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Doctor insights on: How To Taper Off Zoloft

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What symptoms do you have tapering off zoloft (sertraline)?

What symptoms do you have tapering off zoloft (sertraline)?

Unexplained headache: One major symptom may be a headache that can last for several weeks upon stopping zoloft (sertraline) suddenly. You are less likely to have symptoms when you gradually decrease zoloft (sertraline) over a few weeks as opposed to just stopping it cold turkey. ...Read more

Dr. Heidi Fowler
1,070 doctors shared insights

Sertraline (Definition)

Also called zoloft, (sertraline) is one of selective serotonin reuptake inhibitors, with antidepressant/anti-anxiety actions. May cause headaches, nausea & ...Read more


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Taking 12.5 mg Zoloft (sertraline) for 16 days...how do I taper off of it?

Taking 12.5 mg Zoloft (sertraline) for 16 days...how do I taper off of it?

See your physician: See the physician that prescribed the Zoloft (sertraline) to you in order to determine why you would like to taper off of it as well as the safest way to do so. http://www.nlm.nih.gov/medlineplus/druginfo/meds/a697048.html ...Read more

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If you stopped taking it Zoloft (sertraline) without tapering, what happens?

If you stopped taking it Zoloft (sertraline) without tapering, what happens?

Depends: Depends on the dose you were on, and your particular sensitivity to changes in ssri levels. If you're on 50mg or less, chances are you'd tolerate an abrupt discontinuation without side effects. Any higher dose than that, i'd recommend tapering. Personally, since there's virtually no downside to tapering, i taper everyone to 25 mg before discontinuing. Talk to your doc about tapering. ...Read more

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I'm currently taking Zoloft, 50 mg. I want to stop so how do I slowly taper?

I'm currently taking Zoloft, 50 mg. I want to stop so how do I slowly taper?

Slow taper: The ideal route would be to reduce it to 25 mg for 5 days, then take it alternate days for 3 days, then stop. ...Read more

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Can I switch from Paxil (paroxetine) 20 immediately to Zoloft 45 w/o tapering off Paxil (paroxetine)? I've had hard time getting off pax. I don't want to half both and take it.

Can I switch from Paxil (paroxetine) 20 immediately to Zoloft 45 w/o tapering off Paxil (paroxetine)? I've had hard time getting off pax. I don't want to half both and take it.

Switching Rx: That dose of paxil (paroxetine) is not very high, and it's possible you could make the switch. The zoloft should help take its place. If you have any thoughts about how to change from one to the other though, you should get your instructions from your long term provider. They should have a chance to approve anything we say here, at least. ...Read more

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Can i make cross tapering Zoloft (sertraline) to brintellix?

Can i make cross tapering Zoloft (sertraline) to brintellix?

Probably: The best response is to meet with your prescribing physician and discuss this in detail. In my practice, with my patients, I slowly taper them down on the zoloft (sertraline) about 50mgs weekly, and slowly start them on Brintellix, usually mgs daily for one week, then 10mgs for two weeks, then up to 20mgs daily. ...Read more

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I have been takimg 50 mg of zoloft for one week, and want to quit taking it. Do i need to taper, or can i quit cold turkey?

No need to taper: too early to be dependent stop it if wanted , but it can take weeks to take effect , but usually doesn't work well , pray , walk , time is a good healer ...Read more

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It's been about a month tapering Zoloft. But I've been slipping backwards. For example ive quitting the hobbies I used to enjoy. Is this normal?

It's been about a month tapering Zoloft. But I've been slipping backwards. For example ive quitting the hobbies I used to enjoy. Is this normal?

No: Anhedonia, meaning loss of interest or pleasure generally, or in previously enjoyed activities, can be a symptom of depression. Do speak to your prescribing doctor immediately about these concerns. ...Read more

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I'm tapering off Zoloft (sertraline) 75mg that I've been taking daily for 10yrs. I'm taking 50mg but feeling withdrawals already. Will the symptoms ever go away?

I'm tapering off Zoloft (sertraline) 75mg that I've been taking daily for 10yrs.  I'm taking 50mg but feeling withdrawals already.  Will the symptoms ever go away?

Really tricky.: without an exam, I can only give general information, first, withdrawal vs the depression coming back can be tricky. Psychological upset from a change in a helpful med vs physical withdrawal.. tricky Each are mananged differently and have different resolution times. ...Read more

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2 of my Drs gave conflicting advice on best procedure to end my 50mg/day Zoloft (sertraline). What tapering schedule do you recommend to minimize withdrawal sympt?

2 of my Drs gave conflicting advice on best procedure to end my 50mg/day Zoloft (sertraline). What tapering schedule do you recommend to minimize withdrawal sympt?

Tapering: The key is to taper and not stop "cold turkey" ... You probably received different advice on this, as it's not a hard and fast science as some of the other aspects of medical practice. Generally, the goal is to reduce the dose 25% over 4 weeks ... But this can be slowed down or accelerated if need be depending on how you respond. Hope that helps & good luck! ...Read more

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Would a taper from 60 mg of cymbalta (duloxetine) to Zoloft be difficult?

Possibly: It could be difficult because stopping Cymbalta (duloxetine) can lead to the withdrawal syndrome that some patients experience. It is accompanied by severe migraine headaches and electric current sensations over the the top of the head and the neck and just because sertraline is being started does not necessarily prevent it. Talk to your doctor for more details regarding the transition to zoloft! ...Read more

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What would be a good tapering schedule for weaning off of 50mg of zoloft (sertraline)?

Why tapering?: You should talk to the doctor who prescribed it first, to make sure you don't still need the medication to control any symptoms. Otherwise, to taper, decrease to 25 mg daily for two weeks and then stop. You could start to notice a return of depression or anxiety with reducing the dose or stopping it. In that case, just restart it at 50 mg daily. Good luck! ...Read more

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Is it ok to switch from Zoloft to wellbutrin (bupropion) without tapering? because im a nervous wreck!

That depends on dose: If you were on a really low dose - it is probably fine. But if on a higher dose, you may need to taper off of zoloft (sertraline) to prevent discontinuation syndrome. ...Read more

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How easy to taper off or wean off 100 mg Zoloft (sertraline) /day after 6 weeks of usage? What protocol to use?

Taper off slowly: My best advice for you is to check with your doctor because he or she knows your condition. Best. But you should be able to taper your med to 50 mg a day for 2 weeks, then take every other day for 2 more weeks to see if you are ready to get off med. Since there is no dependency with zoloft (sertraline). Again chectk with your doctor. ...Read more

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Switching from 60mg prozac for 4 mnths to zoloft (sertraline). Will I switch right over? Take both concurrent for awhile? Taper then start?

Switching from 60mg prozac for 4 mnths to zoloft (sertraline). Will I switch right over? Take both concurrent for awhile? Taper then start?

Prozac to Zoloft (sertraline): Prozac can stay in your system up to 72 hours, so under supervision of your doctor, it is possible to discontinue Prozac & start low dose Zoloft (sertraline) at 50mg. daily then upgrade the dose every 3 days as tolerated. ...Read more

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Taking Prozac 40mg for 2 months, If I want to try Zoloft, how long should I take for tapering off Prozac before starting Zoloft, a week or two?

Crossover same time: I typically start Zoloft right away. Prozac leaves the body slowly over about a 2 week period of time and Zoloft can be started at a low dose at the same time. Your doctor can then increase the dose of Zoloft if needed once the Prozac has left the body. ...Read more

Dr. Alan Ali
1,024 doctors shared insights

Zoloft (Definition)

Zoloft is a serotonin reuptake blocker which is a kind of ...Read more