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Doctor insights on: Huvec Angiogenesis

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What is an example of defect in angiogenesis?

What is an example of defect in angiogenesis?

Cancer: Abnormal blood vessels both structurally and functional. Cancer is a classic example of both. Just look closely at the circulation inside a big cancer and you will see the defective angiogenesis. ...Read more

Angiogenesis (Definition)

Angiogenesis is the physiological process through which new blood vessels form from pre-existing vessels. This is distinct from vasculogenesis, which is the de novo formation of endothelial cells from mesoderm cell precursors. The first vessels in the embryo form through vasculogenesis, after which angiogenesis is responsible for most, if not all, blood ...Read more


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What is the definition or description of: angiogenesis?

What is the definition or description of: angiogenesis?

See below: Angiogenesis is the physiological process through which new blood vessels form from pre-existing vessels. This is distinct from vasculogenesis, which is the de novo formation of endothelial cells from mesoderm cell precursors. The first vessels in the embryo form through vasculogenesis, after which angiogenesis is responsible for most, if not all, blood vessel growth during development. ...Read more

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What nutrients stimulate angiogenesis?

What nutrients stimulate angiogenesis?

InternalBodyControls: If food made us what we are, they we would likely look like what we eat; reality far more complex. The bodies we inhabit: chemical wizards taking apart molecules & reassembling them like fantastic complex tinker toys under internal controls, called biochemistry. Current knowledge: ischemia, ?pressure diff. & flow may trigger complex responses ?angiogenesis & ?inhibitory controls: balance critical. ...Read more

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Angiogenesis goes along with carcinogenesis, right?

Angiogenesis goes along with carcinogenesis, right?

No, But Necessary: Angio= blood, genesis=origin, creation, beginning, carcino=cancer. Thus both terms refer to origin/beginning, but about very different issues, formation of blood/blood vessels vs. Cancers. The one indirect connection, as mentioned by the other physician, is that no cells, including cancer cells, can survive without nearly by blood flow, thus rapid growing cancers must stimulate blood vessels. ...Read more

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Neovascularization and angiogenesis, any difference?

Neovascularization and angiogenesis, any difference?

About same: Both imply new blood vessel formation. Sometimes it is due to benign causes , then it is called neovascularization. When it is due to cancer, it is often called angiogenesis. ...Read more

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Can someone give me a brief definition of anti - angiogenesis drugs?

Can someone give me a brief definition of anti - angiogenesis drugs?

Prevention of...: Angiogenesis is the growth of new blood vessels. An antiangeogenesis drugs will reduce the ability to form new blood vessels. They have been used to "starve tumors" to slow the growth. ...Read more

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Can you tell me about angiogenesis contributes to carcinogenesis because?

Can you tell me about angiogenesis contributes to carcinogenesis because?

Little: Angiogenesis does not help tumor growth which is involved with anaerobic metabolism. The blood vessels that enter the tumor help with metastasis. To help attack tumor hyperbaric oxygen chambers can improve all forms of cancer therapy. ...Read more

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Just how is angiogenesis related to cancer?

Just how is angiogenesis related to cancer?

It helps tumors grow: Angiogenesis is the process whereby blood vessels develop. This occurs in normal tissue, but also in tumors. Certain drugs, like Avastin (bevacizumab) which is used in combination with chemotherapy for colorectal cancer, target angiogenesis in tumors. ...Read more

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When a drug inhibits angiogenesis in cancer, does it also inhibit angiogenesis throughout the body?

When a drug inhibits angiogenesis in cancer, does it also inhibit angiogenesis throughout the body?

Yes: cancer drugs inevitably are toxic, and need to be in order to get rid of cancer cells, however they can not distinguish good from bad cells hence the bad side affects. ...Read more

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In what way angiogenesis related to cancer & mitosis?

In what way angiogenesis related to cancer & mitosis?

Not really: When Folkman discovered angiostatin as a way of controlling animal tumors it was tried as a way of controlling cancer in patients. It failed. While blood vessels at the surface of the tumor are necessary for metastasis, most if not all tumors function by anaerobic metabolism and don't need blood. To help destroy tumor treat them in a hyperbaric chamber. ...Read more

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How would angiogenesis influence tumor growth and metastasis?

How would angiogenesis influence tumor growth and metastasis?

