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Doctor insights on: How Quickly Does Zoloft Start To Become Effective

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How quickly does Zoloft (sertraline) start to become effective?

How quickly does Zoloft (sertraline) start to become effective?

Zoloft (sertraline) onset: According to research studies, about 75% of patients will improve in the first four weeks, but it may take 4 to 6 weeks for the other 25% to improve with antidepressant treatment. Also, it is important a person takes an adequate dose, for some, this may be as much as 150-200 mgs per day. I would go to a dr. Who would see me every few weeks until i was better. Good luck. ...Read more

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Dr. Heidi Fowler
1,070 doctors shared insights

Sertraline (Definition)

Also called zoloft, (sertraline) is one of selective serotonin reuptake inhibitors, with antidepressant/anti-anxiety actions. May cause headaches, nausea & ...Read more


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How long do the side effects of Zoloft (sertraline) last? How long till the medicine is effective and I start noticing a difference in myself?

How long do the side effects of Zoloft (sertraline) last? How long till the medicine is effective and I start noticing a difference in myself?

Sertraline effects: some Pts notice mild improvement in mood or anxiety within days of starting an SSRI (doses are adjusted daily in hosp). pts will need to be on a therapeutic dose for up to 8 weeks to see full benefits of the med. Pts also differ with respect to SEs. Most Pts have only self limited or rather tolerable SEs (like dry mouth). Rarely, more serious SEs occur. Talk to your doc about your risks/benefits ...Read more

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I was on Zoloft (sertraline) for 8 Month & quit gradullay, Now I rebound and Dr. Prescribed it again, I read on Internet that this may be not effective, I'm afraid?

I was on Zoloft (sertraline) for 8 Month & quit gradullay, Now I rebound and Dr. Prescribed it again, I read on Internet that this may be not effective, I'm afraid?

Restarting Zoloft (sertraline): Your doctor is right to restart Zoloft (sertraline). If it helped you previously, it should be as effective now. Be aware it may take several weeks to adjust the dose so you feel the benefit. Assume you take this for anxiety or depression. I hope this helps. ...Read more

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Is Zoloft (sertraline) better or safer or more effective than luvox ?

Is Zoloft (sertraline) better or safer or more effective than luvox ?

FDA indications: Luvox (Fluvoxamine) is approved by the FDA for the treatment of obsessive compulsive disorder. However, it has been used off-label by some to treat major depressive disorder, PTSD, panic disorder and social anxiety disorder. Sertraline (Zoloft/ Lustral) is an SSRI which is FDA approved for treatment of major depressive disorder, panic disorder, social anxiety disorder, post traumatic disorder ...Read more

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I have anxiety.My Zoloft (sertraline) dose was raised from 50(was fine for 2 years)to100(fine for 6mos and now 150 anxiety back.Have you seen this amount effective?

I have anxiety.My Zoloft (sertraline) dose was raised from 50(was fine for 2 years)to100(fine for 6mos and now 150 anxiety back.Have you seen this amount effective?

Yes: Doses of antidepressants like zoloft (sertraline) needed for symptom control can vary from person to person, and from time to time in their lives. If your prescribing doctor isn't a psychiatrist, it might be time to consult one. Also, working in psychotherapy can help you discover what drives your anxiety, and learn how to modulate it. The book "the mindful way through anxiety" can be very helpful too. ...Read more

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Is Zoloft (sertraline) the most effective medication for anxiety and depression?

One of several: Zoloft (sertraline) is an effective drug for treating anxiety and depression. Other drugs in its class (ssris) are also effective for these conditions. The most effective drug is the one you tolerate which works. ...Read more

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Is Effexor (venlafaxine) more effective for panic disorder than Zoloft?

Is Effexor (venlafaxine) more effective for panic disorder than Zoloft?

Different strokes...: The polls of patients say slightly more prefer Zoloft (sertraline) for panic, but it's a very unique fit. Neither was initially for that - they're antidepressants. That said it's often effective for panic and much, more combined w/ CBT therapy. Discuss w/ Dr. Don't do it yourself! ...Read more

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How effective is sertraline (Zoloft) for treating obsessive compulsive disorder (OCD)?

How effective is sertraline (Zoloft) for treating obsessive compulsive disorder (OCD)?

