Doctor insights on:
How Many People Are Thalassemia Carriers
Millions: Thalassemia is likely the most common one-gene mutation in the world. Overall, an estimated 20-25 million people are carriers (1/300) (about 1/1000 in low-risk peoples, and about 1/30 in high-risk peoples). Low risk: japanese, korean, n. European caucasians, native canadians, native americans. High risk: mediterranean, middle eastern, south asian, south-east asian (western pacific rim), caribbean. ...Read moreSee 1 more doctor answer
I have a friend who is a carrier of thalassemia. The girl he intends to marry is also a carrier. Does this mean they can't have children?
Not infertile: But they have 25% chance that any child will have full blown thalassemia major which is devastating, 50% that child will also be carrier & only 25% child will be thalassemia major or carrier free. They have as much chance of having children as any other couple, but is it worth it? ...Read moreSee 2 more doctor answers
If someone with thalassemia trait were to donate blood, would the recipients of that blood be carriers?
No: The donated blood does not alter the recipients system in the long term.The blood cells each have a lifespan approaching 90-100 days after release, then they are broken down in the body and recycled. Blood donation helps a patient catch up with blood losses in the short term and provide stability of the system while it heals. ...Read moreSee 2 more doctor answers
If one if rhe parents is a thalassemia carrier and the other is normal, all of their kids will get thalassemia?
I am Thalassemia carier and Rh+ blood type, my wife is Rh- and no Thalassemia. If Rh sensitized, will us have problem to get baby?
Rh incompatibiliy: if the baby has Rh +, the baby can have hemolysis ( destruction of the RBC- from the antibody carried by the mother-due to this rh incompatibility). the baby can become anemic and jaundice etc. It however can be prevented- by giving rhogam to the mother during and immediately after delivery. you need to talk and discuss in detail with her OB about this. ...Read moreSee 1 more doctor answer
I'm a beta minor thalassemia carrier. And my soon to be wife is a beta minor as well. Are there treatments to reduce the risk of getting a beta major?
Rule of inheritance: Your chance of a child with homozygous beta thalassemia are 1 in 4, for heterogeneous thalassemia (thalassemia trait) are 1 in 2, and the odds are 1 in 4 for a normal hemoglobin profile. There are procedures commercially available to eliminate the risk of beta thal major if your philosophy allows for it. We can discuss further; www.healthtap.com/dr-nnebe ...Read more
Avoid 2 bad genes: One way to avoid having a child who inherited a bad trait, is to make sure that NOT both parents carry genes for that bad trait. So, a woman carrying a thalassemia gene (beta mutations are on chromosome 16, or alpha on 11) wants to marry a man with NO thalassemia mutations. Likewise, a man with G6PD (on chromosome X) wants to marry a woman with no G6PD. A doctor can check both the man and woman. ...Read more
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