Fundamental!: All living things need a blood supply to deliver food, water, and get rid of waste. A circulating cancer cell needs to evade detection, get out of the blood vessel, and establish that blood supply: angiogenesis!. All these actors under molecular control, and likely normal during in utero development. Cut off the blood supply, choke the tumor. ...Read more

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Resuming exercise program: does muscle growth trigger angiogenesis?

Resuming exercise program: does muscle growth trigger angiogenesis?

It's complicated : Exercise can improve vascularity but it does not create the growth of new blood vessels. Angiogenesis is triggered by injury and cancer as well as during pregnancy. ...Read more

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Please explain why would a cancer cell need to induce angiogenesis?

Please explain why would a cancer cell need to induce angiogenesis?

Supply line: Living tissues need blood supply to deliver nutrients and oxygen and to get rid of cellular waste. This is especially true in fast growing malignant cells. It's a bit more complex than that but i don't have much space. Blocking angiogenesis is one of the current therapies used for many cancers. ...Read more

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Why is it that cancer cells stimulate angiogenesis even if they are known to constitutively perform glycolysis?

Why is it that cancer cells stimulate angiogenesis even if they are known to constitutively perform glycolysis?

Wow...molecular: Listen, i'm just a practicing oncologist but i'll give it a crack. If i remember well, glycolysis is a fairly ineffective way to produce atp compared to cellular respiration so my guess would be that malignant cell will still try to go the route that provides the best production of energy. This requires oxygen and by necessity requires blood flow, achieved by neovascularization thru angiogenesis. ...Read more

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Is anti-angiogenesis (angiogenesis inhibitor) part of treatment for cancer or not? If not why?

For certain cancers: Anti-angiogenic therapies are used in certain malignancies. Whether or not these agents are used in the treatment of a given cancer is based on preclinical and clinical data. Some solid tumors seem to respond, while others devise a way to to become quickly resistant. There are many drugs of this class that target different pathways, and many clinical trials are currently being performed. ...Read more

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Can you tell me about angiogenesis promoting both the growth of cancers and the metastasis of cancer cells to other sites in the body?

Can you tell me about angiogenesis promoting both the growth of cancers and the metastasis of cancer cells to other sites in the body?

Poor response: Tumors grow in general in an anaerobic media and require hyperbaric oxygen to destroy. Folkman developed drug angiostatin which failed to prevent cancer spread. Avastin (bevacizumab) which is an anti vegf drug doesn't destroy blood supply. It appears to help by opening microvasculature to tumors to let chemo enter more effectively. Blood vessels in tumors are the conduit for vessel invasion by tumor cells. ...Read more

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Developed anca positive vasculitis with antihistone ab 1.4 after 2 months on losartan 50. disc reversedanemia. is angiogenesis critical 4 vasculitis?

Developed anca positive vasculitis with antihistone ab 1.4 after 2 months on losartan 50.  disc reversedanemia. is angiogenesis critical 4 vasculitis?

This is more than o: Thisis more than one answer. The histone ab is seen in lupus and drug induced lupus. ANCA positivity can mean a variety of issue related to vasculitis but other conditions also, Uncertin about you commetn on anemia. Angigenesis is usually part of a variety of conditions including vasculitis but is seen in non-vaculitis syndromes also. Would advise you disucss this with your rheumatologis ...Read more

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I read that only having moons on thumbs bottom of nail is an increased risk of cancer cause of angiogenesis is this true? Im worried now

I read that only having moons on thumbs bottom of nail is an increased risk of cancer cause of angiogenesis is this true? Im worried now

No: Once again, this is simply made up. "Angiogenesis"? That means "making blood vessels", and the white lunules aren't even especially vascular. Someone's got an overly active imagination or is messing with you. I'm sorry there's stuff like this online. Phone the folks at the anatomy department of your local medical school, or compare with your friends. ...Read more

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Developed anca positive vasculitis with antihistone ab 1.4 and ESR 80. Can Losartan inhibit angiogenesis and make vasculitis or inflammation worse?

Developed anca positive vasculitis with antihistone ab 1.4 and ESR 80.  Can Losartan inhibit angiogenesis and make vasculitis or inflammation worse?

Rheumatology: Studies show that losartan can be associated with a drug induced ANCA positive Henoch-Schonlein purpura which is a form of vasculitis. Antinuclear antibody test looking to rule out not rule in drug induced systemic lupus erethematosus may have been performed. If you had another ANCA associated vasculitis and you are on losartan rheumatologist will instruct you if you should be taking it, call them ...Read more

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