It's effective: Studies indicate SSRIs including sertraline, fluoxetine (Prozac), citalopram (Celexa) and paroxetine (Paxil) can reduce OCD symptoms by 40-60%. SSRIs may also be used in combination with two empirically validated psychotherapies, Exposure plus Response Prevention and Cognitive Therapy. Ask your doctor for more information about your options. ...Read more

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How much is the probability that Zoloft (sertraline) help me if luvox didn't? Generally, how many ssris in average does every patient try to find the effective one?

How much is the probability that Zoloft (sertraline) help me if luvox didn't? Generally, how many ssris in average does every patient try to find the effective one?

MTHFR genotyping: If you have had failures, a good start is genomind testing which let's you see if you metabolize drugs that go through the cyp2c19 ; cyp2d6 pathways too fast, too slow, or just right. Also if you are + for an abnormal mthfr genotype, treatment with l-methylfolate, p5p, ; methyl cobalamin can help your antidepressant work better because you will be making your own serotonin, dopamine, ; nor-epi! ...Read more

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If Zoloft (sertraline) wasn't effective enough for my OCD on 200mg , nor luvox 200 mg ; what can I try? Would another ssri work ?

I don't think so: All the ssris quite similar mechanisms of action so it is doubtful that another one would help. Unfortunately there are no truly effective meds for ocd although sometimes adding a low dose antipsychotic med might help. Specialized psychotherapy is the best way to go [ask if your psychotherapist thinks that he or she can help]. ...Read more

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If Zoloft 62mg wasn't very effective would going up to 75mg work better? Tried Paxil (paroxetine) before and 20mg helped. Need safest option for breastfeeding.

If Zoloft 62mg wasn't very effective would going up to 75mg work better? Tried Paxil (paroxetine) before and 20mg helped. Need safest option for breastfeeding.

Increase is OK: 62mg of Zoloft (sertraline) is unusual as typically this is prescribed in increments of 25mg. Zoloft (sertraline) is considered a relatively safe drug during pregnancy and breastfeeding. The difference between 62 and 75 is minimal, but if you are experiencing depression, try the increase, with consult with your OB/GYB. You cannot equate effective dosages between medications as their metabolic rate is different. ...Read more

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How effective is Zoloft (sertraline) in treating panic disorder? Social anxiety? I really need to know or am I just wasting my time with it.

How effective is Zoloft (sertraline) in treating panic disorder? Social anxiety? I really need to know or am I just wasting my time with it.

Panic disorder: Medication may play a role in helping but behavioral interventions are very helpful. See a mental health professional who can help w/things like clinical hypnosis, imagery, or the like. See www.relaxationresponse.org for self-help also. Peace and good health. Your sympathetic nervous system is too sensitive. ...Read more

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Is 200mg of COq 10 safe and effective for lowering blood pressure? Current meds are Zoloft losartan betapace and nexium (esomeprazole). Any interactions?

Is 200mg of COq 10 safe and effective for lowering blood pressure?   Current meds are Zoloft losartan betapace and nexium (esomeprazole).  Any interactions?

There are two forms: of CoQ10. Neither has been regulated by the FDA. (One form appears to have more antioxidant properties). Several conditions have been associated with low CoQ10 levels including HTN, heart failure, certain cancers, gingivitis, gastric ulcers, etc. Currently there has not been a consensus arrived at as to the BP lowering effects (due to lack of controlled studies). May affect Zoloft (sertraline) level a bit. ...Read more

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Hello. I have a quick question regarding possible drug interactions. Do the antidepressants Zoloft, Viibryd, and Clonidine make hormonal birth control (Tri Cyclen Sprintec) less effective?

Hello. I have a quick question regarding possible drug interactions. Do the antidepressants Zoloft, Viibryd, and Clonidine make hormonal birth control (Tri Cyclen Sprintec) less effective?

Drug interaction: person of unknown age gender medical Hx or medication Hx asks: I have a quick question regarding possible drug interactions. Do the antidepressants Zoloft, Viibryd, and Clonidine make hormonal birth control (Tri Cyclen Sprintec) less effective? ANS: i would go to Drugs.com and look up drug interactions. It will depend on how each is metabolized in your body. I would ask the team prescribing them. ...Read more

Dr. Alan Ali
1,024 doctors shared insights

Zoloft (Definition)

Zoloft is a serotonin reuptake blocker which is a kind of ...Read more