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Doctor insights on: How To Prevent Sma

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If I have a high positive ANA (1:640) speckled, nucleolar and low positive SMA (1:40), what further tests do I need to do? (Negative SS-A, SS-B, Smith, RNP, SCL-70, Anti Jo Abs)

If I have a high positive ANA (1:640) speckled, nucleolar and low positive SMA (1:40), what further tests do I need to do?  (Negative SS-A, SS-B, Smith, RNP, SCL-70, Anti Jo Abs)

? anti dsDNA: You've probably already had these more basic tests: complete blood count, sedimentation rate, C-reactive protein, urinalysis & rheumatoid factor. It appears to me that the ANA results with slight positive anti-Smith may suggest lupus; you need an antibody to double-stranded DNA (anti dsDNA) which is very specific & somewhat sensitive for lupus.All this needs to be correlated by your doc/specialist ...Read more

Dan Tse
36 doctors shared insights

Sma (Definition)

SMA is an acronym for "Spinal muscular atrophy", "Smooth muscle antibody", ...Read more


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Does spinal muscular atrophy (sma) prevent children from speaking?

Does spinal muscular atrophy (sma) prevent children from speaking?

Yes: If they live long enough and have enough physical strength. This is a family of cruel diseases of widely variable severity. ...Read more

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How is a genetic muscle or nerve degeneration (md, sma) process treated or prevented-current; future?

How is a genetic muscle or nerve degeneration (md, sma) process treated or prevented-current; future?

Gene therapy: Though many things have been tried, really not anything that has been proven to do much yet. Given that sma is a genetic disorder with well known muscle protein abnormalities, it seems a great target for gene therapy type treatments, which are being researched. ...Read more

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How is SMA diagnosed?

See below: (spinal muscular atrophy) defining signs and symptoms are the first clue. To confirm diagnosis, a genetic test is done. If that is negative but the physician still things sma is the cause of the patient's symptoms, an electromyography, enzyme creatnine kinase, and nerve conduction studies can be done. ...Read more

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Can you die from sma?

Can you die from sma?

Depends: Sma type 1, also known as infantile spinal muscular atrophy or werdnig-hoffmann disease, is the most common and severe type of sma. It typically presents in the neonatal period. Majority of affected infants die within a year from respiratory failure. Type 2, 3, and 4 present at a later ages and are milder forms. ...Read more

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What are the tests for sma?

What are the tests for sma?

Different: Spinal muscular atrophy is diagnosed by genetic testing, muscle biopsy, electromyography (electrical muscle test). Superior mesenteric artery syndrome is diagnosed by x-rays, ultrasound, arteriography, ct scans. ...Read more

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What are the symptoms of sma? 

What are the symptoms of sma? 

Symptoms SMA: Areflexia, particularly in extremities overall muscle weakness, poor muscle tone, limpness or a tendency to flop (the "floppy baby" syndrome) difficulty achieving developmental milestones, difficulty sitting/standing/walking in infants: adopting of a frog-leg position when sitting (hips abducted and knees flexed) loss of strength of the pulmonary muscles: weak cough, weak cry. ...Read more

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How are patients with SMA cared for?

How are patients with SMA cared for?

SMA: Spinal muscular atrophy is a rare genetic disease affecting a protein in the spinal cord, leading to nerve death and muscular weakening and shrinkage. Caring for patients depends on the damage done and specific needs. Check the article in wikipedia for general information, and check with you physician for specific specialty referrals as needed. ...Read more

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