be better charaterized. Have another pathologist read it out. There are DNA studies to check for essential thrombocythemia which is our major concern now that we ruled out a bunch of bad things which would have shown on marrow. ...Read more

14

14
Hemolysis recently & bone marrow showed hypocellularity & bite cells. Wouldn't that be consid. Symptomatic 4 g6pdd? Why drs ignoring?

It's usually mild: G6PD deficiency is usually quite mild and most G6PD patients know they have it and by adult life know more about it than their physicians. This is as it should be, and they may be assuming this is true of you. If you're uncertain about your G6PD status, its severity, and whether you were triggered by a medicine, talk with your physician. Best wishes. ...Read more

15

15
Wondering about the cure for all the issue of bonne marrow like mudullary hypoplasia culullarity 25 % cause virus or chemical and more?

Wondering about the cure for all the issue of bonne marrow like mudullary hypoplasia culullarity 25 % cause virus or chemical and more?

Need big picture: If the cellularity of a hip or sternal marrow is only 25% at your age (a bit lower than most), it raises concern, but the needle may simply have hit an island with few cells, and a number like this means nothing without clinical information. If one of the three major cells lines is greatly diminished, or looks abnormal, or there's something else, it would tell us more. Let us know? ...Read more

16

16
Wondering about what can be the reason of bone marrow mudullary hypoplasia culullarity 25 % what's reason behind this tell me the execption please?

Wondering about what can be the reason of bone marrow mudullary hypoplasia culullarity 25 % what's reason behind this tell me the execption please?

Many possibilities: Could be genetic causes or an acquired stem cell injury from viruses, toxins, or chemicals that leads to a quantitative or qualitative abnormality.

Talk to your doctor regarding these questions you have and you will get better answers.

More info available at: http://emedicine. Medscape. Com/article/199003-overview#aw2aab6b2b2aa. ...Read more

17

17
What in laymen terms does. Hyper cellular bone marrow with decreased trilineage hematopeisis mean?

Hematologist: A hematologist is needed in this situation as your bone marrow is overactive but the three types of cells that should be manufactured, red cells, white cells and platelets, are not being made. ...Read more

18

18
Definition of marrow lymphoplasmacytosis please?

Definition of marrow lymphoplasmacytosis please?

Excess plasma cells: Normally in the bone marrow we have a percentage of plasma cells, scattered or in small clumps. But sometimes it may be a big collection of cells. Still it may not be bad as long as u have don't coexisting conditions - multiple myeloma, monoclonal gammopathy of unknown significanace-MUGAS we call-blood related conditions. Have your serum/urine protein studies done by PCP. Chronic infections-can + ...Read more

19

19
What is hypertrophic marrow

What is hypertrophic marrow

Increased marrow: Hypertrophy refers to an increase in mass of an organ. An overworked muscle that enlarges is hypertrophied. For bone marrow, it means there is an increased quantity of blood making cells in the marrow. It does not tell you if those cells are normal blood making cells or a sign of disease. Persistent blood loss, for example, could cause an increase (hypertrophy) in erythroid precursors. ...Read more

21

21
What does diffusely low T1 marrow signal mean?

What does diffusely low T1 marrow signal mean?

Depends: This finding can be a sign of anemia or a much more significant problem with the bone marrow. Feel free to set up a virtual consult and I'd be happy to review your specific MRI imaging and discuss the differential and recommended next steps. ...Read more

22

22
Can a person get atheritis in you spine marrow?

Can a person get atheritis in you spine marrow?

Modic Changes: I believe what you are referring to are modic changes in the bones of the spine. These changes can in some cases be associated with a constant back pain which some attribute to arthritis. This change is detected on MRI which you may have seen or been told of. ...Read more

23

23
What happens to the marrow in myelodysplastic syndrome?

What happens to the marrow in myelodysplastic syndrome?

See below...: The bone marrow is usually hypercellular (high cellularity) in mds, similar to leukemia. However, unlike leukemia, most of these abnormal cells cannot get out of the marrow into the peripheral blood (ineffective hematopoiesis). Consequently, the peripheral blood cell counts are abnormally low (cytopenia), unlike leukemia where the white blood cell count is usually highly elevated. ...Read more

24

24
What are the marrow features in myelodysplastic syndrome?

Myelodysplasia: The typical bone marrow features seen in myelodysplastic syndrome can include a hypercellular marrow (the marrow is too full of cells although in some cases the bone marrow can be more empty (hypocellular). There is typically disorder growth of cells so that they do not mature normally (dypsoiesis). Also, many times the chromosomes (cytogenetics) of the bone marrow cells will be abnormal. ...Read more

25

25
What is subchondrial marrow oedema of the posteriomedial talar dome?

What is subchondrial marrow oedema of the posteriomedial talar dome?

Injury to the bone: This refers to changes below the surface of the articular. Surface coating of one of the major bones in the ankle. Thelocation of the injury is towards the middle and back side of the ankle. This is uaually the result of some injury, over use, or degenerative changes in the joint. Usually will heal with time and treatment. ...Read more

27

27
Dx'd with sarcoidosis and now also have lesions in the marrow in spine does that also mean also have neuro-sarcoidosis?

Dx'd with sarcoidosis and now also have lesions in the marrow in spine does that also mean also have neuro-sarcoidosis?

Not specifically: So it appears that you have bone lesions, but because it's in the marrow of your spine does not mean the nervous system is involved. ...Read more

28

28
Would the body take blood from the marrow if the hemoglobin dropped dangerously low? 2.7. If so, what are the symptoms?

Would the body take blood from the marrow if the hemoglobin dropped dangerously low? 2.7. If so, what are the symptoms?

Yes: The marrow is where the blood cells are produced and thus the circulation mostly gets the cells from the marrow. I think a hemoglobin of 2.7 is life-threatening and I would be surprised if you are not already very tired, short of breath, or fainting. A transfusion is likely needed but more importantly finding out the cause for the low hgb. ...Read more

29

29
What is bone marrow?

What is bone marrow?

Home of blood cells: The cells in your blood are born and reach maturity in the bone marrow. This is the very protected space in the middle of your large bones like your arms, legs, hips and back. Once the cells are mature, they are released into the blood stream where they travel throughout the body preventing infection (granulocytes, lymphocytes), supply oxygen (red cells) and prevent bleeding (platelets). ...Read more

30

30
How is bone marrow donated?

How is bone marrow donated?

Under gen anesthesia: Donating bone marrow for transplantation entails a procedure called bone marrow harvesting. The donor is placed under general anesthesia and turned over to lie on his/her belly to expose the hip bones on the back. Multiple aspirations of bone marrow are collected (average about 1 liter) at adjacent sites on the hip bone on both sides until a particular number of cells are reached. ...Read more