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Doctor insights on: Hypersecretion Of Epinephrine And Norepinephrine

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Is there a difference between epinephrine and norepinephrine?

Is there a difference between epinephrine and norepinephrine?

Synthesis & Locale: Norepinephrine (ne) and Epinephrine (e) are both sympathomimetic catecholamines that are synthesized in the adrenal medulla and terminals of sympathetic neurons. Along the metabolic pathway, ne is synthesized first -- and when an enzyme adds a methyl group, you have epinephrine. Ne is the main catecholamine in peripheral tissue and sympathetic neurons. E is mostly made in the adrenal medulla. ...Read more

Dr. Milroy Samuel
465 Doctors shared insights

Adrenaline (Definition)

Adrenalin (e) / Epinephrine is the hormone produced by the adrenal medulla that speeds and strengths the heart, dilates the airways, and shifts blood flow to the muscles. Often this is in response ...Read more


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What is the difference between epinephrine and norepinephrine?

What is the difference between epinephrine and norepinephrine?

Both: Are made in the adrenal glands of the body and are released in response to a need for increased energy. The fight or flight phenomenon. The biggest difference is that nor-epi causes more vasoconstriction of blood vessels where epi causes more increase in heart rate and cardiac output through contractility. ...Read more

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What is the difference between norepinephrine and epinephrine?

What is the difference between norepinephrine and epinephrine?

1 extra carbon atom: Epinephrine has 1 more carbon & 2 more hydrogen atoms then norepinephrine. This small difference makes the molecules look different, so they interact differently with receptors, and have different effects. One example: norEpinephrine narrows blood vessels, increasing blood pressure; Epinephrine can narrow some arteries while dilating others, and can raise or lower blood pressure. ...Read more

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What happens if I had infinite energy. Could it be a problem with norepinephrine and epinephrine?

What happens if I had infinite energy. Could it be a problem with norepinephrine and epinephrine?

May be thyroid: If you are not takin stimulants like caffeine or energy drinks and have a yearly physical with normal blood work then be thankful. It could be hyper active thyroid but you would also have weight loss with anxiety and difficulty sleep along with other symptom. If not seeing a physician for more than a year it may be time ...Read more

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My 11 year old son has highly elevated levels of norepinephrine and epinephrine. How can we help him?

My 11 year old son has highly elevated levels of norepinephrine and epinephrine. How can we help him?

Elevated epi and nor: You did mention any symptoms yet. There is a condition called pheochromocytoma (tumor of the adrenal gland) which he may have. Speak to his doc and since you 're in North Carolina now the place for him to be seen is Mr Duke's Place (Duke Children's Hospital). Go!! ...Read more

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946 norepinephrine, below 10 epinephrine, 27 metanephrine should I be concerned of these results.

Assuming: This results are serum levels. Norepinephrine level in pg/ml of 946 are high for an adult patient. Epi level appear normal. Serum levels without any more info like 24 hrs urine collection and ct results plus symptoms do not mean a lot. Patient should calm and supine for 30 minutes before collection. Assuming they are working out you for pheocromocytoma. Talk to your doctor with results. ...Read more

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Sine seratonin depletes other nerotransmitters like dopamine, norepinephrine, and epinephrine...By "deplete" does it mean a permanent thing?

Sine seratonin depletes other nerotransmitters like dopamine, norepinephrine, and epinephrine...By "deplete" does it mean a permanent thing?

Not correct: Serotonin does not deplete other neurotransmitters, but there is a balance especially between Dopamine and serotonin. This balance is dynamic and constantly re-establishing itself. Unless there is damage to neurons (which there can be when abusing certain drugs) neurotransmitter changes would not be permanent. ...Read more

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I read that a certain amount of cortisol has to be in the adrenal cortex for norepinephrine to be converted to epinephrine. Can anything substitute?

I read that a certain amount of cortisol has to be in the adrenal cortex for norepinephrine to be converted to epinephrine. Can anything substitute?

