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Doctor insights on: How Often Should One Have Ca 125 Tests

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Hi, I'm 48 yo, have endometriosis, ovarian cysts, uterine fibroids, pre-menopausal. CA 125 was around 200's then 159 the last one was 210 any concerns?

Hi, I'm 48 yo, have endometriosis, ovarian cysts, uterine fibroids, pre-menopausal. CA 125 was around 200's then 159 the last one was 210 any concerns?

Likely, no: CA 125 is not recommended as a screening tool for ovarian cancer when used in risk-based stratification. Meaning, assuming that your mom or sister didn't get diagnosed with ovarian cancer. Normal for women with endometriosis to have elevated CA-125. It sounds like your doctor has done Ultrasound to evaluate ovaries as well. Your MD knows your history and risk, likely this CA-125 level is normal ...Read more

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Dr. Ralph Wharton
125 doctors shared insights

Ca125 (Definition)

Ca-125 (cancer antigen 125 or carbohydrate antigen 125) is a biomarker/tumor marker for ovarian cancer (etc); however, it is not sensitive or specific enough to use as a screening test. Also, a uk study showed that treating based on ca125 level did not improve outcomes. "125" comes from the 125th attempt to develop a marker. It was introduced by bast ...Read more


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How often should one have the ca 125 test done?

Screening? No: Ca 125 is not a screening test. It can be elevated for reasons other than cancer. It should be used for follow up of certain cancers ie ovarian cancer. Even then, it is done periodically as part of surveillance strategy. Also used to help the clinician decide if a patient who is on chemotherapy is responding or not & some oncologists obtain them per 'cycle' of chemotherapy i.e. Every 3-4 wks. ...Read more

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27 y.o with hypoechoic cystic lesions on both ovaries. One 8.4cm another 4cm. CA-125 was 190 then 110 on a second test. GYN wants to do lap surgery. Gyn/Onc wants to do laparotomy. Both suspect endometiomas and endometriosis. Which should I choose?

27 y.o with hypoechoic cystic lesions on both ovaries. One 8.4cm another 4cm. CA-125 was 190 then 110 on a second test. GYN wants to do lap surgery. Gyn/Onc wants to do laparotomy. Both suspect endometiomas and endometriosis. Which should I choose?

Depends: I am not a surgeon maybe I can help. The key issues are the surgeons level of confidence. These being equal, laparoscopic surgery is better due to less trauma to the abdomen. You can check to see if the surgeons post their statistics online for their complication rates. I found these for surgery that I needed. lastly, 8.4 cm is big. it may be hard to do through a scope. ...Read more

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What is the ca-125 test?

What is the ca-125 test?

CA-125: Cancer antigen 125 (ca-125) is a protein found on the surface of many ovarian cancer cells. It also can be found in other cancers and in small amounts in normal tissue. A ca-125 test measures the amount of this protein in the blood and can be used as a tumor marker. ...Read more

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What do you suggest if my ca-125 test came back at 132. I'm scared?

Need for: investigation. An elevated CA 125 does not necessarily mean cancer. All is suggests is that further investigation is needed. Consult this site for more info. http://www.nlm.nih.gov/medlineplus/ency/article/007217.htm ...Read more

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My ca-125 test came back at 132. I'm scared? What do these results mean?

CA-125: This marker is elevated significantly at this value. It's greatest specificity for ovarian cancer is in post-menopausal women, but a variety of things that irritate the lining of the abdomen and even chest, can elevate it mildly. So things like appendicitis, endometriosis, and even diverticulosis can also result in high levels. But, getting checked out for what is behind this is a good idea. ...Read more

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I had the ca-125 test done and it came back with a level 25. Should i be concerned?

Yes and No: Ca-125 is a test for follow-up after diagnosis and with the treatment of ovarian cancer. It is elevated in many other diseases.The test should not be used for a fishing expedition because it would be misleading and concerning for a patient like you. Why was the test done in the first place? Do you have cancer? In any case a 25 level could be normal? What was the normal range.In the lab? ...Read more

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I recently found out that she had cysts in her ovaries, and had a ca125 test.?

No concern: Cysts of the ovary are common. If they are not complex but greater than 5cm, . Removal suggested under 5 cm can be watched. Ca 125 isa carbohydrate marker noted in tumors and inflammatory conditions. Since it is elevated in inflammatory pelvic disease it has no importance in benign disease. And can only be used for monitoring. ...Read more

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What if your ca125 test is 125?

Not a lot: This test can be elevated for several reasons: heart failure, ovarian cancer, and multiple other causes. Without a diagnosis of ovarian cancer all it means is there are a lot of questions. This test should not be ordered without a diagnosis or a very high suspicion of ovarian cancer. Hope this helps. ...Read more

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Certain food affect ca125 tests?

Not likely: Ca 125 test looks for a particular glycoprotein in blood and diet is not likely to affect the results. ...Read more