Doctor insights on:
Hydroxyurea is a cancer agent.
Hydroxyurea is a cancer agent.
HU in sickle cell: Certain patients with sickle cell can be helped by Hydroxyurea (hu). Initially, Hydroxyurea was thought to increase fetal hemoglobin levels (not carrying the sickle cell mutation), but more recently, hu has been shown to decrease high white blood cell counts which can lead to vaso-occlusive crises. Talk with your hematologist to see if hu is right for you. ...Read more
Before 2 yrs old is Hydroxyurea safe for a e beta thallassemia child? She needs transfusion after every 45 days. Pls advice...
Side Effects: There are some serious, but rare, side effects with hydroxyurea, including secondary leukemia, pulmonary fibrosis, pancreatitis, and peripheral neuropathy, or damage to the nerves. Discuss the benefits of decreasing the severity and length of the sickle cell attacks, and the risk of rare side effects as above. ...Read more
Risks vs. Benefits: Hydroxyurea is used to treat sickle cell anemia and some leukemias (blood cancers). As will most medications, there is no official time limit. A medicine that is helpful, is doing a good job, has no equal alternative, and thus is needed, can be used until it is no longer needed. The doctor can explain the risks of "not treating" and of drug side effects, versus the benefits of using hydroxyurea. ...Read more
Depends on situation: What is the reason Hydroxyurea is being given? One use of Hydroxyurea is to treat resistant chronic myelocytic leukemia (cml, a cancer of white blood cells). Cancers increase risk of blood clots (dvt), which can be treated w enoxaparin (clexane) in such a case, both would be given. If in hospital, meds like enoxaparin can be used to prevent dvt. Other scenarios exist in which both could be used. ...Read more
Antimetabolite: Mylocel, or hydroxyurea, is a form of chemotherapy that works to lower blood counts particularly in patients with leukemia such as chronic myelogenous leukemia and myeloproliferative disorders including polycythemia rubra vera and essential thrombocytosis. Short term side effects may include nausea, hair loss, diarrhea, poor appetite, and nail thickening. Long term effects may include infertility. ...Read more
1 month old: Homozygous hemoglobin E disease (genetic; inherited from both parents) gives mild beta thalassemia & anemia & mildly enlarged spleen; probably doesn't need treatment. Hgb E beta thalassemia disease (E from 1 parent, beta thal from the other): severe incurable disease. Hydroxyurea safe in infants. My guess: start early as possible after 1 mo old. Do discuss this with your pediatric hematologist. ...Read more
"Hydroxyurea may affect fertility (ability to have children), whether a man or a woman."Please advice..
It is a chemotherapy drug (a mild one, that doesn't have severe side effects, once it has been checked, worries about it lowering blood counts too much are not much).
It does lower sperm quality and that effect can last after it is stopped.
http://www. Ncbi. Nlm. Nih. Gov/pubmed/17316339 ...Read more
ET: When deciding whether to recommend hydrea, (hydroxyurea) the md takes into account patient's age, underlying cardiovascular risk factors, ; prior history of blood clots. The number of platelets is irrelevant if a patient is otherwise healthy. I have plenty of patients with platelet counts around 1 million. Look for an article from blood journal called "how I treat essential thrombocythemia" for a good summary. ...Read more
Is there any chances of getting cancer if the normal person takes hydroxyurea or anagrelide more than a month?
I say no: The talk of an increased leukemia risk has been with us since the 1970s without anybody being able to measure it. If it's real, it's tiny. Anagrelide isn't under suspicion. If some overzealous practitioner went after a high platelet count without good reason, I'm sorry but you'll be fine. Why do you ask? ...Read more
If a PLT is normal but starts to fall (even getting down to 8) & this is suspected to be a drug effect (Hydroxyurea) & the drug is ceased & the low PLT resolves itself within 7 days then would an undetected infection stop the PLT from normalising?
May I assume that: You're referring to your platelets and that they got down to 80, 000? If not, you can ignore this response! Hydroxyuria can interfere with the production of platelets and discontinuing it may allow the platelet count to return to normal. An "undetected infection" shouldn't, by itself, prevent the platelets from normalizing, especially if they've already done so. Dr. Anne ...Read more
Well tolerated drug.: Hydrea (hydroxyurea) is a chemotherapy like drug that can help prevent painful crises in patients with sickle cell disease. It is well tolerated for the most part. There can be fatigue, mouth sores and loose stools. It will routinely lower the white blood cell count and platelets, but not to dangerous levels. Hemoglobin may actually improve. There is? Of leukemia risk in other diseases, but not in scd. ...Read more
Controversial: There is a risk of transformation to acute leukemia just from having P Vera. But it is very low. Whether hydroxyurea increases that risk has not be definitively answered. Most hematologists find the benefit of controlling the disease greatly outweighs the risk. There is a new drug - Jakafi (ruxolitinib) - just approved for PV if not well controlled or if side effects of HU too great. Talk to your hematologist. ...Read more
Yes: In the treatment of sickle-cell disease, hydroxycarbamide increases the concentration of fetal hemoglobin. The precise mechanism of action is not yet clearbut it seems to activate of gammaglobin synthesis necessary for fetal hemoglobin. This stops the rapidly growing cells that turn into sickle cells. ...Read more
Hydroxyurea: Hydroxyurea is a chemotherapy drug and should not be used in healthy people. It will cause suppression of the bone marrow that can lead to low white blood cells, anemia (low red blood cells) and also low platelets. It is a potentially dangerous medication that should only be used as prescribed by a physician. ...Read more
No: Truly homeopathic "medications" are made by repeated dilutions, so that the ingredient is not really in the medication anymore (just the "essence" of it remains). That means there is no active ingredient left to cause any benefit. However, that also implies that the homeopathic "medicine" should be pretty harmless, unless some other non-homeopathic ingredients were added. ...Read more
Cure?: There are many treatnents used to treat cll. However the only therapy that may be curative is a stem cell or bone marrow transplant from a donor. ...Read more
Possibly: The agent is considered mutagenic and although the risk is low, it is a real one. ...Read more