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Doctor insights on: How Often Is Hemolytic Disease Of The Newborn Fatal

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Dr. James Ferguson Dr. Ferguson
Pediatrics
42 years in practice
University of Texas Medical Branch School of Medicine
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How often is hemolytic disease of the newborn fatal?

How often is hemolytic disease of the newborn fatal?

Depends on form: Decades ago when i started rh hemolytic disease was often fatal during pregnancy & problamatic in newborns. Surviving infants often needed many exchange transfusions & had worrisome futures. Then a treatment called Rhogam came along & has ended that nightmare. In 26 yrs, I have transfused 1-2 ABO babies primarily for late stage anemia but had no fatalities. Rh disease is a problem without rx. ...Read more

Dr. William Singer
1 doctor shared a insight

Neonatal (Definition)

The term neonatal is generally used to describe events that occur with an infant within the first 30 days after birth.Some practitioners are looser with the definition & extend the ...Read more


Dr. James Ferguson Dr. Ferguson
Pediatrics
42 years in practice
University of Texas Medical Branch School of Medicine
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Please tell me the dangers of hemolytic disease of the newborn (abo)?

Please tell me the dangers of hemolytic disease of the newborn (abo)?

Usually mild: Most of these kids have a brief issue with moderate elevations in bilirubin in the first first few days, but may face anemia days and weeks down the road.I remember a single ABO kid needing a transfusion at 6 weeks when this issue arose in 3 decades as a pediatrician. ...Read more

Dr. Rashed Hasan Dr. Hasan
Pediatrics - Critical Care
30 years in practice
King Saud University College of Medicine
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Can symptoms of hemolytic disease of the newborn happen a week after birth?

Can symptoms of hemolytic disease of the newborn happen a week after birth?

HDN: The process of hemolytic disease of the newborn (HDN) starts soon after birth, however the symptoms (mainly jaundice) may not be detected if clinicians do not maintain a high index of suspicion. HDN due to Rh incompatibility is very rare in the US, but ABO incompatibility should be suspected whenever the mother has type O blood and the baby has either type A or B blood and there jaundice. ...Read more

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Dr. Ed Friedlander Dr. Friedlander
Pathology
40 years in practice
Northwestern University Feinberg School of Medicine
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How can hemolytic disease of the newborn occur?

Antibodies: Mom has an antibody against an antigen that baby has on the red cells acquired from dad. The antibody crosses the placenta. Rhogam has done wonders to prevent antibodies against rh/d from causing the devastating illness that used to be common. ...Read more

Dr. Ed Friedlander Dr. Friedlander
Pathology
40 years in practice
Northwestern University Feinberg School of Medicine
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Can you tell me the three classifications of hemolytic disease of the newborn?

Can you clarify?: The three most common blood group systems to cause hemolytic disease of the newborn are rh (usually d antigen, sometimes others), ABO (more common but less troublesome) and kell, though others can do it as well. Was this your question? If not, please write back. ...Read more

Dr. James Cummings Dr. Cummings
Pediatrics - Neonatology
35 years in practice
State University of New York Upstate Medical University
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Are there any major complications to hemolytic disease of the newborn on the baby?

Are there any major complications to hemolytic disease of the newborn on the baby?

Yes: Hemolytic disease of the newborn can result in significant jaundice and/or anemia, either of which may require emergency medical intervention. Even when the jaundice subsides, the infant is at risk for anemia for the first several weeks of life. ...Read more

Dr. James Cummings Dr. Cummings
Pediatrics - Neonatology
35 years in practice
State University of New York Upstate Medical University
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If my 2nd son had hemolytic disease of the newborn, what are the chances the rest of my babies will as well?

If my 2nd son had hemolytic disease of the newborn, what are the chances the rest of my babies will as well?

Depends: Hemolytic disease of the newborn, which is due to rh or ABO incompatibility, happens when the newborn's blood type is incompatible with the mother's, and the mother has passed antibody to the baby in utero. In ABO disease, the mother must be type o and the baby either a or b. In rh disease, the mother must be rh- and the baby rh+. So, subsequent risk depends on the fetus' blood type. ...Read more

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Dr. Golder Wilson Dr. Wilson
Clinical Genetics
years in practice
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Is there a genetic test for hemolytic disease of the newborn?

Yes: Hemolytic disease of the newborn, causing yellow skin and eyes (jaundice) with anemia, is most commonly due to a "set-up"--a blood type difference between mother and child. Blood types are caused by genes at the ABO and other loci (rhesus being most damaging), with o type or rh negative moms making antibodies to red blood cells of a or b or rh+ fetuses (if mom is o and fetus ab, baby switched), . ...Read more

Dr. Steven Hebert Dr. Hebert
Pathology
25 years in practice
Louisiana State University School of Medicine in Shreveport
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Does the possibility of an unborn baby getting antibodies c&d, (hemolytic disease of the newborn) increase with each pregnancy?

Does the possibility of an unborn baby getting antibodies c&d, (hemolytic disease of the newborn)  increase with each pregnancy?

