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Doctor insights on: How Would Angiogenesis Influence Tumor Growth And Metastasis

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How would angiogenesis influence tumor growth and metastasis?

How would angiogenesis influence tumor growth and metastasis?

Fundamental!: All living things need a blood supply to deliver food, water, and get rid of waste. A circulating cancer cell needs to evade detection, get out of the blood vessel, and establish that blood supply: angiogenesis! . All these actors under molecular control, and likely normal during in utero development. Cut off the blood supply, choke the tumor.

Angiogenesis (Definition)

Angiogenesis is the physiological process through which new blood vessels form from pre-existing vessels. This is distinct from vasculogenesis, which is the de novo formation of endothelial cells from mesoderm cell precursors. The first vessels in the embryo form through vasculogenesis, after which angiogenesis is responsible for most, if not all, blood ...Read more


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How can angiogenesis and invasion influence tumor growth and metastasis in a patient with breast cancer?

How can angiogenesis and invasion influence tumor growth and metastasis in a patient with breast cancer?

The general concept: The general concept behind angiogenesis promoting cancer metastasis growth is that cancer cells / tumors use more nutrients and therefore need more blood flow than usual to grow to a large size, and that if we can inhibit this new vessel growth stimulated by tumors, we can limit the growth of the tumor.

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Can you tell me about angiogenesis promoting both the growth of cancers and the metastasis of cancer cells to other sites in the body?

Can you tell me about angiogenesis promoting both the growth of cancers and the metastasis of cancer cells to other sites in the body?

Poor response: Tumors grow in general in an anaerobic media and require hyperbaric oxygen to destroy. Folkman developed drug angiostatin which failed to prevent cancer spread. Avastin (bevacizumab) which is an anti vegf drug doesn't destroy blood supply. It appears to help by opening microvasculature to tumors to let chemo enter more effectively. Blood vessels in tumors are the conduit for vessel invasion by tumor cells.

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How are a cancerous tumor and metastasis different?

How are a cancerous tumor and metastasis different?

Cancer & metastasis: Cancer is a term used for diseases in which abnormal cells divide without control and are able to invade other tissues. Cancer cells can spread to other parts of the body through the blood and lymph systems. When these cancer cells spread beyond the primary organ- we call this metastasis.

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Can malignant tumors that turn into metastasis kill you?

Can malignant tumors that turn into metastasis kill you?

Yes: Metaststic cancers in general no matter what cancer offers a poor prognosis.

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What is more common? Primary brain tumors or from metastasis?

What is more common? Primary brain tumors or from metastasis?

Mets: In adults, metastases from other places are far more common than primary brain cancer by 10 to 1. Lung, breast, kidney, and melanoma are common offenders.

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What are psa and tumor markers for prostate bone metastasis?

What are psa and tumor markers for prostate bone metastasis?

PSA means: Prostate specific antigen. Men all have a level of psa if they have a prostate. Arbitrary normal levels are age & race dependent. If you have prostate cancer, and bones are involved, your psa will likely be greater than 10 ng/ml. Psa levels that double in short intervals are more likely to do this. However, very undifferentiated prostate cancers may not generate psa, and one can have bony mets.

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Typically how large would metastasis tumors to the kidney and liver be? More than 1cm?

Typically how large would metastasis tumors to the kidney and liver be? More than 1cm?

Depends: It depends on the type of primary tumor and how long has the tumor been growing. Often there are multiple metastases, especially in the liver, and these can vary from pin head to 5-6 inches across.

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Malignant tumors shows metastasis but benign tumor not. How do I know if I have a benign tumor?

Benign tumor?: Although benign tumors can be observed and do not normally metastasize, the best way to confirm is to have a biopsy.

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I know malignant tumors shows metastasis but benign tumor not. But there is an example of benign tumo?

I know malignant tumors shows metastasis but benign tumor not. But there is an example of benign tumo?

Some do spread: By definition a benign tumor does not have the potential to spread. Distant spread has occurred when a lesion that is manipulated or curetted has shown signs of spread. This is really not metastasis. A report of benign metastasizing fibroma of the thumb was reported by keasby many years ago. Some benign sweat gland tumors of axilla have been shown to be present in axillary nodes, .

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How much metastasis does there need to be to cause carcinoid syndrome from midgut carcinoid tumors?

How much metastasis does there need to be to cause carcinoid syndrome from midgut carcinoid tumors?

How is the liver?: Typically patients do not develop carcinoid syndrome without having tumor metastases in the liver. So tell us about the results of your X-rays and scans of the chest, abdomen and your liver imaging studies. Then we can help you further.

