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Doctor insights on: How Quickly Does Benadryl Start To Work

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How quickly does Benadryl (diphenhydramine) start to work?

How quickly does Benadryl (diphenhydramine) start to work?

About 30 minutes: Lasts in the body for about 4-6 hours and then it needs to be redosed. ...Read more

Dr. John Chiu
1,047 Doctors shared insights

Diphenhydramine (Definition)

Diphenhydramine is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more


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How fast should Benadryl (diphenhydramine) work?

How fast should Benadryl (diphenhydramine) work?

15 to 60 minutes: It start working within 15 to 60 minutes of ingestion. ...Read more

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Would Benadryl (diphenhydramine) work for my mild sa?

Would Benadryl (diphenhydramine) work for my mild sa?

? sa: I am going to assume "sa" is seasonal allergies. So, yes, Benadryl (diphenhydramine) would work for these, but is certainly not the optimal answer. Benadryl (diphenhydramine) tends to be sedating and also needs to be taken 4 times a day for optimal effect. If you are having to take doses that often to keep symptoms under control, should consider alternative treatment for allergies. If "sa" not allergies, please resubmit question. ...Read more

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Does Benadryl (diphenhydramine) work for anxiety?

Does Benadryl (diphenhydramine) work for anxiety?

Time For DroolSchool: We here on the ranch call it"Benadrool"because it can shlog you out. So yes sometimes it can work for calming down. But too much turns it into Bena-DryMouthBlurredVisionKnockedOut-Dryl. So just take one capsule (25mg)or at most 50mg. It's not usually prescribed for this. There are other medications specifically for anxiety. But Benadryl (diphenhydramine) is a non-prescription medication and usually safe at proper doses ...Read more

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Does Benadryl (diphenhydramine) work for jock itch?

Does Benadryl (diphenhydramine) work for jock itch?

Possibly: Benedryl is an antihistamine which helps itching associated with hypersensitivity reactions such as allergies, bug bites, etc. You may find some transient relief of itching caused by fungal infections, but the ultimate treatment would be that of cure (i.e. topical antifungal cream/powder/spray). ...Read more

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Do Ambien and Benadryl (diphenhydramine) work the same way?

Do Ambien and Benadryl (diphenhydramine) work the same way?

Not at all: Ambien is a prescription only sleep aid which works directly on the brain to reduce electrical activity thereby causing sleep. Benadryl (diphenhydramine) which is used for treatment of allergies causes sleep as a side effect by working on different than Ambien brain receptors called H1. Consult with a physician if you need to take sleep aids on a regular basis. ...Read more

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Which goes to work faster? Claritin or Benadryl (diphenhydramine)

Which goes to work faster? Claritin or Benadryl (diphenhydramine)

About the same speed: Unless Benadryl (diphenhydramine) is injected, either starts to work between 1-2 hrs. ...Read more

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Can allegra work the same as benadryl (diphenhydramine)?

Can allegra work the same as benadryl (diphenhydramine)?

Antihistamines: Both are antihistamines. Benadryl (diphenhydramine) works for a maximum of 6 hours, Allegra works for 24. Allegra is non drowsy but Benadryl (diphenhydramine) is very sedating. ...Read more

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Does Claritin work better than benadryl (diphenhydramine)?

Not necessarily: Claritin is non-sedating at 10 mg and is a once daily medication. It has an onset of action approximately 30 minutes after taking. Benadryl (diphenhydramine) tends to work more quickly but lasts only 4-6 hours and can be sedating. ...Read more

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I used Benadryl (diphenhydramine) and it dried up my rash in two nights. How did it work?

I used Benadryl (diphenhydramine) and it dried up my rash in two nights. How did it work?

By itself: The rash would have dried up in the same time with or without benadryl (diphenhydramine). The only way Benadryl (diphenhydramine) might have helped would be its effect on itching thus cutting your edge to scratch the rash ...Read more

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I'm taking Benadryl (diphenhydramine) due to hives. But I need to go back to work! What should I do?

I'm taking Benadryl (diphenhydramine) due to hives. But I need to go back to work! What should I do?

Combination therapy: One of the most current recommendations for hives (urticaria) treatment is to combine sedating antihistamine, e.g., Atarax or Benadryl (diphenhydramine) taken at night and nonsedating one, e.g., zyrtec, in A.M. ...Read more

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Can a person be truly allergic to benadryl (diphenhydramine)? (not to the die but the drug itself) if so can desensitization work?

Can a person be truly allergic to benadryl (diphenhydramine)? (not to the die but the drug itself) if so can desensitization work?

Diphenhydramine: Allergy to the active component can occur, very rare though, desensitazation can be performed but why? Desensitazation is resorted to for any any drug if it is the only drug available to treat certain condition and no available alternatives, which isn't the case with diphenhydramine, get a second opinion, take care ...Read more

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Long term use of children's Benadryl (diphenhydramine) vs zyrtec. Which one works best with the least chance of becoming tolerant or non responsive? Should I alternate

Allergy Meds: One should see an allergist to identify the allergens ang get appropriate treatment. Long term use of Benadryl (diphenhydramine) or zurtec specially at young age without physician supervision is harmful. ...Read more

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Can you use Benadryl (diphenhydramine) to help you fall asleep before it won't work anymore?

Can you use Benadryl (diphenhydramine) to help you fall asleep before it won't work anymore?

Short term ok: Benadryl (diphenhydramine) should not be used long term for insomnia. It may get you to sleep but over time it will disrupt your deep sleep or rem sleep. That could be detrimental to your health. ...Read more

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How does hydrocodone cream works? How can my hubby be alergic to benadryl (diphenhydramine) but not hydrocodone? Aren't they the same thing?

