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Doctor insights on: Huvec Angiogenesis

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Can gleevec (imatinib) cure retinoblastoma?

Can gleevec (imatinib) cure retinoblastoma?

No data yet...: Gleevec (imatinib) inhibits a number of tyrosine kinases in cells (c-kit, pdgfralpha, c-abl) . There is very recent data that Gleevec (imatinib) may have activity in retinoblastoma, but these experiments where done on isolated retinoblastoma cells grown in culture. There are no clinical trials showing that Gleevec (imatinib) can treat retinoblastoma. Future clinical trials may be planned to address this question. ...Read more

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Angiogenesis (Definition)

Angiogenesis is the physiological process through which new blood vessels form from pre-existing vessels. This is distinct from vasculogenesis, which is the de novo formation of endothelial cells from mesoderm cell precursors. The first vessels in the embryo form through vasculogenesis, after which angiogenesis is responsible for most, if not all, blood ...Read more


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Which is more effective: Avastin (bevacizumab) or Erbitux?

Which is more effective: Avastin (bevacizumab)  or Erbitux?

Identical: Data on Bevacizumab or Erbitux in patients with metastatic colorectal cancer, patients who do not have a KRAS 12/13 gene mutation, have nearly identical survival rates. These identical results were seen after chemotherapy, where survival with chemo alone was about 5 months vs. 7-8 months using either bevacizumab (Avastin) or cetuximab (Erbitux). ...Read more

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What are the benefits of azd 6244 mek inhibitor & mk 2206 akt inhib. For adenocarcinoma. 70yrs..115lbs (lost 40)..8mth chemo..Radio..Gamma-11mth diag?

What are the benefits of azd 6244 mek inhibitor & mk 2206 akt inhib. For adenocarcinoma. 70yrs..115lbs (lost 40)..8mth chemo..Radio..Gamma-11mth
diag?

These are brand new: The drugs that you have mentioned are new anticancer drugs which are still experimental, not fda approved for general use. Your doctor(oncologist) has to answer all your questions that you ask before signing up for receiving these drugs. There is not a lot known about them yet. But azd6244 has been tested and found to have some anticancer activity. But more can be found out from your oncologist. ...Read more

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What is line probe id molecular non tuberculous mycobacteria (ntm) test mean?

What is line probe id molecular non tuberculous mycobacteria (ntm) test mean?

Why are you asking?: It is testing for mycobacteria that are not tuberculosis. There are many of them. Some need treatment and some do not need treatment. ...Read more

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When a drug inhibits angiogenesis in cancer, does it also inhibit angiogenesis throughout the body?

When a drug inhibits angiogenesis in cancer, does it also inhibit angiogenesis throughout the body?

Yes: cancer drugs inevitably are toxic, and need to be in order to get rid of cancer cells, however they can not distinguish good from bad cells hence the bad side affects. ...Read more

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Azd 6244- mek inhibitor- a selective mitogen-activated protein kinase (mek) inhibitor. Mk 2206- akt inhibitor. Why prescription for me? It ? Nsclc/mets

Azd 6244- mek inhibitor- a selective mitogen-activated protein kinase (mek) inhibitor.    Mk 2206-  akt inhibitor.  Why  prescription for me? It ? Nsclc/mets

Molecular targeting: These agents are designed to selectively knock out key pathways your tumor may use to grow. Presumably you already had your tumor tested for these different mutations. Ask the doctor offering these options to explain their rationale. These are investigational studies and many of the treatment costs may be covered-ask. ...Read more

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What drug inhibits estrogen-mediated tumor growth?

What drug inhibits estrogen-mediated tumor growth?

2 means: Hi. Estrogen receptor antagonists, like tamoxifen or raloxifine, or aromatase inhibitors, which prevent the endogenous synthesis of estrogen, are the two major categories. The main estrogen-driven tumors are ER + beast CA and endometrial CA. Good luck, and beat the CA! ...Read more

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What drug inhibits estrogen-mediated tumor growth?

What drug inhibits estrogen-mediated tumor growth?

Tamoxifen: Tamoxifen has been the standard drug that blocks estrogen receptors in patients whose tumors are considered ER+ A new type of anti-estrogen drug appears to work better than the estrogen-blocking drug tamoxifen . Exemestane (Aromasin), belongs to a class of drugs called aromatase inhibitors. But, for exemestane to work in premenopausal women, the drug can only be given when ovarian function is being suppressed.The Aromatase inhibitors, work by preventing other hormones from changing into estrogen, which fuels certain cancer growths ...Read more

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Will telomerase activators prevent or treat Alzheimer's? Telocyte.com says this treatment will prevent microglial aging/degeneration.

