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Doctor insights on: Hyaluronidase

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Hyaluronidase (Overview)

Hyaluronidase is an enzyme that degrades hyaluronic acid. Hyaluronic acid is a mucopolysacharide that is part of the ground substance of the dermis so the enzyme hyaluronidase is part of the bodies homeostatic mechanism. Cosmetically hyaluronic acid is injected into people to improve wrinkles. If too much is injected it can be removed by injecting hyaluronidase.


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I went to a cosmetic surgeon for hyaluronidase injections for lumpy juvederm. He also prescribed two weeks of biaxin (clarithromycin). Have you heard of this?

I went to a cosmetic surgeon for hyaluronidase injections for lumpy juvederm. He also prescribed two weeks of biaxin (clarithromycin). Have you heard of this?

Infection Possible: Your doctor may be concerned that a low grade infection is causing the lumpiness.
So that is why the antibiotic was prescribed.
Rare infections can occur after hyaluronic acid injections. So keep in contact with your doctor. ...Read more

Hyaluronidase (Overview)

Hyaluronidase is an enzyme that degrades hyaluronic acid. Hyaluronic acid is a mucopolysacharide that is part of the ground substance of the dermis so the enzyme hyaluronidase is part of the bodies homeostatic mechanism. Cosmetically hyaluronic acid is injected into people to improve wrinkles. If too much is injected it can be removed by injecting hyaluronidase.


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Is injection the only way to use hyaluronidase? I prefer not to receive injections near my eyes and was hoping that there was a type of hyaluronidase that did not require an injection. Is there a cream or gel that I could use instead? .

Is injection the only way to use hyaluronidase? I prefer not to receive injections near my eyes and was hoping that there was a type of hyaluronidase that did not require an injection. Is there a cream or gel that I could use instead? .

You: You are speaking of injecting hyaluronic acid fillers to plump up the skin and nothing topcical will penetrate the skin, if it was apply to penetrate, then the hyaluronic acid that normally occurs in your skin would be able to leak out and it does not do that. Hyaluronidase is an injection used to dissolve areas of over injected hyaluronic acid fillers. ...Read more

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How long should I wait between hyaluronidase injections? I had some work done under my eyes and do not like the results. I have had one hyaluronidase injection but am not satisfied yet with how I look. How long do I need to wait between injections?

How long should I wait between hyaluronidase injections? I had some work done under my eyes and do not like the results. I have had one hyaluronidase injection but am not satisfied yet with how I look. How long do I need to wait between injections?

Hyaluronidase: The timing and location of hyaluronidase-based product injections should be individualized. It is best make sure that the product is well tolerated and that the patient is satisfied with the improvement the filler provides before proceeding with subsequent injections. An experienced surgeon should be able to advise on the appropriate timing of follow-up injections. ...Read more

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Alternative to hyaluronidase? I'm allergic. Too much lip filler lumpy and on predisolone and e-mycin! Very hard bumpy itchy uneven : (very distressed!

Alternative to hyaluronidase? I'm allergic. Too much lip filler lumpy and on predisolone and e-mycin! Very hard bumpy itchy uneven : (very distressed!

Time: Sorry that you had a bad experience; choose your cosmetic artist well. Fortunately, hla facial fillers have a temporary effect. Hyaluronidase injected at the site can reverse the filler effects quickly. As you have allergy to hyaluronidase, time and local massage are your limited options. Use KY jelly and fingers to massage the lips with moderate pressure no more than 3 times per day with cooling. ...Read more

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What is the definition or description of: hyaluronidase?

Hyaluronidase: Hyaluronidase is an enzyme that degrades hyaluronic acid. Hyaluronic acid is a mucopolysacharide that is part of the ground substance of the dermis so the enzyme hyaluronidase is part of the bodies homeostatic mechanism. Cosmetically hyaluronic acid is injected into people to improve wrinkles. If too much is injected it can be removed by injecting hyaluronidase. ...Read more

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I was given hyaluronidase injections for lumpy juvederm. The areas are still hard and lumpy but have gone down a little. Do I need more?

I was given hyaluronidase injections for lumpy juvederm. The areas are still hard and lumpy but have gone down a little. Do I need more?

I would wait: Without seeing or feeling it, I cannot confidently say you would need more or not. After filler injections (juvederm, restylane, (dermal fillers) or perlane), feeling some lumpiness is common, but it should not be visible. If it is not visible, leave it alone. If it is visible, massaging it gently 30 sec twice daily helps to soften it. Also, fillers are also firm for 1-2 weeks after injecting, then they soften. ...Read more

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What is the function of hyaluronidase in sperm?

What is the function of hyaluronidase in sperm?

