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Doctor insights on: How Many People Have High Ca 125

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Hi, I'm 48 yo, have endometriosis, ovarian cysts, uterine fibroids, pre-menopausal. CA 125 was around 200's then 159 the last one was 210 any concerns?

Hi, I'm 48 yo, have endometriosis, ovarian cysts, uterine fibroids, pre-menopausal. CA 125 was around 200's then 159 the last one was 210 any concerns?

Likely, no: CA 125 is not recommended as a screening tool for ovarian cancer when used in risk-based stratification. Meaning, assuming that your mom or sister didn't get diagnosed with ovarian cancer. Normal for women with endometriosis to have elevated CA-125. It sounds like your doctor has done Ultrasound to evaluate ovaries as well. Your MD knows your history and risk, likely this CA-125 level is normal ...Read more

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Dr. Barbara Lavi
125 doctors shared insights

Ca125 (Definition)

Ca-125 (cancer antigen 125 or carbohydrate antigen 125) is a biomarker/tumor marker for ovarian cancer (etc); however, it is not sensitive or specific enough to use as a screening test. Also, a uk study showed that treating based on ca125 level did not improve outcomes. "125" comes from the 125th attempt to develop a marker. It was introduced by bast ...Read more


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I'm concerned about high ca 125? What should I do?

Incomplete info: Why did you have the test done? All lab results need to be interpreted in the clinical context and the doctor who ordered the test is usually in the best position to do that. Ca 125 is not a good test to diagnose a primary illness. ...Read more

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Could you please tell me if a ca125 blood test is high do I need tahbso?

Could you please tell me if a ca125 blood test is high do I need tahbso?

Not always.: If this test is high, it could mean endometrial cancer, fallopian tube cancer, lung cancer, breast cancer and gastrointestinal cancer. This can also indicate benign conditions, like endometriosis, other ovary disorders, and pregnancy, as well as any inflammatory condition in the abdiminal area. This is a big reason why it is used with other tests in evaluation and to follow treatment response. ...Read more

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Could a high ca125 be due to pelvic adhesions?

No: Adhesions and ca-125 would be unrelated. An isolated elevation of ca-125 with no other clinical information or physical findings is of questionable importance. Would need to see a gynecologist for an evaluation. ...Read more

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Ca-125 was elevated at 40? Once told by gyno that I have precancerous cells. Should this combination worry me?

Yes!: Ca125 is a cancer marker. If elevated is something to worry , even though its not specific. If you were told to have a precancerous lesion , wherever it was, needs to be reevaluated. ...Read more

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Can Lyme disease cause an elevated CA125 reading?

Unknown: At this point in time there is a lot of discussion about this topic and many who feel there may be some association but there has been no known proof of an association of Lyme disease and an elevated CA 125. This is still being researched and nothing that can say a definite cause and affect. Hope this helps. ...Read more

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Should I be concerned about elevated ca-125 of 132 if I have a history of benign cysts?

CA-125: This marker is quite non-specific for cancer, particularly in pre-menopausal women. Any things that irritate the lining of the abdomen (such as cysts, endometriosis, and non-ovarian things as well) can prompt elevations in the range you have noted. Other means of screening for cancer however are also imperfect. If you are at high risk, other follow-up may be needed. ...Read more

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3 plus white cells in urine and ca125 elevated related?

Probably not but...: Here is a possibility; ca125 ( a bad screening test for ovarian cancer due to its lack of specificity) can become elevated with any inflammatory condition of the peritoneal lining of the abdomen. If the WBC in the urine reflect a UTI or infection of the kidney then it is possible the ca125 could be elevated. ...Read more

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My ca 125 blood test result slightly elevated, with a different reading 3 times, what could cause this to happen?

My ca 125 blood test result slightly elevated, with a different reading 3 times, what could cause this to happen?

Many causes: The ca-125 blood test is very sensitive-- in many cases it is too sensitive. In certain cases, it can be a marker of certain types of cancer. But in other patients, a modestly elevated ca-125 is not alarming. Visit with your doctor to better understand the details of your case. ...Read more

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I'm 32 years old and 7 weeks pregnant. My CA125 is over than 1400, I don't know what it means,and really scared. Can this affect to my pregnancy? Or because of my pregnancy so this ca125 is high? Is it normal Ca125 is over than 1400 for a pregnant woman?

Why tested?: Are you sure it was a CA125 or did you mean BHCG? CA-125 is a blood test done to assess the risk for ovarian cancer in specific cases. It is not a typical test to be done during pregnancy. During pregnancy it does not correlate well to cancer risk because of hormonal changes. If this test was ordered then there is likely a specific reason. Contact the ordering physician to interpret the results. ...Read more

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Ca125 high had ovarian cysts now hot sweats extreme fatigue what's the next step?

Next Step: It is unclear what would have lead to testing a Ca-125 in a 26 year old female. Now that it has been demosntrated to be elevated in the setting of ovarian cycsts further evaluation should take place. The likley next step would be pelvic imaging with an US to urther characterize the cysts. It should be noted that ca-125 is not specific and can elevated for many reasons, not just ovarian cancer. ...Read more

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I had uterine cancer. I had a partial hystroctromy at 24. My blood work came back with high amounts of CA 125. What typically are the next steps?

Work up: Two assumptions. Partial hysterectomy was adequate to Nall endometrial Ca. Also at your age ovary's were left behind. Ca125 is not a diagnostic marker intermittently elevated in ovarian Ca, liver disease and other neoplasms. It can only be used for monitoring known disease. Now work up with CAT scan of abdomen necessary and biopsies to be taken if any lesion seen. ...Read more

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My ca 125 result was 4.1. I have diabetes, stage 3 renal failure, high blood pressure, and sinus/allergy problems. Should i be concerned?

My ca 125 result was 4.1.  I have diabetes, stage 3 renal failure, high blood pressure, and sinus/allergy problems.  Should i be concerned?

Not really: Why was ca 125 ordered ? What are we looking for? Ask your doctor and yourself. Do you have any complaints of fullness, abdominal pain, bladder problem etc...? We ususally measure these markers after a diagnosis of cancer is made, but not before. Some markers go up slightly with renal failure. Control of diabetes, blood pressure and renal would be recommended. Thank you for asking. ...Read more

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My ca 125 range is 900 fluid in stomach & cyst in ovary..Biopsy done twice but doc r NT able 2 find why ca125 levels r high ..Cancer not diagnosed yt?

My ca 125 range is 900 fluid in stomach & cyst in ovary..Biopsy done twice but doc r NT able 2 find why ca125 levels r high ..Cancer not diagnosed yt?

Yipes!: Please see a qualified doctor soon! you need to be evaluated by a specialist( i would suggest a referral to gyn-oncologist). Your levels are worrisome, but, yes, there are possibly some non- cancer reasons for this. ...Read more

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Does an elevated ca 125 level always indicate that ovarian cancer is present?

Does an elevated ca 125 level always indicate that ovarian cancer is present?

No: Ca-125 may also be elevated in other cancers (i.e. Endometrial, fallopian tube, lung, breast and gastrointestinal cancers.) it can also be elevated with endometriosis or any inflammatory condition in the abdominal area. ...Read more

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What does it mean when you have mildly elevated ca 125? I have a 15cm ovarian cyst. Does that mean its cancerous?

Nothing out of..: ...Context. Ca.125 is used to follow up response to treatment in patients with cancer of the ovary but a slightly elevated level can come from non malignant causes (and it can be normal even if there is cancer). It is not considered a screening test. Whoever ordered it probably had very valid reasons to do so and i'm sure he/she can explain its implications to you in the proper context. Best 2u. ...Read more