Doctor insights on:
How To Prevent Biliary Cirrhosis
Maybe liver failure: Primary biliary cirrhosis is an insidious disease that tends to be progressive over time. The small ducts that drain bile from the liver will narrow and prevent adequate drainage of bile to the intestine. The liver will experience damage with years of inadequate bile drainage and eventually severe scarring (cirrhosis) occurs. With cirrhosis, the only option is liver transplantation for best chance. ...Read moreSee 1 more doctor answer
Number of things: If caught early, there are medications, particularly ursodeoxycholic acid (actigall) which can slow it down. Preventing and treating complications is also important, especially high pressure in the portal vein, which can be treated with beta blockers (inderal and others) and sometimes surgery. Itching, fatigue and other symptoms can be treated as well, but liver transplant is needed when severe. ...Read more
Liver problems: With primary biliary cirrhosis the small bile ducts in the liver are affected. As time goes on cirrhosis of the liver can result. This results in jaundice and itching. As cirrhosis worsens people have issues with enlarged veins around the esophagus, stomach and rectum. These can cause severe bleeding. Also complete liver failure can result. ...Read moreSee 1 more doctor answer
Autoantibody &Biopsy: In addition to abnormal blood tests due to malfunction of liver, patients with primary biliary cirrhosis have peculiar autoantibodies, anti-mitochondrial antibodies. Blood tests and imaging suggest cirrhosis, confirmation requires biopsy (usually needle biopsy) and examination of the tissue by a pathologist. ...Read more
Bad if untreated: An immuno-genetic disease, of which 90% are female, typically 40-60 years old. The disease affects asians, caucasians, jews, african. Family clustering is common. Early symptoms are fatigue, itching before jaundice, RUQ pain. Untreated pbc leads to progressive liver failure with its sequelae. Advanced age, liver/spleen enlargement, ascites, low albumin, fibrosis, cirrhosis predict worst prognosis. ...Read more
Depends: The degree or severity of the cirrhosis determines what symptoms are present. Early cirrhosis can not cause any symptom. Severe cirrhosis can cause many symptoms including but not limited to bleeding, fluid build up in the abdomen, turning yellow skin and eyes, death. ...Read moreSee 1 more doctor answer
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