Will telomerase activators prevent or treat Alzheimer's? Telocyte.com says this treatment will prevent microglial aging/degeneration.

Definitely maybe!: This is an exciting and cutting-edge are of research. It seems likely that telomerase activators can help prevent and treat Alzheimer's and other neurodegenerative diseases as well as aging in general, but it is difficult to know how long before effective treatments are available and they will need to be evaluated for toxicity, side effects etc. But one can hope this will a true miracle! ...Read more

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Does avastin (bevacizumab) reduce male fertility?

Does avastin (bevacizumab) reduce male fertility?

No (so far): Avastin (bevacizumab) is a monoclonal antibody that inhibits blood vessel growth. It can impair fertility in women, but i don't find any studies that show reduction in male fertility. For the fda prescribing information with all side effects, go here: http://www.Gene.Com/gene/products/information/pdf/avastin-prescribing.Pdf. ...Read more

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Which ingredient is the best way fight wrinkles? Retinol, peptides, collagen, stem cells, plancenta, amino acids or vitamin C

Which ingredient is the best way fight wrinkles? Retinol, peptides, collagen, stem cells, plancenta, amino acids or vitamin C

Growth factors: We have known since the 70s that retinoids and retinols are great collagen stimulators (which equals wrinkle fighters). In this century, we developed collagen growth factors which are derived from actual human skin and are necessary for collagen to thrive, thus reducing and eliminating wrinkles. Note i did not say "appearance of wrinkles". Skinmedica is my favorite product to contain these. ...Read more

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Bonsoir, je veux savoir combien de pourcentage de goudron y a t il dans les poumons après de dix-ans DES cigarettes ? Merciiiiiiiii

Bonsoir, je veux savoir combien de pourcentage de goudron  y a t il  dans les poumons après de dix-ans DES cigarettes  ?
Merciiiiiiiii

Combien?: Dix ANS ...Mais combien des cigarettes-un paquet par jour? Avec vingt cigarettes par jour tu accumuleras 200 grams de goudron dans les poumons chaque an. ...Read more

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What are n-myc and tumor suppressor genes?

What are n-myc and tumor suppressor genes?

"the brakes": You can think of tumor suppressor genes as "the brakes" in a cell. This means that they stop a cell from dividing "too fast". This is opposed to oncogenes which are "the gas" and act to make cells divide faster. N-myc is a type of oncogene. ...Read more

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Is anti-angiogenesis (angiogenesis inhibitor) part of treatment for cancer or not? If not why?

For certain cancers: Anti-angiogenic therapies are used in certain malignancies. Whether or not these agents are used in the treatment of a given cancer is based on preclinical and clinical data. Some solid tumors seem to respond, while others devise a way to to become quickly resistant. There are many drugs of this class that target different pathways, and many clinical trials are currently being performed. ...Read more

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What nutrients stimulate angiogenesis?

What nutrients stimulate angiogenesis?

InternalBodyControls: If food made us what we are, they we would likely look like what we eat; reality far more complex. The bodies we inhabit: chemical wizards taking apart molecules & reassembling them like fantastic complex tinker toys under internal controls, called biochemistry. Current knowledge: ischemia, ?pressure diff. & flow may trigger complex responses ?angiogenesis & ?inhibitory controls: balance critical. ...Read more

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If avodart & flomax are cy3a4 substrates & sprycel (dasatinib) is an inhibitor, why do interaction checkers show a prob. With sprycel (dasatinib) & avodart but not w/flomax?

If avodart & flomax are cy3a4 substrates & sprycel (dasatinib) is an inhibitor, why do interaction checkers show a prob. With sprycel (dasatinib) & avodart but not w/flomax?

Good Question: Avodart (dutasteride) is extensively metabolized in humans by the cyp3a4 and cyp3a5 isoenzymes. Flomax (tamsulosin) is extensively metabolized, mainly by cyp3a4 and cyp2d6 isoenzymes. Sprycel (dasatinib) is also extensively metabolized by the cyp3a4 isoenzyme but is also a weak time-dependent inhibitor of cyp3a4 and may therefore potentially increase the concentrations of Avodart and flomax. ...Read more

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Is matulane (procarbazine) useful to non-hodgkin's lymphomas?

Is matulane (procarbazine) useful to non-hodgkin's lymphomas?

No: Only indication is for hodkin's disease, and even in that condition, where it is used as part of the "mopp" regimen, it has been replaced by other regimens. It may have slight activity in other lymphomas but there are now many other effective chemotherapeutic and biologic choices. ...Read more