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Doctor insights on: How Methylphenidate Works In The Brain

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Am i brain damaged from ritalin (methylphenidate)? How can I tell?

Am i brain damaged from ritalin (methylphenidate)? How can I tell?

No: Ritalin (methylphenidate) does not cause brain damage when used as prescribed. However if it is abused or mixed with drugs that are being abused, you are taking a risk. ...Read more

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Cerebrum (Definition)

Cerebrum essentially refers to the majority of the brain. Embryologically, it develops from the telencephalon, and together with the diencephalon, ...Read more


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What are the long-term effects of ritalin (methylphenidate) -- it interacts with the brain. What happens 30 years later?

What are the long-term effects of ritalin (methylphenidate) -- it interacts with the brain. What happens 30 years later?

More white matter: Long term contrast studies demonstrate normalization of white matter volume (part of brain where connections and neural activity occur) in stimulant treated adhd patients compared to untreated adhd controls. As much as 20 % of white matter is lost if the adhd person does not get a stimulant. That is emphatically why the amer acad peds recommends all children be treated with a stimulant medication. ...Read more

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When i smoke cigarettes i get the same effects that ritalin (methylphenidate) has on my brain. I feel calm and focused, thinking slowly.. I'm curious. Why?

When i smoke cigarettes i get the same effects that ritalin (methylphenidate) has on my brain. I feel calm and focused, thinking slowly.. I'm curious. Why?

Dopamine: It is probably an oversimplification to say that they both increase Dopamine and that is why it works. However, there is likely a strong relationship with changes in synaptic Dopamine levels and attention seen in the context of both nicotine exposure and methylphenidate administration. Research from duke supports this. Smoking may be bad for health although it increases attention. Stay safe! ...Read more

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Does taking less than 60mg/day ritalin (methylphenidate) for 3-4 monthes, lower the brain's ability or cause any long term health problem, afterwards or it's just a myth?

Does taking less than 60mg/day ritalin (methylphenidate) for 3-4 monthes, lower the brain's ability or cause any long term health problem, afterwards or it's just a myth?

Should be safe: No evidence that being on stimulants cause any chronic medical problems. It sounds like you may have specific concerns, which would be best addressed by following up with your physician. Good luck. ...Read more

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Can ritalin (methylphenidate) cause brain damage?

Can ritalin (methylphenidate) cause brain damage?

Not as prescribed: Ritalin (methylphenidate) is safe to take as prescribed. When not used as prescribed and mixed with other drugs that people abuse, it can be dangerous. ...Read more

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How does ritalin (methylphenidate) cause brain damage?

Ritalin (methylphenidate): Ritalin (methylphenidate) does not cause brain damage. It would not be available on the market if it did. Where did you hear this and what context was it in? ...Read more

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Is it true that methylphenidate can cause changes in the brain like neurons structure after long term use (years)?

Is it true that methylphenidate can cause changes in the brain like neurons structure after long term use (years)?

Not in monkeys: There is no data yet that convincingly show long-term problems with methylphenidate. In fact one study done in monkeys specifically showed no change in brain structure on pet scan. The ultimate study of course remains to be done on humans. I think that it's safe to say that the basic science research looks very good but the final studies in human beings still need to be carried out. So far however there was no signal that long-term structural changes are occurring. Hopefully will find this reassuring and helpful. Best wishes. ...Read more

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Does Brintellix in combination with Ritalin (methylphenidate) cause excitotoxicity because AFAIK they both increase glutamate levels in the brain.

Does Brintellix in combination with Ritalin (methylphenidate) cause excitotoxicity because AFAIK they both increase glutamate levels in the brain.

Doses: need to be taken into account. At high doses, both medicines can cause behavioral excitement. This shouldn't be a clinical concern, assuming proper management, unless one has bipolar disorder. However, glutamate is not a primary target neurotransmitter. Generally, drug interaction concerns are often best managed by the prescriber, since individual differences in pharmacokinets are significant. ...Read more

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If ritalin (methylphenidate) is the same as cocain in many ways, then does it cause serious brain damage ? Like killing brain cells.

If ritalin (methylphenidate) is the same as cocain in many ways, then does it cause serious brain damage ? Like killing brain cells.

It depends.: Ritalin or methylphenidate is a stimulant like cocaine. If taken improperly, it may have injurious effects to the brain. If taken as prescribed, then it should create minimal problems and in fact help you focus by stimulating the frontal cortex involved in finishing tasks and paying attention. Side effects include elevated blood pressure, tachycardia, insomnia and mild loss of appetite. ...Read more

Methylphenidate (Definition)

Is the generic name of ritalin (methylphenidate). It is a ...Read more


Dr. Alan Ali
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Ritalin (Definition)

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