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Doctor insights on: Huntington S Disease

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How much earlier than my mom will i get huntington’s disease? I’ve read that symptoms start earlier in each generation because of the way the defective gene repeats. But how much earlier? My mom didn’t have symptoms until she was over 50. I’m only 23, but

How much earlier than my mom will i get huntington’s disease? I’ve read that symptoms start earlier in each generation because of the way the defective gene repeats. But how much earlier? My mom didn’t have symptoms until she was over 50. I’m only 23, but

Huntington's : Huntington's disease is a complicated neurodegenerative disorder that can cause involuntary writhing, dance-like movements of the limbs, other abnormal movements, personality changes and psychiatric symptoms, heart disease and other problems. It is an uncommon condition (about 5-10 cases per 100000 people). Huntington's disease is caused by a mutation in the huntingtin gene. Inside this gene is a stretch of dna that consists of repeating sequences the genetic code letters, or nucelotides, c, a, and g. These three nucleotides can be repeated (cagcagcag...) dozens of times. The number of "trinucleotide repeats" seems to determine if and when the disease will make itself known. People with less than 28 repeats are normal. People with 28 to 35 repeats are "intermediate". People with 35 to 40 repeats may or may not develop huntington's disease. People with more than 40 repeats will usually be affected, and the higher the number of repeats, the earlier the disease starts. Trinucleotide repeat diseases like huntington's disease (there are others), are characterized by a property called "anticipation." anticipation means that children of people with huntington's often develop the disease at an earlier age than their parents did. This was first noticed even before anything was known about trinucleotide repeats. After the repeats were discovered, it was found that children had more repeats than their parents. The number of repeats tends to increase more if the father carried the abnormal gene that if the mother did. It is not possible to pinpoint when exactly someone might develop huntington's disease based on when their affected parent developed the disease. Genetic testing may be helpful to identify the number of trinucleotide repeats that someone carries, but presymptomatic testing is declined by the majority of children of people with huntington's disease. ...Read more

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Is it possible to get huntington’s disease even if neither parent had it? At least, neither of my parents showed symptoms, but they both died before age 50. My doctor wants me to get tested based on my symptoms and the fact that i remember my grandfather

Is it possible to get huntington’s disease even if neither parent had it? At least, neither of my parents showed symptoms, but they both died before age 50. My doctor wants me to get tested based on my symptoms and the fact that i remember my grandfather

Doctors : Doctors who recommend genetic tests, such as a test for huntington's disease, should not do so without providing thorough counseling, including providing information and answering all questions about the reason for ordering the test, the reliability of the test, and the consequences of both positive and negative test results. If they are unable to provide this counseling, they should arrange for referral to a geneticist. Huntington's disease is a complicated neurodegenerative disorder that can cause involuntary writhing, dance-like movements of the limbs, other abnormal movements, personality changes and psychiatric symptoms, heart disease and other problems. It is an uncommon condition (about 5-10 cases per 100000 people). Huntington's disease is caused by a mutation in the huntingtin gene. Inside this gene is a stretch of dna that consists of repeating sequences the genetic code letters, or nucelotides, c, a, and g. These three nucleotides can be repeated (cagcagcag...) dozens of times. The number of "trinucleotide repeats" seems to determine if and when the disease will make itself known. People with less than 28 repeats are normal. People with 28 to 35 repeats are "intermediate". People with 35 to 40 repeats may or may not develop huntington's disease. People with more than 40 repeats will be affected, and the higher the number of repeats, the earlier the disease starts. Trinucleotide repeat diseases like huntington's disease (there are others), are characterized by a property called "anticipation." anticipation means that children of people with huntington's often develop the disease at an earlier age than their parents did. This was first noticed even before anything was known about trinucleotide repeats. After the repeats were discovered, it was found that children had more repeats than their parents. The number of repeats tends to increase more if the father carried the abnormal gene. So, unfortunately, it is possible for a child of parents who never showed any signs of huntington's disease to develop the disease. This is particularly true if the parents died at an early age, before signs of the disease might be noticed. ...Read more

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Is the genetic test for huntington’s disease 100% accurate? My grandmother had huntington’s, and my mother was having what she thought were symptoms, so she got tested. The test was negative. Can we be completely she doesn’t have it, which means i don’t e

Is the genetic test for huntington’s disease 100% accurate? My grandmother had huntington’s, and my mother was having what she thought were symptoms, so she got tested. The test was negative. Can we be completely she doesn’t have it, which means i don’t e

Excellent question: Huntington disease is a serious condition - genetic testing can be extremely helpful. Good information is here: http://www.hdsa.org/. No test is perfect, but the test for HD is 99.9% accurate. To know for sure if your mom had the right test, and to get more info, see a genetic counselor or a clinical geneticist, and take a copy of the test results with you. ...Read more

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What can cause huntington disease to happen?

