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Angiogenesis is the physiological process through which new blood vessels form from pre-existing vessels. This is distinct from vasculogenesis, which is the de novo formation of endothelial cells from mesoderm cell precursors. The first vessels in the embryo form through vasculogenesis, after which angiogenesis is responsible for most, if not all, blood ...Read more
See below: Angiogenesis is the physiological process through which new blood vessels form from pre-existing vessels. This is distinct from vasculogenesis, which is the de novo formation of endothelial cells from mesoderm cell precursors. The first vessels in the embryo form through vasculogenesis, after which angiogenesis is responsible for most, if not all, blood vessel growth during development. ...Read more
InternalBodyControls: If food made us what we are, they we would likely look like what we eat; reality far more complex. The bodies we inhabit: chemical wizards taking apart molecules & reassembling them like fantastic complex tinker toys under internal controls, called biochemistry. Current knowledge: ischemia, ?pressure diff. & flow may trigger complex responses ?angiogenesis & ?inhibitory controls: balance critical. ...Read more
No, But Necessary: Angio= blood, genesis=origin, creation, beginning, carcino=cancer. Thus both terms refer to origin/beginning, but about very different issues, formation of blood/blood vessels vs. Cancers. The one indirect connection, as mentioned by the other physician, is that no cells, including cancer cells, can survive without nearly by blood flow, thus rapid growing cancers must stimulate blood vessels. ...Read moreSee 1 more doctor answer
Prevention of...: Angiogenesis is the growth of new blood vessels. An antiangeogenesis drugs will reduce the ability to form new blood vessels. They have been used to "starve tumors" to slow the growth. ...Read more
It helps tumors grow: Angiogenesis is the process whereby blood vessels develop. This occurs in normal tissue, but also in tumors. Certain drugs, like Avastin (bevacizumab) which is used in combination with chemotherapy for colorectal cancer, target angiogenesis in tumors. ...Read moreSee 2 more doctor answers
When a drug inhibits angiogenesis in cancer, does it also inhibit angiogenesis throughout the body?
Not really: When Folkman discovered angiostatin as a way of controlling animal tumors it was tried as a way of controlling cancer in patients. It failed. While blood vessels at the surface of the tumor are necessary for metastasis, most if not all tumors function by anaerobic metabolism and don't need blood. To help destroy tumor treat them in a hyperbaric chamber. ...Read more
Fundamental!: All living things need a blood supply to deliver food, water, and get rid of waste. A circulating cancer cell needs to evade detection, get out of the blood vessel, and establish that blood supply: angiogenesis!. All these actors under molecular control, and likely normal during in utero development. Cut off the blood supply, choke the tumor. ...Read more
Supply line: Living tissues need blood supply to deliver nutrients and oxygen and to get rid of cellular waste. This is especially true in fast growing malignant cells. It's a bit more complex than that but i don't have much space. Blocking angiogenesis is one of the current therapies used for many cancers. ...Read more
Why is it that cancer cells stimulate angiogenesis even if they are known to constitutively perform glycolysis?
Wow...molecular: Listen, i'm just a practicing oncologist but i'll give it a crack. If i remember well, glycolysis is a fairly ineffective way to produce atp compared to cellular respiration so my guess would be that malignant cell will still try to go the route that provides the best production of energy. This requires oxygen and by necessity requires blood flow, achieved by neovascularization thru angiogenesis. ...Read more
For certain cancers: Anti-angiogenic therapies are used in certain malignancies. Whether or not these agents are used in the treatment of a given cancer is based on preclinical and clinical data. Some solid tumors seem to respond, while others devise a way to to become quickly resistant. There are many drugs of this class that target different pathways, and many clinical trials are currently being performed. ...Read moreSee 2 more doctor answers
Can you tell me about angiogenesis promoting both the growth of cancers and the metastasis of cancer cells to other sites in the body?
Poor response: Tumors grow in general in an anaerobic media and require hyperbaric oxygen to destroy. Folkman developed drug angiostatin which failed to prevent cancer spread. Avastin (bevacizumab) which is an anti vegf drug doesn't destroy blood supply. It appears to help by opening microvasculature to tumors to let chemo enter more effectively. Blood vessels in tumors are the conduit for vessel invasion by tumor cells. ...Read more
Developed anca positive vasculitis with antihistone ab 1.4 after 2 months on losartan 50. disc reversedanemia. is angiogenesis critical 4 vasculitis?
This is more than o: Thisis more than one answer. The histone ab is seen in lupus and drug induced lupus. ANCA positivity can mean a variety of issue related to vasculitis but other conditions also, Uncertin about you commetn on anemia. Angigenesis is usually part of a variety of conditions including vasculitis but is seen in non-vaculitis syndromes also. Would advise you disucss this with your rheumatologis ...Read more
I read that only having moons on thumbs bottom of nail is an increased risk of cancer cause of angiogenesis is this true? Im worried now
No: Once again, this is simply made up. "Angiogenesis"? That means "making blood vessels", and the white lunules aren't even especially vascular. Someone's got an overly active imagination or is messing with you. I'm sorry there's stuff like this online. Phone the folks at the anatomy department of your local medical school, or compare with your friends. ...Read more
After laying on my face for two days now I have little clot looking rash. Is this a sign of poor circulation or something scary like angiogenesis?
It is not a sign of: either one. It is most likely pressure effect on the microcirculatory areas of the skin. ...Read more
Developed anca positive vasculitis with antihistone ab 1.4 and ESR 80. Can Losartan inhibit angiogenesis and make vasculitis or inflammation worse?
Rheumatology: Studies show that losartan can be associated with a drug induced ANCA positive Henoch-Schonlein purpura which is a form of vasculitis. Antinuclear antibody test looking to rule out not rule in drug induced systemic lupus erethematosus may have been performed. If you had another ANCA associated vasculitis and you are on losartan rheumatologist will instruct you if you should be taking it, call them ...Read moreSee 1 more doctor answer