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Can a malignant tumor spread to bones via local metastasis?

Can a malignant tumor spread to bones via local metastasis?

Yes: A malignant tumor can spread to other places, including bones. This can happen directly; that is, if a tumor is near a bone, it can grow directly into the bone. It can also happen from a distance, if tumor cells get into the blood stream and travel to the bone. The picture shows the different places cancer goes in the body. I hope that answers your question!

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Question about cauda equina syndrome caused by spinal nodule/tumor on cauda equina nerve roots - possible metastasis with severe increasing symptoms?

Question about cauda equina syndrome caused by spinal nodule/tumor on cauda equina nerve roots - possible metastasis with severe increasing symptoms?

Don't delay: Cauda equina syndrome is the loss of sensation or strength in the legs, along with loss of bowel and bladder control. It can be caused by tumor masses compressing nerve roots emanating from the lower part of the spinal cord. It is a medical emergency that may require surgery or radiation to prevent a permanent loss of function.

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Plz explain pet/ct scan xrays and images. How it shows the tumor and metastasis in body?

Plz explain pet/ct scan xrays and images. How it shows the tumor and metastasis in body?

The substances used: In PET are radioactive tracers that accumulate to varying degrees in sites of metabolic activity. Cancers typically have altered/increased metabolic activity relative to normal organs and tend to take up more of the tracer. The radioactivity is detected by the scanner and forms an image which lacks anatomic detail, so it is superimposed over a CT scan, which provides the necessary detail.

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Malignant tumor removed surgically from sigmoid colon, the dr. Said he found a very tiny mass on the uterus (millimeters) which didn't appear in ct. Is this considered as metastasis or still stage 3?

Malignant tumor removed surgically from sigmoid colon, the dr. Said he found a very tiny mass on the uterus (millimeters) which didn't appear in ct. Is this considered as metastasis or still stage 3?

Was the mass on: The uterus which touched the sigmoid colon? Was this mass biopsied? More information would be useful. If biopsied and found to be consistent with colon cancer, the uterus is not a distant organ, but would raise the t to t4b and overall stage would become stage iii c.

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How to differentiate primary tumor cells from cells of metastases?

How to differentiate primary tumor cells from cells of metastases?

Close exam: Primary tumor cells are well defined, arising in the organ that initiates the lesion. A cancer of the breast when biopsied shows adenoca cells of breast origin. When metastatic to liver or lung, biopsy will show the same cells as the primary. If the lesion arises in the liver it is not metastatic in terms of cells seen but liver tumor cells or hepatoma.

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Tumor in 2012, but a year later, our doctor found it had diffuse bone metastases. What now?

Tumor in 2012, but a year later, our doctor found it had diffuse bone metastases. What now?

Chemo may help: Mosty lesions that spread to bone have a poor prognosis. This is true of lung cancer, melanoma and colon. Other lesions to bone such as renal cell ca or breast cancer while probably not cureable have known long term survivals on chemo.

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Confussed. Colon tumor. All scans clear so no metastases. Operation march. Sept scan reveals a liver met. Does this mean escaped cells?

Confussed. Colon tumor. All scans clear so no metastases. Operation march. Sept scan reveals a liver met. Does this mean escaped cells?

Most likely: This depends on many factors. This is true for type of tumor and where located on or in the colon. If your doctors believe it is a metastasis then "escaped " cells is a way to explain it. It is also important to be sure it is the only visible metastasis for planning therapy.

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Urgent, doctors :' (my mom has metastases liver cancer, lung and bone nearby left thigh found tumors. Just found out few days ago, is stage 4. How?

Urgent, doctors :' (my mom has metastases liver cancer, lung and bone nearby left thigh found tumors. Just found out few days ago, is stage 4. How?

This is too: Common. Some cancers are quiet until they infest other organs, and it is these organs working poorly or hurting that causes the cancer to be known. Some cancers can have life extended by treatment (prostate and breast), others can be treated to relieve symptoms. But for most, it means time to focus on comfort and symptom relief rather than rigorous treatment.

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Neoplasms (Definition)

"tumor" literally translates as "mass", so even a fresh bruise could be called a "tumor". Doctors use the term "neoplasm" (tranlates literally as new growth) to describe tumors that are abnormal growths of cells. These may be benign or malignant; "malignant" = cancer. In everyday usage, we use "tumor" ...Read more


Metastasis (Definition)

A cancer begins in an organ (say the breast). If it gets into the blood stream or the lymphatic stream the cells can travel to other parts of the body where, in the right environment, they may settle and grow. This development of tumor growth far away from the original site ...Read more