What can cause huntington disease to happen?

YES !!: Huntington's disease (named after the long island doctor who described it ) has dementia , chorea (a dance like involuntary movement) and family history as its main features it is transmitted by a dominant gene (50% chance of it occuring in the offspring). It is at present incurable although the movements can be modified by medication. ...Read more

Dr. Alan Ali Dr. Ali
2 doctors agreed:
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What are presenting symptoms of Huntington disease?

Dr. Alan Ali Dr. Ali
2 doctors agreed:
What are presenting symptoms of Huntington disease?

Huntington: It is a neurodegenerative genetic disorder that affects muscle coordination & leads to cognitive deficits & psychiatric problems. Symptoms become noticeable between ages 35 & 45, & include jerky random uncontrollable movements called chorea, memory problems, mood changes, etc. ...Read more

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Does huntington disease mostly occur in one gender?

Does huntington disease mostly occur in one gender?

NO: As it is due to a dominant gene it can affect males and females. ...Read more

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How much does the huntington disease examination cost?

How much does the huntington disease examination cost?

Varies: Check with your local lab. Some of these screening tests are covered by your insurance. It appears you are 28 years old and likely would have symptoms. Review your family history and see your MD/neurologist. All the best. ...Read more

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Can huntington disease be detected before the child is born?

Can huntington disease be detected before the child is born?

With PGD: I suspect that if a pregnancy is conceived by ivf, preimplantation genetic diagnosis could be used to detect which embryos carry the genetic factors to cause huntington's disease, allowing one to only implant embryos that lack that factor. At this point, it cannot be detected in a natural pregnancy, though technology for noninvasive detection of various disorders is under development. ...Read more

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What is the frequency of huntington disease in the population?

Huntingtons frequenc: The prevalence of Huntingtons disease is about 5 for every 100,000 people in the world. ...Read more

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Would huntington disease be detected before the child is born?

Would huntington disease be detected before the child is born?

Yes in Mom and child: A gene test can be done on any individual. If the mother carries the gene, she will eventually become symptomatic with huntington disease. Any child of hers will have a 50% chance of inheriting the gene and the disease. Prenatal testing of the child in utero can be performed. Any sort of prenatal testing should involve a genetic counselor consultation, as there are many issues to consider. ...Read more

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How old are people typically when the symptoms of huntington disease show up?

Middle adult age: Huntington's most commonly begins in mid adult hood, for example, between 35 and 40 years of age. ...Read more

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Can you tell me, are there carrier forms and or lethal forms of huntington disease?

Dominant gene: By definition you cannot havea carrier form of Huntington's disease 50% of children will be affected although the condition may not cause symptoms until middle age. The disease is a combination of FAMILY HISTORY, DEMENTIA and INVOLUNTARY MOVEMENTS ...Read more

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I have headche for months and we have huntington disease in the family is this an hd symptoms or it can be something else?

Can have many causes: Headache is not considered to be a common symptom of hd. Depending on the type of headaches you have, they can be migraines, tension headache, or cluster headaches. Causes are many; including viral infection, chronic sinusitis, drug/alcohol withdrawal, change of medications, to name a few. Consult your physician if it continues. ...Read more

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What is the mutation that causes huntington disease?

What is the mutation that causes huntington disease?

HD gene: The abnormal gene is located on chromosome 4 and codes for a protein called huntingtin. This protein has many functions in the body and the way the abnormal protein causes huntington's dis is not known, . ...Read more

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Does huntington disease cause headache?

Does huntington disease cause headache?

Tension Headaches: Indirectly yes. Spasms in the neck from Huntington's disease can cause headaches from tense muscles that insert on the skull. These tension headaches are managed with massage, physical therapy, muscle relaxers and Botox injections. ...Read more

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Does huntington disease cause headache?

Does huntington disease cause headache?

Not primarily: Headache is not a core component of huntington's chorea, but no reason why a co-morbidy of migraine, or side effects of medication could not cause headache. ...Read more

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Where in the genome is huntington disease?

Huntington: The answer can be found here: http://www.Genome.Gov/10001215. ...Read more

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Is there any chance to find a cure for huntington disease in the coming years?

Not that I am aware: Of at this time. Unfortunately, this is a genetic condition. I'd highly consider genetic counseling before family planning. ...Read more

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Can you tell me how can trinucleotide repeat mutation cause the symptoms in huntington disease?

Can you tell me how can trinucleotide repeat mutation cause the symptoms in huntington disease?

No. No one can.: We know that too many CAG repeats in the huntingtin gene causes HD, but the function of the gene is not yet known. ...Read more