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Doctor insights on: How Often Should One Have Ca 125 Tests

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Hi, I'm 48 yo, have endometriosis, ovarian cysts, uterine fibroids, pre-menopausal. CA 125 was around 200's then 159 the last one was 210 any concerns?

Hi, I'm 48 yo, have endometriosis, ovarian cysts, uterine fibroids, pre-menopausal. CA 125 was around 200's then 159 the last one was 210 any concerns?

Likely, no: CA 125 is not recommended as a screening tool for ovarian cancer when used in risk-based stratification. Meaning, assuming that your mom or sister didn't get diagnosed with ovarian cancer. Normal for women with endometriosis to have elevated CA-125. It sounds like your doctor has done Ultrasound to evaluate ovaries as well. Your MD knows your history and risk, likely this CA-125 level is normal ...Read more

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Dr. Dariush Saghafi
114 doctors shared insights

Ca125 (Definition)

Ca125 is also known as Cancer antigen 125. Ca-125 (cancer antigen 125 or carbohydrate antigen 125) is a biomarker/tumor marker for ovarian cancer (etc); however, it is not sensitive or specific enough to use as a screening test. Also, a uk study showed that treating based on ca125 level did not improve outcomes. "125" comes from the 125th attempt to develop a marker. It was introduced by bast ...Read more


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How often should one have the ca 125 test done?

Screening? No: Ca 125 is not a screening test. It can be elevated for reasons other than cancer. It should be used for follow up of certain cancers ie ovarian cancer. Even then, it is done periodically as part of surveillance strategy. Also used to help the clinician decide if a patient who is on chemotherapy is responding or not & some oncologists obtain them per 'cycle' of chemotherapy i.e. Every 3-4 wks. ...Read more

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27 y.o with hypoechoic cystic lesions on both ovaries. One 8.4cm another 4cm. CA-125 was 190 then 110 on a second test. GYN wants to do lap surgery. Gyn/Onc wants to do laparotomy. Both suspect endometiomas and endometriosis. Which should I choose?

27 y.o with hypoechoic cystic lesions on both ovaries. One 8.4cm another 4cm. CA-125 was 190 then 110 on a second test. GYN wants to do lap surgery. Gyn/Onc wants to do laparotomy. Both suspect endometiomas and endometriosis. Which should I choose?

Depends: I am not a surgeon maybe I can help. The key issues are the surgeons level of confidence. These being equal, laparoscopic surgery is better due to less trauma to the abdomen. You can check to see if the surgeons post their statistics online for their complication rates. I found these for surgery that I needed. lastly, 8.4 cm is big. it may be hard to do through a scope. ...Read more

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I have an endometriosis cyst on both or sometimes only on one side of my ovaries, do I need to go for a check up for my ca-125 every single year?

I have an endometriosis cyst on both or sometimes only on one side of my ovaries, do I need to go for a check up for my ca-125 every single year?

Complicated: Ca-125 can be useful to follow endometriosis, especially to see how one therapy versus another is working. There is no strict rule as to how often to check it. Generally that is individualized for each patient. ...Read more

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2 ovarian cyst, one 8 CM and the other 6cm. Had vus done, low level echos. Going back in 2 months for review. Ca-125 in normal limits. Concered?

2 ovarian cyst, one 8 CM and the other 6cm. Had vus done, low level echos. Going back in 2 months for review. Ca-125 in normal limits.  Concered?

Low degree of concer: Most common cause of such benign cysts are functional cysts that are very common in reproductive age females. Unless, presenting with symptoms (pain, nausea, vomiting, fever etc), your physician may opt to follow them with a repeat us in 3-6 months. Unless you have strong family hx of cancer, or personal hx of cancer, there is a low level of suspicion for ovarian cancer. ...Read more

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2 cysts on left overy. One is simple at 5cm & other is 3.5cm solid. CA-125 normal. Left ovary vol is 99.8, cause weight gain? Could CA-125 be wrong?

Ovarian cysts: Dear Heather-- Simple cysts seen on transvaginal sonography are almost always benign. Solid cysts need to be followed by a gynecologist because of slight risk of ovarian cancer. CA-125 is usually negative with ovarian cysts. Whenever a test result is questioned it should certainly be repeated. One or several ovarian cysts are not related to weight gain. ...Read more

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Complex ovarian cyst, told need complete hysterectomy & need 2 see oncologic gyn. Is this standard or should I worry? Also sent 4 ca-125 & CEA tests

Complex ovarian cyst, told need complete hysterectomy & need 2 see oncologic gyn. Is this standard or should I worry? Also sent 4 ca-125 & CEA tests

Complex Ovarian Cyst: It is not uncommon for a doctor to be cautious and have you seen by a gyn oncologist with a complex ovarian cyst. Most ovarian cysts are benign but some can be cancerous. The size and ultrasound appearance of the cyst as well as the results of the blood tests may raise or lower the suspicion of cancer. It might be best to ask your doctor what they are thinking because they have those details. ...Read more

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7 CM ovarian cyst, ca-125 levels elevated (48), roma score & all blood tests good. Previously had nasopharyngeal cancer. Recurrence or endometrioma?

Likely endometrioma: At your age, ovarian cancer would be exceedingly rare. Ca-125 levels can be elevated in young women for a variety of reasons that have nothing to do with cancer. Nasopharyngeal cancer and ovarian have no relation to each other. Your doctor should tell you what features or characteristics the ovarian cyst has, this will tell you what kind of cyst it is. Good luck! ...Read more

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What are the necessary blood tests after treatment of breast cancer to detect if your ok . Is ca 125 important?

What are the necessary blood tests after  treatment of breast cancer to detect if your ok . Is ca 125 important?

No: Ca-125 not important for breast cancer. Good test for ovarian cancer. The most important things are routine physical exam. Most recurrences are found by the patient or the physician. Hope this helps. No routine blood tests have been shown to be of benefit. However, if someone received chemotherapy, i typically check blood because they received chemo. ...Read more

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