Fertilization: Most evidence points to HUA activity allowing sperm to penetrate egg. Probably is far more complicated than this simple answer. Look up on Google etc. ...Read more

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Will hyaluronidase also dissolve my body's natural hyaluronic acid? If no, has there been extensive research to verify, including the lower lid area?

Will hyaluronidase also dissolve my body's natural hyaluronic acid? If no, has there been extensive research to verify, including the lower lid area?

Should not: Usually would undo injected medication. Use under the eye works but must be done very carefully be experienced doctor to avoid injection into vessels. ...Read more

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Will hyaluronidase injections dissolve scar tissue?

Will hyaluronidase injections dissolve scar tissue?

Hyaluronidase won't: Hyaluronidase won't help scars. It helps dissolve hyaluronic acid which is present between collagen fibers but scars are made up of dense collagen bundles which are not affected by hyaluronidase. ...Read more

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Does hyaluronidase cause any swelling or redness at the injection site?

Does hyaluronidase cause any swelling or redness at the injection site?

Possibly: Any injection can cause swelling and redness, as there is a puncture to the skin and can cause inflammation or infection. ...Read more

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How long to wait before deciding on hyaluronidase after juvederm tear throughs. It is very blueish, swollen like pillows, lumpy and bumpy.

Wait a Week or Two: Pressure and time can help the swelling and discoloration. Firm massage will help also.
But, if it doesn't improve in two weeks, then consider small doses of hyaluronidase. ...Read more

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How long should I wait between hyaluronidase injections? I had some work done under my eyes and do not like the results. I have had one hyaluronidase injection but am not satisfied yet with how I look. How long do I need to wait between injections?

Hyaluronidase: The timing and location of hyaluronidase-based product injections should be individualized. It is best make sure that the product is well tolerated and that the patient is satisfied with the improvement the filler provides before proceeding with subsequent injections. An experienced surgeon should be able to advise on the appropriate timing of follow-up injections. ...Read more

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Can hyaluronidase injections dissolve scar tissue such as keloids?

Hyaluronidase won't: Hyaluronidase won't help scars. It helps dissolve hyaluronic acid which is present between collagen fibers but scars are made up of dense collagen bundles which are not affected by hyaluronidase. ...Read more

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Is injection the only way to use hyaluronidase? I prefer not to receive injections near my eyes and was hoping that there was a type of hyaluronidase that did not require an injection. Is there a cream or gel that I could use instead?

Is injection the only way to use hyaluronidase? I prefer not to receive injections near my eyes and was hoping that there was a type of hyaluronidase that did not require an injection. Is there a cream or gel that I could use instead?

Hyaluronidase: Hyaluronidase is an enzyme that degrades hyaluronic acid (hyaluronan), a naturally occuring component of the extracellular matrix - the scaffolding that surrounds all our cells. It is also the major part of many injectable fillers such as juvederm and restylane (dermal fillers).

I know of no effective topical hyaluronidase products. Injectable hyaluronidase has been used quite safely for years around the eyes by ophthalmologists. It is no more risky than injecting Botox around the eyes...A technique that is done daily thousands of times. ...Read more

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Is injection the only way to use hyaluronidase? I prefer not to receive injections near my eyes and was hoping that there was a type of hyaluronidase that did not require an injection. Is there a cream or gel that I could use instead? .

You: You are speaking of injecting hyaluronic acid fillers to plump up the skin and nothing topcical will penetrate the skin, if it was apply to penetrate, then the hyaluronic acid that normally occurs in your skin would be able to leak out and it does not do that. Hyaluronidase is an injection used to dissolve areas of over injected hyaluronic acid fillers. ...Read more

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I went to a cosmetic surgeon for hyaluronidase injections for lumpy juvederm. He also prescribed two weeks of biaxin (clarithromycin). Have you heard of this?

Infection Possible: Your doctor may be concerned that a low grade infection is causing the lumpiness.
So that is why the antibiotic was prescribed.
Rare infections can occur after hyaluronic acid injections. So keep in contact with your doctor. ...Read more

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Does hyaluronidase cause any swelling or redness at the injection site? When I receive a hyaluronidase injection, will it leave any visible marks? I will be having an injection under my eyes and am worried that it will be noticeable. If it does leave a ma

Amphadase: Amphadase (hyaluronidase inj) is a preparation of purified bovine testicular hyaluronidase, a protein enzyme. Each vial contains 150 USP units of hyaluronidase per ml with 8.5 mg sodium chloride, 1 mg Edetate disodium, 0.4 mg calcium chloride, monobasic sodium phosphate buffer, and not more than 0.1 mg thimerosal (mercury derivative). It is possible to have an allergic reaction to any or all of these ingredients. If you have had a reaction in the past or suspect that you may be allergic to the contents then you should identify these concerns to your practitioner. Barring allergic reactions there is usually a small amount of redness at the site of injection and this usually goes away in 1-3 hours.
-bwc. ...Read more

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