HDN: With each pregnancy the mother increases her chances of developing antibodies which can in turn cross the placenta and harm the fetus. ...Read more

Dr. Eugene Mahmoud Dr. Mahmoud
Pediatrics - Neonatology
37 years in practice
University of Medicine and Dentistry of New Jersey - New Jersey Medical School
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What is the definition or description of: Hemolytic disease of newborn?

HDN: During pregnancy, red blood cells from the unborn baby can cross into the mother's blood through the placenta. Hemolytic Disease of the Newborn occurs when the immune system of the mother sees a baby's red blood cells as foreign and produces antibodies against the baby's red blood cells. These antibodies attack the red blood cells in the baby's blood and cause them to break down too early. ...Read more

Dr. Tanya Russo Dr. Russo
Pediatrics
21 years in practice
Nova Southeastern University College of Osteopathic Medicine
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How can hemolytic disease be prevented in a newborn?

How can hemolytic disease be prevented in a newborn?

ABO hemolysis: Hemolysis in newborns due to ABO incompatibility is not preventable, but is manageable under the care of an experienced pediatrician or neonatologist. For this reason, newborns from mothers with type O blood type or who are Rh- will be screened closely for this condition, as early recognition and intervention is key to successful recovery. ...Read more

Dr. James Ball Dr. Ball
Pediatrics - Hematology & Oncology
15 years in practice
University of Mississippi School of Medicine
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Whats hemolytic disease of newborn?

Different blood type: Hemolytic disease of newborn is caused by different blood types in mom and baby. Classically, mom is rh negative (a- or o-, etc). The baby is rh positive. Mom then make rh antibodies that cross over to the baby and cause breakdown of the red blood cells. This can make the baby very sick. ...Read more

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Dr. James Ball Dr. Ball
Pediatrics - Hematology & Oncology
15 years in practice
University of Mississippi School of Medicine
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What are the tests for hemolytic disease of newborn?

What are the tests for hemolytic disease of newborn?

Test for mom/baby: The baby will get test like coombs testing, hemoglobin or cbc, bilirubin tests and reticule yet counts. The coombs tests shows that an antibody is cause the hemolysis. The antibody specificity can be determined by additional tests. These antibody levels can be measured in mom and baby. Most of these antibodies will cause hemolysis. Some can cause decreased RBC production in the baby. ...Read more

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Dr. Scott Diede Dr. Diede
Pediatrics - Hematology & Oncology
25 years in practice
University of Chicago Pritzker School of Medicine
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What are the symptoms associated with hemolytic disease of newborn?

Jaundice and anemia: Hemolytic disease of the newborn (hdn) may develop when a mother and her unborn baby have different blood types. The mother produces substances called antibodies that attack the developing baby's red blood cells. The most common form of hdn is ABO incompatibility, which is usually not very severe. The least common form is rh incompatibility, which can be very severe, but can be prevented. ...Read more

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Dr. James Ball Dr. Ball
Pediatrics - Hematology & Oncology
15 years in practice
University of Mississippi School of Medicine
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What is the treatment for hemolytic disease of newborn?

What is the treatment for hemolytic disease of newborn?

Various: Hemolytc disease can be mild and treated with bili lights. In extreme cases, it may be picked up early in pregnancy from an antibody screen. If positive, the antibody is identified. If a concerning antibodies present, the blood counts of the baby will be followed closely. Intrauterine transfusions may be required in these rare instances. ...Read more

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Dr. James Ball Dr. Ball
Pediatrics - Hematology & Oncology
15 years in practice
University of Mississippi School of Medicine
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Can a rh+ baby during pregnancy can lead to hemolytic disease?

Can a rh+ baby during pregnancy can lead to hemolytic disease?

Yes. But only...: Mom would need to be rh negative. This would sensitize the mom, producing an anti-rh antibody that can cross the placenta and began to hemolyze the rh positive cells of the infant. This can began to occur early in the pregnancy, making the unborn child very sick. Or it can be detected at birth and cause prolonged jaundice. Subsequent children may be more affected. Mom needs rhogam. ...Read more

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Dr. Bradford Romans Dr. Romans
Internal Medicine
33 years in practice
University of Texas Southwestern Medical School at Dallas
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Dr. Jason Adler Dr. Adler
Pediatrics - Critical Care
20 years in practice
Tufts University School of Medicine
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Can rds be fatal to a newborn?

Yes, not most: Respiratory distress syndrome (rds), or hyaline membrane disease, predominantly a disease of prematurely born infants, can be fatal. However, the mortality rates associated with this condition have declined over the years and in 2007 about 735 children died in the us from rds or 17 deaths/100, 000 live births. ...Read more

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Dr. Johanna Fricke Dr. Fricke
Pediatrics - Developmental & Behavioral
46 years in practice
University of Alabama School of Medicine
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If a newborn was too catch hsv1 from someone who kissed them at 1 month of age would it still be as fatal if they caught it at birth (neonatal hsv)?

If a newborn was too catch hsv1 from someone who kissed them at 1 month of age would it still be as fatal if they caught it at birth (neonatal hsv)?

The neonatal or: newborn period, the first 6 weeks of life, is the age at which an infant who contracts Herpes Simplex Virus 1 is at risk for it's spreading and causing encephalitis. Generally speaking, if a baby under 3 months old develops a cold sore, you should notify his pediatrician straight away., ...Read more