Catecholamines: E and NE are made in the adrenal medulla. In Addison's, where there is no cortisol circulating, there is higher NE and lower E, presumably due to cortisol effects on the adrenal medulla production of catecholamines. If you have adrenal insufficiency and are taking your hydrocortisone, this should not be an issue. ...Read more

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Blood work showed supine norepinephrine 183pg/ml, epinephrine 11, dopac 1204, dopa 2339; standing norep 639, epi 121, dopac 1099, dopa 1992, normal?

Catecholamine levels: Not sure why you have done these levels, please provide the context, if elevated they suggest an hyper catecholamine state, adrenal tumor etc. ...Read more

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Does low blood pressure cause norepinephrine and epinephrine to be created to raise blood pressure, or am I way off?

Does low blood pressure cause norepinephrine and epinephrine to be created to raise blood pressure, or am I way off?

You're right: Hi. Blood pressure sensors in parts of the aorta and carotid arteries sense low BP and reflexly activate the sympathetic nervous system to help maintain/restore BP, part of which involves adrenomedullary catecholamine secretion. ...Read more

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What are norepinephrine and epinephrine's effects on heart rate, blood pressure, vasoconstriction, sensitivity to pain, and heat production.

What are norepinephrine and epinephrine's effects on heart rate, blood pressure, vasoconstriction, sensitivity to pain, and heat production.

EPI: It increases heart rate and blood pressure (sometimes dangerously). It causes vasoconstriction. Variable effect on pain but generally increases sensitivity and because it ramps up your metabolism it increases heat production. Follow your docs instructions very carefully and don't freelance. ...Read more

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What is norepinephrine? Another type of adrenaline?

Yes: Norepinephrine is epinephrine (adrenalin) minus one small chemical "side group". They are very similar, but do to the molecular difference, even though they do many of the same things, there are subtle differences in function, especially in regards to neurotransmission. ...Read more

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Since metropolol-beta blocker, blocks adrenaline/norephinephrine would it be ok to still use cymbalta (duloxetine) which increases norephinephrine?

Variables: Metoprolol is only 1 of many different beta blockers with differing side effects and potencies both inside ; outside the brain. The blockade is not complete. If done carefully they can be used together but there must be a careful titration to avoid both lack of benefit and production of side effects. ...Read more

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In general, what does epinephrine do, i.e. how does it work to remedy anaphylactic reaction? Thank you.

In many: Ways it helps- acts on a number of receptors causes constriction, or tightening, of the blood vessels, which decreases swelling and also helps to increase blood pressure, increases the heart’s contraction and heart rate, which can help to prevent or reverse cardiovascular collapse. Epinephrine relaxes the muscles around the airways in the lun ...Read more

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Who should not use Epinephrine injections?

Epinephrine injectio: Lidocaine and Epinephrine are often injected together. "Lidocaine is contraindicated in patients with a known history of hypersensitivity to local anesthetics of the amide type." See: http://www. Drugs. Com/pro/lidocaine-and-epinephrine-injection. Html ...Read more

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How do you properly dispose of expired epinephrine shots?

Return to pharmacy: Your pharmacist will likely dispose of them for you. Another option is to ask your blood drawing station. They dispose of needles regularly. ...Read more

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Can a person be allergic to epinephrine?

Unusual: But can rarely occur. Usually the allergy is to a compound in the medication. ...Read more

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What happens after using an epipen (epinephrine)?

What happens after using an epipen (epinephrine)?

Epipen (epinephrine): The Epipen (epinephrine) is used for serious life threatening allergic reactions. In a person afficted with one of those, it will save thier life. No harm.
In a person not afflicted with a life threatening allergic event, it will increase the bp, anxiety, pulse, sweatiness but otherwise should be uneventful unless there is a history of coronary heart disease. ...Read more

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What do you do if you are allergic to epinephrine?

Unlikely: It is unlikely for anyone to be allergic to Epinephrine as it is present in all of us. Commonly, people develop a rapid heart beat, and tremors following an epinpehrine injection and can have a headache from it too, but the side effects are short lived and do not last more than 30 minutes. ...Read more

Dr. Ravi Chand
758 Doctors shared insights

Norepinephrine (Definition)

Norepinephrine is an inotrope which is a kind of heart ...Read more


Dr. Ravi Chand
78 Doctors shared insights

Levophed (Definition)

Levophed is an inotrope which is a kind of heart ...Read more