How does hydrocodone cream works? How can my hubby be alergic to benadryl (diphenhydramine) but not hydrocodone? Aren't they the same thing?

Totally different: Benadryl (diphenhydramine) is an antihistamine and hydrocodone is an analgesic. Benadryl (diphenhydramine) works for allergic diseases, hydrocodone works for certain pain. However I believe you meant hydrocortisone cream which works for allergic skin lesions (contact dermatitis) since I am unaware of the availability of a hydrocodone cream. ...Read more

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I seem to have developed an allergy to our new dogs. Tried several antihistamines but Benadryl (diphenhydramine) works best. Can I take on a regular basis?

I seem to have developed an allergy to our new dogs. Tried several antihistamines but Benadryl (diphenhydramine) works best. Can I take on a regular basis?

Allergy: Remember the best treatment is avoidance and we have the same problem. I'd sacrifice to be with my dogs too, hehehe. If you can tolerate Benadryl (diphenhydramine) and it's the only thing that works, you can take it regularly, but remember, it can make you sleepy. Have fun with the dogs, I hope you will develop tolerance. ...Read more

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I was wondering: if Benadryl (diphenhydramine) only works for 4 hours and it also causes drowsiness, why people use it during the day? That seems dangerous...

I was wondering: if Benadryl (diphenhydramine) only works for 4 hours and it also causes drowsiness, why people use it during the day? That seems dangerous...

Yes, it is: The trouble is that almost any drug has a variable effects from person to person. Some people can get away with using it for their symptoms without becoming drowsy. If you experience drowsiness from the use of this drug, it should not be taken in daytime ...Read more

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I'm 16 years old and I take 3 tablets of Benadryl (diphenhydramine) every night because I have a very hard time sleeping is that okay? I take 3 because 2 doesn't work!

I'm 16 years old and I take 3 tablets of Benadryl (diphenhydramine) every night because I have a very hard time sleeping is that okay? I take 3 because 2 doesn't work!

No: No it is not okay. You need to find out the cause of the sleep issues and then take steps to correct it. Continuing to rely on sedation at age 16 is not good. ...Read more

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What can I do, besides taking benadryl, (diphenhydramine) to treat hives. Ate something that caused my body to break out in hives. Don't want to go to work drowsy. Help!

What can I do, besides taking benadryl, (diphenhydramine) to treat hives. Ate something that caused my body to break out in hives. Don't want to go to work drowsy. Help!

Hives: Non drowsy antihistamines like Allegra (fexofenadine) can help, not usre if it is food that is causing your symptoms if they are persistent, you may want to consider seeing an allergist if theybpersist. ...Read more

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Does Benadryl (diphenhydramine) work for breathing problems?

Does Benadryl (diphenhydramine) work for breathing problems?

Maybe: If cause of breathing difficulty is allergic in origin, Benadryl (diphenhydramine) may help since it's an anti-allergy medication. ...Read more

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Will Benadryl (diphenhydramine) work for fish or shellfish allergies?

Will Benadryl (diphenhydramine) work for fish or shellfish allergies?

Fish allergies: Benadryl (diphenhydramine) could work but with fish and shell fish allergies if it is bad best thing is to avoid eatiing it. Some prepackaged foods have shell fish products in them so please read labels before you consume these. It may be prudent to carry an epi-pen for you and you can have your doc prescribe one for you to carry with you at all times. ...Read more

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10 year old given Benadryl (diphenhydramine) to help with sleep when anxious. If it doesn't work can they take prescribed 1 mg of Ativan?

10 year old given Benadryl (diphenhydramine) to help with sleep when anxious. If it doesn't work can they take prescribed 1 mg of Ativan?

Prefer melatonin: Unless prescribed by his dr. I prefer something over the counter like melatonin 2 mg at bedtime and relaxation exercise with him. ...Read more

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My allergies are worse in the spring. Benadryl (diphenhydramine) works better than Rx but makes me sleepy. Is there anything else that could help?

My allergies are worse in the spring. Benadryl (diphenhydramine) works better than Rx but makes me sleepy. Is there anything else that could help?

Allergies are worse: There are other options to treat your Allergic Rhinitis, and Benadryl (diphenhydramine) is more for allergic reactions to foods, bites, chemicals.
OTC antihistamines such as Zyrtec, Claritin do better for your allergies, and there are nasal sprays with steroids such as Flonase, Nasacort work well without sedative effects.
Singular helps people with asthma+ for many with seasonal allergic rhinitis also. ...Read more

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Is it okay to mix ambien and benadyrl to treat insomnia? I took benadryl (diphenhydramine) around 4hrs after taking ambien bc it didn't work, are there side effects?

Is it okay to mix ambien and benadyrl to treat insomnia? I took benadryl (diphenhydramine) around 4hrs after taking ambien bc it didn't work, are there side effects?

No don't mix drugs: Please don't mix ambien with benadryl (diphenhydramine). I would first suggest you speak with your doctor who prescribed you ambien and him/her that you are still experiencing insomnia. Mixing prescription medication with drugs like benadryl (diphenhydramine) can be dangerous. Perhaps you should improve your sleep hygiene first. Sleep same time every night, bed is used only for sleep, cool dark room, no distractions (TV) etc. ...Read more

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Itching all over no rash for three weeks. Tried Benadryl (diphenhydramine) but it don't work it gets worse at night?

Itching all over no rash for three weeks. Tried Benadryl (diphenhydramine) but it don't work it gets worse at night?

Need Evaluation: You should be seen by your primary care doctor. You could have a number of different issues- thryoid, liver, kidney, etc. Blood work and evaluation may be mandatory! ...Read more

Benadryl (Definition)

Diphenhydramine is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more