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Doctor insights on: Huntington's Diseases

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How much earlier than my mom will i get huntington’s disease? I’ve read that symptoms start earlier in each generation because of the way the defective gene repeats. But how much earlier? My mom didn’t have symptoms until she was over 50. I’m only 23, but

How much earlier than my mom will i get huntington’s disease? I’ve read that symptoms start earlier in each generation because of the way the defective gene repeats. But how much earlier? My mom didn’t have symptoms until she was over 50. I’m only 23, but

Huntington's : Huntington's disease is a complicated neurodegenerative disorder that can cause involuntary writhing, dance-like movements of the limbs, other abnormal movements, personality changes and psychiatric symptoms, heart disease and other problems. It is an uncommon condition (about 5-10 cases per 100000 people). Huntington's disease is caused by a mutation in the huntingtin gene. Inside this gene is a stretch of dna that consists of repeating sequences the genetic code letters, or nucelotides, c, a, and g. These three nucleotides can be repeated (cagcagcag...) dozens of times. The number of "trinucleotide repeats" seems to determine if and when the disease will make itself known. People with less than 28 repeats are normal. People with 28 to 35 repeats are "intermediate". People with 35 to 40 repeats may or may not develop huntington's disease. People with more than 40 repeats will usually be affected, and the higher the number of repeats, the earlier the disease starts. Trinucleotide repeat diseases like huntington's disease (there are others), are characterized by a property called "anticipation." anticipation means that children of people with huntington's often develop the disease at an earlier age than their parents did. This was first noticed even before anything was known about trinucleotide repeats. After the repeats were discovered, it was found that children had more repeats than their parents. The number of repeats tends to increase more if the father carried the abnormal gene that if the mother did. It is not possible to pinpoint when exactly someone might develop huntington's disease based on when their affected parent developed the disease. Genetic testing may be helpful to identify the number of trinucleotide repeats that someone carries, but presymptomatic testing is declined by the majority of children of people with huntington's disease. ...Read more

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Is it possible to get huntington’s disease even if neither parent had it? At least, neither of my parents showed symptoms, but they both died before age 50. My doctor wants me to get tested based on my symptoms and the fact that i remember my grandfather

Is it possible to get huntington’s disease even if neither parent had it? At least, neither of my parents showed symptoms, but they both died before age 50. My doctor wants me to get tested based on my symptoms and the fact that i remember my grandfather

Doctors : Doctors who recommend genetic tests, such as a test for huntington's disease, should not do so without providing thorough counseling, including providing information and answering all questions about the reason for ordering the test, the reliability of the test, and the consequences of both positive and negative test results. If they are unable to provide this counseling, they should arrange for referral to a geneticist. Huntington's disease is a complicated neurodegenerative disorder that can cause involuntary writhing, dance-like movements of the limbs, other abnormal movements, personality changes and psychiatric symptoms, heart disease and other problems. It is an uncommon condition (about 5-10 cases per 100000 people). Huntington's disease is caused by a mutation in the huntingtin gene. Inside this gene is a stretch of dna that consists of repeating sequences the genetic code letters, or nucelotides, c, a, and g. These three nucleotides can be repeated (cagcagcag...) dozens of times. The number of "trinucleotide repeats" seems to determine if and when the disease will make itself known. People with less than 28 repeats are normal. People with 28 to 35 repeats are "intermediate". People with 35 to 40 repeats may or may not develop huntington's disease. People with more than 40 repeats will be affected, and the higher the number of repeats, the earlier the disease starts. Trinucleotide repeat diseases like huntington's disease (there are others), are characterized by a property called "anticipation." anticipation means that children of people with huntington's often develop the disease at an earlier age than their parents did. This was first noticed even before anything was known about trinucleotide repeats. After the repeats were discovered, it was found that children had more repeats than their parents. The number of repeats tends to increase more if the father carried the abnormal gene. So, unfortunately, it is possible for a child of parents who never showed any signs of huntington's disease to develop the disease. This is particularly true if the parents died at an early age, before signs of the disease might be noticed. ...Read more

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Is the genetic test for huntington’s disease 100% accurate? My grandmother had huntington’s, and my mother was having what she thought were symptoms, so she got tested. The test was negative. Can we be completely she doesn’t have it, which means i don’t e

Is the genetic test for huntington’s disease 100% accurate? My grandmother had huntington’s, and my mother was having what she thought were symptoms, so she got tested. The test was negative. Can we be completely she doesn’t have it, which means i don’t e

Excellent question: Huntington disease is a serious condition - genetic testing can be extremely helpful. Good information is here: http://www.hdsa.org/. No test is perfect, but the test for HD is 99.9% accurate. To know for sure if your mom had the right test, and to get more info, see a genetic counselor or a clinical geneticist, and take a copy of the test results with you. ...Read more

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What is the frequency of huntington's disease in our u.S. Population?

What is the frequency of huntington's disease in our u.S. Population?

4.1-8.4 per 100,000: See following reference under epidemiology http://emedicine.Medscape.Com/article/1150165-overview#a0199.

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What is huntington's disease?

What is huntington's disease?

Movement disorder: Hd is the result of an inherited abnormality due to genetic errors resulting in abnormal movements and behavioral problems. Hd can be diagnosed with genetic tests. It is usually apparent clinically in the 4th or 5th decades. ...Read more

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How rare is huntington's disease?

Huntington: The answer can be found here: http://www.Genome.Gov/10001215. ...Read more

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How common is huntington's disease?

How common is huntington's disease?

5-10/100,000: Huntington's disease is a progressive neurodegenerative disease that is autosomal dominant. Most estimate that it occurs in 5-10 per 100, 000 population. There does not appear to be any sexual discrimination. It is a progressive disease that usually becomes manifest in patients 30-40 years old. ...Read more

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How does huntington's disease progress?

How does huntington's disease progress?

Slowly: Most patients start out with muscle twitching, depression, anxiety and progress over time to uncontrolled muscle movements, difficulty speaking and swallowing, and loss of control of bladder and bowels. ...Read more

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What does huntington's disease look like?

What does huntington's disease look like?

Abnormal involuntary: choreiform movements. If you want to see what chorea looks like, a web search for video clips should turn some up. Also check out hdsa.org for more information. ...Read more

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How does a person get huntington's disease?

How does a person get huntington's disease?

Genetic disorder: Huntington's disease named after a long island physician is caused by a dominant gene in either parent it is accompanied by dementia and involuntary movement (chorea). ...Read more